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The map label for this gene is tmk

Identifier: 138893702

GI number: 138893702

Start: 36722

End: 37399

Strand: Direct

Name: tmk

Synonym: GTNG_0023

Alternate gene names: 138893702

Gene position: 36722-37399 (Clockwise)

Preceding gene: 138893701

Following gene: 138893703

Centisome position: 1.03

GC content: 50.0

Gene sequence:

>678_bases
ATGAACGGGTATTTTTTTTCGTTTGAAGGGCCGGAAGGGGCCGGAAAAACAACGATGATTGGCAAGCTTGAGTCATTTTT
GCGCGAGCGAGGCTTTGACGTAATGGTAACGAGGGAGCCTGGTGGAGTGCGCATCGCCGAGGCGATTCGCGCACTCATTT
TAAATCGCGAGTATACGGAAATGGATGGACGAACGGAAGCACTTTTGTATGCAGCGGCGAGGCGACAGCATTTGCTTGAG
AAAATTGTTCCGGCGCTTGAGGCTGGTCGCGTTGTGCTGTGTGACCGATTTGTTGACAGCTCACTCGCCTACCAAGGATT
TGCTCGCGGGCTTGGTGTTGAAGAGGTATGGAAAATTAACGAGTTTGCCATTGACGGATATATGCCGTCGTTGACGGTTT
ATTTTGATATTGATCCGCAAATCGGGCTCGAACGGATTCGGCAAAACCGGGAACGGGAAGTGAACCGGCTTGATCTTGAA
ACATTGTCTTTCCATGATAAGGTAAGGGAAGGATATCGGAAGTTGGCGAAGCGGTTTGCTGAACGGATCGTTGTTATTGA
TGCAAGCCGACCACTCGATGATGTGTTTTCCGAGACGGTGGCGACGGTGCTCTCCCGCCTTGAAGGATCAAAGCGTCATT
TCCATGAATCCAATCGTGATGATTCATGCTGGACATGA

Upstream 100 bases:

>100_bases
AATTCCTCCACCATCAGGCGCATATCCAAGGCGGAAGCCGGCTCAGGGATGGGTTGCTTGTCGTATACGAACTTTGATGA
TGGAAAGGATGCTACGGGCA

Downstream 100 bases:

>100_bases
TAGAATAGAAAATAAGAAATGAGAAAGAGTGATGGCGATGCAATGGGAACAGCTAGCAAAACGCCAGCCAGTAGTGGCGA
AAATGCTGCAAAGCGGCCTT

Product: thymidylate kinase

Products: NA

Alternate protein names: dTMP kinase

Number of amino acids: Translated: 225; Mature: 225

Protein sequence:

>225_residues
MNGYFFSFEGPEGAGKTTMIGKLESFLRERGFDVMVTREPGGVRIAEAIRALILNREYTEMDGRTEALLYAAARRQHLLE
KIVPALEAGRVVLCDRFVDSSLAYQGFARGLGVEEVWKINEFAIDGYMPSLTVYFDIDPQIGLERIRQNREREVNRLDLE
TLSFHDKVREGYRKLAKRFAERIVVIDASRPLDDVFSETVATVLSRLEGSKRHFHESNRDDSCWT

Sequences:

>Translated_225_residues
MNGYFFSFEGPEGAGKTTMIGKLESFLRERGFDVMVTREPGGVRIAEAIRALILNREYTEMDGRTEALLYAAARRQHLLE
KIVPALEAGRVVLCDRFVDSSLAYQGFARGLGVEEVWKINEFAIDGYMPSLTVYFDIDPQIGLERIRQNREREVNRLDLE
TLSFHDKVREGYRKLAKRFAERIVVIDASRPLDDVFSETVATVLSRLEGSKRHFHESNRDDSCWT
>Mature_225_residues
MNGYFFSFEGPEGAGKTTMIGKLESFLRERGFDVMVTREPGGVRIAEAIRALILNREYTEMDGRTEALLYAAARRQHLLE
KIVPALEAGRVVLCDRFVDSSLAYQGFARGLGVEEVWKINEFAIDGYMPSLTVYFDIDPQIGLERIRQNREREVNRLDLE
TLSFHDKVREGYRKLAKRFAERIVVIDASRPLDDVFSETVATVLSRLEGSKRHFHESNRDDSCWT

Specific function: Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis

COG id: COG0125

COG function: function code F; Thymidylate kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidylate kinase family

Homologues:

Organism=Escherichia coli, GI1787340, Length=207, Percent_Identity=34.7826086956522, Blast_Score=110, Evalue=6e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): KTHY_GEOTN (A4IJA6)

Other databases:

- EMBL:   CP000557
- RefSeq:   YP_001124155.1
- ProteinModelPortal:   A4IJA6
- SMR:   A4IJA6
- STRING:   A4IJA6
- GeneID:   4965149
- GenomeReviews:   CP000557_GR
- KEGG:   gtn:GTNG_0023
- NMPDR:   fig|420246.5.peg.22
- eggNOG:   COG0125
- HOGENOM:   HBG626009
- OMA:   LFITLEG
- PhylomeDB:   A4IJA6
- ProtClustDB:   PRK00698
- BioCyc:   GTHE420246:GTNG_0023-MONOMER
- HAMAP:   MF_00165
- InterPro:   IPR018095
- InterPro:   IPR018094
- PANTHER:   PTHR10344
- TIGRFAMs:   TIGR00041

Pfam domain/function: PF02223 Thymidylate_kin

EC number: =2.7.4.9

Molecular weight: Translated: 25802; Mature: 25802

Theoretical pI: Translated: 5.78; Mature: 5.78

Prosite motif: PS01331 THYMIDYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNGYFFSFEGPEGAGKTTMIGKLESFLRERGFDVMVTREPGGVRIAEAIRALILNREYTE
CCCEEEEECCCCCCCCHHHHHHHHHHHHHCCCEEEEEECCCCEEHHHHHHHHHHCCHHHH
MDGRTEALLYAAARRQHLLEKIVPALEAGRVVLCDRFVDSSLAYQGFARGLGVEEVWKIN
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHHCCCHHHHHHHH
EFAIDGYMPSLTVYFDIDPQIGLERIRQNREREVNRLDLETLSFHDKVREGYRKLAKRFA
HHEECCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ERIVVIDASRPLDDVFSETVATVLSRLEGSKRHFHESNRDDSCWT
HEEEEEECCCCHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCCCC
>Mature Secondary Structure
MNGYFFSFEGPEGAGKTTMIGKLESFLRERGFDVMVTREPGGVRIAEAIRALILNREYTE
CCCEEEEECCCCCCCCHHHHHHHHHHHHHCCCEEEEEECCCCEEHHHHHHHHHHCCHHHH
MDGRTEALLYAAARRQHLLEKIVPALEAGRVVLCDRFVDSSLAYQGFARGLGVEEVWKIN
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHHCCCHHHHHHHH
EFAIDGYMPSLTVYFDIDPQIGLERIRQNREREVNRLDLETLSFHDKVREGYRKLAKRFA
HHEECCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ERIVVIDASRPLDDVFSETVATVLSRLEGSKRHFHESNRDDSCWT
HEEEEEECCCCHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA