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The map label for this gene is mtlA [H]

Identifier: 138895499

GI number: 138895499

Start: 1969710

End: 1971161

Strand: Reverse

Name: mtlA [H]

Synonym: GTNG_1847

Alternate gene names: 138895499

Gene position: 1971161-1969710 (Counterclockwise)

Preceding gene: 138895500

Following gene: 138895498

Centisome position: 55.52

GC content: 48.76

Gene sequence:

>1452_bases
ATGACGCATACAACCGGAAATGAAACAGGCTTCCGTGTGAAGATTCAACGGTTTGGCAGTTATTTGAGCGGCATGATTAT
GCCGAATATCGGAGCCTTTATCGCTTGGGGGTTAATTACGGCGTTATTTATCCCGACTGGCTGGTGGCCAAATGAGACGT
TTGCCAAGCTCGTCGGGCCAATGATTACGTATTTGCTGCCACTATTAATTGGATATACAGGCGGCAAAATGATTTATGAC
GTCCGTGGTGGCGTCGTCGGGGCAACGGCGACGATGGGGGTGATCGTCGGCTCGGAAATTCCGATGTTTTTAGGTGCAAT
GATCATGGGTCCGCTTGGCGGCTATGTGATGAAAAAAGTGGATGCCCTCTTCCAAGGAAAAGTGAAGCAAGGGTTTGAGA
TGCTTGTTAACAACTTCTCAGCCGGGATTATCGGCGCTCTGTTGACGTTGCTCGCCTTTAAAGGAATCGGTCCGGTCGTC
ACCGCCATCAGCAAAACATTAGCCTCTGGAGTAGAAAAAATTATCGATTGGCACTTGTTGCCGCTGGCGAGTATTTTCAT
TGAGCCAGGGAAAGTGCTGTTCTTGAATAACGCGATCAACCATGGGATTTTAAGCCCACTTGGCGTCGAGCAAGCGGCGC
AAACCGGAAAATCGATTTTATTCTTGTTGGAAACCAACCCTGGTCCAGGACTCGGTATTTTGCTGGCGTACTGCCTGTTT
GGCAAAGGAATGGCAAAACAATCGGCACCGGGGGCGGCTATTATCCACTTTCTAGGCGGGATTCATGAAATTTACTTCCC
GTACATTCTTATGCGCCCGATCTTAATGTTAGCGGTAATTGCCGGCGGAGTGAGCGGAGTGTTCACGTTTACGGTTCTCC
ACGCCGGACTGGTGGCCGTGCCGTCGCCAGGAAGTATTTTTGCCCTGCTGGCGATGACACCGAAAGGGAATTATTTCAGT
GTACTTGCTGGCGTGTTTGCCGCCACAGCGGTGTCATTCCTCGTAGCTTCAATTTGCTTAAAAACAGCAAAACAAAACGA
AGAGGAAGAAGATTTGACGAAAGCAGCGGAAAAAATGGAACAGCTGAAAGGGAAAAAGAGCCAAGTAGCTGCAACTCTGC
AACAAAAAGATGAAGCTGCTTCGGCAGGCGTCGCTTCAGCGGTTCCTGACCGTGTGAAAAAAATTGTGTTCGCGTGTGAC
GCAGGAATGGGATCGAGTGCGATGGGAGCATCGATTTTGCGAAACAAAGTGCAAAAGGCTGGACTCAGTATCGAAGTAAC
GAACACCGCGATCAACCAACTGCCGGCAGACGCCGATATTGTTATCACCCATCAAAATTTAACCGACCGGGCGAAAGCAA
AATTGCCAAACGCTTACCACGTATCGGTCGAAAACTTCTTGAACAGTCCGAAATACGATGAGTTGATCGAACAGTTAAAA
CAAAACGCATAA

Upstream 100 bases:

>100_bases
ATAGTCCCCTTGACAAAATCACATTTACTTATCATTGAAGGTAGGTTGTAAGCGTTTGTAATATAGAAGTACAGTCAAGC
AAAAAAGGAGGAACATCTTC

Downstream 100 bases:

>100_bases
CATAGCAGTAGACGCAGGGGAATCATGGCACCTCTGCGTCTTTATTTACACCTTGCGCGAACGGCATTCCTTTGTCTCGG
CCTGCACGGATCAGATTGAC

Product: mannitol transport protein

Products: NA

Alternate protein names: EIICB-Mtl; EII-Mtl; Mannitol permease IIC component; PTS system mannitol-specific EIIC component; Mannitol-specific phosphotransferase enzyme IIB component; PTS system mannitol-specific EIIB component [H]

Number of amino acids: Translated: 483; Mature: 482

Protein sequence:

>483_residues
MTHTTGNETGFRVKIQRFGSYLSGMIMPNIGAFIAWGLITALFIPTGWWPNETFAKLVGPMITYLLPLLIGYTGGKMIYD
VRGGVVGATATMGVIVGSEIPMFLGAMIMGPLGGYVMKKVDALFQGKVKQGFEMLVNNFSAGIIGALLTLLAFKGIGPVV
TAISKTLASGVEKIIDWHLLPLASIFIEPGKVLFLNNAINHGILSPLGVEQAAQTGKSILFLLETNPGPGLGILLAYCLF
GKGMAKQSAPGAAIIHFLGGIHEIYFPYILMRPILMLAVIAGGVSGVFTFTVLHAGLVAVPSPGSIFALLAMTPKGNYFS
VLAGVFAATAVSFLVASICLKTAKQNEEEEDLTKAAEKMEQLKGKKSQVAATLQQKDEAASAGVASAVPDRVKKIVFACD
AGMGSSAMGASILRNKVQKAGLSIEVTNTAINQLPADADIVITHQNLTDRAKAKLPNAYHVSVENFLNSPKYDELIEQLK
QNA

Sequences:

>Translated_483_residues
MTHTTGNETGFRVKIQRFGSYLSGMIMPNIGAFIAWGLITALFIPTGWWPNETFAKLVGPMITYLLPLLIGYTGGKMIYD
VRGGVVGATATMGVIVGSEIPMFLGAMIMGPLGGYVMKKVDALFQGKVKQGFEMLVNNFSAGIIGALLTLLAFKGIGPVV
TAISKTLASGVEKIIDWHLLPLASIFIEPGKVLFLNNAINHGILSPLGVEQAAQTGKSILFLLETNPGPGLGILLAYCLF
GKGMAKQSAPGAAIIHFLGGIHEIYFPYILMRPILMLAVIAGGVSGVFTFTVLHAGLVAVPSPGSIFALLAMTPKGNYFS
VLAGVFAATAVSFLVASICLKTAKQNEEEEDLTKAAEKMEQLKGKKSQVAATLQQKDEAASAGVASAVPDRVKKIVFACD
AGMGSSAMGASILRNKVQKAGLSIEVTNTAINQLPADADIVITHQNLTDRAKAKLPNAYHVSVENFLNSPKYDELIEQLK
QNA
>Mature_482_residues
THTTGNETGFRVKIQRFGSYLSGMIMPNIGAFIAWGLITALFIPTGWWPNETFAKLVGPMITYLLPLLIGYTGGKMIYDV
RGGVVGATATMGVIVGSEIPMFLGAMIMGPLGGYVMKKVDALFQGKVKQGFEMLVNNFSAGIIGALLTLLAFKGIGPVVT
AISKTLASGVEKIIDWHLLPLASIFIEPGKVLFLNNAINHGILSPLGVEQAAQTGKSILFLLETNPGPGLGILLAYCLFG
KGMAKQSAPGAAIIHFLGGIHEIYFPYILMRPILMLAVIAGGVSGVFTFTVLHAGLVAVPSPGSIFALLAMTPKGNYFSV
LAGVFAATAVSFLVASICLKTAKQNEEEEDLTKAAEKMEQLKGKKSQVAATLQQKDEAASAGVASAVPDRVKKIVFACDA
GMGSSAMGASILRNKVQKAGLSIEVTNTAINQLPADADIVITHQNLTDRAKAKLPNAYHVSVENFLNSPKYDELIEQLKQ
NA

Specific function: The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This

COG id: COG2213

COG function: function code G; Phosphotransferase system, mannitol-specific IIBC component

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PTS EIIC type-2 domain [H]

Homologues:

Organism=Escherichia coli, GI1790027, Length=472, Percent_Identity=63.771186440678, Blast_Score=587, Evalue=1e-169,
Organism=Escherichia coli, GI1789301, Length=468, Percent_Identity=54.2735042735043, Blast_Score=505, Evalue=1e-144,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013011
- InterPro:   IPR003501
- InterPro:   IPR003352
- InterPro:   IPR013014
- InterPro:   IPR004718 [H]

Pfam domain/function: PF02378 PTS_EIIC; PF02302 PTS_IIB [H]

EC number: =2.7.1.69 [H]

Molecular weight: Translated: 51101; Mature: 50970

Theoretical pI: Translated: 9.46; Mature: 9.46

Prosite motif: PS51099 PTS_EIIB_TYPE_2 ; PS51104 PTS_EIIC_TYPE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTHTTGNETGFRVKIQRFGSYLSGMIMPNIGAFIAWGLITALFIPTGWWPNETFAKLVGP
CCCCCCCCCCCEEEHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
MITYLLPLLIGYTGGKMIYDVRGGVVGATATMGVIVGSEIPMFLGAMIMGPLGGYVMKKV
HHHHHHHHHHCCCCCCEEEEECCCEEEHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHH
DALFQGKVKQGFEMLVNNFSAGIIGALLTLLAFKGIGPVVTAISKTLASGVEKIIDWHLL
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHH
PLASIFIEPGKVLFLNNAINHGILSPLGVEQAAQTGKSILFLLETNPGPGLGILLAYCLF
HHHHHHCCCCCEEEEECCCCCCCCCCCCHHHHHCCCCEEEEEEECCCCCCHHHHHHHHHH
GKGMAKQSAPGAAIIHFLGGIHEIYFPYILMRPILMLAVIAGGVSGVFTFTVLHAGLVAV
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCEEC
PSPGSIFALLAMTPKGNYFSVLAGVFAATAVSFLVASICLKTAKQNEEEEDLTKAAEKME
CCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
QLKGKKSQVAATLQQKDEAASAGVASAVPDRVKKIVFACDAGMGSSAMGASILRNKVQKA
HHCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHC
GLSIEVTNTAINQLPADADIVITHQNLTDRAKAKLPNAYHVSVENFLNSPKYDELIEQLK
CCEEEEEHHHHHHCCCCCEEEEEECCCHHHHHHHCCCCEEEEHHHHCCCCCHHHHHHHHH
QNA
HCC
>Mature Secondary Structure 
THTTGNETGFRVKIQRFGSYLSGMIMPNIGAFIAWGLITALFIPTGWWPNETFAKLVGP
CCCCCCCCCCEEEHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
MITYLLPLLIGYTGGKMIYDVRGGVVGATATMGVIVGSEIPMFLGAMIMGPLGGYVMKKV
HHHHHHHHHHCCCCCCEEEEECCCEEEHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHH
DALFQGKVKQGFEMLVNNFSAGIIGALLTLLAFKGIGPVVTAISKTLASGVEKIIDWHLL
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHH
PLASIFIEPGKVLFLNNAINHGILSPLGVEQAAQTGKSILFLLETNPGPGLGILLAYCLF
HHHHHHCCCCCEEEEECCCCCCCCCCCCHHHHHCCCCEEEEEEECCCCCCHHHHHHHHHH
GKGMAKQSAPGAAIIHFLGGIHEIYFPYILMRPILMLAVIAGGVSGVFTFTVLHAGLVAV
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCEEC
PSPGSIFALLAMTPKGNYFSVLAGVFAATAVSFLVASICLKTAKQNEEEEDLTKAAEKME
CCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
QLKGKKSQVAATLQQKDEAASAGVASAVPDRVKKIVFACDAGMGSSAMGASILRNKVQKA
HHCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHC
GLSIEVTNTAINQLPADADIVITHQNLTDRAKAKLPNAYHVSVENFLNSPKYDELIEQLK
CCEEEEEHHHHHHCCCCCEEEEEECCCHHHHHHHCCCCEEEEHHHHCCCCCHHHHHHHHH
QNA
HCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8824601 [H]