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The map label for this gene is arlS [H]

Identifier: 138895735

GI number: 138895735

Start: 2227325

End: 2228722

Strand: Reverse

Name: arlS [H]

Synonym: GTNG_2091

Alternate gene names: 138895735

Gene position: 2228722-2227325 (Counterclockwise)

Preceding gene: 138895736

Following gene: 138895734

Centisome position: 62.78

GC content: 49.21

Gene sequence:

>1398_bases
ATGAAACGACTTCGCCTCCACCGTCTGTCGTTGAAAGGGAAGCTGACCGTTTTATCCGCCGGCGCGATTTTTATTACGTA
TTTTATTTTCACATTTTTGCAATACCATATTGTGAGGCAATGGCTGCTCAACGAAGAAGAAAAAACGATGGAACAAACTG
TGATAGAAATTGAAACTTATTACGCTGAAAAACGTAATGTATCATGGGAAGATATTCGCCGCAGCCGTTCGTTTCTCGAA
AAACTGAATGAGCGCTATCAGCTCATTCGTGTCACCGACCGTGACGGAAACGTTATCGTCTCTGTTTCCAACGGTGCGAC
AGTATCGCTGTCAACAGGCGGCGTGCCTGACAAGCTGAAAATGGATGAACACTTCATCAACAATGAGCGGTTTTTGTTGC
TTCGCCAACCGCTTCATATCGGGGACTTGTCTGGGACGATTGAAGTCGCCCGCCGATTGACGAAATTCGAACAAGTGACG
AACACGCTATTTGTCATTATGACAGTGCTTGGTTTTGCGGCCATGGCAGCGAGCGCGCTCGCCGGACGGCTTGTGGCACA
AAGCTTTATCCGGCCGTTGAAAACGTTGGCAAAAACGATGGCCGACATTAAAAACAACGGGTTAAAGCAGCGCATCGATG
TGCCTTCGGCGCGTGACGAGGTCACCGAGCTCATGATGATGTTCAACAGCATGATGGACGAAATTGAACGTTCATTTGCC
CTGCAGAAGCAGTTCGTCGAGGATGCGTCCCATGAATTGCGGACACCGCTAGCCATTTTGCAAGGCCATCTTTCCTTGTT
GCAGCGGTGGGGCAAGCACAATCCAGAGATTTTGGAAGAATCGCTTGAGGCGGCGGTGAAAGAGGCAGAACGGCTGAAGC
GCCTTGTTCTTGAGCTGCTTGATCTATCGCGTACCGAGGAGATGGAAGTGCCAAAAGAGCTCACGCCTATTGATGCTGCC
GCAGCCATCGGGCAAATTGTGAAAAATTTCCGTATTTTGCACCCGGATTTTCAATCCATTGTTGATCAACCGGAAAAACC
GTTGGCGCGCGTAGCGATCGCAAAACATCATTTTGAACAATTGCTGTTCATTTTGCTTGACAATGCGGTAAAATATTCTC
AACAGGTCAAAAAAATCGCTCTTTCGTTGCGCGAGGAAGGATCGTTTGTTACGGTGGCCATCCGCGACTATGGTATCGGC
ATTCCACGCGAAGAGCTGGAAAACGTCTTTTTACGTTTTTATCGCGTCGATAAGGCGCGCAGCCGCGAACAAGGCGGCGC
CGGGCTCGGTCTTTCGATCGCCAAGGAAATGATCGATAAATACGGCGGGCAAATTACGATGGAAAGCGAAGCCGGTCAAG
GAACAACGGTTGAGCTCGCCATTCCGAAAGCAGAATAG

Upstream 100 bases:

>100_bases
TTGTGGACGTCTATGTCCGCTATTTACGGCAAAAGCTTGACGAACACAATAAAGAGCGGTACATCCAAACGGTGCGCGGC
GCGGGATATGTGATGCGGCC

Downstream 100 bases:

>100_bases
GAGAGGAGTTGAGACAATGGGGCATTTTCATGAAGAAGAGGCGGTGGGCAAAAAAGCGATTCATCATGTCGTGGAGAAGT
TCCGCAAGCGCGGAGTGAAA

Product: two-component sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 465; Mature: 465

Protein sequence:

>465_residues
MKRLRLHRLSLKGKLTVLSAGAIFITYFIFTFLQYHIVRQWLLNEEEKTMEQTVIEIETYYAEKRNVSWEDIRRSRSFLE
KLNERYQLIRVTDRDGNVIVSVSNGATVSLSTGGVPDKLKMDEHFINNERFLLLRQPLHIGDLSGTIEVARRLTKFEQVT
NTLFVIMTVLGFAAMAASALAGRLVAQSFIRPLKTLAKTMADIKNNGLKQRIDVPSARDEVTELMMMFNSMMDEIERSFA
LQKQFVEDASHELRTPLAILQGHLSLLQRWGKHNPEILEESLEAAVKEAERLKRLVLELLDLSRTEEMEVPKELTPIDAA
AAIGQIVKNFRILHPDFQSIVDQPEKPLARVAIAKHHFEQLLFILLDNAVKYSQQVKKIALSLREEGSFVTVAIRDYGIG
IPREELENVFLRFYRVDKARSREQGGAGLGLSIAKEMIDKYGGQITMESEAGQGTTVELAIPKAE

Sequences:

>Translated_465_residues
MKRLRLHRLSLKGKLTVLSAGAIFITYFIFTFLQYHIVRQWLLNEEEKTMEQTVIEIETYYAEKRNVSWEDIRRSRSFLE
KLNERYQLIRVTDRDGNVIVSVSNGATVSLSTGGVPDKLKMDEHFINNERFLLLRQPLHIGDLSGTIEVARRLTKFEQVT
NTLFVIMTVLGFAAMAASALAGRLVAQSFIRPLKTLAKTMADIKNNGLKQRIDVPSARDEVTELMMMFNSMMDEIERSFA
LQKQFVEDASHELRTPLAILQGHLSLLQRWGKHNPEILEESLEAAVKEAERLKRLVLELLDLSRTEEMEVPKELTPIDAA
AAIGQIVKNFRILHPDFQSIVDQPEKPLARVAIAKHHFEQLLFILLDNAVKYSQQVKKIALSLREEGSFVTVAIRDYGIG
IPREELENVFLRFYRVDKARSREQGGAGLGLSIAKEMIDKYGGQITMESEAGQGTTVELAIPKAE
>Mature_465_residues
MKRLRLHRLSLKGKLTVLSAGAIFITYFIFTFLQYHIVRQWLLNEEEKTMEQTVIEIETYYAEKRNVSWEDIRRSRSFLE
KLNERYQLIRVTDRDGNVIVSVSNGATVSLSTGGVPDKLKMDEHFINNERFLLLRQPLHIGDLSGTIEVARRLTKFEQVT
NTLFVIMTVLGFAAMAASALAGRLVAQSFIRPLKTLAKTMADIKNNGLKQRIDVPSARDEVTELMMMFNSMMDEIERSFA
LQKQFVEDASHELRTPLAILQGHLSLLQRWGKHNPEILEESLEAAVKEAERLKRLVLELLDLSRTEEMEVPKELTPIDAA
AAIGQIVKNFRILHPDFQSIVDQPEKPLARVAIAKHHFEQLLFILLDNAVKYSQQVKKIALSLREEGSFVTVAIRDYGIG
IPREELENVFLRFYRVDKARSREQGGAGLGLSIAKEMIDKYGGQITMESEAGQGTTVELAIPKAE

Specific function: Member of the two-component regulatory system ArlS/ArlR involved in the regulation of adhesion, autolysis, multidrug resistance and virulence. ArlS probably functions as a sensor protein kinase which is autophosphorylated at a histidine residue and transf

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1786783, Length=277, Percent_Identity=27.4368231046931, Blast_Score=110, Evalue=3e-25,
Organism=Escherichia coli, GI1788393, Length=283, Percent_Identity=28.2685512367491, Blast_Score=105, Evalue=7e-24,
Organism=Escherichia coli, GI1790346, Length=274, Percent_Identity=28.4671532846715, Blast_Score=104, Evalue=1e-23,
Organism=Escherichia coli, GI145693157, Length=238, Percent_Identity=29.4117647058824, Blast_Score=102, Evalue=5e-23,
Organism=Escherichia coli, GI1786600, Length=231, Percent_Identity=29.4372294372294, Blast_Score=101, Evalue=9e-23,
Organism=Escherichia coli, GI48994928, Length=236, Percent_Identity=28.8135593220339, Blast_Score=92, Evalue=7e-20,
Organism=Escherichia coli, GI1788713, Length=256, Percent_Identity=29.296875, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1787894, Length=248, Percent_Identity=27.4193548387097, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1786912, Length=224, Percent_Identity=28.125, Blast_Score=79, Evalue=8e-16,
Organism=Escherichia coli, GI1788279, Length=279, Percent_Identity=24.7311827956989, Blast_Score=78, Evalue=9e-16,
Organism=Escherichia coli, GI1789149, Length=245, Percent_Identity=26.1224489795918, Blast_Score=77, Evalue=3e-15,
Organism=Escherichia coli, GI1790861, Length=231, Percent_Identity=28.5714285714286, Blast_Score=76, Evalue=4e-15,
Organism=Escherichia coli, GI1790436, Length=242, Percent_Identity=27.2727272727273, Blast_Score=74, Evalue=3e-14,
Organism=Escherichia coli, GI87082128, Length=234, Percent_Identity=29.0598290598291, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI1789403, Length=291, Percent_Identity=26.8041237113402, Blast_Score=67, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 52894; Mature: 52894

Theoretical pI: Translated: 7.42; Mature: 7.42

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRLRLHRLSLKGKLTVLSAGAIFITYFIFTFLQYHIVRQWLLNEEEKTMEQTVIEIETY
CCCCHHHHHCCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
YAEKRNVSWEDIRRSRSFLEKLNERYQLIRVTDRDGNVIVSVSNGATVSLSTGGVPDKLK
HHHHCCCCHHHHHHHHHHHHHHHHHEEEEEEEECCCCEEEEECCCCEEEEECCCCCCCCC
MDEHFINNERFLLLRQPLHIGDLSGTIEVARRLTKFEQVTNTLFVIMTVLGFAAMAASAL
CHHHHCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AGRLVAQSFIRPLKTLAKTMADIKNNGLKQRIDVPSARDEVTELMMMFNSMMDEIERSFA
HHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
LQKQFVEDASHELRTPLAILQGHLSLLQRWGKHNPEILEESLEAAVKEAERLKRLVLELL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
DLSRTEEMEVPKELTPIDAAAAIGQIVKNFRILHPDFQSIVDQPEKPLARVAIAKHHFEQ
HCCCCHHCCCCCCCCCHHHHHHHHHHHHHHEECCCCHHHHHCCCCHHHHHHHHHHHHHHH
LLFILLDNAVKYSQQVKKIALSLREEGSFVTVAIRDYGIGIPREELENVFLRFYRVDKAR
HHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHH
SREQGGAGLGLSIAKEMIDKYGGQITMESEAGQGTTVELAIPKAE
HHCCCCCCCCHHHHHHHHHHHCCEEEEECCCCCCCEEEEEECCCC
>Mature Secondary Structure
MKRLRLHRLSLKGKLTVLSAGAIFITYFIFTFLQYHIVRQWLLNEEEKTMEQTVIEIETY
CCCCHHHHHCCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
YAEKRNVSWEDIRRSRSFLEKLNERYQLIRVTDRDGNVIVSVSNGATVSLSTGGVPDKLK
HHHHCCCCHHHHHHHHHHHHHHHHHEEEEEEEECCCCEEEEECCCCEEEEECCCCCCCCC
MDEHFINNERFLLLRQPLHIGDLSGTIEVARRLTKFEQVTNTLFVIMTVLGFAAMAASAL
CHHHHCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AGRLVAQSFIRPLKTLAKTMADIKNNGLKQRIDVPSARDEVTELMMMFNSMMDEIERSFA
HHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
LQKQFVEDASHELRTPLAILQGHLSLLQRWGKHNPEILEESLEAAVKEAERLKRLVLELL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
DLSRTEEMEVPKELTPIDAAAAIGQIVKNFRILHPDFQSIVDQPEKPLARVAIAKHHFEQ
HCCCCHHCCCCCCCCCHHHHHHHHHHHHHHEECCCCHHHHHCCCCHHHHHHHHHHHHHHH
LLFILLDNAVKYSQQVKKIALSLREEGSFVTVAIRDYGIGIPREELENVFLRFYRVDKAR
HHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHH
SREQGGAGLGLSIAKEMIDKYGGQITMESEAGQGTTVELAIPKAE
HHCCCCCCCCHHHHHHHHHHHCCEEEEECCCCCCCEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA