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The map label for this gene is bioF [H]

Identifier: 134301847

GI number: 134301847

Start: 808114

End: 809241

Strand: Reverse

Name: bioF [H]

Synonym: FTW_0830

Alternate gene names: 134301847

Gene position: 809241-808114 (Counterclockwise)

Preceding gene: 134301848

Following gene: 134301846

Centisome position: 42.63

GC content: 30.32

Gene sequence:

>1128_bases
ATGTTAAACCTACAAGATAAATATACTCAATATCAAAGAGATAATTTATTAAGAGAGTTAACTCCTTTTATAAAAGATGA
CTCTATTATAGATTTTACAACTAGTGACTATTTAAATCTATCATCAGCACACAACTTAAAACATGCCATAGTAAATGGTT
TTGATAAATATGGCTTTGGTAGTAAAGGATCTAATATAGTTTGTGGCTATACTGATGAGACACAACAGTTTGAACATGAG
TTTGCAAAGTTTATTAACTATCCTAGAGCAATATTTTTTAGTTCAGGTTTTATGGCAAATTTAGCAATTTATTCAACACT
GTTTAGTAAACATGATAGTATCTTTGCAGATAAGTATATCCATGCATCTATTATTGATGGAATCAAGCTTTCACAAGCTA
AGCTAAGAAGATATAAACATCAGCAATTAAGCCAACTTCAAGATATTTATGATGGTAAAAGTTTTATAACTACAGAAGGA
GTTTTTAGTACCTCAGGATCAATTACTCAACTTGATAAGCTTGCTAAAATCACACCAGAAAAGCTTATAGTTGATGAAGC
TCATAGTTTTGGAGTTTTGGGTAAAAATGGTCGCGGTGCGATCAACAGCTTTCGAATAAGCTATAAAAATTGTCCAATCT
GTGTTTTCCCTCTTGGTAAAGCATTTGGTGGAGTTGGTGCTGTGGTTTGTACTACAGAAGCAATTGCAGAATATCTAATA
CAATTTGCGCGTAACTATATCTATACAACAGCATTACCACCAATGATATTAAAAGCTGCTTTAATACAACTAAAAAACCT
TGAAAATGCTAATGATAATCGAGCAAGACTTCAGCAAAATATCACTTTTTTTAATGAGTTATGTGATGCTAAAGATCTTG
AGTTAGTCTCTAAAGATTTATCTCCTATTAGAAGTATTCAACTAAATAATGCTAATCTAGCAATTAGATTAAAAGATAAG
CTCTTTGAGAATAAAATAATAGTATCTTGTTTTAGATATCCTACTGTACCTAAAGACCAAGCTATACTAAGATTTTCGCT
ACATAGTAATAATACTTTTGATCAGATTCAACAAGCTTTAAAAATTATTTCCAAAGAGGTTAAGTATGAGTATATACGAT
CAAATTAG

Upstream 100 bases:

>100_bases
CAATATTTTATGGTAATAAGTTATTAACAGAAAATAATGCTACTGTTAATTCTGATAATTTTTTATTAGCTAAGCTTGGC
TTAAAATCAAATGCTGAATT

Downstream 100 bases:

>100_bases
AGGTAACTTTTCAAAAGCTACAGAATATTCTAAAAATTCGGCTATTCAAAATCAAGTTCGCCAACTACTTTTAGAACAAA
CGCTGAATTATTCAAGATTA

Product: 8-amino-7-oxononanoate synthase

Products: NA

Alternate protein names: AONS; 7-keto-8-amino-pelargonic acid synthase; 7-KAP synthase; KAPA synthase; 8-amino-7-ketopelargonate synthase; L-alanine--pimeloyl-CoA ligase [H]

Number of amino acids: Translated: 375; Mature: 375

Protein sequence:

>375_residues
MLNLQDKYTQYQRDNLLRELTPFIKDDSIIDFTTSDYLNLSSAHNLKHAIVNGFDKYGFGSKGSNIVCGYTDETQQFEHE
FAKFINYPRAIFFSSGFMANLAIYSTLFSKHDSIFADKYIHASIIDGIKLSQAKLRRYKHQQLSQLQDIYDGKSFITTEG
VFSTSGSITQLDKLAKITPEKLIVDEAHSFGVLGKNGRGAINSFRISYKNCPICVFPLGKAFGGVGAVVCTTEAIAEYLI
QFARNYIYTTALPPMILKAALIQLKNLENANDNRARLQQNITFFNELCDAKDLELVSKDLSPIRSIQLNNANLAIRLKDK
LFENKIIVSCFRYPTVPKDQAILRFSLHSNNTFDQIQQALKIISKEVKYEYIRSN

Sequences:

>Translated_375_residues
MLNLQDKYTQYQRDNLLRELTPFIKDDSIIDFTTSDYLNLSSAHNLKHAIVNGFDKYGFGSKGSNIVCGYTDETQQFEHE
FAKFINYPRAIFFSSGFMANLAIYSTLFSKHDSIFADKYIHASIIDGIKLSQAKLRRYKHQQLSQLQDIYDGKSFITTEG
VFSTSGSITQLDKLAKITPEKLIVDEAHSFGVLGKNGRGAINSFRISYKNCPICVFPLGKAFGGVGAVVCTTEAIAEYLI
QFARNYIYTTALPPMILKAALIQLKNLENANDNRARLQQNITFFNELCDAKDLELVSKDLSPIRSIQLNNANLAIRLKDK
LFENKIIVSCFRYPTVPKDQAILRFSLHSNNTFDQIQQALKIISKEVKYEYIRSN
>Mature_375_residues
MLNLQDKYTQYQRDNLLRELTPFIKDDSIIDFTTSDYLNLSSAHNLKHAIVNGFDKYGFGSKGSNIVCGYTDETQQFEHE
FAKFINYPRAIFFSSGFMANLAIYSTLFSKHDSIFADKYIHASIIDGIKLSQAKLRRYKHQQLSQLQDIYDGKSFITTEG
VFSTSGSITQLDKLAKITPEKLIVDEAHSFGVLGKNGRGAINSFRISYKNCPICVFPLGKAFGGVGAVVCTTEAIAEYLI
QFARNYIYTTALPPMILKAALIQLKNLENANDNRARLQQNITFFNELCDAKDLELVSKDLSPIRSIQLNNANLAIRLKDK
LFENKIIVSCFRYPTVPKDQAILRFSLHSNNTFDQIQQALKIISKEVKYEYIRSN

Specific function: Catalyzes the decarboxylative condensation of pimeloyl- CoA and L-alanine to produce 8-amino-7-oxononanoate (AON), coenzyme A, and carbon dioxide [H]

COG id: COG0156

COG function: function code H; 7-keto-8-aminopelargonate synthetase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. BioF subfamily [H]

Homologues:

Organism=Homo sapiens, GI7657118, Length=360, