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The map label for this gene is holB [H]

Identifier: 138893703

GI number: 138893703

Start: 37431

End: 38423

Strand: Direct

Name: holB [H]

Synonym: GTNG_0024

Alternate gene names: 138893703

Gene position: 37431-38423 (Clockwise)

Preceding gene: 138893702

Following gene: 138893704

Centisome position: 1.05

GC content: 50.45

Gene sequence:

>993_bases
ATGGCGATGCAATGGGAACAGCTAGCAAAACGCCAGCCAGTAGTGGCGAAAATGCTGCAAAGCGGCCTTGAAAAAGGGCG
GATTTCCCATGCGTACTTGTTTGAGGGACAGCGGGGGACGGGAAAAAAGGCAGCCAGTTTGTTGTTGGCAAAAAGCTTAT
TTTGTCTATCCCCGTCAGGAATTGCCCCGTGCTTGGAATGCCGCAACTGCCGACGCATTGAATCCGGTAACCATCCGGAC
GTTCGGGTAATCAGCCCGGATGGCGGATCGATTAAGAAAGAACAAATCGAATGGTTGCAACAGGAGTTCACGAAAACGGC
AGTGGAGTCCGACAAAAAAATGTATATTGTCGAACACGCCGATCAAATGACGACAAGCGCTGCTAACAGCCTTCTAAAAT
TTTTAGAGGAACCGCATCCGGGAACGGTGGCGGTGTTGTTGACCGAGCAATACCATCGATTGTTAGAAACGGTCATTTCC
CGCTGTCAAGTACTTTCCTTCCGGCCGCTGCCGCCGGCAGAACTCGCCGATCAGCTCGTTAAAGAGCGTGTGCCGCTGAC
GTTGGCGTTGCTCGCCGCTCACTTAACAAATAGCTACGACGAGGCGTTGGCGCTCAGCCAAGATCGTTGGTTTGCCGAGG
CACGAACATTAGTGCTACAATTATATGAGATGCTTGGCAAGCCAGAGTTGCAGCTTCTGTTTTTTATCCACGACCGTTTA
CTTTCGCATTTTCCGGAAAAGCATCAGCTCAACCTCGGGCTTGATTTGCTTTTATATATATACCGCGATTTGTTGCACAT
TCAAGCTGGACGGAAGGATAGCGCATTATACCGGGATGAGCTTGACCGCCTGCAGCGTTGGGCGCTTTCTTGCCCACAGC
GACGGGTTTTAGATGGCATGGAGGCGATTTTACAGGCAAAAGCACGTTTAAATATGACGAATATGAGCACGGCGCTGCTG
ATGGAGCAGTTGGCTCTTCAATTAAAGCGGTAA

Upstream 100 bases:

>100_bases
CTCTCCCGCCTTGAAGGATCAAAGCGTCATTTCCATGAATCCAATCGTGATGATTCATGCTGGACATGATAGAATAGAAA
ATAAGAAATGAGAAAGAGTG

Downstream 100 bases:

>100_bases
AGGAGGGAGAACCGTTGTATACTGTAGTCGGCGTCCGCTTTAAAAAGGCGGGAAAAATTTATTATTTTGACCCAGGCGAT
TTTGTCATTCCTGCCGGTGA

Product: DNA polymerase III subunit delta'

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 330; Mature: 329

Protein sequence:

>330_residues
MAMQWEQLAKRQPVVAKMLQSGLEKGRISHAYLFEGQRGTGKKAASLLLAKSLFCLSPSGIAPCLECRNCRRIESGNHPD
VRVISPDGGSIKKEQIEWLQQEFTKTAVESDKKMYIVEHADQMTTSAANSLLKFLEEPHPGTVAVLLTEQYHRLLETVIS
RCQVLSFRPLPPAELADQLVKERVPLTLALLAAHLTNSYDEALALSQDRWFAEARTLVLQLYEMLGKPELQLLFFIHDRL
LSHFPEKHQLNLGLDLLLYIYRDLLHIQAGRKDSALYRDELDRLQRWALSCPQRRVLDGMEAILQAKARLNMTNMSTALL
MEQLALQLKR

Sequences:

>Translated_330_residues
MAMQWEQLAKRQPVVAKMLQSGLEKGRISHAYLFEGQRGTGKKAASLLLAKSLFCLSPSGIAPCLECRNCRRIESGNHPD
VRVISPDGGSIKKEQIEWLQQEFTKTAVESDKKMYIVEHADQMTTSAANSLLKFLEEPHPGTVAVLLTEQYHRLLETVIS
RCQVLSFRPLPPAELADQLVKERVPLTLALLAAHLTNSYDEALALSQDRWFAEARTLVLQLYEMLGKPELQLLFFIHDRL
LSHFPEKHQLNLGLDLLLYIYRDLLHIQAGRKDSALYRDELDRLQRWALSCPQRRVLDGMEAILQAKARLNMTNMSTALL
MEQLALQLKR
>Mature_329_residues
AMQWEQLAKRQPVVAKMLQSGLEKGRISHAYLFEGQRGTGKKAASLLLAKSLFCLSPSGIAPCLECRNCRRIESGNHPDV
RVISPDGGSIKKEQIEWLQQEFTKTAVESDKKMYIVEHADQMTTSAANSLLKFLEEPHPGTVAVLLTEQYHRLLETVISR
CQVLSFRPLPPAELADQLVKERVPLTLALLAAHLTNSYDEALALSQDRWFAEARTLVLQLYEMLGKPELQLLFFIHDRLL
SHFPEKHQLNLGLDLLLYIYRDLLHIQAGRKDSALYRDELDRLQRWALSCPQRRVLDGMEAILQAKARLNMTNMSTALLM
EQLALQLKR

Specific function: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria [H]

COG id: COG0470

COG function: function code L; ATPase involved in DNA replication

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1786676, Length=200, Percent_Identity=34.5, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1787341, Length=200, Percent_Identity=32, Blast_Score=73, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004622 [H]

Pfam domain/function: NA

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 37578; Mature: 37447

Theoretical pI: Translated: 8.37; Mature: 8.37

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAMQWEQLAKRQPVVAKMLQSGLEKGRISHAYLFEGQRGTGKKAASLLLAKSLFCLSPSG
CCCCHHHHHHCCCHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHHHCCCCC
IAPCLECRNCRRIESGNHPDVRVISPDGGSIKKEQIEWLQQEFTKTAVESDKKMYIVEHA
CCHHHHHHCCHHCCCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEECH
DQMTTSAANSLLKFLEEPHPGTVAVLLTEQYHRLLETVISRCQVLSFRPLPPAELADQLV
HHHHHHHHHHHHHHHHCCCCCEEEEEEHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHH
KERVPLTLALLAAHLTNSYDEALALSQDRWFAEARTLVLQLYEMLGKPELQLLFFIHDRL
HHCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
LSHFPEKHQLNLGLDLLLYIYRDLLHIQAGRKDSALYRDELDRLQRWALSCPQRRVLDGM
HHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHH
EAILQAKARLNMTNMSTALLMEQLALQLKR
HHHHHHHHHCCHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
AMQWEQLAKRQPVVAKMLQSGLEKGRISHAYLFEGQRGTGKKAASLLLAKSLFCLSPSG
CCCHHHHHHCCCHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHHHCCCCC
IAPCLECRNCRRIESGNHPDVRVISPDGGSIKKEQIEWLQQEFTKTAVESDKKMYIVEHA
CCHHHHHHCCHHCCCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEECH
DQMTTSAANSLLKFLEEPHPGTVAVLLTEQYHRLLETVISRCQVLSFRPLPPAELADQLV
HHHHHHHHHHHHHHHHCCCCCEEEEEEHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHH
KERVPLTLALLAAHLTNSYDEALALSQDRWFAEARTLVLQLYEMLGKPELQLLFFIHDRL
HHCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
LSHFPEKHQLNLGLDLLLYIYRDLLHIQAGRKDSALYRDELDRLQRWALSCPQRRVLDGM
HHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHH
EAILQAKARLNMTNMSTALLMEQLALQLKR
HHHHHHHHHCCHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7584024; 9384377 [H]