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The map label for this gene is lpxP [H]

Identifier: 134302670

GI number: 134302670

Start: 1744002

End: 1744925

Strand: Direct

Name: lpxP [H]

Synonym: FTW_1858

Alternate gene names: 134302670

Gene position: 1744002-1744925 (Clockwise)

Preceding gene: 134302669

Following gene: 134302671

Centisome position: 91.86

GC content: 33.55

Gene sequence:

>924_bases
ATGAATAATAACAAGTTTAGTCCTAAAAACTGGGGTATCTGGATTGTCGTTGGTATAATGAACTGCGGCTCGAAGCTACC
TTTATTTACACATAAATATATAGTTTTAACTATTGGTCTTATTATTAAACCTTTTTTAAAAAGTCGTAATGATATCGCTT
ATGAGAACCTTAAGATAGCTTTTCCTGAGAAATCTAACAAAGAAATAAAAAAACTAGTCAAAAAAAGTTATTATTCAATG
GTGTTATCTGGAGCTGAAACAACCGCCGCATGGTTTCTCTCTAAAAAAAGATTTAATAAAATTGAGTTTAAATGGGAAGA
AGGCTCTAGGGAAAGATTCGAAAAATATCATAATGATCCTGATAAAAAACTAATTATCTTAGGTTTTCACTTTCATTGTA
TCGAGATCATCGGTAGATATATGGGGCAAGAGTTTCCGCCATTTACCGTAATGTATCAAAAAAATGGTAATGACCTTATA
GAAGACTTAATTAAAGAATATCGCGAAAAAAGCCTATATAAGTGTCTTGATAGCAAGAACTTTGTTTCTGTTATTAAAAG
CCTAAAAAAAGGCTATACAATGTGGTACGCTCCAGATCAGGACTTTGGTTTAGAAAGCACCGGCTTAGAAAATTCGGTAT
TTGCTCCTTTTTTTGGTAAACTATGCTCAACTTTAACTGTAACTCCTTGGCTTGCCCAAAAAACGGGAGCTGTTGTAATA
CCTGCATATTATGTTAGAGAAAAGTGTCTAAAAAAATATAAAATAGTCACTGGAGAGCCTTTCGAGTTTACAGGTGACGC
CTATAAAGATGCTGAAATGACAAATAAATTCCTAGAAGATGCGGTAAGAAAATATCCAGAACAATATCTATGGCAGCATC
GTCGCTATAGAACCAGACCAAATGGTGAGCCACAAATATACTAA

Upstream 100 bases:

>100_bases
CTATAAAACAAGACCACTAGGTGAAGAAAAAATTTATTAGTATTTATGATTGTTAAAGTATATGTTAAAATGTCAATAGC
GTTTTAATGTTAAGAAGTAA

Downstream 100 bases:

>100_bases
GGCTTTTATTAAATGTTAGATAAAAAAGGTTTTTCTTTAGTTGAGTTAATAGTGGTAATAGCAATTATAGCTATTCTTGC
ATCTATAGGTATACCTATGT

Product: putative lipid A biosynthesis acyltransferase

Products: KDO2-(palmitoleoyl)-lipid IVA [C]

Alternate protein names: NA

Number of amino acids: Translated: 307; Mature: 307

Protein sequence:

>307_residues
MNNNKFSPKNWGIWIVVGIMNCGSKLPLFTHKYIVLTIGLIIKPFLKSRNDIAYENLKIAFPEKSNKEIKKLVKKSYYSM
VLSGAETTAAWFLSKKRFNKIEFKWEEGSRERFEKYHNDPDKKLIILGFHFHCIEIIGRYMGQEFPPFTVMYQKNGNDLI
EDLIKEYREKSLYKCLDSKNFVSVIKSLKKGYTMWYAPDQDFGLESTGLENSVFAPFFGKLCSTLTVTPWLAQKTGAVVI
PAYYVREKCLKKYKIVTGEPFEFTGDAYKDAEMTNKFLEDAVRKYPEQYLWQHRRYRTRPNGEPQIY

Sequences:

>Translated_307_residues
MNNNKFSPKNWGIWIVVGIMNCGSKLPLFTHKYIVLTIGLIIKPFLKSRNDIAYENLKIAFPEKSNKEIKKLVKKSYYSM
VLSGAETTAAWFLSKKRFNKIEFKWEEGSRERFEKYHNDPDKKLIILGFHFHCIEIIGRYMGQEFPPFTVMYQKNGNDLI
EDLIKEYREKSLYKCLDSKNFVSVIKSLKKGYTMWYAPDQDFGLESTGLENSVFAPFFGKLCSTLTVTPWLAQKTGAVVI
PAYYVREKCLKKYKIVTGEPFEFTGDAYKDAEMTNKFLEDAVRKYPEQYLWQHRRYRTRPNGEPQIY
>Mature_307_residues
MNNNKFSPKNWGIWIVVGIMNCGSKLPLFTHKYIVLTIGLIIKPFLKSRNDIAYENLKIAFPEKSNKEIKKLVKKSYYSM
VLSGAETTAAWFLSKKRFNKIEFKWEEGSRERFEKYHNDPDKKLIILGFHFHCIEIIGRYMGQEFPPFTVMYQKNGNDLI
EDLIKEYREKSLYKCLDSKNFVSVIKSLKKGYTMWYAPDQDFGLESTGLENSVFAPFFGKLCSTLTVTPWLAQKTGAVVI
PAYYVREKCLKKYKIVTGEPFEFTGDAYKDAEMTNKFLEDAVRKYPEQYLWQHRRYRTRPNGEPQIY

Specific function: Unknown

COG id: COG1560

COG function: function code M; Lauroyl/myristoyl acyltransferase

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the htrB/msbB family [H]

Homologues:

Organism=Escherichia coli, GI87082094, Length=304, Percent_Identity=31.25, Blast_Score=160, Evalue=1e-40,
Organism=Escherichia coli, GI1787292, Length=314, Percent_Identity=32.8025477707006, Blast_Score=158, Evalue=5e-40,
Organism=Escherichia coli, GI1788161, Length=304, Percent_Identity=25.3289473684211, Blast_Score=82, Evalue=3e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004960
- InterPro:   IPR011920 [H]

Pfam domain/function: PF03279 Lip_A_acyltrans [H]

EC number: NA

Molecular weight: Translated: 36070; Mature: 36070

Theoretical pI: Translated: 9.78; Mature: 9.78

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNNNKFSPKNWGIWIVVGIMNCGSKLPLFTHKYIVLTIGLIIKPFLKSRNDIAYENLKIA
CCCCCCCCCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEECCEEEE
FPEKSNKEIKKLVKKSYYSMVLSGAETTAAWFLSKKRFNKIEFKWEEGSRERFEKYHNDP
CCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHCCCC
DKKLIILGFHFHCIEIIGRYMGQEFPPFTVMYQKNGNDLIEDLIKEYREKSLYKCLDSKN
CCEEEEEEHHHHHHHHHHHHHCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCH
FVSVIKSLKKGYTMWYAPDQDFGLESTGLENSVFAPFFGKLCSTLTVTPWLAQKTGAVVI
HHHHHHHHHCCCEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCHHHCCCCCEEE
PAYYVREKCLKKYKIVTGEPFEFTGDAYKDAEMTNKFLEDAVRKYPEQYLWQHRRYRTRP
HHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
NGEPQIY
CCCCCCC
>Mature Secondary Structure
MNNNKFSPKNWGIWIVVGIMNCGSKLPLFTHKYIVLTIGLIIKPFLKSRNDIAYENLKIA
CCCCCCCCCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEECCEEEE
FPEKSNKEIKKLVKKSYYSMVLSGAETTAAWFLSKKRFNKIEFKWEEGSRERFEKYHNDP
CCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHCCCC
DKKLIILGFHFHCIEIIGRYMGQEFPPFTVMYQKNGNDLIEDLIKEYREKSLYKCLDSKN
CCEEEEEEHHHHHHHHHHHHHCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCH
FVSVIKSLKKGYTMWYAPDQDFGLESTGLENSVFAPFFGKLCSTLTVTPWLAQKTGAVVI
HHHHHHHHHCCCEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCHHHCCCCCEEE
PAYYVREKCLKKYKIVTGEPFEFTGDAYKDAEMTNKFLEDAVRKYPEQYLWQHRRYRTRP
HHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
NGEPQIY
CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: KDO2-lipid IVA; palmitoleoyl-ACP [C]

Specific reaction: KDO2-lipid IVA + palmitoleoyl-ACP = KDO2-(palmitoleoyl)-lipid IVA + [acyl carrier protein] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9205837; 9278503 [H]