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The map label for this gene is arlR [H]

Identifier: 138895736

GI number: 138895736

Start: 2228719

End: 2229393

Strand: Reverse

Name: arlR [H]

Synonym: GTNG_2092

Alternate gene names: 138895736

Gene position: 2229393-2228719 (Counterclockwise)

Preceding gene: 138895737

Following gene: 138895735

Centisome position: 62.79

GC content: 49.48

Gene sequence:

>675_bases
ATGAATGGACGGATTTTATTGGTCGAAGATGAAGCAGGGTTGGCTCGCTTTTTGGAACTTGACTTGATGCATGAAGGATT
CGATGTGCATGTATGCGGAGATGGGCGCGAAGGGCTTGAGCTCGCTCTCTCTGAACCGTGGGATCTCATTTTACTTGATG
TTATGCTGCCAAGCTTAAACGGCATGGAAGTCTGCCGGCGCATTCGGGCGGCGAAATCGACGCCAATCATCATGATCACG
GCGCGCGACAGCGTATTTGATCGCGTCATGGGGTTGGATAACGGAGCAGATGACTATATTGTCAAGCCGTTTGCGATTGA
AGAACTTCTCGCCCGCATCCGCGCTTTGTTTCGCCGCGTTCATCCTGAATCGGGCGGACAAGTGTTGACGTTTAAAGACT
TAGTCGTCGATATGCAGGCGCGTACGGTCAAAAAAGGGAATGCGTTTATCGAATTGACGAAACGTGAGTATGATTTGCTC
GTCGCCTTTATGCAAAATATCAATGTTGTGTTGACGCGTGATTTGCTACTTGAGAAAGTATGGGGATTTGACACTGAGGT
GGAGACGAATGTTGTGGACGTCTATGTCCGCTATTTACGGCAAAAGCTTGACGAACACAATAAAGAGCGGTACATCCAAA
CGGTGCGCGGCGCGGGATATGTGATGCGGCCATGA

Upstream 100 bases:

>100_bases
TTTCGAAGGCCGGCCGCCGCCGCCGGTTCGCTTTTGTAGTAAAATTGAATTAAGTCCGGAACGGGAAAAGAAAATAGACG
CAGGAGATGAGGAATGGCCG

Downstream 100 bases:

>100_bases
AACGACTTCGCCTCCACCGTCTGTCGTTGAAAGGGAAGCTGACCGTTTTATCCGCCGGCGCGATTTTTATTACGTATTTT
ATTTTCACATTTTTGCAATA

Product: two-component response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 224; Mature: 224

Protein sequence:

>224_residues
MNGRILLVEDEAGLARFLELDLMHEGFDVHVCGDGREGLELALSEPWDLILLDVMLPSLNGMEVCRRIRAAKSTPIIMIT
ARDSVFDRVMGLDNGADDYIVKPFAIEELLARIRALFRRVHPESGGQVLTFKDLVVDMQARTVKKGNAFIELTKREYDLL
VAFMQNINVVLTRDLLLEKVWGFDTEVETNVVDVYVRYLRQKLDEHNKERYIQTVRGAGYVMRP

Sequences:

>Translated_224_residues
MNGRILLVEDEAGLARFLELDLMHEGFDVHVCGDGREGLELALSEPWDLILLDVMLPSLNGMEVCRRIRAAKSTPIIMIT
ARDSVFDRVMGLDNGADDYIVKPFAIEELLARIRALFRRVHPESGGQVLTFKDLVVDMQARTVKKGNAFIELTKREYDLL
VAFMQNINVVLTRDLLLEKVWGFDTEVETNVVDVYVRYLRQKLDEHNKERYIQTVRGAGYVMRP
>Mature_224_residues
MNGRILLVEDEAGLARFLELDLMHEGFDVHVCGDGREGLELALSEPWDLILLDVMLPSLNGMEVCRRIRAAKSTPIIMIT
ARDSVFDRVMGLDNGADDYIVKPFAIEELLARIRALFRRVHPESGGQVLTFKDLVVDMQARTVKKGNAFIELTKREYDLL
VAFMQNINVVLTRDLLLEKVWGFDTEVETNVVDVYVRYLRQKLDEHNKERYIQTVRGAGYVMRP

Specific function: Member of the two-component regulatory system ArlS/ArlR involved in the regulation of adhesion, autolysis, multidrug resistance and virulence [H]

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI87082012, Length=217, Percent_Identity=41.0138248847926, Blast_Score=176, Evalue=1e-45,
Organism=Escherichia coli, GI1786784, Length=223, Percent_Identity=43.0493273542601, Blast_Score=170, Evalue=9e-44,
Organism=Escherichia coli, GI1786599, Length=224, Percent_Identity=40.625, Blast_Score=156, Evalue=1e-39,
Organism=Escherichia coli, GI1789402, Length=220, Percent_Identity=36.8181818181818, Blast_Score=142, Evalue=2e-35,
Organism=Escherichia coli, GI1786911, Length=218, Percent_Identity=37.1559633027523, Blast_Score=138, Evalue=3e-34,
Organism=Escherichia coli, GI1790552, Length=220, Percent_Identity=39.0909090909091, Blast_Score=137, Evalue=4e-34,
Organism=Escherichia coli, GI1789809, Length=231, Percent_Identity=36.7965367965368, Blast_Score=135, Evalue=3e-33,
Organism=Escherichia coli, GI2367329, Length=227, Percent_Identity=38.3259911894273, Blast_Score=125, Evalue=2e-30,
Organism=Escherichia coli, GI1790860, Length=222, Percent_Identity=35.1351351351351, Blast_Score=125, Evalue=3e-30,
Organism=Escherichia coli, GI1788394, Length=221, Percent_Identity=33.4841628959276, Blast_Score=122, Evalue=2e-29,
Organism=Escherichia coli, GI1787375, Length=222, Percent_Identity=35.1351351351351, Blast_Score=120, Evalue=8e-29,
Organism=Escherichia coli, GI1787229, Length=229, Percent_Identity=32.7510917030568, Blast_Score=118, Evalue=3e-28,
Organism=Escherichia coli, GI145693140, Length=232, Percent_Identity=32.3275862068966, Blast_Score=104, Evalue=5e-24,
Organism=Escherichia coli, GI1790863, Length=226, Percent_Identity=29.2035398230088, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI1788550, Length=157, Percent_Identity=29.9363057324841, Blast_Score=75, Evalue=2e-15,
Organism=Escherichia coli, GI1790437, Length=118, Percent_Identity=30.5084745762712, Blast_Score=63, Evalue=2e-11,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR016032
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 25654; Mature: 25654

Theoretical pI: Translated: 5.04; Mature: 5.04

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00217 SUGAR_TRANSPORT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNGRILLVEDEAGLARFLELDLMHEGFDVHVCGDGREGLELALSEPWDLILLDVMLPSLN
CCCEEEEEECCCHHHHHHHHHHHHCCCEEEEECCCCCCCEEECCCCHHHEEHHHHHCCCC
GMEVCRRIRAAKSTPIIMITARDSVFDRVMGLDNGADDYIVKPFAIEELLARIRALFRRV
HHHHHHHHHHCCCCCEEEEEECHHHHHHHHCCCCCCCCCEECHHHHHHHHHHHHHHHHHH
HPESGGQVLTFKDLVVDMQARTVKKGNAFIELTKREYDLLVAFMQNINVVLTRDLLLEKV
CCCCCCEEEEHHHHHHHHHHHHHHCCCEEEEEEHHHHHHHHHHHHCCCEEEHHHHHHHHH
WGFDTEVETNVVDVYVRYLRQKLDEHNKERYIQTVRGAGYVMRP
HCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCEEECC
>Mature Secondary Structure
MNGRILLVEDEAGLARFLELDLMHEGFDVHVCGDGREGLELALSEPWDLILLDVMLPSLN
CCCEEEEEECCCHHHHHHHHHHHHCCCEEEEECCCCCCCEEECCCCHHHEEHHHHHCCCC
GMEVCRRIRAAKSTPIIMITARDSVFDRVMGLDNGADDYIVKPFAIEELLARIRALFRRV
HHHHHHHHHHCCCCCEEEEEECHHHHHHHHCCCCCCCCCEECHHHHHHHHHHHHHHHHHH
HPESGGQVLTFKDLVVDMQARTVKKGNAFIELTKREYDLLVAFMQNINVVLTRDLLLEKV
CCCCCCEEEEHHHHHHHHHHHHHHCCCEEEEEEHHHHHHHHHHHHCCCEEEHHHHHHHHH
WGFDTEVETNVVDVYVRYLRQKLDEHNKERYIQTVRGAGYVMRP
HCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA