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The map label for this gene is yrbE [H]

Identifier: 138895469

GI number: 138895469

Start: 1929117

End: 1930169

Strand: Reverse

Name: yrbE [H]

Synonym: GTNG_1817

Alternate gene names: 138895469

Gene position: 1930169-1929117 (Counterclockwise)

Preceding gene: 138895471

Following gene: 138895468

Centisome position: 54.37

GC content: 40.84

Gene sequence:

>1053_bases
ATGATGGAGAAAGTAAAAGTGGGGATTGTAGGTTTAGGGAGATTAGGTAGAAGGCATGCGGAAAATTTAGCGTTTAGAAT
TCCGAATTGTGAGTTATTGGCTGTTTGTAGTGTAAATGCGGAAGAAGTTGAACAGGTTCAACACGATTGGAATATTAAGT
ACGGTTATACGGATTTTGATAGGATGTTGGAAAATAAGGAGTTAGATGCCATTTTTATTTCGTCTCCGTCTGGGTTTCAT
TGTGAGCAAATTCAGAAGGCATTAAATGCAGGTTTTCATGTTTTTTGTGAGAAGCCGCTCGGATTATATTTAGAGGAAGC
CTTGTTGGTTCAAGAGGTCGTTCGGAAGCACAAAGATAAGGTCTTTATGATTGGTTTCATGAGGAGATACGATAAGTCTT
ATGCTTATGCGAAAAAGAAAATTGAGGAAGGGAAAATTGGAGAGCCGATTTTAATTCGCTGTTATAGTCTTGATCCGGCG
AAGGCAATTCGTGGGTTTATGCAGTTTGCAAAGAGTAATTACAGTGGTGGGTTGTTCTTGGATATGGCCATCCATGACTT
GGATTTGGCTCGTTGGTACTTAGGGGCTGAGGCGAAACAAGTATGGGCTGTCGGAGGGGCTTATGCTCATCCGGAGTTTA
GGGAACTAAATGACGCAGAAACTGGAGCTGTGTTAGTAAAGTTCGAAAACGATAAAATCGGTATTTTTGTTGCCGGCCGA
AACTGTGCGCACGGGTACCATATCGAGACAGAAATCATTGGTACGAAAGGAACATTAAGGATCGGAACAATTCCTGAAAA
AAATATGGTCACTGTCTTTGATGAAAACGGTGCTATCAAAGAATGCTCAGATGGGTTTTTAGAGAGATTTGAGCAGGCGT
ATTTAAGTGAGGCTGAAGAGTTCATTTCATGTATTAGGGAGAATAGACAGCCAAAGGTCACTGTAGAAGACGGGGTAATT
TCAACAGCTCTTGGTTATGCATGTAAGAAATCATTTGAAACAGGAGAACTGGTTAATGTTGAATCTCTGATGAACACGGT
TGCTTCCTCTTAA

Upstream 100 bases:

>100_bases
AGTATAATGGCAGCAAGGAAAGCGTTTACCTAGAAAGATACGCCTAGTTAGGGTAAGCGCTTAACCTAACAATGGATAAA
ATGTTAAAAGGCAGGTCAAG

Downstream 100 bases:

>100_bases
GTCTCAGACACTGCTTATAAGCACCTATATATGTGCTTATCAAAGACAACGCTATTACATAAACGGGAGGATAGATAGGG
TGAGAATACGTTGGGGGATA

Product: myo-inositol 2-dehydrogenase

Products: 2,4,6/3,5-pentahydroxycyclohexanone; NADH; H+

Alternate protein names: NA

Number of amino acids: Translated: 350; Mature: 350

Protein sequence:

>350_residues
MMEKVKVGIVGLGRLGRRHAENLAFRIPNCELLAVCSVNAEEVEQVQHDWNIKYGYTDFDRMLENKELDAIFISSPSGFH
CEQIQKALNAGFHVFCEKPLGLYLEEALLVQEVVRKHKDKVFMIGFMRRYDKSYAYAKKKIEEGKIGEPILIRCYSLDPA
KAIRGFMQFAKSNYSGGLFLDMAIHDLDLARWYLGAEAKQVWAVGGAYAHPEFRELNDAETGAVLVKFENDKIGIFVAGR
NCAHGYHIETEIIGTKGTLRIGTIPEKNMVTVFDENGAIKECSDGFLERFEQAYLSEAEEFISCIRENRQPKVTVEDGVI
STALGYACKKSFETGELVNVESLMNTVASS

Sequences:

>Translated_350_residues
MMEKVKVGIVGLGRLGRRHAENLAFRIPNCELLAVCSVNAEEVEQVQHDWNIKYGYTDFDRMLENKELDAIFISSPSGFH
CEQIQKALNAGFHVFCEKPLGLYLEEALLVQEVVRKHKDKVFMIGFMRRYDKSYAYAKKKIEEGKIGEPILIRCYSLDPA
KAIRGFMQFAKSNYSGGLFLDMAIHDLDLARWYLGAEAKQVWAVGGAYAHPEFRELNDAETGAVLVKFENDKIGIFVAGR
NCAHGYHIETEIIGTKGTLRIGTIPEKNMVTVFDENGAIKECSDGFLERFEQAYLSEAEEFISCIRENRQPKVTVEDGVI
STALGYACKKSFETGELVNVESLMNTVASS
>Mature_350_residues
MMEKVKVGIVGLGRLGRRHAENLAFRIPNCELLAVCSVNAEEVEQVQHDWNIKYGYTDFDRMLENKELDAIFISSPSGFH
CEQIQKALNAGFHVFCEKPLGLYLEEALLVQEVVRKHKDKVFMIGFMRRYDKSYAYAKKKIEEGKIGEPILIRCYSLDPA
KAIRGFMQFAKSNYSGGLFLDMAIHDLDLARWYLGAEAKQVWAVGGAYAHPEFRELNDAETGAVLVKFENDKIGIFVAGR
NCAHGYHIETEIIGTKGTLRIGTIPEKNMVTVFDENGAIKECSDGFLERFEQAYLSEAEEFISCIRENRQPKVTVEDGVI
STALGYACKKSFETGELVNVESLMNTVASS

Specific function: Unknown

COG id: COG0673

COG function: function code R; Predicted dehydrogenases and related proteins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gfo/idh/mocA family [H]

Homologues:

Organism=Escherichia coli, GI87082405, Length=264, Percent_Identity=27.2727272727273, Blast_Score=76, Evalue=3e-15,
Organism=Escherichia coli, GI1787574, Length=196, Percent_Identity=29.0816326530612, Blast_Score=75, Evalue=8e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016040
- InterPro:   IPR000683
- InterPro:   IPR004104 [H]

Pfam domain/function: PF01408 GFO_IDH_MocA; PF02894 GFO_IDH_MocA_C [H]

EC number: 1.1.1.18

Molecular weight: Translated: 39369; Mature: 39369

Theoretical pI: Translated: 5.67; Mature: 5.67

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMEKVKVGIVGLGRLGRRHAENLAFRIPNCELLAVCSVNAEEVEQVQHDWNIKYGYTDFD
CCCEEEEEEEECCHHHHHHHCCCEEECCCCCEEEEECCCHHHHHHHHHCCCEEECCCHHH
RMLENKELDAIFISSPSGFHCEQIQKALNAGFHVFCEKPLGLYLEEALLVQEVVRKHKDK
HHHCCCCCCEEEEECCCCCCHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHHHHCCC
VFMIGFMRRYDKSYAYAKKKIEEGKIGEPILIRCYSLDPAKAIRGFMQFAKSNYSGGLFL
EEEEHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCHHHHHHHHHHHHHCCCCCCEEE
DMAIHDLDLARWYLGAEAKQVWAVGGAYAHPEFRELNDAETGAVLVKFENDKIGIFVAGR
EEEHHHHHHHHHHHCCCHHHEEEECCCCCCCCHHHCCCCCCCEEEEEEECCEEEEEEECC
NCAHGYHIETEIIGTKGTLRIGTIPEKNMVTVFDENGAIKECSDGFLERFEQAYLSEAEE
CCCCCEEEEEEEECCCCEEEECCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHH
FISCIRENRQPKVTVEDGVISTALGYACKKSFETGELVNVESLMNTVASS
HHHHHHCCCCCEEEECCCHHHHHHHHHHHCCCCCCCEEEHHHHHHHHHCC
>Mature Secondary Structure
MMEKVKVGIVGLGRLGRRHAENLAFRIPNCELLAVCSVNAEEVEQVQHDWNIKYGYTDFD
CCCEEEEEEEECCHHHHHHHCCCEEECCCCCEEEEECCCHHHHHHHHHCCCEEECCCHHH
RMLENKELDAIFISSPSGFHCEQIQKALNAGFHVFCEKPLGLYLEEALLVQEVVRKHKDK
HHHCCCCCCEEEEECCCCCCHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHHHHCCC
VFMIGFMRRYDKSYAYAKKKIEEGKIGEPILIRCYSLDPAKAIRGFMQFAKSNYSGGLFL
EEEEHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCHHHHHHHHHHHHHCCCCCCEEE
DMAIHDLDLARWYLGAEAKQVWAVGGAYAHPEFRELNDAETGAVLVKFENDKIGIFVAGR
EEEHHHHHHHHHHHCCCHHHEEEECCCCCCCCHHHCCCCCCCEEEEEEECCEEEEEEECC
NCAHGYHIETEIIGTKGTLRIGTIPEKNMVTVFDENGAIKECSDGFLERFEQAYLSEAEE
CCCCCEEEEEEEECCCCEEEECCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHH
FISCIRENRQPKVTVEDGVISTALGYACKKSFETGELVNVESLMNTVASS
HHHHHHCCCCCEEEECCCHHHHHHHHHHHCCCCCCCEEEHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: myo-inositol; NAD+

Specific reaction: myo-inositol + NAD+ = 2,4,6/3,5-pentahydroxycyclohexanone + NADH + H+

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377; 9025289 [H]