Click here to switch to the map view.

The map label for this gene is pepA [H]

Identifier: 134302302

GI number: 134302302

Start: 1310420

End: 1311799

Strand: Reverse

Name: pepA [H]

Synonym: FTW_1400

Alternate gene names: 134302302

Gene position: 1311799-1310420 (Counterclockwise)

Preceding gene: 134302303

Following gene: 134302301

Centisome position: 69.1

GC content: 34.78

Gene sequence:

>1380_bases
ATGTATATATCAACCAAATTAGAGTGTTTTACACAACATAAACAAAATGATTCTTTGCCAATTTTTGTGATTAATAAGGA
TAATTTTGCAAATTGGCTTAGTAGTCAAGATAGTTTTTTACAGAACTTTATTAAGCAGTTTGATGAAAAAACAAAAATTA
TAACTGTTCCAAATAATTTAGGGAATATTCAAAAAGTAATTTGTCTTGTATCTGAGGATATGTTTGGCATTGCGAATTTA
CCAAATCAGCTAGCACAAGGAAATTACCATATTGAATATACTGATATCGCTGACTTGTCACTTTATTATATAGGCTTTGC
TTTAGGAAGTTATAAGTTTGAGAAATACAAATCTAAAACACAACAATCAAAAGTAAAATTATATTTACCACAACAATATC
AGCATATATTAGCAACTATAGAAGCTAATTATTTAGTAAGAGATATGATTACTACCCCAGCCGAAGATATGGGGCCAGCT
GATATTGCTAATGTGATACAACAACTAGCCAAAGAGTTTAATGCTGATTTTGAGGAGATCGTTGGTGAAGAACTTGTCGA
ACAAGGTTATATGGGTATCTATACTGTTGGTAAAGGTAGTCATAGAGCTCCTAGACTTGTGCGATTAAATTGGGGTGATA
CAACTCACCCTACGGTATCAATAGTCGGTAAAGGTGTGGCTTTTGATACAGGTGGTTTAGATGTCAAACCATCATCAGCA
ATGCAACTAATGCACAAAGATATGGGTGGTAGTGCTAATGCTATCGGTCTTGCCTATATGATTATGAAACATAAATTGCC
TATTAGATTAAGCTTGGTAATTCCTACTGTTGAAAATGCTATAGATGCAAAATCATATCGACCTAGTGATATTATTAAGA
TGAAAAATGGTACTAATGTACAAGTTACTAACACAGATGCTGAAGGGCGTTTGATTTTAGCTGAACCACTATATGAAGAG
GCACAAAAAAAACCTCAATATTTAATCGACTTCTCAACACTTACAGGAGCAGCTAGAGTCGCTGTTGGACTTGAGATTGC
AGCATTTTTCTGTAATAATGATGATGTGGCTAGCCAAGTATATAAGTATGCTCAGGCGACGCAAGATCAAGTTTGGCGTC
TACCATTAGCTGATTGTTATAGAAAGAATCTAGAAACTGAGTTTGCAGATATTTCACACTGTGATTTATCACCATTTGCA
GGAGCTGTGAAGGCGGCATTATTTATGGAGCATTTTGTTGGTATAAAAGATGCACCTACCTGGATTCATTTTGATATGAT
GGCATGGAATATTAGCTCTACGCCAGGTAAACCTAAAGGTGGAGAAATGATGGCTGTTAGAGCTATGTTTGAGATGCTTA
AGGATAAGTTTCCAGCTTAA

Upstream 100 bases:

>100_bases
GATTTTTAAGTTTATACAAAACAGCTGGTATTTTAACAGCTAAAACAGTGCAAGATTTTAATAATTGGTTACTATTAGGT
CAAGACGTGGAGCTATAAAG

Downstream 100 bases:

>100_bases
ATTAATTAATGGATATAGTAATACTACTCATGAATAAGTTATATTTTTTAGTATATAAACATAGCTAGTTTATTTACTAA
TGTATCTGAAGTTGTATACT

Product: cytosol aminopeptidase

Products: NA

Alternate protein names: Leucine aminopeptidase; LAP; Leucyl aminopeptidase [H]

Number of amino acids: Translated: 459; Mature: 459

Protein sequence:

>459_residues
MYISTKLECFTQHKQNDSLPIFVINKDNFANWLSSQDSFLQNFIKQFDEKTKIITVPNNLGNIQKVICLVSEDMFGIANL
PNQLAQGNYHIEYTDIADLSLYYIGFALGSYKFEKYKSKTQQSKVKLYLPQQYQHILATIEANYLVRDMITTPAEDMGPA
DIANVIQQLAKEFNADFEEIVGEELVEQGYMGIYTVGKGSHRAPRLVRLNWGDTTHPTVSIVGKGVAFDTGGLDVKPSSA
MQLMHKDMGGSANAIGLAYMIMKHKLPIRLSLVIPTVENAIDAKSYRPSDIIKMKNGTNVQVTNTDAEGRLILAEPLYEE
AQKKPQYLIDFSTLTGAARVAVGLEIAAFFCNNDDVASQVYKYAQATQDQVWRLPLADCYRKNLETEFADISHCDLSPFA
GAVKAALFMEHFVGIKDAPTWIHFDMMAWNISSTPGKPKGGEMMAVRAMFEMLKDKFPA

Sequences:

>Translated_459_residues
MYISTKLECFTQHKQNDSLPIFVINKDNFANWLSSQDSFLQNFIKQFDEKTKIITVPNNLGNIQKVICLVSEDMFGIANL
PNQLAQGNYHIEYTDIADLSLYYIGFALGSYKFEKYKSKTQQSKVKLYLPQQYQHILATIEANYLVRDMITTPAEDMGPA
DIANVIQQLAKEFNADFEEIVGEELVEQGYMGIYTVGKGSHRAPRLVRLNWGDTTHPTVSIVGKGVAFDTGGLDVKPSSA
MQLMHKDMGGSANAIGLAYMIMKHKLPIRLSLVIPTVENAIDAKSYRPSDIIKMKNGTNVQVTNTDAEGRLILAEPLYEE
AQKKPQYLIDFSTLTGAARVAVGLEIAAFFCNNDDVASQVYKYAQATQDQVWRLPLADCYRKNLETEFADISHCDLSPFA
GAVKAALFMEHFVGIKDAPTWIHFDMMAWNISSTPGKPKGGEMMAVRAMFEMLKDKFPA
>Mature_459_residues
MYISTKLECFTQHKQNDSLPIFVINKDNFANWLSSQDSFLQNFIKQFDEKTKIITVPNNLGNIQKVICLVSEDMFGIANL
PNQLAQGNYHIEYTDIADLSLYYIGFALGSYKFEKYKSKTQQSKVKLYLPQQYQHILATIEANYLVRDMITTPAEDMGPA
DIANVIQQLAKEFNADFEEIVGEELVEQGYMGIYTVGKGSHRAPRLVRLNWGDTTHPTVSIVGKGVAFDTGGLDVKPSSA
MQLMHKDMGGSANAIGLAYMIMKHKLPIRLSLVIPTVENAIDAKSYRPSDIIKMKNGTNVQVTNTDAEGRLILAEPLYEE
AQKKPQYLIDFSTLTGAARVAVGLEIAAFFCNNDDVASQVYKYAQATQDQVWRLPLADCYRKNLETEFADISHCDLSPFA
GAVKAALFMEHFVGIKDAPTWIHFDMMAWNISSTPGKPKGGEMMAVRAMFEMLKDKFPA

Specific function: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides [H]

COG id: COG0260

COG function: function code E; Leucyl aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M17 family [H]

Homologues:

Organism=Homo sapiens, GI41393561, Length=375, Percent_Identity=31.7333333333333, Blast_Score=183, Evalue=3e-46,
Organism=Homo sapiens, GI47155554, Length=293, Percent_Identity=31.3993174061433, Blast_Score=127, Evalue=2e-29,
Organism=Escherichia coli, GI87082123, Length=291, Percent_Identity=38.8316151202749, Blast_Score=205, Evalue=5e-54,
Organism=Escherichia coli, GI1790710, Length=334, Percent_Identity=32.9341317365269, Blast_Score=172, Evalue=3e-44,
Organism=Caenorhabditis elegans, GI17556903, Length=287, Percent_Identity=33.1010452961672, Blast_Score=150, Evalue=1e-36,
Organism=Caenorhabditis elegans, GI17565172, Length=326, Percent_Identity=27.9141104294479, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI21357381, Length=294, Percent_Identity=30.2721088435374, Blast_Score=132, Evalue=4e-31,
Organism=Drosophila melanogaster, GI221379063, Length=294, Percent_Identity=30.2721088435374, Blast_Score=132, Evalue=5e-31,
Organism=Drosophila melanogaster, GI221379062, Length=294, Percent_Identity=30.2721088435374, Blast_Score=132, Evalue=5e-31,
Organism=Drosophila melanogaster, GI24662227, Length=331, Percent_Identity=26.5861027190332, Blast_Score=126, Evalue=3e-29,
Organism=Drosophila melanogaster, GI24661038, Length=300, Percent_Identity=30.3333333333333, Blast_Score=126, Evalue=4e-29,
Organism=Drosophila melanogaster, GI21355725, Length=351, Percent_Identity=27.0655270655271, Blast_Score=125, Evalue=6e-29,
Organism=Drosophila melanogaster, GI21355645, Length=356, Percent_Identity=24.438202247191, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI24662223, Length=356, Percent_Identity=24.438202247191, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI20129969, Length=289, Percent_Identity=26.643598615917, Blast_Score=116, Evalue=3e-26,
Organism=Drosophila melanogaster, GI161077148, Length=359, Percent_Identity=24.2339832869081, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI20130057, Length=359, Percent_Identity=24.2339832869081, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI20129963, Length=333, Percent_Identity=24.3243243243243, Blast_Score=109, Evalue=4e-24,
Organism=Drosophila melanogaster, GI19922386, Length=344, Percent_Identity=23.546511627907, Blast_Score=105, Evalue=6e-23,
Organism=Drosophila melanogaster, GI24646701, Length=225, Percent_Identity=25.7777777777778, Blast_Score=76, Evalue=5e-14,
Organism=Drosophila melanogaster, GI24646703, Length=225, Percent_Identity=25.7777777777778, Blast_Score=76, Evalue=5e-14,
Organism=Drosophila melanogaster, GI21358201, Length=225, Percent_Identity=25.7777777777778, Blast_Score=76, Evalue=5e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011356
- InterPro:   IPR000819
- InterPro:   IPR023042
- InterPro:   IPR008283 [H]

Pfam domain/function: PF00883 Peptidase_M17; PF02789 Peptidase_M17_N [H]

EC number: =3.4.11.1; =3.4.11.10 [H]

Molecular weight: Translated: 51372; Mature: 51372

Theoretical pI: Translated: 6.02; Mature: 6.02

Prosite motif: PS00631 CYTOSOL_AP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYISTKLECFTQHKQNDSLPIFVINKDNFANWLSSQDSFLQNFIKQFDEKTKIITVPNNL
CCCCCHHHHHHHCCCCCCCEEEEEECCCHHHHHCCHHHHHHHHHHHHCCCCEEEECCCCC
GNIQKVICLVSEDMFGIANLPNQLAQGNYHIEYTDIADLSLYYIGFALGSYKFEKYKSKT
CCHHHHHHHHHCCCCCHHCCCHHHHCCCEEEEEECCCHHHHHHHHHHHCCHHHHHHHHHH
QQSKVKLYLPQQYQHILATIEANYLVRDMITTPAEDMGPADIANVIQQLAKEFNADFEEI
HHCEEEEECCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCHHHH
VGEELVEQGYMGIYTVGKGSHRAPRLVRLNWGDTTHPTVSIVGKGVAFDTGGLDVKPSSA
HHHHHHHCCCCEEEEECCCCCCCCEEEEEECCCCCCCEEEEEECCEEECCCCCCCCCHHH
MQLMHKDMGGSANAIGLAYMIMKHKLPIRLSLVIPTVENAIDAKSYRPSDIIKMKNGTNV
HHHHHHHCCCCCCHHHHHHHHHHCCCCEEEEEEECCHHHHHCCCCCCCCCEEEECCCCEE
QVTNTDAEGRLILAEPLYEEAQKKPQYLIDFSTLTGAARVAVGLEIAAFFCNNDDVASQV
EEECCCCCCEEEEECHHHHHHHCCCCEEEEEHHHCCHHHHHHHEEEEEEEECCCHHHHHH
YKYAQATQDQVWRLPLADCYRKNLETEFADISHCDLSPFAGAVKAALFMEHFVGIKDAPT
HHHHHHCHHHHEECCHHHHHHHCCCCHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCC
WIHFDMMAWNISSTPGKPKGGEMMAVRAMFEMLKDKFPA
EEEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MYISTKLECFTQHKQNDSLPIFVINKDNFANWLSSQDSFLQNFIKQFDEKTKIITVPNNL
CCCCCHHHHHHHCCCCCCCEEEEEECCCHHHHHCCHHHHHHHHHHHHCCCCEEEECCCCC
GNIQKVICLVSEDMFGIANLPNQLAQGNYHIEYTDIADLSLYYIGFALGSYKFEKYKSKT
CCHHHHHHHHHCCCCCHHCCCHHHHCCCEEEEEECCCHHHHHHHHHHHCCHHHHHHHHHH
QQSKVKLYLPQQYQHILATIEANYLVRDMITTPAEDMGPADIANVIQQLAKEFNADFEEI
HHCEEEEECCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCHHHH
VGEELVEQGYMGIYTVGKGSHRAPRLVRLNWGDTTHPTVSIVGKGVAFDTGGLDVKPSSA
HHHHHHHCCCCEEEEECCCCCCCCEEEEEECCCCCCCEEEEEECCEEECCCCCCCCCHHH
MQLMHKDMGGSANAIGLAYMIMKHKLPIRLSLVIPTVENAIDAKSYRPSDIIKMKNGTNV
HHHHHHHCCCCCCHHHHHHHHHHCCCCEEEEEEECCHHHHHCCCCCCCCCEEEECCCCEE
QVTNTDAEGRLILAEPLYEEAQKKPQYLIDFSTLTGAARVAVGLEIAAFFCNNDDVASQV
EEECCCCCCEEEEECHHHHHHHCCCCEEEEEHHHCCHHHHHHHEEEEEEEECCCHHHHHH
YKYAQATQDQVWRLPLADCYRKNLETEFADISHCDLSPFAGAVKAALFMEHFVGIKDAPT
HHHHHHCHHHHEECCHHHHHHHCCCCHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCC
WIHFDMMAWNISSTPGKPKGGEMMAVRAMFEMLKDKFPA
EEEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA