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The map label for this gene is gyrA [H]

Identifier: 138893685

GI number: 138893685

Start: 6531

End: 8999

Strand: Direct

Name: gyrA [H]

Synonym: GTNG_0006

Alternate gene names: 138893685

Gene position: 6531-8999 (Clockwise)

Preceding gene: 138893684

Following gene: 138893686

Centisome position: 0.18

GC content: 49.53

Gene sequence:

>2469_bases
ATGGCAGAACACGAACAACCACGCATTCGCGAAGTGAATATTAGCCAAGAAATGCGCTCTTCGTTCCTCGATTATGCAAT
GAGCGTCATCGTTTCGCGCGCCTTGCCGGATGTGCGCGACGGATTGAAACCGGTGCACCGCCGCATTTTATACGCCATGC
ACGATCTTGGCATGACCGCCGATAAACCGTACAAAAAATCGGCTCGCATTGTCGGCGAAGTGATCGGGAAATACCATCCG
CACGGCGATGCCGCCGTGTATGATACGATGGTGCGCATGGCGCAAGATTTCAACTATCGATATATGCTCGTTGATGGGCA
CGGCAACTTTGGATCGATCGACGGCGATGCAGCGGCCGCCATGCGTTATACGGAAGCGCGGATGTCCAAAATCGCGATGG
AACTGTTGCGTGATATCAACAAAGATACGATCGACTACCAAGACAACTATGATGGCTCGGAAAAAGAGCCGGTGGTGCTG
CCGTCTCGGTTTCCAAACTTGCTTGTCAATGGTTCATCGGGTATCGCTGTTGGGATGGCGACGAACATTCCGCCGCATCA
GCTTGGTGAGGTAATCGACGCTTTGTTGGCGCTAAGCCAAAACCCGGAAATGACAGTCGCTGACTTAATGGAATACATCC
CTGGTCCTGATTTTCCGACTGCCGGACAAATTATCGGCCGCAGCGGCATCCGCAAAGCGTATGAAACGGGACGAGGCTCG
ATTACATTGCGCGCTAAGGCTGAAATTGAGCAGCATGCCAATGGCAAAGAAACGATTATTGTCAGTGAACTCCCTTACCA
AGTGAACAAAGCGAAACTGATTGAACGGATTGCTGAGCTTGTACGTGAGAGAAAAATTGACGGGATTACTGACTTGCGCG
ACGAGTCGGACCGGAACGGTATGCGCATCGTCATTGAAGTGCGGCGTGATGCGAACGCGAAAGTCGTTTTAAACAATTTG
TACAAATATACAGCCCTACAAACAAGTTTCGGAATTAATATGCTCGCCTTAGTGAACGGCGAGCCGAAAGTGCTGAACTT
AAAAGAATGCTTGGAGCATTATTTAAACCATCAAAAAACGGTCATTCGCCGCCGGACGGCATTCGAACTCAAAAAGGCTG
AGGCACGCGCCCACATTTTGGAAGGTTTGCGTATCGCCCTCGATCATTTGGATGAAGTGATCGACTTGATCCGACGTTCG
CAGACAACGGAGGCAGCACGCGAAGGATTGATGGAGCGATTCTCGCTCAGTGAACGGCAGGCACAAGCGATCTTGGATAT
GCGTCTACAGCGGCTGACCGGCCTTGAACGGGAGAAAATTGAACAAGAATATCAAGACATTGTCCGTCTCATCGCTGAAC
TGAGAGCGGTGTTGGCTGACGAAGAGAAAGTGTTGCAAATTATTCGCGACGAGCTTAGCGAGATTAAAGAACGATTTAAC
GATGAGCGGCGTACGGAAATCGTTGTTGGAGCTGTCGAACAGCTGGACGACGAAGACTTAATTCCGCATGAGCATATTGT
CATTACACTCACCCATAAAGGCTATATTAAGCGTCTACCTTTATCGACATATCGGAGTCAAAAGCGCGGTGGCCGAGGCG
TGCAAGGGATGCACACATCGGAAGACGATTTTGTCGAACATTTGCTTATTACATCGACCCATGACACCGTACTATTTTTT
ACAAACAAAGGGAAAGTATATCAGGCGAAAGGCTACGAAATCCCAGAGTTCGGCCGAACGGCCAAAGGACTGCCGATCAT
TAACTTGCTTGAGCTCGATAAAGACGAGTGGATTAACGCTATGATCCCGATTGAAACATTTGACGACGAACGTTACCTTG
TGTTTTCGACAAAACAAGGGATCGCCAAGCGCTCCTCACTCTCCTCCTTCGCCCATATTCGCAACAATGGGCTCATTGCT
ATTCATTTGCGCGAAGGGGATGAGCTGATTTCCGTCAGATTGACGGACGGCCAAAAACATTTGATTATCGGCACGAAAAA
TGGGATGCTTATCCGTTTCCCGGAAACCGATGTGCGAACGATGGGCCGTAGCGCAACCGGAGTCAAAGCAATCACGCTTG
ATGACAATGATGAAGTCGTTAGCATGGAGATTTTAGAAGACCACCACGACGTGCTTGTTGTCACGAAAAAAGGATTCGGT
AAGCGCACTCCGGCCTCGGAATACCGAGTGCAAAGCCGCGGCGGCAAGGGATTGAAAACATGCAACGTTACAGAAAGAAA
CGGTTCTGTCGTCGCAGTGACGACTGTCGTTGGCAATGAAGACTTAATGGTGATTACGACCAGTGGTGTACTCATCCGTA
TTTCGGTCAGTGATATTTCCCGAACAGGGAGAGTCGCTCAAGGTGTGAAACTTATTCGCCTATCTGGTGAAGATGAACAC
GAGTGCGTCGCCACCGTAGCAAAGGTAACCGAGGAAGAAAAAGAGGAAGAGGAAGGCCATTCGGCTTAG

Upstream 100 bases:

>100_bases
TCACCCGGCGCGCGAGCGAAGCGGCGCGCGCCGCTTGTCTGTTTCTGCCGCTTATAAGGCAGAACGGAGCGGTGGAGGTT
CAAAAGGGAGGTTTGGACGA

Downstream 100 bases:

>100_bases
CTTCTATGACGTTCCGTCCATTAAGGTACGGAGCGTCTTTCTTTTTTTTTTGGGCCGAAAGCACTGCCATTGGAAGGAAA
ATCATGTTACGATAGAAATA

Product: DNA gyrase subunit A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 822; Mature: 821

Protein sequence:

>822_residues
MAEHEQPRIREVNISQEMRSSFLDYAMSVIVSRALPDVRDGLKPVHRRILYAMHDLGMTADKPYKKSARIVGEVIGKYHP
HGDAAVYDTMVRMAQDFNYRYMLVDGHGNFGSIDGDAAAAMRYTEARMSKIAMELLRDINKDTIDYQDNYDGSEKEPVVL
PSRFPNLLVNGSSGIAVGMATNIPPHQLGEVIDALLALSQNPEMTVADLMEYIPGPDFPTAGQIIGRSGIRKAYETGRGS
ITLRAKAEIEQHANGKETIIVSELPYQVNKAKLIERIAELVRERKIDGITDLRDESDRNGMRIVIEVRRDANAKVVLNNL
YKYTALQTSFGINMLALVNGEPKVLNLKECLEHYLNHQKTVIRRRTAFELKKAEARAHILEGLRIALDHLDEVIDLIRRS
QTTEAAREGLMERFSLSERQAQAILDMRLQRLTGLEREKIEQEYQDIVRLIAELRAVLADEEKVLQIIRDELSEIKERFN
DERRTEIVVGAVEQLDDEDLIPHEHIVITLTHKGYIKRLPLSTYRSQKRGGRGVQGMHTSEDDFVEHLLITSTHDTVLFF
TNKGKVYQAKGYEIPEFGRTAKGLPIINLLELDKDEWINAMIPIETFDDERYLVFSTKQGIAKRSSLSSFAHIRNNGLIA
IHLREGDELISVRLTDGQKHLIIGTKNGMLIRFPETDVRTMGRSATGVKAITLDDNDEVVSMEILEDHHDVLVVTKKGFG
KRTPASEYRVQSRGGKGLKTCNVTERNGSVVAVTTVVGNEDLMVITTSGVLIRISVSDISRTGRVAQGVKLIRLSGEDEH
ECVATVAKVTEEEKEEEEGHSA

Sequences:

>Translated_822_residues
MAEHEQPRIREVNISQEMRSSFLDYAMSVIVSRALPDVRDGLKPVHRRILYAMHDLGMTADKPYKKSARIVGEVIGKYHP
HGDAAVYDTMVRMAQDFNYRYMLVDGHGNFGSIDGDAAAAMRYTEARMSKIAMELLRDINKDTIDYQDNYDGSEKEPVVL
PSRFPNLLVNGSSGIAVGMATNIPPHQLGEVIDALLALSQNPEMTVADLMEYIPGPDFPTAGQIIGRSGIRKAYETGRGS
ITLRAKAEIEQHANGKETIIVSELPYQVNKAKLIERIAELVRERKIDGITDLRDESDRNGMRIVIEVRRDANAKVVLNNL
YKYTALQTSFGINMLALVNGEPKVLNLKECLEHYLNHQKTVIRRRTAFELKKAEARAHILEGLRIALDHLDEVIDLIRRS
QTTEAAREGLMERFSLSERQAQAILDMRLQRLTGLEREKIEQEYQDIVRLIAELRAVLADEEKVLQIIRDELSEIKERFN
DERRTEIVVGAVEQLDDEDLIPHEHIVITLTHKGYIKRLPLSTYRSQKRGGRGVQGMHTSEDDFVEHLLITSTHDTVLFF
TNKGKVYQAKGYEIPEFGRTAKGLPIINLLELDKDEWINAMIPIETFDDERYLVFSTKQGIAKRSSLSSFAHIRNNGLIA
IHLREGDELISVRLTDGQKHLIIGTKNGMLIRFPETDVRTMGRSATGVKAITLDDNDEVVSMEILEDHHDVLVVTKKGFG
KRTPASEYRVQSRGGKGLKTCNVTERNGSVVAVTTVVGNEDLMVITTSGVLIRISVSDISRTGRVAQGVKLIRLSGEDEH
ECVATVAKVTEEEKEEEEGHSA
>Mature_821_residues
AEHEQPRIREVNISQEMRSSFLDYAMSVIVSRALPDVRDGLKPVHRRILYAMHDLGMTADKPYKKSARIVGEVIGKYHPH
GDAAVYDTMVRMAQDFNYRYMLVDGHGNFGSIDGDAAAAMRYTEARMSKIAMELLRDINKDTIDYQDNYDGSEKEPVVLP
SRFPNLLVNGSSGIAVGMATNIPPHQLGEVIDALLALSQNPEMTVADLMEYIPGPDFPTAGQIIGRSGIRKAYETGRGSI
TLRAKAEIEQHANGKETIIVSELPYQVNKAKLIERIAELVRERKIDGITDLRDESDRNGMRIVIEVRRDANAKVVLNNLY
KYTALQTSFGINMLALVNGEPKVLNLKECLEHYLNHQKTVIRRRTAFELKKAEARAHILEGLRIALDHLDEVIDLIRRSQ
TTEAAREGLMERFSLSERQAQAILDMRLQRLTGLEREKIEQEYQDIVRLIAELRAVLADEEKVLQIIRDELSEIKERFND
ERRTEIVVGAVEQLDDEDLIPHEHIVITLTHKGYIKRLPLSTYRSQKRGGRGVQGMHTSEDDFVEHLLITSTHDTVLFFT
NKGKVYQAKGYEIPEFGRTAKGLPIINLLELDKDEWINAMIPIETFDDERYLVFSTKQGIAKRSSLSSFAHIRNNGLIAI
HLREGDELISVRLTDGQKHLIIGTKNGMLIRFPETDVRTMGRSATGVKAITLDDNDEVVSMEILEDHHDVLVVTKKGFGK
RTPASEYRVQSRGGKGLKTCNVTERNGSVVAVTTVVGNEDLMVITTSGVLIRISVSDISRTGRVAQGVKLIRLSGEDEHE
CVATVAKVTEEEKEEEEGHSA

Specific function: DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings [H]

COG id: COG0188

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the topoisomerase gyrA/parC subunit family [H]

Homologues:

Organism=Homo sapiens, GI19913406, Length=321, Percent_Identity=25.5451713395639, Blast_Score=77, Evalue=5e-14,
Organism=Homo sapiens, GI19913408, Length=318, Percent_Identity=24.2138364779874, Blast_Score=71, Evalue=5e-12,
Organism=Escherichia coli, GI1788562, Length=844, Percent_Identity=52.0142180094787, Blast_Score=870, Evalue=0.0,
Organism=Escherichia coli, GI1789396, Length=671, Percent_Identity=37.5558867362146, Blast_Score=433, Evalue=1e-122,
Organism=Caenorhabditis elegans, GI17535065, Length=176, Percent_Identity=33.5227272727273, Blast_Score=71, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6324241, Length=207, Percent_Identity=28.5024154589372, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI17136538, Length=249, Percent_Identity=29.3172690763052, Blast_Score=75, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020899
- InterPro:   IPR005743
- InterPro:   IPR006691
- InterPro:   IPR002205
- InterPro:   IPR013758
- InterPro:   IPR013757
- InterPro:   IPR013760 [H]

Pfam domain/function: PF03989 DNA_gyraseA_C; PF00521 DNA_topoisoIV [H]

EC number: =5.99.1.3 [H]

Molecular weight: Translated: 92485; Mature: 92354

Theoretical pI: Translated: 6.23; Mature: 6.23

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAEHEQPRIREVNISQEMRSSFLDYAMSVIVSRALPDVRDGLKPVHRRILYAMHDLGMTA
CCCCCCCCCEEECCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCC
DKPYKKSARIVGEVIGKYHPHGDAAVYDTMVRMAQDFNYRYMLVDGHGNFGSIDGDAAAA
CCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCHHHH
MRYTEARMSKIAMELLRDINKDTIDYQDNYDGSEKEPVVLPSRFPNLLVNGSSGIAVGMA
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEECCCCCCCEEEECCCCEEEEEE
TNIPPHQLGEVIDALLALSQNPEMTVADLMEYIPGPDFPTAGQIIGRSGIRKAYETGRGS
CCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCC
ITLRAKAEIEQHANGKETIIVSELPYQVNKAKLIERIAELVRERKIDGITDLRDESDRNG
EEEEEEHHHHHCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
MRIVIEVRRDANAKVVLNNLYKYTALQTSFGINMLALVNGEPKVLNLKECLEHYLNHQKT
CEEEEEEECCCCCEEEEHHHHHHHHHHHHCCCEEEEEECCCCCEECHHHHHHHHHCHHHH
VIRRRTAFELKKAEARAHILEGLRIALDHLDEVIDLIRRSQTTEAAREGLMERFSLSERQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCHHHH
AQAILDMRLQRLTGLEREKIEQEYQDIVRLIAELRAVLADEEKVLQIIRDELSEIKERFN
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHC
DERRTEIVVGAVEQLDDEDLIPHEHIVITLTHKGYIKRLPLSTYRSQKRGGRGVQGMHTS
CHHHHEEEEEHHHHCCCCCCCCCCEEEEEEECCCCCEECCCHHHHHHHCCCCCCCCCCCC
EDDFVEHLLITSTHDTVLFFTNKGKVYQAKGYEIPEFGRTAKGLPIINLLELDKDEWINA
HHHHHHHHHEECCCCEEEEEECCCEEEEECCCCCCCCCCCCCCCCEEEEEECCCCCCCEE
MIPIETFDDERYLVFSTKQGIAKRSSLSSFAHIRNNGLIAIHLREGDELISVRLTDGQKH
EEEEEECCCCEEEEEECCCCHHHHHHHHHHHHHCCCCEEEEEEECCCEEEEEEEECCCEE
LIIGTKNGMLIRFPETDVRTMGRSATGVKAITLDDNDEVVSMEILEDHHDVLVVTKKGFG
EEEECCCCEEEECCCCHHHHCCCCCCCEEEEEECCCCCEEEEEEECCCCCEEEEEECCCC
KRTPASEYRVQSRGGKGLKTCNVTERNGSVVAVTTVVGNEDLMVITTSGVLIRISVSDIS
CCCCHHHHEECCCCCCCCEEEEEECCCCCEEEEEEEECCCCEEEEEECCEEEEEEHHHHH
RTGRVAQGVKLIRLSGEDEHECVATVAKVTEEEKEEEEGHSA
HCCHHHCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
AEHEQPRIREVNISQEMRSSFLDYAMSVIVSRALPDVRDGLKPVHRRILYAMHDLGMTA
CCCCCCCCEEECCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCC
DKPYKKSARIVGEVIGKYHPHGDAAVYDTMVRMAQDFNYRYMLVDGHGNFGSIDGDAAAA
CCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCHHHH
MRYTEARMSKIAMELLRDINKDTIDYQDNYDGSEKEPVVLPSRFPNLLVNGSSGIAVGMA
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEECCCCCCCEEEECCCCEEEEEE
TNIPPHQLGEVIDALLALSQNPEMTVADLMEYIPGPDFPTAGQIIGRSGIRKAYETGRGS
CCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCC
ITLRAKAEIEQHANGKETIIVSELPYQVNKAKLIERIAELVRERKIDGITDLRDESDRNG
EEEEEEHHHHHCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
MRIVIEVRRDANAKVVLNNLYKYTALQTSFGINMLALVNGEPKVLNLKECLEHYLNHQKT
CEEEEEEECCCCCEEEEHHHHHHHHHHHHCCCEEEEEECCCCCEECHHHHHHHHHCHHHH
VIRRRTAFELKKAEARAHILEGLRIALDHLDEVIDLIRRSQTTEAAREGLMERFSLSERQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCHHHH
AQAILDMRLQRLTGLEREKIEQEYQDIVRLIAELRAVLADEEKVLQIIRDELSEIKERFN
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHC
DERRTEIVVGAVEQLDDEDLIPHEHIVITLTHKGYIKRLPLSTYRSQKRGGRGVQGMHTS
CHHHHEEEEEHHHHCCCCCCCCCCEEEEEEECCCCCEECCCHHHHHHHCCCCCCCCCCCC
EDDFVEHLLITSTHDTVLFFTNKGKVYQAKGYEIPEFGRTAKGLPIINLLELDKDEWINA
HHHHHHHHHEECCCCEEEEEECCCEEEEECCCCCCCCCCCCCCCCEEEEEECCCCCCCEE
MIPIETFDDERYLVFSTKQGIAKRSSLSSFAHIRNNGLIAIHLREGDELISVRLTDGQKH
EEEEEECCCCEEEEEECCCCHHHHHHHHHHHHHCCCCEEEEEEECCCEEEEEEEECCCEE
LIIGTKNGMLIRFPETDVRTMGRSATGVKAITLDDNDEVVSMEILEDHHDVLVVTKKGFG
EEEECCCCEEEECCCCHHHHCCCCCCCEEEEEECCCCCEEEEEEECCCCCEEEEEECCCC
KRTPASEYRVQSRGGKGLKTCNVTERNGSVVAVTTVVGNEDLMVITTSGVLIRISVSDIS
CCCCHHHHEECCCCCCCCEEEEEECCCCCEEEEEEEECCCCEEEEEECCEEEEEEHHHHH
RTGRVAQGVKLIRLSGEDEHECVATVAKVTEEEKEEEEGHSA
HCCHHHCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2987847; 7584024; 9384377 [H]