Click here to switch to the map view.

The map label for this gene is yngG [H]

Identifier: 138895112

GI number: 138895112

Start: 1535266

End: 1536165

Strand: Direct

Name: yngG [H]

Synonym: GTNG_1450

Alternate gene names: 138895112

Gene position: 1535266-1536165 (Clockwise)

Preceding gene: 138895111

Following gene: 138895113

Centisome position: 43.24

GC content: 53.78

Gene sequence:

>900_bases
ATGGGGCGATGGCCGACGAAGGTGACGATTAAGGAAGTCGGCCCGCGCGACGGTCTGCAAAACGAAGCATCACCGGTCGC
CACGGCTGACAAAATTGCTTGGATCAATTTATTATCGGAAACCGGGTTGTCGTATATTGAAGTGACGTCATTTGTCCATC
CAAAATGGATTCCGCAGCTTGCCGATGCCGCCGAAGTCGCAGCCGGCATCCGCCGCAAAGACGGCGTCACGTATGCTGCG
CTCGTTCCGAATGAAAAAGGATTAGAACGGGCGCTTCGTGTCGGGGTGGATGAAGTCGGCGTCTTCATGTCAGCAAGCGA
GACGCATAACCAAAAAAACATTAACAAAACAATCGCTGCTACGTTTCCGGTGTTGGAAGGTGTCGTGAAAGCGGCGAAGC
AAGAAAGAAAAACGGTGCGCGGCTACGTTTCGACAGTGTTTGGCTGTCCGTACGAAGGGACGGTTGCTGTCGATCAAGTG
CTCATGGTCGCTGACCGGTTGTTTGCGATGGGGGTCGATGAGCTGTCGTTAGGCGATACGATCGGTGTGGCGACGCCAAA
ACAAGTCGAAGACGTGCTTGCCGAGGTGCTCCGCCGTTTTCCGGCTGAGCAGATCGCCATGCATTTTCACGACACGAGGG
GGACGGCGCTCGCCAATATTTTAGTCTCGATGGAGATGGGAATCACAACGTTTGACAGCTCTCTTGGCGGTCTTGGCGGT
TGCCCGTATGCCCCCGGGGCATCAGGAAACGTTGCCACCGATGATTTAGTGTACATGCTGCATGGCATGGGGGTTGAAAC
CGGCATTGATGTGGAGCAACTGACGAAAGCAGCCTTGTTTATTCGCGACAAAATTGGTCGTCCGCTCCCAAGCCGCTATT
TACAAACGATTTCATCATAA

Upstream 100 bases:

>100_bases
CCGTTCTACCAACAATGAAGTTCAGACTCGCCATCAGACGTGGCGAAAGGAACAAAAAGTACCTGAGGGACGGGGATAAA
ACGAAAAGGGGGGAGCGGAC

Downstream 100 bases:

>100_bases
GCAAATTCATTTTGGGAGGAAGAGGAAAGTGGGAACGTTCGTATCGTTTGACATGCAGGAAAACGGCATTGGTATTGTGA
CGTTAAACCGCCCCGAGGCG

Product: hydroxymethylglutaryl-CoA lyase

Products: NA

Alternate protein names: HL; HMG-CoA lyase; 3-hydroxy-3-methylglutarate-CoA lyase [H]

Number of amino acids: Translated: 299; Mature: 298

Protein sequence:

>299_residues
MGRWPTKVTIKEVGPRDGLQNEASPVATADKIAWINLLSETGLSYIEVTSFVHPKWIPQLADAAEVAAGIRRKDGVTYAA
LVPNEKGLERALRVGVDEVGVFMSASETHNQKNINKTIAATFPVLEGVVKAAKQERKTVRGYVSTVFGCPYEGTVAVDQV
LMVADRLFAMGVDELSLGDTIGVATPKQVEDVLAEVLRRFPAEQIAMHFHDTRGTALANILVSMEMGITTFDSSLGGLGG
CPYAPGASGNVATDDLVYMLHGMGVETGIDVEQLTKAALFIRDKIGRPLPSRYLQTISS

Sequences:

>Translated_299_residues
MGRWPTKVTIKEVGPRDGLQNEASPVATADKIAWINLLSETGLSYIEVTSFVHPKWIPQLADAAEVAAGIRRKDGVTYAA
LVPNEKGLERALRVGVDEVGVFMSASETHNQKNINKTIAATFPVLEGVVKAAKQERKTVRGYVSTVFGCPYEGTVAVDQV
LMVADRLFAMGVDELSLGDTIGVATPKQVEDVLAEVLRRFPAEQIAMHFHDTRGTALANILVSMEMGITTFDSSLGGLGG
CPYAPGASGNVATDDLVYMLHGMGVETGIDVEQLTKAALFIRDKIGRPLPSRYLQTISS
>Mature_298_residues
GRWPTKVTIKEVGPRDGLQNEASPVATADKIAWINLLSETGLSYIEVTSFVHPKWIPQLADAAEVAAGIRRKDGVTYAAL
VPNEKGLERALRVGVDEVGVFMSASETHNQKNINKTIAATFPVLEGVVKAAKQERKTVRGYVSTVFGCPYEGTVAVDQVL
MVADRLFAMGVDELSLGDTIGVATPKQVEDVLAEVLRRFPAEQIAMHFHDTRGTALANILVSMEMGITTFDSSLGGLGGC
PYAPGASGNVATDDLVYMLHGMGVETGIDVEQLTKAALFIRDKIGRPLPSRYLQTISS

Specific function: Involved in the catabolism of branched amino acids such as leucine (Probable) [H]

COG id: COG0119

COG function: function code E; Isopropylmalate/homocitrate/citramalate synthases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMG-CoA lyase family [H]

Homologues:

Organism=Homo sapiens, GI62198232, Length=295, Percent_Identity=49.8305084745763, Blast_Score=310, Evalue=1e-84,
Organism=Homo sapiens, GI109150427, Length=291, Percent_Identity=49.8281786941581, Blast_Score=294, Evalue=7e-80,
Organism=Homo sapiens, GI109150422, Length=291, Percent_Identity=49.8281786941581, Blast_Score=294, Evalue=7e-80,
Organism=Homo sapiens, GI260654708, Length=133, Percent_Identity=49.6240601503759, Blast_Score=147, Evalue=9e-36,
Organism=Caenorhabditis elegans, GI17510563, Length=288, Percent_Identity=48.6111111111111, Blast_Score=273, Evalue=1e-73,
Organism=Drosophila melanogaster, GI24582381, Length=287, Percent_Identity=52.9616724738676, Blast_Score=303, Evalue=9e-83,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000891 [H]

Pfam domain/function: PF00682 HMGL-like [H]

EC number: =4.1.3.4 [H]

Molecular weight: Translated: 32117; Mature: 31986

Theoretical pI: Translated: 5.41; Mature: 5.41

Prosite motif: PS50991 PYR_CT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGRWPTKVTIKEVGPRDGLQNEASPVATADKIAWINLLSETGLSYIEVTSFVHPKWIPQL
CCCCCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHCCCHHHHHH
ADAAEVAAGIRRKDGVTYAALVPNEKGLERALRVGVDEVGVFMSASETHNQKNINKTIAA
HHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHCHHHHHHEEECHHHCCHHHHHHHHHH
TFPVLEGVVKAAKQERKTVRGYVSTVFGCPYEGTVAVDQVLMVADRLFAMGVDELSLGDT
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCHHCCCCC
IGVATPKQVEDVLAEVLRRFPAEQIAMHFHDTRGTALANILVSMEMGITTFDSSLGGLGG
CCCCCHHHHHHHHHHHHHHCCHHHHHHHHHCCCHHHHHHHHHHHHCCCEEHHHCCCCCCC
CPYAPGASGNVATDDLVYMLHGMGVETGIDVEQLTKAALFIRDKIGRPLPSRYLQTISS
CCCCCCCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHCC
>Mature Secondary Structure 
GRWPTKVTIKEVGPRDGLQNEASPVATADKIAWINLLSETGLSYIEVTSFVHPKWIPQL
CCCCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHCCCHHHHHH
ADAAEVAAGIRRKDGVTYAALVPNEKGLERALRVGVDEVGVFMSASETHNQKNINKTIAA
HHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHCHHHHHHEEECHHHCCHHHHHHHHHH
TFPVLEGVVKAAKQERKTVRGYVSTVFGCPYEGTVAVDQVLMVADRLFAMGVDELSLGDT
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCHHCCCCC
IGVATPKQVEDVLAEVLRRFPAEQIAMHFHDTRGTALANILVSMEMGITTFDSSLGGLGG
CCCCCHHHHHHHHHHHHHHCCHHHHHHHHHCCCHHHHHHHHHHHHCCCEEHHHCCCCCCC
CPYAPGASGNVATDDLVYMLHGMGVETGIDVEQLTKAALFIRDKIGRPLPSRYLQTISS
CCCCCCCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9387222; 9384377 [H]