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The map label for this gene is pdhA [H]

Identifier: 138895559

GI number: 138895559

Start: 2035451

End: 2036521

Strand: Reverse

Name: pdhA [H]

Synonym: GTNG_1912

Alternate gene names: 138895559

Gene position: 2036521-2035451 (Counterclockwise)

Preceding gene: 138895560

Following gene: 138895558

Centisome position: 57.36

GC content: 50.79

Gene sequence:

>1071_bases
ATGGAACGGGACTTTCCGATTTGGCAAGTATTGAATGAAGAAGGAACAGTAGTGCAGCCCGAGTATCGCGAACGAATAAC
AAAAGAATTGACGATGGTGATGTATCGCCATCTGATTCGTACGAGAACGTTTGATAGAAAATGTGTCAGTCTTCAACGGC
AAGGGCGCATCGGCACTTATGTGCCGTACGAAGGGCAAGAGGCATGTCAAGTTGGAAGTGCGCTAGCGCTCAACGATGAG
GATTGGATGTTTCCGACTTACCGCGATCACGGGGCGATGATGACGTTTGGCCGGTCTTTAGTGAACACACTTTTGTATTG
GAAGGGACGGACAGAAGGGTGTGTTCCGCCTGAAGGGAAAAAAATCGTTCCGCCGAGCGTTCCGATTGCCACGCAGCTTC
CCCATGCGGCGGGAGCAGCGTGTGCTGAGAAATGGAAGGGAACGAAAAATGCCGTCATTGTGTACTTCGGGGATGGAGCG
ACATCGGAAGGAGATTTTCATGAGGGATTGAATTTTGCGAGCGTTTTCAATGCCCCTGTCGTCTTTTTCAATCAAAACAA
CCAATATGCGATTTCCGTTCCGATCACCCGCCAGATGAGGTCAAAGACGATTGCACAAAAAGCGCTGGCATACGACATCC
CTGGTGTCCGCATCGATGGAAATGACGTGTTTGCCGTGTATTTTCAAACAGCTGAGGCGCTCGAACGAGCGAGACACGGA
GGAGGACCGACGTTAATCGAAGCGGTAACATGGCGCTATGGCGCTCATACGACATCCGACGATCCGTCAAGATATCGTGA
CCAAGAAGAGAGCAAGAAACGGCGTGAAACCACTGACCCCATCAAGCGGGTGGTGCGATTGATGCAAAGGGAAGGCTGGT
GGAATGAACAATGGGCAAATCAAGTACAGGAAGAAGTCAACGCGGAGATCGAGCAGGCGGTGGCTGAGATGGAGCGCTAT
CCAAAAGCCAACGCGTCTGACATGTTTGATTACGTATTCGCTGAACCGACGTGGACGATTGCTGAGCAGAAAGAGGCTTA
TCTTCATTGGAAACGGGTGATGGAAGGATGA

Upstream 100 bases:

>100_bases
CGCATCCGTGGGGAACAACTAGCGAGTGATCGGGCGGTATTGAGCTAATCGAGCGGTCAGATGCTTATACAATGAGCCAA
TCATGGAGAGGAGGAATGTT

Downstream 100 bases:

>100_bases
GTGTAAAAGTAAGCACAAAATCGCTCACACTCGTGCAGGCGGTCAATGATGCGCTTCGCATCATGTTAAAAGAGCGCGAC
GATGTCGTTTTGCTCGGAGA

Product: pyruvate decarboxylase subunit alpha-like protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 356; Mature: 356

Protein sequence:

>356_residues
MERDFPIWQVLNEEGTVVQPEYRERITKELTMVMYRHLIRTRTFDRKCVSLQRQGRIGTYVPYEGQEACQVGSALALNDE
DWMFPTYRDHGAMMTFGRSLVNTLLYWKGRTEGCVPPEGKKIVPPSVPIATQLPHAAGAACAEKWKGTKNAVIVYFGDGA
TSEGDFHEGLNFASVFNAPVVFFNQNNQYAISVPITRQMRSKTIAQKALAYDIPGVRIDGNDVFAVYFQTAEALERARHG
GGPTLIEAVTWRYGAHTTSDDPSRYRDQEESKKRRETTDPIKRVVRLMQREGWWNEQWANQVQEEVNAEIEQAVAEMERY
PKANASDMFDYVFAEPTWTIAEQKEAYLHWKRVMEG

Sequences:

>Translated_356_residues
MERDFPIWQVLNEEGTVVQPEYRERITKELTMVMYRHLIRTRTFDRKCVSLQRQGRIGTYVPYEGQEACQVGSALALNDE
DWMFPTYRDHGAMMTFGRSLVNTLLYWKGRTEGCVPPEGKKIVPPSVPIATQLPHAAGAACAEKWKGTKNAVIVYFGDGA
TSEGDFHEGLNFASVFNAPVVFFNQNNQYAISVPITRQMRSKTIAQKALAYDIPGVRIDGNDVFAVYFQTAEALERARHG
GGPTLIEAVTWRYGAHTTSDDPSRYRDQEESKKRRETTDPIKRVVRLMQREGWWNEQWANQVQEEVNAEIEQAVAEMERY
PKANASDMFDYVFAEPTWTIAEQKEAYLHWKRVMEG
>Mature_356_residues
MERDFPIWQVLNEEGTVVQPEYRERITKELTMVMYRHLIRTRTFDRKCVSLQRQGRIGTYVPYEGQEACQVGSALALNDE
DWMFPTYRDHGAMMTFGRSLVNTLLYWKGRTEGCVPPEGKKIVPPSVPIATQLPHAAGAACAEKWKGTKNAVIVYFGDGA
TSEGDFHEGLNFASVFNAPVVFFNQNNQYAISVPITRQMRSKTIAQKALAYDIPGVRIDGNDVFAVYFQTAEALERARHG
GGPTLIEAVTWRYGAHTTSDDPSRYRDQEESKKRRETTDPIKRVVRLMQREGWWNEQWANQVQEEVNAEIEQAVAEMERY
PKANASDMFDYVFAEPTWTIAEQKEAYLHWKRVMEG

Specific function: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydroge

COG id: COG1071

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI11386135, Length=358, Percent_Identity=38.5474860335196, Blast_Score=231, Evalue=1e-60,
Organism=Homo sapiens, GI258645172, Length=358, Percent_Identity=38.5474860335196, Blast_Score=226, Evalue=2e-59,
Organism=Homo sapiens, GI4885543, Length=335, Percent_Identity=29.2537313432836, Blast_Score=143, Evalue=2e-34,
Organism=Homo sapiens, GI4505685, Length=296, Percent_Identity=29.7297297297297, Blast_Score=130, Evalue=1e-30,
Organism=Homo sapiens, GI291084742, Length=296, Percent_Identity=29.7297297297297, Blast_Score=130, Evalue=2e-30,
Organism=Homo sapiens, GI291084744, Length=303, Percent_Identity=29.042904290429, Blast_Score=126, Evalue=3e-29,
Organism=Homo sapiens, GI291084757, Length=290, Percent_Identity=27.5862068965517, Blast_Score=101, Evalue=8e-22,
Organism=Caenorhabditis elegans, GI86563355, Length=351, Percent_Identity=35.3276353276353, Blast_Score=218, Evalue=4e-57,
Organism=Caenorhabditis elegans, GI86563357, Length=351, Percent_Identity=35.3276353276353, Blast_Score=218, Evalue=5e-57,
Organism=Caenorhabditis elegans, GI32564172, Length=303, Percent_Identity=28.7128712871287, Blast_Score=136, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI17536047, Length=303, Percent_Identity=28.7128712871287, Blast_Score=135, Evalue=2e-32,
Organism=Saccharomyces cerevisiae, GI6321026, Length=332, Percent_Identity=28.3132530120482, Blast_Score=130, Evalue=2e-31,
Organism=Drosophila melanogaster, GI21355903, Length=353, Percent_Identity=33.1444759206799, Blast_Score=200, Evalue=1e-51,
Organism=Drosophila melanogaster, GI24639744, Length=323, Percent_Identity=27.5541795665635, Blast_Score=126, Evalue=2e-29,
Organism=Drosophila melanogaster, GI28571106, Length=323, Percent_Identity=27.5541795665635, Blast_Score=126, Evalue=2e-29,
Organism=Drosophila melanogaster, GI24639740, Length=323, Percent_Identity=27.5541795665635, Blast_Score=126, Evalue=2e-29,
Organism=Drosophila melanogaster, GI24639746, Length=280, Percent_Identity=29.6428571428571, Blast_Score=123, Evalue=2e-28,
Organism=Drosophila melanogaster, GI24639748, Length=290, Percent_Identity=27.9310344827586, Blast_Score=117, Evalue=1e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001017
- InterPro:   IPR017596 [H]

Pfam domain/function: PF00676 E1_dh [H]

EC number: =1.2.4.1 [H]

Molecular weight: Translated: 40808; Mature: 40808

Theoretical pI: Translated: 6.20; Mature: 6.20

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MERDFPIWQVLNEEGTVVQPEYRERITKELTMVMYRHLIRTRTFDRKCVSLQRQGRIGTY
CCCCCCHHHHCCCCCCEECCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCC
VPYEGQEACQVGSALALNDEDWMFPTYRDHGAMMTFGRSLVNTLLYWKGRTEGCVPPEGK
CCCCCHHHHHCCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
KIVPPSVPIATQLPHAAGAACAEKWKGTKNAVIVYFGDGATSEGDFHEGLNFASVFNAPV
EECCCCCCHHHCCCCHHHHHHHHHCCCCCCEEEEEECCCCCCCCCHHHCCCHHHHHCCCE
VFFNQNNQYAISVPITRQMRSKTIAQKALAYDIPGVRIDGNDVFAVYFQTAEALERARHG
EEEECCCCEEEECCHHHHHHHHHHHHHHHHHCCCCEEECCCCEEEEEEHHHHHHHHHHCC
GGPTLIEAVTWRYGAHTTSDDPSRYRDQEESKKRRETTDPIKRVVRLMQREGWWNEQWAN
CCCHHHHHHHHHCCCCCCCCCHHHHCCHHHHHHHCCCHHHHHHHHHHHHHCCCCCHHHHH
QVQEEVNAEIEQAVAEMERYPKANASDMFDYVFAEPTWTIAEQKEAYLHWKRVMEG
HHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MERDFPIWQVLNEEGTVVQPEYRERITKELTMVMYRHLIRTRTFDRKCVSLQRQGRIGTY
CCCCCCHHHHCCCCCCEECCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCC
VPYEGQEACQVGSALALNDEDWMFPTYRDHGAMMTFGRSLVNTLLYWKGRTEGCVPPEGK
CCCCCHHHHHCCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
KIVPPSVPIATQLPHAAGAACAEKWKGTKNAVIVYFGDGATSEGDFHEGLNFASVFNAPV
EECCCCCCHHHCCCCHHHHHHHHHCCCCCCEEEEEECCCCCCCCCHHHCCCHHHHHCCCE
VFFNQNNQYAISVPITRQMRSKTIAQKALAYDIPGVRIDGNDVFAVYFQTAEALERARHG
EEEECCCCEEEECCHHHHHHHHHHHHHHHHHCCCCEEECCCCEEEEEEHHHHHHHHHHCC
GGPTLIEAVTWRYGAHTTSDDPSRYRDQEESKKRRETTDPIKRVVRLMQREGWWNEQWAN
CCCHHHHHHHHHCCCCCCCCCHHHHCCHHHHHHHCCCHHHHHHHHHHHHHCCCCCHHHHH
QVQEEVNAEIEQAVAEMERYPKANASDMFDYVFAEPTWTIAEQKEAYLHWKRVMEG
HHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2200674 [H]