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The map label for this gene is ywcA [H]

Identifier: 138894486

GI number: 138894486

Start: 889134

End: 890669

Strand: Reverse

Name: ywcA [H]

Synonym: GTNG_0816

Alternate gene names: 138894486

Gene position: 890669-889134 (Counterclockwise)

Preceding gene: 138894487

Following gene: 138894475

Centisome position: 25.09

GC content: 49.61

Gene sequence:

>1536_bases
ATGAACGGATTAGCCTTTTTCCTCTTCCTTGTCATCGTCGCCTTGACGCTTGTCATTACGTACTATGCTTCGAAACGAAC
GAAAACGACAAGCGAATTTTACACCGCTGACAGCAGCTTGACCGGCTGGCAAAATGGGCTCGCCATCGCTGGCGACTATA
TGTCTGCTGCTTCCTTTTTAGGCATTGCTGGCATGATCGCCCTAGCCGGGTTTGACGGCTTCTTTTACAGCATCGGATTC
CTTGTCGCCTATCTTGTCGTCTTATATATCGTCGCTGAACCCCTTCGCAACCTTGGCAAGTACACGATGGCCGATATGAT
CGCCGCTCGTTTTGACGATAAAAAAGTGCGCGGTGTCGCCGCTTTGAATACGATCGCCATCTCAACTTTTTATATGATCG
CACAGCTTGTCGGGGCCGGCGGCCTTATTAAGCTCCTACTCGGGATCGATTACATTTATTCTGTCTTGATCGTCGGTATT
TTAATGACCGTGTATGTCGTGTTCGGCGGCATGACAGCGACAAGCTGGGTGCAGATCATCAAAGCGGTCCTGTTGATGAT
CGGTACATTTATCATTTCCTTAATCGTCTTTGGAAAATTCGACTTCAGCATCGCTAAAATGTTCCATCAGTTAAAAACAG
CAACACCGCTTGGCGATGCATTTTTAACCCCAGGCAACAAGTTTAAAAATCCACTGGACACGATCTCGCTAAACCTAGCA
CTCGTTTTAGGAACAGCTGGGCTCCCGCACATTTTGATCCGCTTCTTCACTGTCAAAGATGCGCCGACTGCGCGTAAATC
AGTCGTTTATGCGACATGGATCATCGGTATTTTTTATGTATTAACTATCTTTTTAGGGTTTGGCGCCGCCGCGTTCGTTG
GTCATGACAAAATCATCGCCGCTGACCCTGCCGGCAATATGGCGGCTCCGCTGTTAGCTGAGGCGCTTGGCGGAGATTTC
TTATTCGCTTTTGTTGCCGCTGTTGCTTTTGCGACGATTTTGGCTGTTGTCGCCGGTCTTGTTTTGTCAGCTGCTTCCGC
ATTCGCTCATGACTTTTACAGCCACATCATCCGGCGCGGCCAAGCGACGGAAAAAGAACAAATGCTTGCCGCCCGCTGGG
CATCGATCGGCGTCTCAGTATTGTCGATTTTGTTAGCGCTCTTTGCTCAAAAAATGAACGTCGCCTTCCTTGTGTCACTC
GCATTTGCCGTCGCCGCAAGCGCCAACTTGCCGACGATCGTCTTTACGATCTTCTGGCGCCGCTTTAATACGACAGGGGC
AATTACCGGAATGCTCGTTGGCTTGATTAGCGCCCTGTTGCTTGTCTTCTTCAGCCCGAACGTCTGGTCACCGGAACCGG
GAGCTGCCATTTTTGTCGGCGAGCCGCTCTTTAAACTTTCCAATCCGGGCATTATTTCCATTCCGCTCGGTTTTATCGGC
GCTATCATCGGCACACTCGTTTCAGCGAAAAAAGCAGACGAAAAGAAATTTACCGAAATCCTCGTCAAAGCAAATACTGG
AATCGGGCGGGTGTAA

Upstream 100 bases:

>100_bases
TGACTTGGGCTTTATGCATCCTTTATTCGAAACGGGCCGTCAAGTTTGACGAAATCGTCGAACAAATGAAGCAAGAAGCG
AAGGAAGGAGGAAACGTCTA

Downstream 100 bases:

>100_bases
CACAACAGGGAAGCCGGCATGGCCGCTGGTTTCCCTATTTTTTTGGACACATCTTCTGAAACAGCAAACGGTTCGCCGCA
TCTCTTAGTCCGAAGCATCC

Product: Sodium/proline symporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 511; Mature: 511

Protein sequence:

>511_residues
MNGLAFFLFLVIVALTLVITYYASKRTKTTSEFYTADSSLTGWQNGLAIAGDYMSAASFLGIAGMIALAGFDGFFYSIGF
LVAYLVVLYIVAEPLRNLGKYTMADMIAARFDDKKVRGVAALNTIAISTFYMIAQLVGAGGLIKLLLGIDYIYSVLIVGI
LMTVYVVFGGMTATSWVQIIKAVLLMIGTFIISLIVFGKFDFSIAKMFHQLKTATPLGDAFLTPGNKFKNPLDTISLNLA
LVLGTAGLPHILIRFFTVKDAPTARKSVVYATWIIGIFYVLTIFLGFGAAAFVGHDKIIAADPAGNMAAPLLAEALGGDF
LFAFVAAVAFATILAVVAGLVLSAASAFAHDFYSHIIRRGQATEKEQMLAARWASIGVSVLSILLALFAQKMNVAFLVSL
AFAVAASANLPTIVFTIFWRRFNTTGAITGMLVGLISALLLVFFSPNVWSPEPGAAIFVGEPLFKLSNPGIISIPLGFIG
AIIGTLVSAKKADEKKFTEILVKANTGIGRV

Sequences:

>Translated_511_residues
MNGLAFFLFLVIVALTLVITYYASKRTKTTSEFYTADSSLTGWQNGLAIAGDYMSAASFLGIAGMIALAGFDGFFYSIGF
LVAYLVVLYIVAEPLRNLGKYTMADMIAARFDDKKVRGVAALNTIAISTFYMIAQLVGAGGLIKLLLGIDYIYSVLIVGI
LMTVYVVFGGMTATSWVQIIKAVLLMIGTFIISLIVFGKFDFSIAKMFHQLKTATPLGDAFLTPGNKFKNPLDTISLNLA
LVLGTAGLPHILIRFFTVKDAPTARKSVVYATWIIGIFYVLTIFLGFGAAAFVGHDKIIAADPAGNMAAPLLAEALGGDF
LFAFVAAVAFATILAVVAGLVLSAASAFAHDFYSHIIRRGQATEKEQMLAARWASIGVSVLSILLALFAQKMNVAFLVSL
AFAVAASANLPTIVFTIFWRRFNTTGAITGMLVGLISALLLVFFSPNVWSPEPGAAIFVGEPLFKLSNPGIISIPLGFIG
AIIGTLVSAKKADEKKFTEILVKANTGIGRV
>Mature_511_residues
MNGLAFFLFLVIVALTLVITYYASKRTKTTSEFYTADSSLTGWQNGLAIAGDYMSAASFLGIAGMIALAGFDGFFYSIGF
LVAYLVVLYIVAEPLRNLGKYTMADMIAARFDDKKVRGVAALNTIAISTFYMIAQLVGAGGLIKLLLGIDYIYSVLIVGI
LMTVYVVFGGMTATSWVQIIKAVLLMIGTFIISLIVFGKFDFSIAKMFHQLKTATPLGDAFLTPGNKFKNPLDTISLNLA
LVLGTAGLPHILIRFFTVKDAPTARKSVVYATWIIGIFYVLTIFLGFGAAAFVGHDKIIAADPAGNMAAPLLAEALGGDF
LFAFVAAVAFATILAVVAGLVLSAASAFAHDFYSHIIRRGQATEKEQMLAARWASIGVSVLSILLALFAQKMNVAFLVSL
AFAVAASANLPTIVFTIFWRRFNTTGAITGMLVGLISALLLVFFSPNVWSPEPGAAIFVGEPLFKLSNPGIISIPLGFIG
AIIGTLVSAKKADEKKFTEILVKANTGIGRV

Specific function: Unknown

COG id: COG4147

COG function: function code R; Predicted symporter

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family [H]

Homologues:

Organism=Homo sapiens, GI310128183, Length=448, Percent_Identity=25.4464285714286, Blast_Score=98, Evalue=2e-20,
Organism=Homo sapiens, GI14140236, Length=471, Percent_Identity=21.2314225053079, Blast_Score=73, Evalue=7e-13,
Organism=Homo sapiens, GI4507031, Length=465, Percent_Identity=21.2903225806452, Blast_Score=66, Evalue=1e-10,
Organism=Escherichia coli, GI1790503, Length=517, Percent_Identity=45.2611218568665, Blast_Score=433, Evalue=1e-122,
Organism=Escherichia coli, GI1787251, Length=448, Percent_Identity=24.7767857142857, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI87082237, Length=432, Percent_Identity=23.6111111111111, Blast_Score=89, Evalue=6e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001734
- InterPro:   IPR018212
- InterPro:   IPR019900 [H]

Pfam domain/function: PF00474 SSF [H]

EC number: NA

Molecular weight: Translated: 54508; Mature: 54508

Theoretical pI: Translated: 9.95; Mature: 9.95

Prosite motif: PS00456 NA_SOLUT_SYMP_1 ; PS00457 NA_SOLUT_SYMP_2 ; PS50283 NA_SOLUT_SYMP_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure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HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7934828; 9384377 [H]