Click here to switch to the map view.

The map label for this gene is cytR [H]

Identifier: 138895661

GI number: 138895661

Start: 2135008

End: 2136012

Strand: Reverse

Name: cytR [H]

Synonym: GTNG_2017

Alternate gene names: 138895661

Gene position: 2136012-2135008 (Counterclockwise)

Preceding gene: 138895662

Following gene: 138895660

Centisome position: 60.16

GC content: 54.53

Gene sequence:

>1005_bases
ATGGCAAGCATAAAAGACGTAGCGAAACGGGCAAACGTATCGACGGCGACCGTGTCGCGCGTATTGCGCAACGCCGGCAA
CGTCACCGAAGAGACGAAGCAACGCGTGCTCGAGGCGATCGAAGCGCTCAACTACCAGCCGAACGTGCTTGGCCGGTATT
TGCGTCGCATGGAAACAGAAACGGTGCTCGTTGTCGTGCCCGATATTACGAACCCGTTTTTTTCGAAGGTGCTGCGCGGC
ATTGAAGCGGTTGCTCTCGAACACGGGTACCAAGTGCTGCTTGGCGATACGCAAAATGATGCTCAGCTTGAGGAGCAATA
TTTGAATGTACTGCCGCAAAGGCAAGTAGACGGGATGATTTTTTTAACTGCTCGCATCCGCAAAGAACTGATGGAAGAAA
TGGCGCGGCAGTTTCCGATTGTCCTCGCGTGCGAATATTTGGAGGGGACCGATATCCCGACCGTATCGATCGACAACATT
AGCAGCGCCCGCAAGGCAACGGAACATTTGATTCATCTCGGCCATCGCCGCATCGCCCATCTGTCCGGCCCGATGGATGT
CATTTTGGGGCGAGATCGGCTGCGCGGCTATTATCAAGCGTTGGCGCAGCATGGAATCGATGCCGACCCAGCACTCGTGC
AAGAAGGTGACTTTTCCTACGAATCGGGATACAACATGACATTGAAGTTGCTCGCCCTTGAAGAACCACCGACAGCGATT
TTCGCCGCCAATGACGAGATGGCGATCGGGGCGATCAAAGCGATCCGTCACCGCGGTGGTCGTGTTCCAGATGATGTCGC
CGTTGTCGGGTTTGACGATATCCAAATGGCCTCGATTTTTGAACCTGCTGTCACGACGATCGCCCAGCCGACGTTTGAGA
TCGGCCAAAAAGCGATGGAGCTTTTGCTTCAGCTGATTGAAGGGAACGAGGTCAGCCGCCGTCAGCTTGTTTTGCCTGAT
CACCTTGTCATTCGTGAGTCATGCGGGGGGAAGTGCTCGGTTTGA

Upstream 100 bases:

>100_bases
TTGAAGATTTTTAATCGTATGAAAAGGGGACTTGACAACGGTACTAAGCTTCATATACGATGGTAATGTAATCGATTACA
TATTTGAGAGGATTTCATCT

Downstream 100 bases:

>100_bases
TGAAAGCGCTCCCCTCGTTGGCGGCGGAGAATAGGCGGATTTTTTTGTAAGGGTGATGTAATCGATTACATCACTCGATG
TGTTGCTTCAGATAAGTGGC

Product: transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 334; Mature: 333

Protein sequence:

>334_residues
MASIKDVAKRANVSTATVSRVLRNAGNVTEETKQRVLEAIEALNYQPNVLGRYLRRMETETVLVVVPDITNPFFSKVLRG
IEAVALEHGYQVLLGDTQNDAQLEEQYLNVLPQRQVDGMIFLTARIRKELMEEMARQFPIVLACEYLEGTDIPTVSIDNI
SSARKATEHLIHLGHRRIAHLSGPMDVILGRDRLRGYYQALAQHGIDADPALVQEGDFSYESGYNMTLKLLALEEPPTAI
FAANDEMAIGAIKAIRHRGGRVPDDVAVVGFDDIQMASIFEPAVTTIAQPTFEIGQKAMELLLQLIEGNEVSRRQLVLPD
HLVIRESCGGKCSV

Sequences:

>Translated_334_residues
MASIKDVAKRANVSTATVSRVLRNAGNVTEETKQRVLEAIEALNYQPNVLGRYLRRMETETVLVVVPDITNPFFSKVLRG
IEAVALEHGYQVLLGDTQNDAQLEEQYLNVLPQRQVDGMIFLTARIRKELMEEMARQFPIVLACEYLEGTDIPTVSIDNI
SSARKATEHLIHLGHRRIAHLSGPMDVILGRDRLRGYYQALAQHGIDADPALVQEGDFSYESGYNMTLKLLALEEPPTAI
FAANDEMAIGAIKAIRHRGGRVPDDVAVVGFDDIQMASIFEPAVTTIAQPTFEIGQKAMELLLQLIEGNEVSRRQLVLPD
HLVIRESCGGKCSV
>Mature_333_residues
ASIKDVAKRANVSTATVSRVLRNAGNVTEETKQRVLEAIEALNYQPNVLGRYLRRMETETVLVVVPDITNPFFSKVLRGI
EAVALEHGYQVLLGDTQNDAQLEEQYLNVLPQRQVDGMIFLTARIRKELMEEMARQFPIVLACEYLEGTDIPTVSIDNIS
SARKATEHLIHLGHRRIAHLSGPMDVILGRDRLRGYYQALAQHGIDADPALVQEGDFSYESGYNMTLKLLALEEPPTAIF
AANDEMAIGAIKAIRHRGGRVPDDVAVVGFDDIQMASIFEPAVTTIAQPTFEIGQKAMELLLQLIEGNEVSRRQLVLPDH
LVIRESCGGKCSV

Specific function: This protein negatively controls the transcription initiation of genes such as deoCABD, udp, and cdd encoding catabolizing enzymes and nupC, nupG, and tsx encoding transporting and pore-forming proteins. Binds cytidine and adenosine as effectors [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lacI-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1790369, Length=327, Percent_Identity=42.2018348623853, Blast_Score=279, Evalue=2e-76,
Organism=Escherichia coli, GI1790194, Length=330, Percent_Identity=35.1515151515151, Blast_Score=203, Evalue=1e-53,
Organism=Escherichia coli, GI1787948, Length=309, Percent_Identity=35.2750809061489, Blast_Score=198, Evalue=4e-52,
Organism=Escherichia coli, GI1789068, Length=316, Percent_Identity=36.0759493670886, Blast_Score=182, Evalue=3e-47,
Organism=Escherichia coli, GI1789202, Length=291, Percent_Identity=35.3951890034364, Blast_Score=175, Evalue=5e-45,
Organism=Escherichia coli, GI1787580, Length=331, Percent_Identity=32.3262839879154, Blast_Score=174, Evalue=7e-45,
Organism=Escherichia coli, GI1788474, Length=332, Percent_Identity=31.9277108433735, Blast_Score=172, Evalue=4e-44,
Organism=Escherichia coli, GI1786540, Length=329, Percent_Identity=33.1306990881459, Blast_Score=153, Evalue=1e-38,
Organism=Escherichia coli, GI48994940, Length=322, Percent_Identity=32.2981366459627, Blast_Score=145, Evalue=5e-36,
Organism=Escherichia coli, GI1790715, Length=325, Percent_Identity=25.2307692307692, Blast_Score=124, Evalue=6e-30,
Organism=Escherichia coli, GI1787906, Length=334, Percent_Identity=29.0419161676647, Blast_Score=123, Evalue=2e-29,
Organism=Escherichia coli, GI1789456, Length=320, Percent_Identity=27.5, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI1790689, Length=321, Percent_Identity=24.2990654205607, Blast_Score=93, Evalue=2e-20,
Organism=Escherichia coli, GI1786268, Length=309, Percent_Identity=23.3009708737864, Blast_Score=88, Evalue=9e-19,
Organism=Escherichia coli, GI1790192, Length=278, Percent_Identity=26.978417266187, Blast_Score=87, Evalue=2e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000843
- InterPro:   IPR010982
- InterPro:   IPR001761 [H]

Pfam domain/function: PF00356 LacI; PF00532 Peripla_BP_1 [H]

EC number: NA

Molecular weight: Translated: 37044; Mature: 36913

Theoretical pI: Translated: 5.13; Mature: 5.13

Prosite motif: PS00356 HTH_LACI_1 ; PS50932 HTH_LACI_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASIKDVAKRANVSTATVSRVLRNAGNVTEETKQRVLEAIEALNYQPNVLGRYLRRMETE
CCCHHHHHHHCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCC
TVLVVVPDITNPFFSKVLRGIEAVALEHGYQVLLGDTQNDAQLEEQYLNVLPQRQVDGMI
EEEEEECCCCCHHHHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHCCCCCCCCEE
FLTARIRKELMEEMARQFPIVLACEYLEGTDIPTVSIDNISSARKATEHLIHLGHRRIAH
EEHHHHHHHHHHHHHHHCCEEEEEECCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHH
LSGPMDVILGRDRLRGYYQALAQHGIDADPALVQEGDFSYESGYNMTLKLLALEEPPTAI
HCCCHHHHHCHHHHHHHHHHHHHCCCCCCCCHHCCCCCCCCCCCCEEEEEEEECCCCCEE
FAANDEMAIGAIKAIRHRGGRVPDDVAVVGFDDIQMASIFEPAVTTIAQPTFEIGQKAME
EECCCCHHHHHHHHHHHCCCCCCCCEEEEECCCHHHHHHHHHHHHHHCCCHHHHHHHHHH
LLLQLIEGNEVSRRQLVLPDHLVIRESCGGKCSV
HHHHHHCCCCCCCCEEECCCHHEEECCCCCCCCC
>Mature Secondary Structure 
ASIKDVAKRANVSTATVSRVLRNAGNVTEETKQRVLEAIEALNYQPNVLGRYLRRMETE
CCHHHHHHHCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCC
TVLVVVPDITNPFFSKVLRGIEAVALEHGYQVLLGDTQNDAQLEEQYLNVLPQRQVDGMI
EEEEEECCCCCHHHHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHCCCCCCCCEE
FLTARIRKELMEEMARQFPIVLACEYLEGTDIPTVSIDNISSARKATEHLIHLGHRRIAH
EEHHHHHHHHHHHHHHHCCEEEEEECCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHH
LSGPMDVILGRDRLRGYYQALAQHGIDADPALVQEGDFSYESGYNMTLKLLALEEPPTAI
HCCCHHHHHCHHHHHHHHHHHHHCCCCCCCCHHCCCCCCCCCCCCEEEEEEEECCCCCEE
FAANDEMAIGAIKAIRHRGGRVPDDVAVVGFDDIQMASIFEPAVTTIAQPTFEIGQKAME
EECCCCHHHHHHHHHHHCCCCCCCCEEEEECCCHHHHHHHHHHHHHHCCCHHHHHHHHHH
LLLQLIEGNEVSRRQLVLPDHLVIRESCGGKCSV
HHHHHHCCCCCCCCEEECCCHHEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]