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The map label for this gene is gltP [H]

Identifier: 138895471

GI number: 138895471

Start: 1931885

End: 1933126

Strand: Reverse

Name: gltP [H]

Synonym: GTNG_1819

Alternate gene names: 138895471

Gene position: 1933126-1931885 (Counterclockwise)

Preceding gene: 138895472

Following gene: 138895469

Centisome position: 54.45

GC content: 39.37

Gene sequence:

>1242_bases
ATGAAAAAGCTAAAAGCCTATCGTTTTTCTATTATCCTCCTATTATCCATTGCTATTGGTGCAATGATAGGGATAGCTTT
GAAAGAAAAAGCGGTCGTATTGAAACCGATTGGTGACGTTTTTCTCAATCTGTTATTTACGATCGTTGTTCCTTTGATTT
TCTTTACGATTTCTTCTTCGATCGCGAATATGAATGGCGCGAAACGATTAGGAAAAATAATGAGCAGTATGTTAGGGACA
TTTCTTTTTACTGGGTTAGTTTCTGCCATTTATATGCTTATCATTGTCAAATTGGTTCCGCCAGCTGAAGGAGTTACACT
AAAATTAGTGAAACCGGAAACACCTGAAGAAGTTAGTTTGGCAGAACAAATTGTCAAAACGTTTACGGTATCCGATTTTG
TTGAGCTCTTTTCAAGAAGTAATATGTTGGCGCTTATCGTCATCTCCATTTTCGTCGGATTTGGTGCTCAATTGGCTGGC
GAACGTGGAAAAGCATTTACAACATTCTTGACATCTGGATCTGAAGTAATGATGAAAGTCGTTTCTATTATAATGTATAT
CGCCCCAATTGGGCTGGGTGCCTATTTTGCTACTTTGATTGGAGAATACGGGCCGCTACTTTTAGGATCTTATGTGAAAG
CTGGTGCTGCATATTATTTAGGTTCACTGGCGTATTTCTTTATCGCTTTTACTATTTATGCGTTTATGGCTGGAAGAAAA
CAAGGAGTAAAAATCTTTTGGAGAAATATGTTAACCCCTACGATTACTTCCCTGGCAACTTGCTCGAGTGCCGCTACCAT
TCCGGCGAACTTAGAAGCTTCGCAAAAAATGGGGGTTAATAAAGATATTCGCGAAACAGTGATTCCGCTCGGAGCAGCTT
TACATAAAGATGGATCTGTAATGGGTGGGGTTTTGAAGATCGCATTTCTTTTTGGTATCTTCAATATGAATTTTTCGGGA
TTAGGAACGTTATCTCTTGTGATAGGTATTTCTTTATTGGTTGGTGTCGTAATGGGAGCAATTCCAAGTGGCGGAATGAT
CGGAGAAATGTTGATCCTAACGCTGTTTGGATTCCCTCCAGAAGCACTACCTATCATTGCTGCGATTAGCACCTTAATTG
ACCCACCTGCTACAATGTTGAATGCCAGTGGAGATAATGTTACAGCTATGATGGTCTCTCGTTTGGTTGAGGGGAAAAAT
TGGATAAAAACAGCGGAAAAAGTAGAATTAAAAGGAGCTTAA

Upstream 100 bases:

>100_bases
TAAATTTTTAAGAGAGCATGGAATGATTATTTAATAAGCTATAAAATAGATGCGTATATATCTCTTATCTACATCATATT
GAAAAAAGGAGAATTAAAAA

Downstream 100 bases:

>100_bases
GCAGCTCCTTTTAGTGTATTTCCGTACAAGCGTTCTCGATGATATATCGGCTTTGGAAAATGGGAGAATTTGAATGCCTC
TTTGTTCTAATTTTTTTGAG

Product: proton/glutamate symporter family protein

Products: orotate [Cytoplasm]; fumarate [Cytoplasm]; malate [Cytoplasm]; Na (I) [Cytoplasm]; succinate [Cytoplasm] [C]

Alternate protein names: Glutamate-aspartate carrier protein [H]

Number of amino acids: Translated: 413; Mature: 413

Protein sequence:

>413_residues
MKKLKAYRFSIILLLSIAIGAMIGIALKEKAVVLKPIGDVFLNLLFTIVVPLIFFTISSSIANMNGAKRLGKIMSSMLGT
FLFTGLVSAIYMLIIVKLVPPAEGVTLKLVKPETPEEVSLAEQIVKTFTVSDFVELFSRSNMLALIVISIFVGFGAQLAG
ERGKAFTTFLTSGSEVMMKVVSIIMYIAPIGLGAYFATLIGEYGPLLLGSYVKAGAAYYLGSLAYFFIAFTIYAFMAGRK
QGVKIFWRNMLTPTITSLATCSSAATIPANLEASQKMGVNKDIRETVIPLGAALHKDGSVMGGVLKIAFLFGIFNMNFSG
LGTLSLVIGISLLVGVVMGAIPSGGMIGEMLILTLFGFPPEALPIIAAISTLIDPPATMLNASGDNVTAMMVSRLVEGKN
WIKTAEKVELKGA

Sequences:

>Translated_413_residues
MKKLKAYRFSIILLLSIAIGAMIGIALKEKAVVLKPIGDVFLNLLFTIVVPLIFFTISSSIANMNGAKRLGKIMSSMLGT
FLFTGLVSAIYMLIIVKLVPPAEGVTLKLVKPETPEEVSLAEQIVKTFTVSDFVELFSRSNMLALIVISIFVGFGAQLAG
ERGKAFTTFLTSGSEVMMKVVSIIMYIAPIGLGAYFATLIGEYGPLLLGSYVKAGAAYYLGSLAYFFIAFTIYAFMAGRK
QGVKIFWRNMLTPTITSLATCSSAATIPANLEASQKMGVNKDIRETVIPLGAALHKDGSVMGGVLKIAFLFGIFNMNFSG
LGTLSLVIGISLLVGVVMGAIPSGGMIGEMLILTLFGFPPEALPIIAAISTLIDPPATMLNASGDNVTAMMVSRLVEGKN
WIKTAEKVELKGA
>Mature_413_residues
MKKLKAYRFSIILLLSIAIGAMIGIALKEKAVVLKPIGDVFLNLLFTIVVPLIFFTISSSIANMNGAKRLGKIMSSMLGT
FLFTGLVSAIYMLIIVKLVPPAEGVTLKLVKPETPEEVSLAEQIVKTFTVSDFVELFSRSNMLALIVISIFVGFGAQLAG
ERGKAFTTFLTSGSEVMMKVVSIIMYIAPIGLGAYFATLIGEYGPLLLGSYVKAGAAYYLGSLAYFFIAFTIYAFMAGRK
QGVKIFWRNMLTPTITSLATCSSAATIPANLEASQKMGVNKDIRETVIPLGAALHKDGSVMGGVLKIAFLFGIFNMNFSG
LGTLSLVIGISLLVGVVMGAIPSGGMIGEMLILTLFGFPPEALPIIAAISTLIDPPATMLNASGDNVTAMMVSRLVEGKN
WIKTAEKVELKGA

Specific function: This carrier protein is part of the Na(+)-dependent, binding-protein-independent glutamate-aspartate transport system [H]

COG id: COG1301

COG function: function code C; Na+/H+-dicarboxylate symporters

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family [H]

Homologues:

Organism=Homo sapiens, GI21314632, Length=277, Percent_Identity=26.7148014440433, Blast_Score=97, Evalue=3e-20,
Organism=Homo sapiens, GI169790839, Length=260, Percent_Identity=28.4615384615385, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI4827012, Length=284, Percent_Identity=27.112676056338, Blast_Score=89, Evalue=6e-18,
Organism=Homo sapiens, GI223468564, Length=264, Percent_Identity=27.2727272727273, Blast_Score=89, Evalue=7e-18,
Organism=Homo sapiens, GI223468566, Length=264, Percent_Identity=27.2727272727273, Blast_Score=89, Evalue=8e-18,
Organism=Homo sapiens, GI5032093, Length=263, Percent_Identity=26.2357414448669, Blast_Score=85, Evalue=1e-16,
Organism=Homo sapiens, GI40254478, Length=438, Percent_Identity=24.2009132420091, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI66773030, Length=300, Percent_Identity=27, Blast_Score=79, Evalue=6e-15,
Organism=Homo sapiens, GI262359914, Length=209, Percent_Identity=30.1435406698565, Blast_Score=73, Evalue=4e-13,
Organism=Homo sapiens, GI194239697, Length=263, Percent_Identity=23.9543726235741, Blast_Score=67, Evalue=2e-11,
Organism=Escherichia coli, GI1789947, Length=419, Percent_Identity=25.0596658711217, Blast_Score=107, Evalue=2e-24,
Organism=Escherichia coli, GI1790514, Length=414, Percent_Identity=23.9130434782609, Blast_Score=92, Evalue=4e-20,
Organism=Escherichia coli, GI1788024, Length=409, Percent_Identity=24.2053789731051, Blast_Score=79, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI193206505, Length=461, Percent_Identity=23.8611713665944, Blast_Score=98, Evalue=8e-21,
Organism=Caenorhabditis elegans, GI71983099, Length=440, Percent_Identity=24.3181818181818, Blast_Score=96, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI71983106, Length=440, Percent_Identity=24.3181818181818, Blast_Score=96, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI17537407, Length=389, Percent_Identity=23.9074550128535, Blast_Score=93, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI71996953, Length=455, Percent_Identity=23.956043956044, Blast_Score=91, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI193206654, Length=452, Percent_Identity=21.6814159292035, Blast_Score=79, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI17541374, Length=406, Percent_Identity=22.9064039408867, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24583025, Length=469, Percent_Identity=22.6012793176972, Blast_Score=99, Evalue=8e-21,
Organism=Drosophila melanogaster, GI17137668, Length=469, Percent_Identity=22.6012793176972, Blast_Score=99, Evalue=8e-21,
Organism=Drosophila melanogaster, GI24583023, Length=469, Percent_Identity=22.6012793176972, Blast_Score=99, Evalue=8e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001991
- InterPro:   IPR018107 [H]

Pfam domain/function: PF00375 SDF [H]

EC number: NA

Molecular weight: Translated: 43962; Mature: 43962

Theoretical pI: Translated: 10.02; Mature: 10.02

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
5.1 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
5.1 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHHHCCCHHHHCCCCCCHHHHHHHHHHCCHHHHHHHHHHCCCCC
>Mature Secondary Structure
MKKLKAYRFSIILLLSIAIGAMIGIALKEKAVVLKPIGDVFLNLLFTIVVPLIFFTISSS
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHEEHHHHHHHHHHHHHHHHHHHHHHHHHH
IANMNGAKRLGKIMSSMLGTFLFTGLVSAIYMLIIVKLVPPAEGVTLKLVKPETPEEVSL
HHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCHHHHH
AEQIVKTFTVSDFVELFSRSNMLALIVISIFVGFGAQLAGERGKAFTTFLTSGSEVMMKV
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCHHHCCCCCCCHHHHHCCCHHHHHHH
VSIIMYIAPIGLGAYFATLIGEYGPLLLGSYVKAGAAYYLGSLAYFFIAFTIYAFMAGRK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
QGVKIFWRNMLTPTITSLATCSSAATIPANLEASQKMGVNKDIRETVIPLGAALHKDGSV
CCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHCCCCHHHHHHHHHHHHHHCCCCCH
MGGVLKIAFLFGIFNMNFSGLGTLSLVIGISLLVGVVMGAIPSGGMIGEMLILTLFGFPP
HHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCC
EALPIIAAISTLIDPPATMLNASGDNVTAMMVSRLVEGKNWIKTAEKVELKGA
HHHHHHHHHHHHHCCCHHHHCCCCCCHHHHHHHHHHCCHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: orotate [Periplasm]; fumarate [Periplasm]; malate [Periplasm]; Na (I) [Periplasm]; succinate [Periplasm] [C]

Specific reaction: Na (I) [Periplasm] + orotate [Periplasm] = Na (I) [Cytoplasm] + orotate [Cytoplasm] Na (I) [Periplasm] + fumarate [Periplasm] = Na (I) [Cytoplasm] + fumarate [Cytoplasm] Na (I) [Periplasm] + malate [Periplasm] = Na (I) [Cytoplasm] + malate [Cytoplasm] Na

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7751298; 9384377 [H]