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The map label for this gene is glcK [H]

Identifier: 134302680

GI number: 134302680

Start: 1443374

End: 1444339

Strand: Reverse

Name: glcK [H]

Synonym: FTW_2105

Alternate gene names: 134302680

Gene position: 1444339-1443374 (Counterclockwise)

Preceding gene: 134302402

Following gene: 134302401

Centisome position: 76.08

GC content: 34.37

Gene sequence:

>966_bases
ATGTACATAGGTTTAGATATTGGCGGTAGTAATATCTCTGCTGGTATTTTTGATGAGCAAAAGAACCTTATTAAAACTGC
AAAGGTTAAATCAAAAGGCAAAAGTGATGCTGATGTAATTCTAGCGCAGATTTTCAAAGTGATTAATAAACTACTTGATA
GTTCAAATAAAAATAAGATAAAAGCTATAGGTATTGGCATTGCTGGTTTTGTTGATTCAAAATCAGGTGTCTTAAATTTC
AGTGCTAATATCAACCTTAATGGTATAAATATTGCTCAAGAAGTCAGCCAAAAATTTGCAAATGTACCAGTATTTATCGA
AAATGATGTAAATGTGGGTGTTATTGGTGAATGGAAATATGGTGCTGGTAGAAGCCATCAAAATATTGTTGGTATATTTG
CAGGCACTGGTATTGGTGGCGGTCTTGTGGTAAATAATCAGTTTTTGTATGGAGTTACAGGAGGTGCAGGCGCAGTTGGG
CATGTGACTATTAATAGTCAAGGAGCTTATTGTCAGAGCTGTGGATCACAAGGATGTTTAGAAACTTATGCTGGTAAAGT
TGGTATTGAAAATAGACTTATGAATTTGCATAAAAAAGGTATAAAAAGCATCCTGATAGATTTTGTTTTAGAAAATAAAG
GTAAACTCAAGGGTTCTCATCTTAAAAAAGCTTTAGCAGCCAAAGATAAAATAGCTGAAGATATAATGACCAATGCAATG
TCTAATCTAGGAATTGCTGTGGCAAACTATATCAATCTTTTAAACCCGTCAATGGTATTGTTCGGTGGTGGGATTATTGA
GGCAGTTGGACAGCAGTACTTAGATACTATTTATCAGTCATATTCAAAATATGCTTTCAAAACGATGTTAGATGCTTGTG
AGTTGAAAATCGCAACATTAGGCGATAATTCAGGTGTGTATAGTGCTATGGATATAGCAGTTAATCGGTTAGAGGGAAAT
TGGTAA

Upstream 100 bases:

>100_bases
CAAAGGTTATAAACTAATAAGTGCTGGTGTAATGGATATGTTCCCTCATACAATGCATGTTGAGTCAATAGCTGTTTTTG
AGAAGATCTAGGAGACATTT

Downstream 100 bases:

>100_bases
TGTTTATAGGCGTTGATATTGGTGGCTCAAATATGGCTGCGGGCTTGTTTGATGAAAGTAAAAATCTAGTCACAACAGCA
AAGGTTAAATCAAAAGCTAA

Product: ROK family glucokinase

Products: NA

Alternate protein names: Glucose kinase [H]

Number of amino acids: Translated: 321; Mature: 321

Protein sequence:

>321_residues
MYIGLDIGGSNISAGIFDEQKNLIKTAKVKSKGKSDADVILAQIFKVINKLLDSSNKNKIKAIGIGIAGFVDSKSGVLNF
SANINLNGINIAQEVSQKFANVPVFIENDVNVGVIGEWKYGAGRSHQNIVGIFAGTGIGGGLVVNNQFLYGVTGGAGAVG
HVTINSQGAYCQSCGSQGCLETYAGKVGIENRLMNLHKKGIKSILIDFVLENKGKLKGSHLKKALAAKDKIAEDIMTNAM
SNLGIAVANYINLLNPSMVLFGGGIIEAVGQQYLDTIYQSYSKYAFKTMLDACELKIATLGDNSGVYSAMDIAVNRLEGN
W

Sequences:

>Translated_321_residues
MYIGLDIGGSNISAGIFDEQKNLIKTAKVKSKGKSDADVILAQIFKVINKLLDSSNKNKIKAIGIGIAGFVDSKSGVLNF
SANINLNGINIAQEVSQKFANVPVFIENDVNVGVIGEWKYGAGRSHQNIVGIFAGTGIGGGLVVNNQFLYGVTGGAGAVG
HVTINSQGAYCQSCGSQGCLETYAGKVGIENRLMNLHKKGIKSILIDFVLENKGKLKGSHLKKALAAKDKIAEDIMTNAM
SNLGIAVANYINLLNPSMVLFGGGIIEAVGQQYLDTIYQSYSKYAFKTMLDACELKIATLGDNSGVYSAMDIAVNRLEGN
W
>Mature_321_residues
MYIGLDIGGSNISAGIFDEQKNLIKTAKVKSKGKSDADVILAQIFKVINKLLDSSNKNKIKAIGIGIAGFVDSKSGVLNF
SANINLNGINIAQEVSQKFANVPVFIENDVNVGVIGEWKYGAGRSHQNIVGIFAGTGIGGGLVVNNQFLYGVTGGAGAVG
HVTINSQGAYCQSCGSQGCLETYAGKVGIENRLMNLHKKGIKSILIDFVLENKGKLKGSHLKKALAAKDKIAEDIMTNAM
SNLGIAVANYINLLNPSMVLFGGGIIEAVGQQYLDTIYQSYSKYAFKTMLDACELKIATLGDNSGVYSAMDIAVNRLEGN
W

Specific function: Acts As A Repressor Of The Nagebacd Operon And Acts Both As An Activator And A Repressor For The Transcription Of The Glmsu Operon. [C]

COG id: COG1940

COG function: function code KG; Transcriptional regulator/sugar kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ROK (nagC/xylR) family [H]

Homologues:

Organism=Homo sapiens, GI298566325, Length=266, Percent_Identity=26.6917293233083, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI298566315, Length=266, Percent_Identity=26.6917293233083, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI190014632, Length=266, Percent_Identity=26.6917293233083, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI4885285, Length=266, Percent_Identity=26.6917293233083, Blast_Score=93, Evalue=3e-19,
Organism=Escherichia coli, GI1786891, Length=295, Percent_Identity=25.0847457627119, Blast_Score=105, Evalue=4e-24,
Organism=Escherichia coli, GI87081733, Length=327, Percent_Identity=25.0764525993884, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI1787878, Length=272, Percent_Identity=23.1617647058824, Blast_Score=85, Evalue=5e-18,
Organism=Escherichia coli, GI1787363, Length=291, Percent_Identity=23.0240549828179, Blast_Score=82, Evalue=4e-17,
Organism=Escherichia coli, GI87082127, Length=216, Percent_Identity=24.537037037037, Blast_Score=66, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000600
- InterPro:   IPR004654 [H]

Pfam domain/function: PF00480 ROK [H]

EC number: =2.7.1.2 [H]

Molecular weight: Translated: 34024; Mature: 34024

Theoretical pI: Translated: 9.19; Mature: 9.19

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYIGLDIGGSNISAGIFDEQKNLIKTAKVKSKGKSDADVILAQIFKVINKLLDSSNKNKI
CEEEEEECCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCEE
KAIGIGIAGFVDSKSGVLNFSANINLNGINIAQEVSQKFANVPVFIENDVNVGVIGEWKY
EEEEEEEEEEECCCCCEEEEEEEEEECCCHHHHHHHHHHCCCCEEEECCCCEEEEEEECC
GAGRSHQNIVGIFAGTGIGGGLVVNNQFLYGVTGGAGAVGHVTINSQGAYCQSCGSQGCL
CCCCCCCCEEEEEECCCCCCCEEEECEEEEEECCCCCCEEEEEECCCCCHHHHCCCCCCH
ETYAGKVGIENRLMNLHKKGIKSILIDFVLENKGKLKGSHLKKALAAKDKIAEDIMTNAM
HHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
SNLGIAVANYINLLNPSMVLFGGGIIEAVGQQYLDTIYQSYSKYAFKTMLDACELKIATL
HHCCHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEE
GDNSGVYSAMDIAVNRLEGNW
CCCCCCHHHHHHHHHHCCCCC
>Mature Secondary Structure
MYIGLDIGGSNISAGIFDEQKNLIKTAKVKSKGKSDADVILAQIFKVINKLLDSSNKNKI
CEEEEEECCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCEE
KAIGIGIAGFVDSKSGVLNFSANINLNGINIAQEVSQKFANVPVFIENDVNVGVIGEWKY
EEEEEEEEEEECCCCCEEEEEEEEEECCCHHHHHHHHHHCCCCEEEECCCCEEEEEEECC
GAGRSHQNIVGIFAGTGIGGGLVVNNQFLYGVTGGAGAVGHVTINSQGAYCQSCGSQGCL
CCCCCCCCEEEEEECCCCCCCEEEECEEEEEECCCCCCEEEEEECCCCCHHHHCCCCCCH
ETYAGKVGIENRLMNLHKKGIKSILIDFVLENKGKLKGSHLKKALAAKDKIAEDIMTNAM
HHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
SNLGIAVANYINLLNPSMVLFGGGIIEAVGQQYLDTIYQSYSKYAFKTMLDACELKIATL
HHCCHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEE
GDNSGVYSAMDIAVNRLEGNW
CCCCCCHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11058132 [H]