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The map label for this gene is mtnA

Identifier: 138894507

GI number: 138894507

Start: 911617

End: 912684

Strand: Reverse

Name: mtnA

Synonym: GTNG_0837

Alternate gene names: 138894507

Gene position: 912684-911617 (Counterclockwise)

Preceding gene: 138894508

Following gene: 138894506

Centisome position: 25.71

GC content: 53.09

Gene sequence:

>1068_bases
ATGAGCACATTTGCTATCCCGCGCTCAGTTGAATGGCACGAAACGCATGTGACGATTTTAAATCAACAAAAGCTGCCGTC
GGTAACTGAATATCTCGACTTGCATACGCTCGAAGATGTACATGACGCGATCGTGACACTGAAAGTGCGCGGGGCACCGG
CGATCGGCATCACCGCCGCCTATGGCTTGGCGCTTGCTGCTTCCCGCTACGAAACCGAATCCGTCGACGAGTTTCAGCGC
CGTTTAAAACAAGACCGCGATTATTTGGCGAGTGCTCGCCCGACGGCCGTCAATTTGTTTTGGGCGCTTGATCGGCTCGT
TGCCGCCGCTAAAAGCGCCGCTTCCGTCAACGAAGCAAAAACAACACTCGTTCACGAAGCGATCCGCATTCAAATCGAAG
ATGAAGATGTGTGCCGTCGCATCGGCGAGCATGCCTTGTCTCTTTTTCATCGAGGCGATCGAATCATGACCATCTGCAAC
GCTGGCTCGATCGCCACCGCCCGCTACGGAACGGCACTCGCCCCATTTTATTTGGCAAAAGAAAAAGGGATTGAGTTGTC
CGTCTATGCCTTGGAAACGCGGCCTGTCTTGCAAGGAGCTCGTCTGACCGCCTGGGAACTCATGCAAGCAGGTGTCGATG
TGACACTCATTACTGACAATATGGCCGCACAAACGATCAAGGCGAAAAACATTAATGCTATTATCGTCGGCGCTGACCGG
ATCGCACAAAACGGCGATACAGCGAATAAAATCGGCACATTTGGGCTCGCCTTGCTCGCCCAATCGTTTGGCATCCCGTT
TTACGTCGCTGCCCCGCTGTCAACGATCGACCTGGCGACGAAAACAGGGGCGGATATCCCAATTGAAGAGCGTCATCCAG
ATGAAGTGACCCATCTAAACGGGGTGCGCATCGCCCCGGAAGGCGTCAACGTATACAACCCGGCGTTTGATGTCACACCA
AACGAACTCATTACCGCCATCATTACCGAAAAAGGCATCGTCTACGGAGACTATGAAACGGAGCTGCCATCGTTAGTTGC
AAAGGAGGAGCACCATGAAACAGCTTAA

Upstream 100 bases:

>100_bases
GGCTGTTTGTCGAGACGGAACGATAACACCACTCTCTCAAGACGGCCGTTCAACACCACTCCAGGCAAACTGAAACATGT
ACAAGGAAAGGAAGACGACG

Downstream 100 bases:

>100_bases
AATCTCATCGTTCCTTCTTTTCTTGGCCATGTTCTTTGTCTTAGCGGGCTGCACAAATGAGCAAGACGCAATGAGCGCAA
AGCCGGCCAATGAAACGAAG

Product: methylthioribose-1-phosphate isomerase

Products: NA

Alternate protein names: M1Pi; MTR-1-P isomerase; S-methyl-5-thioribose-1-phosphate isomerase

Number of amino acids: Translated: 355; Mature: 354

Protein sequence:

>355_residues
MSTFAIPRSVEWHETHVTILNQQKLPSVTEYLDLHTLEDVHDAIVTLKVRGAPAIGITAAYGLALAASRYETESVDEFQR
RLKQDRDYLASARPTAVNLFWALDRLVAAAKSAASVNEAKTTLVHEAIRIQIEDEDVCRRIGEHALSLFHRGDRIMTICN
AGSIATARYGTALAPFYLAKEKGIELSVYALETRPVLQGARLTAWELMQAGVDVTLITDNMAAQTIKAKNINAIIVGADR
IAQNGDTANKIGTFGLALLAQSFGIPFYVAAPLSTIDLATKTGADIPIEERHPDEVTHLNGVRIAPEGVNVYNPAFDVTP
NELITAIITEKGIVYGDYETELPSLVAKEEHHETA

Sequences:

>Translated_355_residues
MSTFAIPRSVEWHETHVTILNQQKLPSVTEYLDLHTLEDVHDAIVTLKVRGAPAIGITAAYGLALAASRYETESVDEFQR
RLKQDRDYLASARPTAVNLFWALDRLVAAAKSAASVNEAKTTLVHEAIRIQIEDEDVCRRIGEHALSLFHRGDRIMTICN
AGSIATARYGTALAPFYLAKEKGIELSVYALETRPVLQGARLTAWELMQAGVDVTLITDNMAAQTIKAKNINAIIVGADR
IAQNGDTANKIGTFGLALLAQSFGIPFYVAAPLSTIDLATKTGADIPIEERHPDEVTHLNGVRIAPEGVNVYNPAFDVTP
NELITAIITEKGIVYGDYETELPSLVAKEEHHETA
>Mature_354_residues
STFAIPRSVEWHETHVTILNQQKLPSVTEYLDLHTLEDVHDAIVTLKVRGAPAIGITAAYGLALAASRYETESVDEFQRR
LKQDRDYLASARPTAVNLFWALDRLVAAAKSAASVNEAKTTLVHEAIRIQIEDEDVCRRIGEHALSLFHRGDRIMTICNA
GSIATARYGTALAPFYLAKEKGIELSVYALETRPVLQGARLTAWELMQAGVDVTLITDNMAAQTIKAKNINAIIVGADRI
AQNGDTANKIGTFGLALLAQSFGIPFYVAAPLSTIDLATKTGADIPIEERHPDEVTHLNGVRIAPEGVNVYNPAFDVTPN
ELITAIITEKGIVYGDYETELPSLVAKEEHHETA

Specific function: Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P)

COG id: COG0182

COG function: function code J; Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily

Homologues:

Organism=Homo sapiens, GI72534748, Length=339, Percent_Identity=41.2979351032448, Blast_Score=220, Evalue=2e-57,
Organism=Homo sapiens, GI23943880, Length=329, Percent_Identity=38.9057750759878, Blast_Score=193, Evalue=3e-49,
Organism=Homo sapiens, GI78000158, Length=345, Percent_Identity=24.0579710144928, Blast_Score=68, Evalue=1e-11,
Organism=Homo sapiens, GI78000156, Length=345, Percent_Identity=24.0579710144928, Blast_Score=68, Evalue=1e-11,
Organism=Homo sapiens, GI187607323, Length=345, Percent_Identity=24.0579710144928, Blast_Score=68, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17557462, Length=345, Percent_Identity=38.2608695652174, Blast_Score=205, Evalue=4e-53,
Organism=Caenorhabditis elegans, GI17557123, Length=274, Percent_Identity=27.3722627737226, Blast_Score=69, Evalue=5e-12,
Organism=Saccharomyces cerevisiae, GI6325375, Length=385, Percent_Identity=36.3636363636364, Blast_Score=212, Evalue=6e-56,
Organism=Saccharomyces cerevisiae, GI6322878, Length=193, Percent_Identity=31.0880829015544, Blast_Score=67, Evalue=6e-12,
Organism=Drosophila melanogaster, GI21357667, Length=345, Percent_Identity=41.4492753623188, Blast_Score=243, Evalue=2e-64,
Organism=Drosophila melanogaster, GI24651647, Length=345, Percent_Identity=41.4492753623188, Blast_Score=243, Evalue=2e-64,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MTNA_GEOTN (A4ILL1)

Other databases:

- EMBL:   CP000557
- RefSeq:   YP_001124960.1
- ProteinModelPortal:   A4ILL1
- SMR:   A4ILL1
- STRING:   A4ILL1
- GeneID:   4965780
- GenomeReviews:   CP000557_GR
- KEGG:   gtn:GTNG_0837
- NMPDR:   fig|420246.5.peg.804
- eggNOG:   COG0182
- HOGENOM:   HBG682649
- OMA:   LNQTKLP
- PhylomeDB:   A4ILL1
- ProtClustDB:   PRK05720
- BioCyc:   GTHE420246:GTNG_0837-MONOMER
- HAMAP:   MF_01678
- InterPro:   IPR000649
- InterPro:   IPR005251
- InterPro:   IPR011559
- PANTHER:   PTHR10233
- TIGRFAMs:   TIGR00524
- TIGRFAMs:   TIGR00512

Pfam domain/function: PF01008 IF-2B

EC number: =5.3.1.23

Molecular weight: Translated: 38737; Mature: 38606

Theoretical pI: Translated: 5.12; Mature: 5.12

Prosite motif: NA

Important sites: ACT_SITE 239-239 BINDING 93-93 BINDING 198-198

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTFAIPRSVEWHETHVTILNQQKLPSVTEYLDLHTLEDVHDAIVTLKVRGAPAIGITAA
CCCCCCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHCEEEEEEECCCCCCHHHHH
YGLALAASRYETESVDEFQRRLKQDRDYLASARPTAVNLFWALDRLVAAAKSAASVNEAK
HHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
TTLVHEAIRIQIEDEDVCRRIGEHALSLFHRGDRIMTICNAGSIATARYGTALAPFYLAK
HHHHEEEEEEEECCHHHHHHHHHHHHHHHHCCCEEEEEECCCCEEEHHCCCHHHHHHHHH
EKGIELSVYALETRPVLQGARLTAWELMQAGVDVTLITDNMAAQTIKAKNINAIIVGADR
CCCCEEEEEEEECCHHHCCCCCHHHHHHHCCCCEEEEECCHHHHEEEECCCCEEEEEHHH
IAQNGDTANKIGTFGLALLAQSFGIPFYVAAPLSTIDLATKTGADIPIEERHPDEVTHLN
HHCCCCCHHHHHHHHHHHHHHHCCCCEEEECCCCHHEHHHCCCCCCCCCCCCCCHHHHCC
GVRIAPEGVNVYNPAFDVTPNELITAIITEKGIVYGDYETELPSLVAKEEHHETA
CEEECCCCCCEECCCCCCCHHHHHHHHHHCCCEEEECCHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
STFAIPRSVEWHETHVTILNQQKLPSVTEYLDLHTLEDVHDAIVTLKVRGAPAIGITAA
CCCCCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHCEEEEEEECCCCCCHHHHH
YGLALAASRYETESVDEFQRRLKQDRDYLASARPTAVNLFWALDRLVAAAKSAASVNEAK
HHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
TTLVHEAIRIQIEDEDVCRRIGEHALSLFHRGDRIMTICNAGSIATARYGTALAPFYLAK
HHHHEEEEEEEECCHHHHHHHHHHHHHHHHCCCEEEEEECCCCEEEHHCCCHHHHHHHHH
EKGIELSVYALETRPVLQGARLTAWELMQAGVDVTLITDNMAAQTIKAKNINAIIVGADR
CCCCEEEEEEEECCHHHCCCCCHHHHHHHCCCCEEEEECCHHHHEEEECCCCEEEEEHHH
IAQNGDTANKIGTFGLALLAQSFGIPFYVAAPLSTIDLATKTGADIPIEERHPDEVTHLN
HHCCCCCHHHHHHHHHHHHHHHCCCCEEEECCCCHHEHHHCCCCCCCCCCCCCCHHHHCC
GVRIAPEGVNVYNPAFDVTPNELITAIITEKGIVYGDYETELPSLVAKEEHHETA
CEEECCCCCCEECCCCCCCHHHHHHHHHHCCCEEEECCHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA