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The map label for this gene is folK [H]

Identifier: 138893750

GI number: 138893750

Start: 82786

End: 83313

Strand: Direct

Name: folK [H]

Synonym: GTNG_0071

Alternate gene names: 138893750

Gene position: 82786-83313 (Clockwise)

Preceding gene: 138893749

Following gene: 138893751

Centisome position: 2.33

GC content: 43.94

Gene sequence:

>528_bases
ATGGAAAACATTGTATATATTTCCTTAGGTTCTAACTTAGGGGATCGTGTCTATTATTTACGTTCGGCCATTGAAGCACT
TGATCGCTACGAGGGAATTTCTGTAAAGTCGAGTTCGTCCATCTATGAAACGGATCCGGTTGGTTACGTCCATCAAGACA
AGTTTTTAAACATGGTAGTCGAGGTGGCGACGACGTTGTCACCATTTTCCTTGTTGAACGTGACGCAACAAATTGAACAG
GAATTTGGGAGAAAAAGGGGAATTCGCTGGGGGCCGCGTACGTTAGACCTTGACATTTTGCTGTATAATCATGAAAATAT
TGAAACAGAGCAACTAGTCATTCCGCATCCGCGTATGGCGGAGCGGGCGTTTGTTCTTATCCCGTTGCTCGAAATCAATT
CCCATTTAACAATACCGAACATTTTCGAGCCGTTAACAGACATCGTTGATCGACTACCTGACAAAGAAGGAGTTCGCGTA
TGGAAGCAGAAAGATGGGGAAGACGTATTCGCGCTTTTCGAAAGCTAA

Upstream 100 bases:

>100_bases
TCCTGCCATTCAGCGTTGTACCGTGAGGGTGACGAAGCCAAATCCACCAATCCGCGGACATTACAAGCATGTCGCCGTTG
AAATTGTTAGGGGGCGTTAA

Downstream 100 bases:

>100_bases
AAGGATATACACAAGAAAGGCTGGCTAAGGAGCTCGGCGTTTCTGTCTCAATCCTTGGTGAAATTGAACGGGGGAATCGG
ATGCCGTCCGATTCGCTCGT

Product: 2-amino-4-hydroxy-6- hydroxymethyldihydropteridinepyrophosphokinase

Products: NA

Alternate protein names: 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase; PPPK; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase; HPPK [H]

Number of amino acids: Translated: 175; Mature: 175

Protein sequence:

>175_residues
MENIVYISLGSNLGDRVYYLRSAIEALDRYEGISVKSSSSIYETDPVGYVHQDKFLNMVVEVATTLSPFSLLNVTQQIEQ
EFGRKRGIRWGPRTLDLDILLYNHENIETEQLVIPHPRMAERAFVLIPLLEINSHLTIPNIFEPLTDIVDRLPDKEGVRV
WKQKDGEDVFALFES

Sequences:

>Translated_175_residues
MENIVYISLGSNLGDRVYYLRSAIEALDRYEGISVKSSSSIYETDPVGYVHQDKFLNMVVEVATTLSPFSLLNVTQQIEQ
EFGRKRGIRWGPRTLDLDILLYNHENIETEQLVIPHPRMAERAFVLIPLLEINSHLTIPNIFEPLTDIVDRLPDKEGVRV
WKQKDGEDVFALFES
>Mature_175_residues
MENIVYISLGSNLGDRVYYLRSAIEALDRYEGISVKSSSSIYETDPVGYVHQDKFLNMVVEVATTLSPFSLLNVTQQIEQ
EFGRKRGIRWGPRTLDLDILLYNHENIETEQLVIPHPRMAERAFVLIPLLEINSHLTIPNIFEPLTDIVDRLPDKEGVRV
WKQKDGEDVFALFES

Specific function: Dihydrofolate biosynthesis; first step. [C]

COG id: COG0801

COG function: function code H; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HPPK family [H]

Homologues:

Organism=Escherichia coli, GI1786335, Length=138, Percent_Identity=43.4782608695652, Blast_Score=114, Evalue=3e-27,
Organism=Saccharomyces cerevisiae, GI6324073, Length=159, Percent_Identity=37.7358490566038, Blast_Score=108, Evalue=5e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000550 [H]

Pfam domain/function: PF01288 HPPK [H]

EC number: =2.7.6.3 [H]

Molecular weight: Translated: 20121; Mature: 20121

Theoretical pI: Translated: 4.57; Mature: 4.57

Prosite motif: PS00794 HPPK

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MENIVYISLGSNLGDRVYYLRSAIEALDRYEGISVKSSSSIYETDPVGYVHQDKFLNMVV
CCCEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCEECCCCCCCHHHHHHHHHH
EVATTLSPFSLLNVTQQIEQEFGRKRGIRWGPRTLDLDILLYNHENIETEQLVIPHPRMA
HHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEEEECCCCCCCEEEECCCCHH
ERAFVLIPLLEINSHLTIPNIFEPLTDIVDRLPDKEGVRVWKQKDGEDVFALFES
CCEEEEEEEEECCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHCCCCCEEEEEECC
>Mature Secondary Structure
MENIVYISLGSNLGDRVYYLRSAIEALDRYEGISVKSSSSIYETDPVGYVHQDKFLNMVV
CCCEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCEECCCCCCCHHHHHHHHHH
EVATTLSPFSLLNVTQQIEQEFGRKRGIRWGPRTLDLDILLYNHENIETEQLVIPHPRMA
HHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEEEECCCCCCCEEEECCCCHH
ERAFVLIPLLEINSHLTIPNIFEPLTDIVDRLPDKEGVRVWKQKDGEDVFALFES
CCEEEEEEEEECCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHCCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7584024; 9384377; 2123867 [H]