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The map label for this gene is lldD [H]

Identifier: 134302604

GI number: 134302604

Start: 1673202

End: 1674359

Strand: Direct

Name: lldD [H]

Synonym: FTW_1782

Alternate gene names: 134302604

Gene position: 1673202-1674359 (Clockwise)

Preceding gene: 134302603

Following gene: 134302617

Centisome position: 88.13

GC content: 36.44

Gene sequence:

>1158_bases
ATGAAATCTAATTTAACTAAAATCACATCGCTTGATGATATGCGTAAAGTTTATCATCGTAGAGTTCCTAAAATGTTCGT
AGACTATTGTGAAGCTGGTTCATGGCAACAGCAAACCCTAAAATATAATCAACAAGATTTTGGCAATTATCTCTTTAGGC
AAAAAGTTCTCACAGATATACAAAACCGCTCACTAAAAACCAAAATCCTAGGACAAGAGTATAAAATGCCTTTAGTATTT
GCTCCAATAGGACTACTTGGAATGCAACATGCTGATGGTGAAATTCATGCTGCTAGAGCTGCTGAGAAATTTGGTATACC
TTTTACCCTATCGACAATGTCTATCTGCTCTACAGAAGAAGTTGCTAAACATACAACTAAGCCATTCTGGTTTCAGTTGT
ATATGATGAAAGATAGAAAATTCATGGCAAATCTCATAGCAAGCGCAAAGCATGCTGGTTGTAGTGCCCTAGTACTAACA
GCTGACTTACAAATGCTTGGCGATCGCCACGCCGATATAAAAAATGGTCTAACAGTACCACCTAAGCCAACCCTTAAAAA
TTTAATTAACCTAAGCACTAAAGTCCCTTGGTGCTTAAATATGCTAAAAACTAGTAATAGAACTTTTGGTAATATTGTAA
ATCATGCTGCTAACAAAGGTGGCTTTGCATCTCTAGGTAAATGGACAAATGAGCAATTTGATTTAAGTCTAAATTGGCAC
GATGTCGAATGGATACAAAAGCAATGGAATGGTCGGATGATTATCAAAGGTATTATGGATACTCAAGATGCTATTATGGC
TCAAAATACTGGTGCTGATGCAATAGTAGTATCAAACCATGGTGGCCGTCAACTTGATGGTGCTCCTTCAAGTATATCTG
TACTTGAAGAAATAATTGATGCAGTCGATAGAAAACTTGAAGTTCTAATTGATAGCGGTATTCGCACTGGTCAAGATTTA
CTCAAAGCAAAAGCTCTCGGTGCTACAGCTGGACTAATTGGTAGACCAATGGTTTATGGTCTTGGTGCTTATGGCGAACA
AGGAGCTTATAGAGTGCTTGAAATTTTCTATCAAGAAATGGATAAAACCATGGCATTTTGTGGGCATACTAATATTAATA
ATGTCGATAAATCAATTTTGATAAAAAGGAATACTTAA

Upstream 100 bases:

>100_bases
TATAGCTCTGAAGATGATTTTAATGCTAAGCTACCTAAATCAAGACTTCCTGAGGAAAAAATCTTTACTGAAGTTTATTA
TATCTATCGGAAATATCTCA

Downstream 100 bases:

>100_bases
GCACTTAAATAATATAATATCTCAGCAGCAATAAGATGTTGAATAAAGTATAAAACTACGATTGAAATTATCATCGGAGC
TACTAATAACTTTTTGTTGG

Product: L-lactate dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 385; Mature: 385

Protein sequence:

>385_residues
MKSNLTKITSLDDMRKVYHRRVPKMFVDYCEAGSWQQQTLKYNQQDFGNYLFRQKVLTDIQNRSLKTKILGQEYKMPLVF
APIGLLGMQHADGEIHAARAAEKFGIPFTLSTMSICSTEEVAKHTTKPFWFQLYMMKDRKFMANLIASAKHAGCSALVLT
ADLQMLGDRHADIKNGLTVPPKPTLKNLINLSTKVPWCLNMLKTSNRTFGNIVNHAANKGGFASLGKWTNEQFDLSLNWH
DVEWIQKQWNGRMIIKGIMDTQDAIMAQNTGADAIVVSNHGGRQLDGAPSSISVLEEIIDAVDRKLEVLIDSGIRTGQDL
LKAKALGATAGLIGRPMVYGLGAYGEQGAYRVLEIFYQEMDKTMAFCGHTNINNVDKSILIKRNT

Sequences:

>Translated_385_residues
MKSNLTKITSLDDMRKVYHRRVPKMFVDYCEAGSWQQQTLKYNQQDFGNYLFRQKVLTDIQNRSLKTKILGQEYKMPLVF
APIGLLGMQHADGEIHAARAAEKFGIPFTLSTMSICSTEEVAKHTTKPFWFQLYMMKDRKFMANLIASAKHAGCSALVLT
ADLQMLGDRHADIKNGLTVPPKPTLKNLINLSTKVPWCLNMLKTSNRTFGNIVNHAANKGGFASLGKWTNEQFDLSLNWH
DVEWIQKQWNGRMIIKGIMDTQDAIMAQNTGADAIVVSNHGGRQLDGAPSSISVLEEIIDAVDRKLEVLIDSGIRTGQDL
LKAKALGATAGLIGRPMVYGLGAYGEQGAYRVLEIFYQEMDKTMAFCGHTNINNVDKSILIKRNT
>Mature_385_residues
MKSNLTKITSLDDMRKVYHRRVPKMFVDYCEAGSWQQQTLKYNQQDFGNYLFRQKVLTDIQNRSLKTKILGQEYKMPLVF
APIGLLGMQHADGEIHAARAAEKFGIPFTLSTMSICSTEEVAKHTTKPFWFQLYMMKDRKFMANLIASAKHAGCSALVLT
ADLQMLGDRHADIKNGLTVPPKPTLKNLINLSTKVPWCLNMLKTSNRTFGNIVNHAANKGGFASLGKWTNEQFDLSLNWH
DVEWIQKQWNGRMIIKGIMDTQDAIMAQNTGADAIVVSNHGGRQLDGAPSSISVLEEIIDAVDRKLEVLIDSGIRTGQDL
LKAKALGATAGLIGRPMVYGLGAYGEQGAYRVLEIFYQEMDKTMAFCGHTNINNVDKSILIKRNT

Specific function: Unknown

COG id: COG1304

COG function: function code C; L-lactate dehydrogenase (FMN-dependent) and related alpha-hydroxy acid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FMN hydroxy acid dehydrogenase domain [H]

Homologues:

Organism=Homo sapiens, GI11068137, Length=381, Percent_Identity=34.3832020997375, Blast_Score=239, Evalue=3e-63,
Organism=Homo sapiens, GI54234014, Length=374, Percent_Identity=32.3529411764706, Blast_Score=193, Evalue=2e-49,
Organism=Homo sapiens, GI7705393, Length=374, Percent_Identity=32.3529411764706, Blast_Score=193, Evalue=2e-49,
Organism=Escherichia coli, GI1790033, Length=376, Percent_Identity=39.0957446808511, Blast_Score=295, Evalue=3e-81,
Organism=Caenorhabditis elegans, GI193208036, Length=372, Percent_Identity=33.0645161290323, Blast_Score=210, Evalue=1e-54,
Organism=Caenorhabditis elegans, GI32566217, Length=291, Percent_Identity=31.6151202749141, Blast_Score=150, Evalue=7e-37,
Organism=Saccharomyces cerevisiae, GI6323587, Length=391, Percent_Identity=29.6675191815857, Blast_Score=173, Evalue=4e-44,
Organism=Drosophila melanogaster, GI281363140, Length=378, Percent_Identity=33.5978835978836, Blast_Score=229, Evalue=3e-60,
Organism=Drosophila melanogaster, GI78707190, Length=378, Percent_Identity=33.5978835978836, Blast_Score=229, Evalue=3e-60,
Organism=Drosophila melanogaster, GI78707188, Length=378, Percent_Identity=33.3333333333333, Blast_Score=228, Evalue=5e-60,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR012133
- InterPro:   IPR000262
- InterPro:   IPR008259
- InterPro:   IPR020920 [H]

Pfam domain/function: PF01070 FMN_dh [H]

EC number: =1.1.2.3 [H]

Molecular weight: Translated: 43078; Mature: 43078

Theoretical pI: Translated: 9.63; Mature: 9.63

Prosite motif: PS00557 FMN_HYDROXY_ACID_DH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSNLTKITSLDDMRKVYHRRVPKMFVDYCEAGSWQQQTLKYNQQDFGNYLFRQKVLTDI
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCHHHHHHHHHHHHHHHHH
QNRSLKTKILGQEYKMPLVFAPIGLLGMQHADGEIHAARAAEKFGIPFTLSTMSICSTEE
HCCCHHHHHCCHHCCCCEEEECHHHHCCCCCCCCHHHHHHHHHCCCCEEEHHHHHCCHHH
VAKHTTKPFWFQLYMMKDRKFMANLIASAKHAGCSALVLTADLQMLGDRHADIKNGLTVP
HHHHCCCCEEEEEEEHHHHHHHHHHHHHHHCCCCEEEEEEHHHHHHCCCCCHHHCCCCCC
PKPTLKNLINLSTKVPWCLNMLKTSNRTFGNIVNHAANKGGFASLGKWTNEQFDLSLNWH
CCHHHHHHHHHCCCCHHHHHHHHHCCCHHHHHHHHHCCCCCCCHHCCCCCCEEEEEECCC
DVEWIQKQWNGRMIIKGIMDTQDAIMAQNTGADAIVVSNHGGRQLDGAPSSISVLEEIID
HHHHHHHHCCCEEEEEEHHCCHHHHHCCCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHH
AVDRKLEVLIDSGIRTGQDLLKAKALGATAGLIGRPMVYGLGAYGEQGAYRVLEIFYQEM
HHHHHHHHHHHCCCCCHHHHHHHHHHCCHHHHHCCCHHHCCCCCCCCCHHHHHHHHHHHH
DKTMAFCGHTNINNVDKSILIKRNT
HHHHHHHCCCCCCCCCCEEEEEECC
>Mature Secondary Structure
MKSNLTKITSLDDMRKVYHRRVPKMFVDYCEAGSWQQQTLKYNQQDFGNYLFRQKVLTDI
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCHHHHHHHHHHHHHHHHH
QNRSLKTKILGQEYKMPLVFAPIGLLGMQHADGEIHAARAAEKFGIPFTLSTMSICSTEE
HCCCHHHHHCCHHCCCCEEEECHHHHCCCCCCCCHHHHHHHHHCCCCEEEHHHHHCCHHH
VAKHTTKPFWFQLYMMKDRKFMANLIASAKHAGCSALVLTADLQMLGDRHADIKNGLTVP
HHHHCCCCEEEEEEEHHHHHHHHHHHHHHHCCCCEEEEEEHHHHHHCCCCCHHHCCCCCC
PKPTLKNLINLSTKVPWCLNMLKTSNRTFGNIVNHAANKGGFASLGKWTNEQFDLSLNWH
CCHHHHHHHHHCCCCHHHHHHHHHCCCHHHHHHHHHCCCCCCCHHCCCCCCEEEEEECCC
DVEWIQKQWNGRMIIKGIMDTQDAIMAQNTGADAIVVSNHGGRQLDGAPSSISVLEEIID
HHHHHHHHCCCEEEEEEHHCCHHHHHCCCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHH
AVDRKLEVLIDSGIRTGQDLLKAKALGATAGLIGRPMVYGLGAYGEQGAYRVLEIFYQEM
HHHHHHHHHHHCCCCCHHHHHHHHHHCCHHHHHCCCHHHCCCCCCCCCHHHHHHHHHHHH
DKTMAFCGHTNINNVDKSILIKRNT
HHHHHHHCCCCCCCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA