Click here to switch to the map view.

The map label for this gene is aes [C]

Identifier: 134301922

GI number: 134301922

Start: 894261

End: 896096

Strand: Reverse

Name: aes [C]

Synonym: FTW_0929

Alternate gene names: 134301922

Gene position: 896096-894261 (Counterclockwise)

Preceding gene: 134301923

Following gene: 134301921

Centisome position: 47.2

GC content: 33.39

Gene sequence:

>1836_bases
ATGTGGGCAATTGTAGGAAGTAGTGGTTTTGAATCTTTTGATGACTTTGAGATTATAGAAGAATTGCCACGAGAAACGCC
ATTTGGTTTGTGTTCGAATGGTTTATTTAAAATAAAAGTTGAAGATAAAGAGGTATTATTTCTCAATAGAACTGGTTTGG
GTCAGAATATATTACCCCATCAAATAAACTACAAAGCTAATATTTACGCACTAAAGAAATATGGAGCTACTTCAATTATT
GCTTTATCTTCGGTTAGAAGCTTAAGAGAAGAGCTAAAACCTGGTGATATGGTTATTCCATATCAGTTTATCGATAGAAC
CAAATCTCTAAGAGAGTTTACATTTTGTGAACAAGGATTGCTAAACTATGTTTCACTTTCAAAACCTATAACAGAGAGTA
TTGCCGAAGAGATTAGAGCAAAGAAAAAAGAATTTGATTTTGAGATTCATTTTAAACAAAGTTATGTCTGTATCGAAGGT
CCACAGTTTCCAACTATAATCGATGCTAAATGTTTTCAAAGTATGGGTGGTGGTGTTATAGGTATGACAGCATTTCCAGA
ATTTGCTTTAGCAAGGGAAGCTGGATTGAACTATATTAGCTGTAATTTTATTGTTGACTATGTGCCTTGGTCGTATGATG
TTAGAAATTTATATAACGTTTTAGAAATACGTGAAACAAGTAATCTCAAAGCAGAAAAATTAGTTAAATGGCTAGTAAAT
AATTTACCATTTTATGCTGAGAATGATTGTCATGAGTTAGGTATTGCTAGATATCTATCAACACCAATAGAATCATTACC
ACCAAATAAAAAAGCATGGCTAAAAGTTATCGCTAAAGATAATTCTGAACATGAAGAAGCACTTGAGGCTGAAATTCTTA
AAAAAGTTCCAGATTTATATGGTGGTATTAAAACTATACCAGCAAAATTACAAGATTTATTAACCTTTATCGGTAAATAT
GATCGTGAGGGAAATAGAAAAGATTTAGAAGCAACTCGAAAGGCTGCTGCATCATTAGATCTATATAGCTACCCTAAAGT
TGATCTAGAAAATGTTGAAGATATCCAAATCACTCATGATGATGATGGTCATAATATTCCAGTTAGAGTATATAACCCTA
AAGTTGATGAAAAACTCAAAGTGATAATTTTTTCTCATGGTGGTGGCTTTGTATCTGGTACTTTAGATTCGTTTGATGCT
TTTTGTCGCAAACTTGCACTAACTACGAATAGGGTAGTTTTCTCGGTTGATTATCGCCTAGCTCCGGAGCATAAATTCCC
AGCAGGTCTAAATGATGTTGAATTTGTTGCTGAACATATTTTCAAACATTCCAAGAAATTTGGAGTTTCCAAAAAGAAAT
TTACACTGATGGGCGACAGTGCTGGAGCTAACTTAACTGTCTTAGCGACATATAATTTACTACAGAAAGACACTGTTAAA
ATTGCTAATAATATTATCCTATATCCTTCAGTTGATTTATCGCACATGCCTACAAAATCACTAGAAGATTTTGCTAGTGG
TTATATCTTAACTAAAGCGAAAACGATGTGGTACTCCGAGCTATATGTGCCTGAAAATATCGATAAACGCTCTCCTGAAG
TTTCTCCTTTTTATATTAAAGAATTAGATAATATGCCGAGAACTTTAGTCATGACGGTAGGTTATGACCCACTAAGAGAT
GAAGGGTTACTATTTGCTGAAAGGCTTCTTAGACATGATGTTGAGGTGCAGCACTATCATTTTGATAGTTTGGTTCATGG
TTTTATCAATTTCTCAAAACTTATTCCAAAAGAAATGGATGTTCTGCATTCTAGAGTTGTTAAATTTCTTGGCTAA

Upstream 100 bases:

>100_bases
TAAAGGTGTTGGTGTAGTAAATACTGGTGATAAGTTTAAAATCGAGTTATTTTGTAGAGATAAAAAAATATTAGCAACAA
CTTTTTAGGTATATAAAAAT

Downstream 100 bases:

>100_bases
TTATGAAAAACTACCTACTACAAATCGAATACTTTGGCAAAAACTACTGTGGTTGGCAAAGACAATCTCATTCACCAAGT
GTGCAAGAATCGCTTGAAAA

Product: phosphorylase family 2 protein

Products: alcohol; a carboxylate [C]

Alternate protein names: NA

Number of amino acids: Translated: 611; Mature: 611

Protein sequence:

>611_residues
MWAIVGSSGFESFDDFEIIEELPRETPFGLCSNGLFKIKVEDKEVLFLNRTGLGQNILPHQINYKANIYALKKYGATSII
ALSSVRSLREELKPGDMVIPYQFIDRTKSLREFTFCEQGLLNYVSLSKPITESIAEEIRAKKKEFDFEIHFKQSYVCIEG
PQFPTIIDAKCFQSMGGGVIGMTAFPEFALAREAGLNYISCNFIVDYVPWSYDVRNLYNVLEIRETSNLKAEKLVKWLVN
NLPFYAENDCHELGIARYLSTPIESLPPNKKAWLKVIAKDNSEHEEALEAEILKKVPDLYGGIKTIPAKLQDLLTFIGKY
DREGNRKDLEATRKAAASLDLYSYPKVDLENVEDIQITHDDDGHNIPVRVYNPKVDEKLKVIIFSHGGGFVSGTLDSFDA
FCRKLALTTNRVVFSVDYRLAPEHKFPAGLNDVEFVAEHIFKHSKKFGVSKKKFTLMGDSAGANLTVLATYNLLQKDTVK
IANNIILYPSVDLSHMPTKSLEDFASGYILTKAKTMWYSELYVPENIDKRSPEVSPFYIKELDNMPRTLVMTVGYDPLRD
EGLLFAERLLRHDVEVQHYHFDSLVHGFINFSKLIPKEMDVLHSRVVKFLG

Sequences:

>Translated_611_residues
MWAIVGSSGFESFDDFEIIEELPRETPFGLCSNGLFKIKVEDKEVLFLNRTGLGQNILPHQINYKANIYALKKYGATSII
ALSSVRSLREELKPGDMVIPYQFIDRTKSLREFTFCEQGLLNYVSLSKPITESIAEEIRAKKKEFDFEIHFKQSYVCIEG
PQFPTIIDAKCFQSMGGGVIGMTAFPEFALAREAGLNYISCNFIVDYVPWSYDVRNLYNVLEIRETSNLKAEKLVKWLVN
NLPFYAENDCHELGIARYLSTPIESLPPNKKAWLKVIAKDNSEHEEALEAEILKKVPDLYGGIKTIPAKLQDLLTFIGKY
DREGNRKDLEATRKAAASLDLYSYPKVDLENVEDIQITHDDDGHNIPVRVYNPKVDEKLKVIIFSHGGGFVSGTLDSFDA
FCRKLALTTNRVVFSVDYRLAPEHKFPAGLNDVEFVAEHIFKHSKKFGVSKKKFTLMGDSAGANLTVLATYNLLQKDTVK
IANNIILYPSVDLSHMPTKSLEDFASGYILTKAKTMWYSELYVPENIDKRSPEVSPFYIKELDNMPRTLVMTVGYDPLRD
EGLLFAERLLRHDVEVQHYHFDSLVHGFINFSKLIPKEMDVLHSRVVKFLG
>Mature_611_residues
MWAIVGSSGFESFDDFEIIEELPRETPFGLCSNGLFKIKVEDKEVLFLNRTGLGQNILPHQINYKANIYALKKYGATSII
ALSSVRSLREELKPGDMVIPYQFIDRTKSLREFTFCEQGLLNYVSLSKPITESIAEEIRAKKKEFDFEIHFKQSYVCIEG
PQFPTIIDAKCFQSMGGGVIGMTAFPEFALAREAGLNYISCNFIVDYVPWSYDVRNLYNVLEIRETSNLKAEKLVKWLVN
NLPFYAENDCHELGIARYLSTPIESLPPNKKAWLKVIAKDNSEHEEALEAEILKKVPDLYGGIKTIPAKLQDLLTFIGKY
DREGNRKDLEATRKAAASLDLYSYPKVDLENVEDIQITHDDDGHNIPVRVYNPKVDEKLKVIIFSHGGGFVSGTLDSFDA
FCRKLALTTNRVVFSVDYRLAPEHKFPAGLNDVEFVAEHIFKHSKKFGVSKKKFTLMGDSAGANLTVLATYNLLQKDTVK
IANNIILYPSVDLSHMPTKSLEDFASGYILTKAKTMWYSELYVPENIDKRSPEVSPFYIKELDNMPRTLVMTVGYDPLRD
EGLLFAERLLRHDVEVQHYHFDSLVHGFINFSKLIPKEMDVLHSRVVKFLG

Specific function: Has An Esterase Activity. Triacetyl Glycerol (Triacetin) Is A Substrate Of The Enzyme. [C]

COG id: COG0657

COG function: function code I; Esterase/lipase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PNP/MTAP phosphorylase family [H]

Homologues:

Organism=Homo sapiens, GI47132622, Length=250, Percent_Identity=34.8, Blast_Score=142, Evalue=1e-33,
Organism=Homo sapiens, GI157041239, Length=310, Percent_Identity=26.4516129032258, Blast_Score=93, Evalue=9e-19,
Organism=Homo sapiens, GI68299767, Length=317, Percent_Identity=31.5457413249211, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI206597554, Length=193, Percent_Identity=32.6424870466321, Blast_Score=89, Evalue=1e-17,
Organism=Homo sapiens, GI68051721, Length=327, Percent_Identity=24.7706422018349, Blast_Score=87, Evalue=4e-17,
Organism=Homo sapiens, GI61966717, Length=287, Percent_Identity=25.0871080139373, Blast_Score=84, Evalue=4e-16,
Organism=Homo sapiens, GI226423947, Length=335, Percent_Identity=24.1791044776119, Blast_Score=81, Evalue=2e-15,
Organism=Escherichia coli, GI1786682, Length=234, Percent_Identity=25.6410256410256, Blast_Score=98, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI71980569, Length=213, Percent_Identity=28.6384976525822, Blast_Score=105, Evalue=9e-23,
Organism=Caenorhabditis elegans, GI71996133, Length=173, Percent_Identity=32.9479768786127, Blast_Score=104, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI17540028, Length=173, Percent_Identity=33.5260115606936, Blast_Score=103, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI17567059, Length=266, Percent_Identity=26.6917293233083, Blast_Score=100, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI72001146, Length=149, Percent_Identity=35.5704697986577, Blast_Score=92, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI115533412, Length=121, Percent_Identity=29.7520661157025, Blast_Score=68, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI115533410, Length=121, Percent_Identity=29.7520661157025, Blast_Score=68, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6323045, Length=286, Percent_Identity=30.0699300699301, Blast_Score=126, Evalue=1e-29,
Organism=Drosophila melanogaster, GI20130079, Length=259, Percent_Identity=34.7490347490347, Blast_Score=142, Evalue=5e-34,
Organism=Drosophila melanogaster, GI221459247, Length=232, Percent_Identity=29.3103448275862, Blast_Score=111, Evalue=2e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010044
- InterPro:   IPR000845
- InterPro:   IPR001369
- InterPro:   IPR018099 [H]

Pfam domain/function: PF01048 PNP_UDP_1 [H]

EC number: 3.1.1.- [C]

Molecular weight: Translated: 69533; Mature: 69533

Theoretical pI: Translated: 6.32; Mature: 6.32

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MWAIVGSSGFESFDDFEIIEELPRETPFGLCSNGLFKIKVEDKEVLFLNRTGLGQNILPH
CEEEECCCCCCCCCHHHHHHHCCCCCCCCCCCCCEEEEEECCCEEEEEECCCCCCCCCCC
QINYKANIYALKKYGATSIIALSSVRSLREELKPGDMVIPYQFIDRTKSLREFTFCEQGL
CCCCCEEEEEEECCCCHHHHHHHHHHHHHHHCCCCCEEECHHHHHHHHHHHHHHHHHHHH
LNYVSLSKPITESIAEEIRAKKKEFDFEIHFKQSYVCIEGPQFPTIIDAKCFQSMGGGVI
HHHHHHCCHHHHHHHHHHHHHHHHCCEEEEEECEEEEEECCCCCCEECHHHHHHHCCCEE
GMTAFPEFALAREAGLNYISCNFIVDYVPWSYDVRNLYNVLEIRETSNLKAEKLVKWLVN
EECCCCHHHHHHHHCCCEEEEEEEEECCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHH
NLPFYAENDCHELGIARYLSTPIESLPPNKKAWLKVIAKDNSEHEEALEAEILKKVPDLY
CCCCCCCCCHHHHHHHHHHHCCHHHCCCCHHHHEEEEECCCCHHHHHHHHHHHHHHHHHH
GGIKTIPAKLQDLLTFIGKYDREGNRKDLEATRKAAASLDLYSYPKVDLENVEDIQITHD
CCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEC
DDGHNIPVRVYNPKVDEKLKVIIFSHGGGFVSGTLDSFDAFCRKLALTTNRVVFSVDYRL
CCCCCCCEEEECCCCCCEEEEEEEECCCCEEECCHHHHHHHHHHHHHCCCEEEEEEEEEE
APEHKFPAGLNDVEFVAEHIFKHSKKFGVSKKKFTLMGDSAGANLTVLATYNLLQKDTVK
CCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCEEEEEEECHHHHHHHH
IANNIILYPSVDLSHMPTKSLEDFASGYILTKAKTMWYSELYVPENIDKRSPEVSPFYIK
HHCCEEEEECCCCCCCCCHHHHHHHCCEEEEEHHHHHHHEEECCCCCCCCCCCCCCHHHH
ELDNMPRTLVMTVGYDPLRDEGLLFAERLLRHDVEVQHYHFDSLVHGFINFSKLIPKEMD
HHCCCCCEEEEEECCCCCCCCHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHCHHHHH
VLHSRVVKFLG
HHHHHHHHHCC
>Mature Secondary Structure
MWAIVGSSGFESFDDFEIIEELPRETPFGLCSNGLFKIKVEDKEVLFLNRTGLGQNILPH
CEEEECCCCCCCCCHHHHHHHCCCCCCCCCCCCCEEEEEECCCEEEEEECCCCCCCCCCC
QINYKANIYALKKYGATSIIALSSVRSLREELKPGDMVIPYQFIDRTKSLREFTFCEQGL
CCCCCEEEEEEECCCCHHHHHHHHHHHHHHHCCCCCEEECHHHHHHHHHHHHHHHHHHHH
LNYVSLSKPITESIAEEIRAKKKEFDFEIHFKQSYVCIEGPQFPTIIDAKCFQSMGGGVI
HHHHHHCCHHHHHHHHHHHHHHHHCCEEEEEECEEEEEECCCCCCEECHHHHHHHCCCEE
GMTAFPEFALAREAGLNYISCNFIVDYVPWSYDVRNLYNVLEIRETSNLKAEKLVKWLVN
EECCCCHHHHHHHHCCCEEEEEEEEECCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHH
NLPFYAENDCHELGIARYLSTPIESLPPNKKAWLKVIAKDNSEHEEALEAEILKKVPDLY
CCCCCCCCCHHHHHHHHHHHCCHHHCCCCHHHHEEEEECCCCHHHHHHHHHHHHHHHHHH
GGIKTIPAKLQDLLTFIGKYDREGNRKDLEATRKAAASLDLYSYPKVDLENVEDIQITHD
CCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEC
DDGHNIPVRVYNPKVDEKLKVIIFSHGGGFVSGTLDSFDAFCRKLALTTNRVVFSVDYRL
CCCCCCCEEEECCCCCCEEEEEEEECCCCEEECCHHHHHHHHHHHHHCCCEEEEEEEEEE
APEHKFPAGLNDVEFVAEHIFKHSKKFGVSKKKFTLMGDSAGANLTVLATYNLLQKDTVK
CCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCEEEEEEECHHHHHHHH
IANNIILYPSVDLSHMPTKSLEDFASGYILTKAKTMWYSELYVPENIDKRSPEVSPFYIK
HHCCEEEEECCCCCCCCCHHHHHHHCCEEEEEHHHHHHHEEECCCCCCCCCCCCCCHHHH
ELDNMPRTLVMTVGYDPLRDEGLLFAERLLRHDVEVQHYHFDSLVHGFINFSKLIPKEMD
HHCCCCCEEEEEECCCCCCCCHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHCHHHHH
VLHSRVVKFLG
HHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Carboxylic ester; H2O [C]

Specific reaction: Carboxylic ester + H2O = an alcohol + carboxylate [C]

General reaction: Hydrolase; Acting on ester bonds; Carboxylic ester hydrolases [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12622808 [H]