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The map label for this gene is serS [H]

Identifier: 138893692

GI number: 138893692

Start: 21871

End: 23145

Strand: Direct

Name: serS [H]

Synonym: GTNG_0013

Alternate gene names: 138893692

Gene position: 21871-23145 (Clockwise)

Preceding gene: 138893691

Following gene: 138893694

Centisome position: 0.62

GC content: 52.08

Gene sequence:

>1275_bases
ATGCTGGATGTGAAATTACTACGCACCCAATTTCAAGAGGTGAAAGAAAAACTGCTGCAGCGCGGCGACGACTTGGCCAA
CATCGACCGGTTTGAGCAGCTTGATAAAGAGCGTCGTCGTTTGATCGCTCAGGTGGAGGAGTTAAAAAGCAAGCGCAATG
AGGTGTCGCAACAAATTGCTGTCTTAAAGCGTGAAAAAAAGGACGCCGAGTCGTTGATCGCCGAAATGCGCGAAGTCGGC
GACCGCATTAAACAAATGGACGAGCAAATTCGCCAACTTGAAGAAGAGCTCGACAGCCTTCTGTTATCGATTCCGAATGT
ACCGCATGAGTCAGTGCCAGTCGGCCAGTCGGAAGAAGATAATGTCGAAGTGCGAAGATGGGGGGAACCGCGTTCGTTCT
CGTTCGAACCGAAGCCACATTGGGACATTGCTGACCAACTCGGTTTGCTCGATTTTGAGCGGGCCGCCAAAGTGGCAGGA
AGTCGGTTTGTGTTTTACAAAGGACTAGGGGCTCGTCTTGAGCGGGCATTAATCAACTTTATGCTCGACATCCATCTCGA
TGAATTTGGCTATCAAGAGGTGTTGCCGCCATACTTAGTGAACCGGGCGAGCATGATCGGAACAGGGCAATTGCCAAAAT
TTGCGGAAGACGCGTTCCACTTGGACAATGAAGACTATTTTCTCATTCCAACAGCGGAAGTGCCTGTGACGAATTTGCAT
CGCGATGAAATTTTAACGGCTGATGACTTGCCGCTTTACTATGCGGCTTACAGCGCGTGCTTCCGCGCCGAAGCTGGCTC
GGCTGGCCGTGACACGCGGGGGCTCATCCGCCAGCACCAATTCAATAAAGTGGAGCTCGTCAAGTTCGTCAAGCCGGAGG
ATTCATATGACGAGTTGGAAAAATTGACGCACCAAGCCGAAACGATCCTGCAACGGCTCGGGCTTCCGTATCGCGTCGTA
GCCTTGTGTACAGGAGATCTGGGATTTTCAGCGGCGAAGACGTATGATATTGAGGTGTGGCTGCCAAGCTATGGAACGTA
TCGGGAAATTTCGTCGTGCAGCAACTTTGAGGCGTTCCAGGCGCGCCGAGCTAATATCCGCTTCCGTCGCGAGCCGAAAG
CAAAGCCAGAATATGTGCATACGCTAAACGGTTCGGGGCTAGCCATCGGCCGCACGGTTGCTGCCATTTTGGAAAACTAC
CAACAAGAAGACGGATCGGTCGTCATCCCGGGAGCGCTCCGTCCATATATGGGGAATCGGGATGTCATTCGCTAA

Upstream 100 bases:

>100_bases
GTGGCCTTCAATAAGGGTGGCACCGCGGGAACGCTCCCGTCCCTTTTTGGGACGGGAGCATTTTTATGTATAATAAATGG
TGGATAAGGAGGTAAAGCGA

Downstream 100 bases:

>100_bases
ACAAAAGGTACGTTTTCCTAGATAAATCGTTGGTTGACTTTTCCCGGTAACCATGTTATATTGAATGACGTTGGCAACGA
GGATAAAGGGATGGCGGATG

Product: seryl-tRNA synthetase

Products: NA

Alternate protein names: Serine--tRNA ligase; SerRS; Seryl-tRNA(Ser/Sec) synthetase [H]

Number of amino acids: Translated: 424; Mature: 424

Protein sequence:

>424_residues
MLDVKLLRTQFQEVKEKLLQRGDDLANIDRFEQLDKERRRLIAQVEELKSKRNEVSQQIAVLKREKKDAESLIAEMREVG
DRIKQMDEQIRQLEEELDSLLLSIPNVPHESVPVGQSEEDNVEVRRWGEPRSFSFEPKPHWDIADQLGLLDFERAAKVAG
SRFVFYKGLGARLERALINFMLDIHLDEFGYQEVLPPYLVNRASMIGTGQLPKFAEDAFHLDNEDYFLIPTAEVPVTNLH
RDEILTADDLPLYYAAYSACFRAEAGSAGRDTRGLIRQHQFNKVELVKFVKPEDSYDELEKLTHQAETILQRLGLPYRVV
ALCTGDLGFSAAKTYDIEVWLPSYGTYREISSCSNFEAFQARRANIRFRREPKAKPEYVHTLNGSGLAIGRTVAAILENY
QQEDGSVVIPGALRPYMGNRDVIR

Sequences:

>Translated_424_residues
MLDVKLLRTQFQEVKEKLLQRGDDLANIDRFEQLDKERRRLIAQVEELKSKRNEVSQQIAVLKREKKDAESLIAEMREVG
DRIKQMDEQIRQLEEELDSLLLSIPNVPHESVPVGQSEEDNVEVRRWGEPRSFSFEPKPHWDIADQLGLLDFERAAKVAG
SRFVFYKGLGARLERALINFMLDIHLDEFGYQEVLPPYLVNRASMIGTGQLPKFAEDAFHLDNEDYFLIPTAEVPVTNLH
RDEILTADDLPLYYAAYSACFRAEAGSAGRDTRGLIRQHQFNKVELVKFVKPEDSYDELEKLTHQAETILQRLGLPYRVV
ALCTGDLGFSAAKTYDIEVWLPSYGTYREISSCSNFEAFQARRANIRFRREPKAKPEYVHTLNGSGLAIGRTVAAILENY
QQEDGSVVIPGALRPYMGNRDVIR
>Mature_424_residues
MLDVKLLRTQFQEVKEKLLQRGDDLANIDRFEQLDKERRRLIAQVEELKSKRNEVSQQIAVLKREKKDAESLIAEMREVG
DRIKQMDEQIRQLEEELDSLLLSIPNVPHESVPVGQSEEDNVEVRRWGEPRSFSFEPKPHWDIADQLGLLDFERAAKVAG
SRFVFYKGLGARLERALINFMLDIHLDEFGYQEVLPPYLVNRASMIGTGQLPKFAEDAFHLDNEDYFLIPTAEVPVTNLH
RDEILTADDLPLYYAAYSACFRAEAGSAGRDTRGLIRQHQFNKVELVKFVKPEDSYDELEKLTHQAETILQRLGLPYRVV
ALCTGDLGFSAAKTYDIEVWLPSYGTYREISSCSNFEAFQARRANIRFRREPKAKPEYVHTLNGSGLAIGRTVAAILENY
QQEDGSVVIPGALRPYMGNRDVIR

Specific function: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) [H]

COG id: COG0172

COG function: function code J; Seryl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily [H]

Homologues:

Organism=Homo sapiens, GI16306548, Length=449, Percent_Identity=34.5211581291759, Blast_Score=233, Evalue=2e-61,
Organism=Homo sapiens, GI8923421, Length=421, Percent_Identity=32.0665083135392, Blast_Score=201, Evalue=1e-51,
Organism=Homo sapiens, GI225579074, Length=334, Percent_Identity=35.3293413173653, Blast_Score=193, Evalue=3e-49,
Organism=Escherichia coli, GI1787120, Length=430, Percent_Identity=51.3953488372093, Blast_Score=442, Evalue=1e-125,
Organism=Caenorhabditis elegans, GI17539260, Length=464, Percent_Identity=30.8189655172414, Blast_Score=209, Evalue=3e-54,
Organism=Caenorhabditis elegans, GI17542084, Length=359, Percent_Identity=28.133704735376, Blast_Score=133, Evalue=1e-31,
Organism=Saccharomyces cerevisiae, GI6320226, Length=395, Percent_Identity=35.6962025316456, Blast_Score=240, Evalue=3e-64,
Organism=Saccharomyces cerevisiae, GI6321799, Length=415, Percent_Identity=32.0481927710843, Blast_Score=214, Evalue=2e-56,
Organism=Drosophila melanogaster, GI24581334, Length=447, Percent_Identity=32.8859060402685, Blast_Score=210, Evalue=2e-54,
Organism=Drosophila melanogaster, GI17737985, Length=391, Percent_Identity=33.2480818414322, Blast_Score=164, Evalue=9e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR002317
- InterPro:   IPR015866
- InterPro:   IPR010978 [H]

Pfam domain/function: PF02403 Seryl_tRNA_N; PF00587 tRNA-synt_2b [H]

EC number: =6.1.1.11 [H]

Molecular weight: Translated: 48621; Mature: 48621

Theoretical pI: Translated: 5.12; Mature: 5.12

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDVKLLRTQFQEVKEKLLQRGDDLANIDRFEQLDKERRRLIAQVEELKSKRNEVSQQIA
CCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VLKREKKDAESLIAEMREVGDRIKQMDEQIRQLEEELDSLLLSIPNVPHESVPVGQSEED
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
NVEVRRWGEPRSFSFEPKPHWDIADQLGLLDFERAAKVAGSRFVFYKGLGARLERALINF
CCHHEECCCCCCCCCCCCCCCCHHHHHCCHHHHHHHHHHCCEEEEECCHHHHHHHHHHHH
MLDIHLDEFGYQEVLPPYLVNRASMIGTGQLPKFAEDAFHLDNEDYFLIPTAEVPVTNLH
HHHHHHHHCCHHHCCCHHHHCCHHHCCCCCCCHHHHHHHCCCCCCEEEEECCCCCCCCCC
RDEILTADDLPLYYAAYSACFRAEAGSAGRDTRGLIRQHQFNKVELVKFVKPEDSYDELE
HHHCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCEEEHEEECCCCCHHHHH
KLTHQAETILQRLGLPYRVVALCTGDLGFSAAKTYDIEVWLPSYGTYREISSCSNFEAFQ
HHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCEEEEEEEEECCCCCHHHHHCCCCHHHHH
ARRANIRFRREPKAKPEYVHTLNGSGLAIGRTVAAILENYQQEDGSVVIPGALRPYMGNR
HHHCCCEECCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHCCCCEEECCCCCCCCCCC
DVIR
CCCC
>Mature Secondary Structure
MLDVKLLRTQFQEVKEKLLQRGDDLANIDRFEQLDKERRRLIAQVEELKSKRNEVSQQIA
CCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VLKREKKDAESLIAEMREVGDRIKQMDEQIRQLEEELDSLLLSIPNVPHESVPVGQSEED
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
NVEVRRWGEPRSFSFEPKPHWDIADQLGLLDFERAAKVAGSRFVFYKGLGARLERALINF
CCHHEECCCCCCCCCCCCCCCCHHHHHCCHHHHHHHHHHCCEEEEECCHHHHHHHHHHHH
MLDIHLDEFGYQEVLPPYLVNRASMIGTGQLPKFAEDAFHLDNEDYFLIPTAEVPVTNLH
HHHHHHHHCCHHHCCCHHHHCCHHHCCCCCCCHHHHHHHCCCCCCEEEEECCCCCCCCCC
RDEILTADDLPLYYAAYSACFRAEAGSAGRDTRGLIRQHQFNKVELVKFVKPEDSYDELE
HHHCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCEEEHEEECCCCCHHHHH
KLTHQAETILQRLGLPYRVVALCTGDLGFSAAKTYDIEVWLPSYGTYREISSCSNFEAFQ
HHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCEEEEEEEEECCCCCHHHHHCCCCHHHHH
ARRANIRFRREPKAKPEYVHTLNGSGLAIGRTVAAILENYQQEDGSVVIPGALRPYMGNR
HHHCCCEECCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHCCCCEEECCCCCCCCCCC
DVIR
CCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA