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The map label for this gene is guaB [H]

Identifier: 138893688

GI number: 138893688

Start: 17037

End: 18503

Strand: Direct

Name: guaB [H]

Synonym: GTNG_0009

Alternate gene names: 138893688

Gene position: 17037-18503 (Clockwise)

Preceding gene: 138893686

Following gene: 138893689

Centisome position: 0.48

GC content: 51.33

Gene sequence:

>1467_bases
ATGTGGGAAGCGAAATTCGCGAAGGAAGGATTGACGTTTGACGATGTTCTTCTCATCCCGGCAAAATCTGACGTGCTGCC
GCGCGATGTTGATGTCACGACGAGGTTAAGTGACACACTGCAGTTGAACATCCCGATTATTAGCGCTGGCATGGATACCG
TCACCGAGGCCGAAATGGCGATTGCGATGGCGCGTCAAGGTGGTCTTGGTATCATCCACAAAAACATGTCCATTGAGCAG
CAAGCTGAGCAAGTCGATAAAGTAAAACGGTCGGAGCGAGGGGTTATTACTGATCCGTTTTTCTTAACGCCTGATCATCA
AGTGTACGATGCGGAGCATTTAATGGGCAAATACCGCATCTCAGGTGTGCCGATCGTGAACAACGCTGAGGAACAAAAGC
TTGTTGGGATTATTACAAACCGCGATTTGCGTTTTATTCAAGACTACTCGATTAAAATTTCCGAGGTAATGACGAAAGAA
AATTTGATCACAGCTCCGGTTGGAACAACGTTAGAGGAAGCGGAGAAAATTTTGCAACAACATAAAGTCGAGAAATTGCC
GCTTGTTGATGAAAACGGGATACTAAAAGGGTTAATTACCATCAAGGACATTGAGAAGGTGATTGAGTTCCCGAACTCGG
CGAAGGACGCGAAAGGACGGCTTGTCGTCGGGGCGGCTGTTGGAGTGACAGCGGACACGATGATCCGTGTTAAAAAACTC
GTTGAGGCAGGGGTTGACGTCATTGTCGTCGACACGGCGCACGGCCACTCCAAAGGTGTCCTCGAGACAGTGGCCAATAT
CCGTCGCCAGTACCCAGATTTGAACATTATCGCTGGGAATGTCGCGACAGCTGAGGCGACGCGCGACTTAATTGAAGCGG
GAGCAAACATTATTAAAGTCGGGATCGGTCCGGGATCTATTTGCACGACACGGGTTGTCGCCGGGGTTGGAGTGCCGCAA
ATTACAGCCATTTACGATTGTGCGACGGAGGCGCGCAAACATGGCGTTCCGATTATCGCTGACGGCGGGATCAAATATTC
CGGCGACATCGTGAAGGCGATGGCGGCTGGAGCGCATGCTGTTATGCTTGGTAGTTTGCTCGCCGGCGTCTCAGAAAGCC
CAGGTGAGACGGAAATTTATCAAGGACGTCGCTTTAAAGTGTACCGGGGTATGGGATCGGTCGCGTCAATGGAGCGAGGC
AGCAAGGACCGCTATTTCCAAGAGGAAGCGAAAAAGTTTGTCCCGGAAGGCATCGAGGGACGCGTGCCATACAAAGGACC
GCTCGCTGATACGATTTACCAGCTCGTCGGCGGACTGCGTGCTGGTATGGGCTACTGCGGAACGCGGAACTTGGACGAGT
TGCGGGAGAAAACACAATTTATCCGCATGACGGGCGCAGGACTCCGTGAAAGCCATCCGCACGATGTACAAATTACGAAA
GAGGCGCCAAACTACTCTGCGTTTTAA

Upstream 100 bases:

>100_bases
AGGGAAATAACTGAAAAGTAGGACATTTTTTTGATTCCTTGACAGTAGTTTAACCAGTTGTTAAGCTACTAATAATATTT
CCGGACAAGGGGGAGAAAAC

Downstream 100 bases:

>100_bases
GCGAGGTTGCGCCAATCGACCTAACTTTGACGGAGACATGTTCTCCGTCTATTTTTTTGGCTGTCCATATGTTACAATAA
CGGTTGTGTAAGGAGGGTGC

Product: inosine 5'-monophosphate dehydrogenase

Products: NA

Alternate protein names: IMP dehydrogenase; IMPD; IMPDH; Superoxide-inducible protein 12; SOI12 [H]

Number of amino acids: Translated: 488; Mature: 488

Protein sequence:

>488_residues
MWEAKFAKEGLTFDDVLLIPAKSDVLPRDVDVTTRLSDTLQLNIPIISAGMDTVTEAEMAIAMARQGGLGIIHKNMSIEQ
QAEQVDKVKRSERGVITDPFFLTPDHQVYDAEHLMGKYRISGVPIVNNAEEQKLVGIITNRDLRFIQDYSIKISEVMTKE
NLITAPVGTTLEEAEKILQQHKVEKLPLVDENGILKGLITIKDIEKVIEFPNSAKDAKGRLVVGAAVGVTADTMIRVKKL
VEAGVDVIVVDTAHGHSKGVLETVANIRRQYPDLNIIAGNVATAEATRDLIEAGANIIKVGIGPGSICTTRVVAGVGVPQ
ITAIYDCATEARKHGVPIIADGGIKYSGDIVKAMAAGAHAVMLGSLLAGVSESPGETEIYQGRRFKVYRGMGSVASMERG
SKDRYFQEEAKKFVPEGIEGRVPYKGPLADTIYQLVGGLRAGMGYCGTRNLDELREKTQFIRMTGAGLRESHPHDVQITK
EAPNYSAF

Sequences:

>Translated_488_residues
MWEAKFAKEGLTFDDVLLIPAKSDVLPRDVDVTTRLSDTLQLNIPIISAGMDTVTEAEMAIAMARQGGLGIIHKNMSIEQ
QAEQVDKVKRSERGVITDPFFLTPDHQVYDAEHLMGKYRISGVPIVNNAEEQKLVGIITNRDLRFIQDYSIKISEVMTKE
NLITAPVGTTLEEAEKILQQHKVEKLPLVDENGILKGLITIKDIEKVIEFPNSAKDAKGRLVVGAAVGVTADTMIRVKKL
VEAGVDVIVVDTAHGHSKGVLETVANIRRQYPDLNIIAGNVATAEATRDLIEAGANIIKVGIGPGSICTTRVVAGVGVPQ
ITAIYDCATEARKHGVPIIADGGIKYSGDIVKAMAAGAHAVMLGSLLAGVSESPGETEIYQGRRFKVYRGMGSVASMERG
SKDRYFQEEAKKFVPEGIEGRVPYKGPLADTIYQLVGGLRAGMGYCGTRNLDELREKTQFIRMTGAGLRESHPHDVQITK
EAPNYSAF
>Mature_488_residues
MWEAKFAKEGLTFDDVLLIPAKSDVLPRDVDVTTRLSDTLQLNIPIISAGMDTVTEAEMAIAMARQGGLGIIHKNMSIEQ
QAEQVDKVKRSERGVITDPFFLTPDHQVYDAEHLMGKYRISGVPIVNNAEEQKLVGIITNRDLRFIQDYSIKISEVMTKE
NLITAPVGTTLEEAEKILQQHKVEKLPLVDENGILKGLITIKDIEKVIEFPNSAKDAKGRLVVGAAVGVTADTMIRVKKL
VEAGVDVIVVDTAHGHSKGVLETVANIRRQYPDLNIIAGNVATAEATRDLIEAGANIIKVGIGPGSICTTRVVAGVGVPQ
ITAIYDCATEARKHGVPIIADGGIKYSGDIVKAMAAGAHAVMLGSLLAGVSESPGETEIYQGRRFKVYRGMGSVASMERG
SKDRYFQEEAKKFVPEGIEGRVPYKGPLADTIYQLVGGLRAGMGYCGTRNLDELREKTQFIRMTGAGLRESHPHDVQITK
EAPNYSAF

Specific function: GMP biosynthesis from IMP; first step. [C]

COG id: COG0516

COG function: function code F; IMP dehydrogenase/GMP reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains [H]

Homologues:

Organism=Homo sapiens, GI217035146, Length=456, Percent_Identity=44.5175438596491, Blast_Score=371, Evalue=1e-103,
Organism=Homo sapiens, GI34328930, Length=455, Percent_Identity=44.6153846153846, Blast_Score=370, Evalue=1e-102,
Organism=Homo sapiens, GI34328928, Length=455, Percent_Identity=44.6153846153846, Blast_Score=370, Evalue=1e-102,
Organism=Homo sapiens, GI156616279, Length=455, Percent_Identity=44.6153846153846, Blast_Score=370, Evalue=1e-102,
Organism=Homo sapiens, GI66933016, Length=453, Percent_Identity=42.8256070640177, Blast_Score=364, Evalue=1e-100,
Organism=Homo sapiens, GI217035152, Length=447, Percent_Identity=44.7427293064877, Blast_Score=361, Evalue=1e-100,
Organism=Homo sapiens, GI217035148, Length=456, Percent_Identity=43.640350877193, Blast_Score=358, Evalue=4e-99,
Organism=Homo sapiens, GI217035150, Length=456, Percent_Identity=41.6666666666667, Blast_Score=333, Evalue=2e-91,
Organism=Homo sapiens, GI50541954, Length=246, Percent_Identity=41.869918699187, Blast_Score=179, Evalue=4e-45,
Organism=Homo sapiens, GI50541952, Length=246, Percent_Identity=41.869918699187, Blast_Score=179, Evalue=4e-45,
Organism=Homo sapiens, GI50541948, Length=246, Percent_Identity=41.869918699187, Blast_Score=179, Evalue=4e-45,
Organism=Homo sapiens, GI50541956, Length=246, Percent_Identity=41.869918699187, Blast_Score=179, Evalue=5e-45,
Organism=Homo sapiens, GI156104880, Length=248, Percent_Identity=40.3225806451613, Blast_Score=174, Evalue=2e-43,
Organism=Escherichia coli, GI1788855, Length=484, Percent_Identity=55.9917355371901, Blast_Score=493, Evalue=1e-140,
Organism=Escherichia coli, GI1786293, Length=256, Percent_Identity=37.890625, Blast_Score=172, Evalue=6e-44,
Organism=Caenorhabditis elegans, GI71994385, Length=474, Percent_Identity=37.3417721518987, Blast_Score=300, Evalue=1e-81,
Organism=Caenorhabditis elegans, GI71994389, Length=422, Percent_Identity=38.3886255924171, Blast_Score=281, Evalue=7e-76,
Organism=Caenorhabditis elegans, GI17560440, Length=219, Percent_Identity=40.6392694063927, Blast_Score=173, Evalue=2e-43,
Organism=Saccharomyces cerevisiae, GI6323585, Length=458, Percent_Identity=41.2663755458515, Blast_Score=343, Evalue=4e-95,
Organism=Saccharomyces cerevisiae, GI6322012, Length=458, Percent_Identity=39.7379912663755, Blast_Score=337, Evalue=2e-93,
Organism=Saccharomyces cerevisiae, GI6323464, Length=458, Percent_Identity=40.6113537117904, Blast_Score=333, Evalue=3e-92,
Organism=Saccharomyces cerevisiae, GI6319352, Length=338, Percent_Identity=40.2366863905325, Blast_Score=257, Evalue=3e-69,
Organism=Saccharomyces cerevisiae, GI6319353, Length=116, Percent_Identity=40.5172413793103, Blast_Score=84, Evalue=7e-17,
Organism=Drosophila melanogaster, GI24641071, Length=479, Percent_Identity=41.1273486430063, Blast_Score=355, Evalue=3e-98,
Organism=Drosophila melanogaster, GI24641073, Length=479, Percent_Identity=41.1273486430063, Blast_Score=355, Evalue=3e-98,
Organism=Drosophila melanogaster, GI28571163, Length=437, Percent_Identity=41.6475972540046, Blast_Score=321, Evalue=8e-88,

Paralogues:

None

Copy number: 600 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000644
- InterPro:   IPR005990
- InterPro:   IPR018529
- InterPro:   IPR015875
- InterPro:   IPR001093 [H]

Pfam domain/function: PF00571 CBS; PF00478 IMPDH [H]

EC number: =1.1.1.205 [H]

Molecular weight: Translated: 52946; Mature: 52946

Theoretical pI: Translated: 6.37; Mature: 6.37

Prosite motif: PS00487 IMP_DH_GMP_RED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MWEAKFAKEGLTFDDVLLIPAKSDVLPRDVDVTTRLSDTLQLNIPIISAGMDTVTEAEMA
CCCCHHHHCCCCCCCEEEEECCCCCCCCCCCCCEECCCEEEEEEEEEECCCCHHHHHHHH
IAMARQGGLGIIHKNMSIEQQAEQVDKVKRSERGVITDPFFLTPDHQVYDAEHLMGKYRI
HHHHHCCCCEEEECCCCHHHHHHHHHHHHHHCCCCCCCCEEECCCCCEECHHHHHHHHEE
SGVPIVNNAEEQKLVGIITNRDLRFIQDYSIKISEVMTKENLITAPVGTTLEEAEKILQQ
CCCCEECCCCCCEEEEEEECCCEEEECCCCEEHHHHHHHCCEEECCCCCCHHHHHHHHHH
HKVEKLPLVDENGILKGLITIKDIEKVIEFPNSAKDAKGRLVVGAAVGVTADTMIRVKKL
HCHHCCCCCCCCCCEEEEHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCHHHHHHHHHH
VEAGVDVIVVDTAHGHSKGVLETVANIRRQYPDLNIIAGNVATAEATRDLIEAGANIIKV
HHCCCCEEEEECCCCCCCHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHCCCCEEEE
GIGPGSICTTRVVAGVGVPQITAIYDCATEARKHGVPIIADGGIKYSGDIVKAMAAGAHA
ECCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCEEECCCEEECCHHHHHHHCCHHH
VMLGSLLAGVSESPGETEIYQGRRFKVYRGMGSVASMERGSKDRYFQEEAKKFVPEGIEG
HHHHHHHHCCCCCCCCCHHHCCCEEEEEECCCCHHHHHCCCCCHHHHHHHHHHCCCCCCC
RVPYKGPLADTIYQLVGGLRAGMGYCGTRNLDELREKTQFIRMTGAGLRESHPHDVQITK
CCCCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCEEEEE
EAPNYSAF
CCCCCCCC
>Mature Secondary Structure
MWEAKFAKEGLTFDDVLLIPAKSDVLPRDVDVTTRLSDTLQLNIPIISAGMDTVTEAEMA
CCCCHHHHCCCCCCCEEEEECCCCCCCCCCCCCEECCCEEEEEEEEEECCCCHHHHHHHH
IAMARQGGLGIIHKNMSIEQQAEQVDKVKRSERGVITDPFFLTPDHQVYDAEHLMGKYRI
HHHHHCCCCEEEECCCCHHHHHHHHHHHHHHCCCCCCCCEEECCCCCEECHHHHHHHHEE
SGVPIVNNAEEQKLVGIITNRDLRFIQDYSIKISEVMTKENLITAPVGTTLEEAEKILQQ
CCCCEECCCCCCEEEEEEECCCEEEECCCCEEHHHHHHHCCEEECCCCCCHHHHHHHHHH
HKVEKLPLVDENGILKGLITIKDIEKVIEFPNSAKDAKGRLVVGAAVGVTADTMIRVKKL
HCHHCCCCCCCCCCEEEEHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCHHHHHHHHHH
VEAGVDVIVVDTAHGHSKGVLETVANIRRQYPDLNIIAGNVATAEATRDLIEAGANIIKV
HHCCCCEEEEECCCCCCCHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHCCCCEEEE
GIGPGSICTTRVVAGVGVPQITAIYDCATEARKHGVPIIADGGIKYSGDIVKAMAAGAHA
ECCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCEEECCCEEECCHHHHHHHCCHHH
VMLGSLLAGVSESPGETEIYQGRRFKVYRGMGSVASMERGSKDRYFQEEAKKFVPEGIEG
HHHHHHHHCCCCCCCCCHHHCCCEEEEEECCCCHHHHHCCCCCHHHHHHHHHHCCCCCCC
RVPYKGPLADTIYQLVGGLRAGMGYCGTRNLDELREKTQFIRMTGAGLRESHPHDVQITK
CCCCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCEEEEE
EAPNYSAF
CCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1979163; 7584024; 9384377; 9298659 [H]