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The map label for this gene is clpC [H]

Identifier: 138893757

GI number: 138893757

Start: 94900

End: 97335

Strand: Direct

Name: clpC [H]

Synonym: GTNG_0078

Alternate gene names: 138893757

Gene position: 94900-97335 (Clockwise)

Preceding gene: 138893756

Following gene: 138893758

Centisome position: 2.67

GC content: 51.56

Gene sequence:

>2436_bases
ATGATGTTCGGCAGATTTACGGAACGGGCGCAAAAGGTATTGGCGTTGGCACAGGAAGAAGCCATTCGCCTTGGCCATAA
CAATATTGGCACAGAGCACATTTTGCTTGGGTTGATCCGCGAAGGAGAAGGAATCGCCGCTAAAGCGCTTATGGCGCTTG
GCCTTGGTCCAGATAAAATTCAGAAAGAAGTGGAATCGCTCATTGGCCGTGGGAACGAGGTATCACATACGATTCACTAC
ACACCGCGGGCGAAGAAAGTGATTGAGCTGTCAATGGATGAAGCGCGGAAGCTCGGTCATTCGTACGTCGGCACGGAACA
TATTTTGCTTGGATTGATCCGCGAGGGCGAAGGAGTGGCCGCCCGCGTGTTAAACAACTTAGGGGTGAGCTTGAACAAGG
CGCGCCAACAAGTATTGCAGCTGCTCGGCAGCAATGAATCAGTATCGGGCCATGGTGGTGGAGGTGCCTCGCATGTAAAC
ACGCCGACGCTTGACAGCCTCGCCCGTGATTTAACGGCGATCGCCCGTGAAGGGCGGCTTGATCCGGTCATTGGCCGGAG
CAAAGAAATCCAGCGCGTTATTGAAGTGTTGAGCCGACGGACGAAAAACAACCCGGTGCTGATCGGTGAACCGGGTGTCG
GGAAAACAGCGATCGCCGAAGGATTGGCTCAACAAATTGTCAATAACGAGGTGCCGGAAACGTTGCGCGACAAGCGGGTC
ATGACGCTCGATATGGGTACAGTTGTGGCCGGGACGAAATACCGTGGCGAGTTTGAGGATCGGTTGAAAAAAGTGATGGA
TGAGATTCGCCAAGCAGGCAACATCATTTTGTTCATCGATGAGCTCCATACGCTAATCGGCGCTGGCGGAGCCGAAGGAG
CGATCGATGCATCGAACATTTTAAAACCAGCGTTGGCGCGTGGCGAACTGCAATGCATTGGAGCGACGACGCTTGATGAG
TATCGGAAATATATCGAGAAAGATGCCGCGCTTGAGCGCCGTTTCCAGCCGATTCATGTCGATGAGCCAACTGTGGAAGA
ATCGATCCAAATTTTAAAAGGGCTGCGCGACCGTTATGAAGCGCACCATCGCGTCTCGATTTCCGATGAGGCGATCGTGC
AGGCGGTCAAACTGTCGGACCGTTACATTACCGACCGTTTTCTGCCGGATAAAGCGATCGACTTAATTGATGAAGCTTGC
TCAAAAGTGCGCCTCCGCTCGTTCACGGCGCCGCCGAAACTGAAAGAGCTGGAGCAAAAGCTCGAGGAAGTGCGGAAAGA
AAAAGACGCGGCCGTACAAAGCCAAGAGTTTGAAAAAGCAGCCTCGTTGCGTGATATGGAACAACGGTTGCGCGAAGAGC
TCGAGGAAACAAAACGGGCATGGAAAGAAAAGCAAGGTCAAGAAAATTCTGAGGTGACAGTTGAAGATATTGCTGCAGTT
GTCTCGAGTTGGACCGGCATTCCGGTATCGAAACTCGCTGAGACGGAAACGGAGCGGTTGCTCAAGCTTGAAGAAATTTT
GCATGCGCGCGTTGTCGGCCAAGACGAGGCGGTCAAAGCGGTTGCGAAAGCCGTGCGCCGTGCCCGGGCCGGTTTGAAAG
ACCCGAAACGCCCGATCGGTTCATTTATTTTCCTCGGTCCGACAGGTGTCGGGAAAACAGAATTGGCCCGCGCATTGGCA
GAAGCCATGTTTGGCGATGAAGACGCCCTGATCCGCATCGATATGTCCGAGTATATGGAAAAACACTCGACATCGCGGCT
CATCGGTTCGCCGCCAGGGTATGTCGGCTACGAAGAAGGCGGCCAGCTGACAGAAAAAGTGCGTCGCAAGCCGTACTCGG
TCGTTCTGTTGGATGAAATGGAAAAAGCGCACCCAGACGTATTTAACATTTTGCTGCAAGTATTAGAAGACGGGCGGTTG
ACTGACTCGAAAGGGCGGACGGTCGACTTCCGCAATACGATTATCATTATGACGTCCAATGTTGGTGCTGATGCGCTGAA
ACGGAACAAGTACGTCGGCTTTAATATTCAAGATGGGAACCAACAATATAAGGACATGAAAGGCAAAGTGATGGATGAAC
TGAAAAAAGCGTTCCGTCCGGAGTTTTTGAACCGGATCGATGAAATCATCGTCTTCCATTCACTCGAAAAAGACCATCTG
AAACAAATTGTCCGCTTGATGGCTGATACGCTTGTGAAGCGGCTGAAGGAACAAGATATCGATCTTGAACTGACTGAAGC
AGCGATTGAGAAAATTGCTGCCGAAGGGTTTGATCTGGAATACGGTGCCCGTCCGCTGCGCCGCGCCTTGCAAAAACATA
TTGAAGACCGTTTGTCCGAAGAATTATTAAAAGGCACGATCGCCAAAGGTCAAAAAGTTGCTGTCGATGTGAAAGATGGA
GAATTTGTCGTGTTGTCGAAACAGGCGGTCGTGTAA

Upstream 100 bases:

>100_bases
GTGGGGCACTCCGCCCCGAGGAACGGGATGTCCGCCGGGCGGCATTAATTCGGGAACGCTTAAAGATGGAAGAACGAAGA
AAGATGGAGGGTGATGAACG

Downstream 100 bases:

>100_bases
AGGAAAAAGGTATGCGGCAGCTTGCTGCCCATACCTTATTTTATATGGAACATGTTGCAGAAAGGGTTAGACGGATGGCG
AAAAAGAAAACAAAATTTGT

Product: negative regulator of genetic competence ClpC/MecB

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 811; Mature: 811

Protein sequence:

>811_residues
MMFGRFTERAQKVLALAQEEAIRLGHNNIGTEHILLGLIREGEGIAAKALMALGLGPDKIQKEVESLIGRGNEVSHTIHY
TPRAKKVIELSMDEARKLGHSYVGTEHILLGLIREGEGVAARVLNNLGVSLNKARQQVLQLLGSNESVSGHGGGGASHVN
TPTLDSLARDLTAIAREGRLDPVIGRSKEIQRVIEVLSRRTKNNPVLIGEPGVGKTAIAEGLAQQIVNNEVPETLRDKRV
MTLDMGTVVAGTKYRGEFEDRLKKVMDEIRQAGNIILFIDELHTLIGAGGAEGAIDASNILKPALARGELQCIGATTLDE
YRKYIEKDAALERRFQPIHVDEPTVEESIQILKGLRDRYEAHHRVSISDEAIVQAVKLSDRYITDRFLPDKAIDLIDEAC
SKVRLRSFTAPPKLKELEQKLEEVRKEKDAAVQSQEFEKAASLRDMEQRLREELEETKRAWKEKQGQENSEVTVEDIAAV
VSSWTGIPVSKLAETETERLLKLEEILHARVVGQDEAVKAVAKAVRRARAGLKDPKRPIGSFIFLGPTGVGKTELARALA
EAMFGDEDALIRIDMSEYMEKHSTSRLIGSPPGYVGYEEGGQLTEKVRRKPYSVVLLDEMEKAHPDVFNILLQVLEDGRL
TDSKGRTVDFRNTIIIMTSNVGADALKRNKYVGFNIQDGNQQYKDMKGKVMDELKKAFRPEFLNRIDEIIVFHSLEKDHL
KQIVRLMADTLVKRLKEQDIDLELTEAAIEKIAAEGFDLEYGARPLRRALQKHIEDRLSEELLKGTIAKGQKVAVDVKDG
EFVVLSKQAVV

Sequences:

>Translated_811_residues
MMFGRFTERAQKVLALAQEEAIRLGHNNIGTEHILLGLIREGEGIAAKALMALGLGPDKIQKEVESLIGRGNEVSHTIHY
TPRAKKVIELSMDEARKLGHSYVGTEHILLGLIREGEGVAARVLNNLGVSLNKARQQVLQLLGSNESVSGHGGGGASHVN
TPTLDSLARDLTAIAREGRLDPVIGRSKEIQRVIEVLSRRTKNNPVLIGEPGVGKTAIAEGLAQQIVNNEVPETLRDKRV
MTLDMGTVVAGTKYRGEFEDRLKKVMDEIRQAGNIILFIDELHTLIGAGGAEGAIDASNILKPALARGELQCIGATTLDE
YRKYIEKDAALERRFQPIHVDEPTVEESIQILKGLRDRYEAHHRVSISDEAIVQAVKLSDRYITDRFLPDKAIDLIDEAC
SKVRLRSFTAPPKLKELEQKLEEVRKEKDAAVQSQEFEKAASLRDMEQRLREELEETKRAWKEKQGQENSEVTVEDIAAV
VSSWTGIPVSKLAETETERLLKLEEILHARVVGQDEAVKAVAKAVRRARAGLKDPKRPIGSFIFLGPTGVGKTELARALA
EAMFGDEDALIRIDMSEYMEKHSTSRLIGSPPGYVGYEEGGQLTEKVRRKPYSVVLLDEMEKAHPDVFNILLQVLEDGRL
TDSKGRTVDFRNTIIIMTSNVGADALKRNKYVGFNIQDGNQQYKDMKGKVMDELKKAFRPEFLNRIDEIIVFHSLEKDHL
KQIVRLMADTLVKRLKEQDIDLELTEAAIEKIAAEGFDLEYGARPLRRALQKHIEDRLSEELLKGTIAKGQKVAVDVKDG
EFVVLSKQAVV
>Mature_811_residues
MMFGRFTERAQKVLALAQEEAIRLGHNNIGTEHILLGLIREGEGIAAKALMALGLGPDKIQKEVESLIGRGNEVSHTIHY
TPRAKKVIELSMDEARKLGHSYVGTEHILLGLIREGEGVAARVLNNLGVSLNKARQQVLQLLGSNESVSGHGGGGASHVN
TPTLDSLARDLTAIAREGRLDPVIGRSKEIQRVIEVLSRRTKNNPVLIGEPGVGKTAIAEGLAQQIVNNEVPETLRDKRV
MTLDMGTVVAGTKYRGEFEDRLKKVMDEIRQAGNIILFIDELHTLIGAGGAEGAIDASNILKPALARGELQCIGATTLDE
YRKYIEKDAALERRFQPIHVDEPTVEESIQILKGLRDRYEAHHRVSISDEAIVQAVKLSDRYITDRFLPDKAIDLIDEAC
SKVRLRSFTAPPKLKELEQKLEEVRKEKDAAVQSQEFEKAASLRDMEQRLREELEETKRAWKEKQGQENSEVTVEDIAAV
VSSWTGIPVSKLAETETERLLKLEEILHARVVGQDEAVKAVAKAVRRARAGLKDPKRPIGSFIFLGPTGVGKTELARALA
EAMFGDEDALIRIDMSEYMEKHSTSRLIGSPPGYVGYEEGGQLTEKVRRKPYSVVLLDEMEKAHPDVFNILLQVLEDGRL
TDSKGRTVDFRNTIIIMTSNVGADALKRNKYVGFNIQDGNQQYKDMKGKVMDELKKAFRPEFLNRIDEIIVFHSLEKDHL
KQIVRLMADTLVKRLKEQDIDLELTEAAIEKIAAEGFDLEYGARPLRRALQKHIEDRLSEELLKGTIAKGQKVAVDVKDG
EFVVLSKQAVV

