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The map label for this gene is paaH [H]

Identifier: 138895568

GI number: 138895568

Start: 2045001

End: 2045864

Strand: Reverse

Name: paaH [H]

Synonym: GTNG_1921

Alternate gene names: 138895568

Gene position: 2045864-2045001 (Counterclockwise)

Preceding gene: 138895569

Following gene: 138895567

Centisome position: 57.62

GC content: 49.88

Gene sequence:

>864_bases
ATGATCGAACGTCTTGTTGTTGTCGGCAGCGGCGTGATGGGGAGAGGAATTGCTTACGTTGGCGCTGTCGGAGGGTTTCA
GACGACGTTGGTTGATGTGAAGCAAGAACAACTAGACAGTGCTCGGAACGAAATCACTTCCATTTTTGAACAAGCGGTCG
CTCGAGGAAAATTGACGCCTGGCGCGCGCCAAGAAGCGGAGACGCGCCTTTCGTATTCGCTTGATCTAGTTGCTGCGGTA
CAGGGAGCTGATTTGGTTATTGAGGCAGTACCGGAAAAGCTAGAGTTGAAAAAACAAGTATTTGAGACAATCGATGCTCA
TGCGCCGGCATCTTGTTATTTGGCCACCAATACGTCCACGATGAGCCCGACGGAGATCGGCTCGTTTACGAAGCGGCCGG
ATCGAGTGATCGCCATGCACTTTTTCAACCCGGTGCATAAAATGAAGCTCGTTGAAATTATCCGCGGCTTGGAGACGAGT
GATGAGACGGCGCAAGTCGTGAAAGAAGTCGCTGAGCGAATGGGGAAAGAGACCGTTGTTGTCAATGAGTTTCCGGGGTT
TGTGACAAGCCGAATCAGCGCGCTTGTCGGTAATGAAGCGTTCTATATGCTTCAAGAAGGAGTGGGTACGCCGGAAGAAA
TCGATAAAGCCATTAAACTTGGCCTGAATTTTCCAATGGGCCCGTTTGAGCTGGCTGATTTAGTCGGGCTTGATACACGG
TTGAACAACTTAAAATATTTGCATGAAAAATTAGGTGAAAAGTATCGCCCAGCGCCGCTGCTTGAACAATACGTGAAGGC
CGGCCGTCTTGGCCGCAAAACTGGCCGTGGTGTCTATGATTATACGAATCGAGAAAACGACTGA

Upstream 100 bases:

>100_bases
CCATCGTTGTTGTTGGAAACGGTTCCGCCGTTTGGCGACGAGCATCCGACGACTTGCAGTGTTCACCGCTATACACGTGA
AATAGGAGAGGGGGAAGACG

Downstream 100 bases:

>100_bases
CAAGCCGATCGCTCGGCTACGGTTGGCAAGGGGGAGAAAAGATGGGAAGAGAGGTTGTCATTGTTGATGCTGTGCGCACA
CCGATCGGCCGCTACAAAGG

Product: 3-hydroxybutyryl-CoA dehydrogenase

Products: NA

Alternate protein names: Beta-hydroxybutyryl-CoA dehydrogenase; BHBD [H]

Number of amino acids: Translated: 287; Mature: 287

Protein sequence:

>287_residues
MIERLVVVGSGVMGRGIAYVGAVGGFQTTLVDVKQEQLDSARNEITSIFEQAVARGKLTPGARQEAETRLSYSLDLVAAV
QGADLVIEAVPEKLELKKQVFETIDAHAPASCYLATNTSTMSPTEIGSFTKRPDRVIAMHFFNPVHKMKLVEIIRGLETS
DETAQVVKEVAERMGKETVVVNEFPGFVTSRISALVGNEAFYMLQEGVGTPEEIDKAIKLGLNFPMGPFELADLVGLDTR
LNNLKYLHEKLGEKYRPAPLLEQYVKAGRLGRKTGRGVYDYTNREND

Sequences:

>Translated_287_residues
MIERLVVVGSGVMGRGIAYVGAVGGFQTTLVDVKQEQLDSARNEITSIFEQAVARGKLTPGARQEAETRLSYSLDLVAAV
QGADLVIEAVPEKLELKKQVFETIDAHAPASCYLATNTSTMSPTEIGSFTKRPDRVIAMHFFNPVHKMKLVEIIRGLETS
DETAQVVKEVAERMGKETVVVNEFPGFVTSRISALVGNEAFYMLQEGVGTPEEIDKAIKLGLNFPMGPFELADLVGLDTR
LNNLKYLHEKLGEKYRPAPLLEQYVKAGRLGRKTGRGVYDYTNREND
>Mature_287_residues
MIERLVVVGSGVMGRGIAYVGAVGGFQTTLVDVKQEQLDSARNEITSIFEQAVARGKLTPGARQEAETRLSYSLDLVAAV
QGADLVIEAVPEKLELKKQVFETIDAHAPASCYLATNTSTMSPTEIGSFTKRPDRVIAMHFFNPVHKMKLVEIIRGLETS
DETAQVVKEVAERMGKETVVVNEFPGFVTSRISALVGNEAFYMLQEGVGTPEEIDKAIKLGLNFPMGPFELADLVGLDTR
LNNLKYLHEKLGEKYRPAPLLEQYVKAGRLGRKTGRGVYDYTNREND

Specific function: Butyrate/butanol-producing pathway. Phenylacetic acid aerobic catabolism. [C]

COG id: COG1250

COG function: function code I; 3-hydroxyacyl-CoA dehydrogenase

Gene ontology:

Cell location: Mitochondria or Peroxisomes [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI296179429, Length=289, Percent_Identity=35.6401384083045, Blast_Score=181, Evalue=9e-46,
Organism=Homo sapiens, GI20127408, Length=283, Percent_Identity=37.4558303886926, Blast_Score=172, Evalue=4e-43,
Organism=Homo sapiens, GI296179427, Length=306, Percent_Identity=33.6601307189542, Blast_Score=170, Evalue=1e-42,
Organism=Homo sapiens, GI68989263, Length=287, Percent_Identity=36.9337979094077, Blast_Score=161, Evalue=6e-40,
Organism=Homo sapiens, GI261878539, Length=287, Percent_Identity=36.9337979094077, Blast_Score=161, Evalue=6e-40,
Organism=Homo sapiens, GI115430219, Length=238, Percent_Identity=31.5126050420168, Blast_Score=112, Evalue=5e-25,
Organism=Escherichia coli, GI1787661, Length=282, Percent_Identity=39.7163120567376, Blast_Score=198, Evalue=4e-52,
Organism=Escherichia coli, GI1788682, Length=269, Percent_Identity=35.3159851301115, Blast_Score=140, Evalue=9e-35,
Organism=Escherichia coli, GI1790281, Length=267, Percent_Identity=32.5842696629214, Blast_Score=135, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI17549919, Length=287, Percent_Identity=36.2369337979094, Blast_Score=189, Evalue=2e-48,
Organism=Caenorhabditis elegans, GI17553560, Length=290, Percent_Identity=37.2413793103448, Blast_Score=181, Evalue=3e-46,
Organism=Caenorhabditis elegans, GI17563036, Length=287, Percent_Identity=34.8432055749129, Blast_Score=174, Evalue=4e-44,
Organism=Caenorhabditis elegans, GI25144276, Length=282, Percent_Identity=37.5886524822695, Blast_Score=172, Evalue=2e-43,
Organism=Caenorhabditis elegans, GI17508951, Length=282, Percent_Identity=37.5886524822695, Blast_Score=172, Evalue=2e-43,
Organism=Caenorhabditis elegans, GI17508953, Length=282, Percent_Identity=37.5886524822695, Blast_Score=172, Evalue=2e-43,
Organism=Caenorhabditis elegans, GI17558304, Length=282, Percent_Identity=36.1702127659575, Blast_Score=164, Evalue=4e-41,
Organism=Caenorhabditis elegans, GI71985923, Length=292, Percent_Identity=33.2191780821918, Blast_Score=159, Evalue=2e-39,
Organism=Caenorhabditis elegans, GI71985930, Length=292, Percent_Identity=28.7671232876712, Blast_Score=136, Evalue=1e-32,
Organism=Drosophila melanogaster, GI19921000, Length=281, Percent_Identity=35.2313167259786, Blast_Score=163, Evalue=1e-40,
Organism=Drosophila melanogaster, GI24583077, Length=281, Percent_Identity=35.2313167259786, Blast_Score=163, Evalue=1e-40,
Organism=Drosophila melanogaster, GI24583079, Length=281, Percent_Identity=35.2313167259786, Blast_Score=163, Evalue=1e-40,
Organism=Drosophila melanogaster, GI45549573, Length=241, Percent_Identity=31.9502074688797, Blast_Score=111, Evalue=5e-25,
Organism=Drosophila melanogaster, GI20129993, Length=240, Percent_Identity=26.6666666666667, Blast_Score=89, Evalue=4e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022694
- InterPro:   IPR006180
- InterPro:   IPR006176
- InterPro:   IPR006108
- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00725 3HCDH; PF02737 3HCDH_N [H]

EC number: =1.1.1.157 [H]

Molecular weight: Translated: 31596; Mature: 31596

Theoretical pI: Translated: 5.49; Mature: 5.49

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIERLVVVGSGVMGRGIAYVGAVGGFQTTLVDVKQEQLDSARNEITSIFEQAVARGKLTP
CCCEEEEECCCCHHCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
GARQEAETRLSYSLDLVAAVQGADLVIEAVPEKLELKKQVFETIDAHAPASCYLATNTST
CCHHHHHHHHHHHHHHHHHHCCCHHHHHHCCHHHHHHHHHHHHHHCCCCCEEEEEECCCC
MSPTEIGSFTKRPDRVIAMHFFNPVHKMKLVEIIRGLETSDETAQVVKEVAERMGKETVV
CCCHHHCCCCCCCCCEEEHHHHCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCEEE
VNEFPGFVTSRISALVGNEAFYMLQEGVGTPEEIDKAIKLGLNFPMGPFELADLVGLDTR
EECCCCHHHHHHHHHHCCHHHHHHHHCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHH
LNNLKYLHEKLGEKYRPAPLLEQYVKAGRLGRKTGRGVYDYTNREND
HHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCHHCCCCCCCCCCCCCC
>Mature Secondary Structure
MIERLVVVGSGVMGRGIAYVGAVGGFQTTLVDVKQEQLDSARNEITSIFEQAVARGKLTP
CCCEEEEECCCCHHCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
GARQEAETRLSYSLDLVAAVQGADLVIEAVPEKLELKKQVFETIDAHAPASCYLATNTST
CCHHHHHHHHHHHHHHHHHHCCCHHHHHHCCHHHHHHHHHHHHHHCCCCCEEEEEECCCC
MSPTEIGSFTKRPDRVIAMHFFNPVHKMKLVEIIRGLETSDETAQVVKEVAERMGKETVV
CCCHHHCCCCCCCCCEEEHHHHCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCEEE
VNEFPGFVTSRISALVGNEAFYMLQEGVGTPEEIDKAIKLGLNFPMGPFELADLVGLDTR
EECCCCHHHHHHHHHHCCHHHHHHHHCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHH
LNNLKYLHEKLGEKYRPAPLLEQYVKAGRLGRKTGRGVYDYTNREND
HHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8759838; 8969508; 9384377 [H]