Specific function: Competence gene repressor; required for cell growth at high temperature. Negative regulator of comK expression. May interact with MecA to negatively regulate comK [H]

COG id: COG0542

COG function: function code O; ATPases with chaperone activity, ATP-binding subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain [H]

Homologues:

Organism=Homo sapiens, GI13540606, Length=322, Percent_Identity=36.6459627329193, Blast_Score=214, Evalue=3e-55,
Organism=Escherichia coli, GI1788943, Length=877, Percent_Identity=46.1801596351197, Blast_Score=726, Evalue=0.0,
Organism=Escherichia coli, GI1787109, Length=786, Percent_Identity=39.1857506361323, Blast_Score=530, Evalue=1e-151,
Organism=Saccharomyces cerevisiae, GI6320464, Length=707, Percent_Identity=49.5049504950495, Blast_Score=652, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6323002, Length=878, Percent_Identity=38.2687927107062, Blast_Score=550, Evalue=1e-157,

Paralogues:

None

Copy number: 560 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR003959
- InterPro:   IPR018368
- InterPro:   IPR001270
- InterPro:   IPR019489
- InterPro:   IPR004176
- InterPro:   IPR023150
- InterPro:   IPR001943 [H]

Pfam domain/function: PF00004 AAA; PF07724 AAA_2; PF02861 Clp_N; PF10431 ClpB_D2-small; PF02151 UVR [H]

EC number: NA

Molecular weight: Translated: 90265; Mature: 90265

Theoretical pI: Translated: 6.54; Mature: 6.54

Prosite motif: PS50151 UVR ; PS00870 CLPAB_1 ; PS00871 CLPAB_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMFGRFTERAQKVLALAQEEAIRLGHNNIGTEHILLGLIREGEGIAAKALMALGLGPDKI
CCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCHHHHHHHHHCCCHHHH
QKEVESLIGRGNEVSHTIHYTPRAKKVIELSMDEARKLGHSYVGTEHILLGLIREGEGVA
HHHHHHHHCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCHH
ARVLNNLGVSLNKARQQVLQLLGSNESVSGHGGGGASHVNTPTLDSLARDLTAIAREGRL
HHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCC
DPVIGRSKEIQRVIEVLSRRTKNNPVLIGEPGVGKTAIAEGLAQQIVNNEVPETLRDKRV
CCCCCCCHHHHHHHHHHHHCCCCCCEEEECCCCCHHHHHHHHHHHHHCCCCCHHHHCCEE
MTLDMGTVVAGTKYRGEFEDRLKKVMDEIRQAGNIILFIDELHTLIGAGGAEGAIDASNI
EEEECCCEEECCCCCCCHHHHHHHHHHHHHHHCCEEEEHHHHHHHHCCCCCCCCCCHHHH
LKPALARGELQCIGATTLDEYRKYIEKDAALERRFQPIHVDEPTVEESIQILKGLRDRYE
HHHHHHCCCEEEECCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHH
AHHRVSISDEAIVQAVKLSDRYITDRFLPDKAIDLIDEACSKVRLRSFTAPPKLKELEQK
HHCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
LEEVRKEKDAAVQSQEFEKAASLRDMEQRLREELEETKRAWKEKQGQENSEVTVEDIAAV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEHHHHHHH
VSSWTGIPVSKLAETETERLLKLEEILHARVVGQDEAVKAVAKAVRRARAGLKDPKRPIG
HHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCC
SFIFLGPTGVGKTELARALAEAMFGDEDALIRIDMSEYMEKHSTSRLIGSPPGYVGYEEG
CEEEECCCCCCHHHHHHHHHHHHCCCCCCEEEECHHHHHHHHCCCCCCCCCCCCCCCCCC
GQLTEKVRRKPYSVVLLDEMEKAHPDVFNILLQVLEDGRLTDSKGRTVDFRNTIIIMTSN
CHHHHHHHCCCCEEEEEHHHHHHCCHHHHHHHHHHHCCCCCCCCCCEEEECCEEEEEECC
VGADALKRNKYVGFNIQDGNQQYKDMKGKVMDELKKAFRPEFLNRIDEIIVFHSLEKDHL
CCHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCHHHH
KQIVRLMADTLVKRLKEQDIDLELTEAAIEKIAAEGFDLEYGARPLRRALQKHIEDRLSE
HHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHH
ELLKGTIAKGQKVAVDVKDGEFVVLSKQAVV
HHHHHHHCCCCEEEEEECCCCEEEEECCCCC
>Mature Secondary Structure
MMFGRFTERAQKVLALAQEEAIRLGHNNIGTEHILLGLIREGEGIAAKALMALGLGPDKI
CCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCHHHHHHHHHCCCHHHH
QKEVESLIGRGNEVSHTIHYTPRAKKVIELSMDEARKLGHSYVGTEHILLGLIREGEGVA
HHHHHHHHCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCHH
ARVLNNLGVSLNKARQQVLQLLGSNESVSGHGGGGASHVNTPTLDSLARDLTAIAREGRL
HHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCC
DPVIGRSKEIQRVIEVLSRRTKNNPVLIGEPGVGKTAIAEGLAQQIVNNEVPETLRDKRV
CCCCCCCHHHHHHHHHHHHCCCCCCEEEECCCCCHHHHHHHHHHHHHCCCCCHHHHCCEE
MTLDMGTVVAGTKYRGEFEDRLKKVMDEIRQAGNIILFIDELHTLIGAGGAEGAIDASNI
EEEECCCEEECCCCCCCHHHHHHHHHHHHHHHCCEEEEHHHHHHHHCCCCCCCCCCHHHH
LKPALARGELQCIGATTLDEYRKYIEKDAALERRFQPIHVDEPTVEESIQILKGLRDRYE
HHHHHHCCCEEEECCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHH
AHHRVSISDEAIVQAVKLSDRYITDRFLPDKAIDLIDEACSKVRLRSFTAPPKLKELEQK
HHCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
LEEVRKEKDAAVQSQEFEKAASLRDMEQRLREELEETKRAWKEKQGQENSEVTVEDIAAV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEHHHHHHH
VSSWTGIPVSKLAETETERLLKLEEILHARVVGQDEAVKAVAKAVRRARAGLKDPKRPIG
HHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCC
SFIFLGPTGVGKTELARALAEAMFGDEDALIRIDMSEYMEKHSTSRLIGSPPGYVGYEEG
CEEEECCCCCCHHHHHHHHHHHHCCCCCCEEEECHHHHHHHHCCCCCCCCCCCCCCCCCC
GQLTEKVRRKPYSVVLLDEMEKAHPDVFNILLQVLEDGRLTDSKGRTVDFRNTIIIMTSN
CHHHHHHHCCCCEEEEEHHHHHHCCHHHHHHHHHHHCCCCCCCCCCEEEECCEEEEEECC
VGADALKRNKYVGFNIQDGNQQYKDMKGKVMDELKKAFRPEFLNRIDEIIVFHSLEKDHL
CCHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCHHHH
KQIVRLMADTLVKRLKEQDIDLELTEAAIEKIAAEGFDLEYGARPLRRALQKHIEDRLSE
HHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHH
ELLKGTIAKGQKVAVDVKDGEFVVLSKQAVV
HHHHHHHCCCCEEEEEECCCCEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases); Serine endopeptidases [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8016066; 7584024; 9384377; 8195092 [H]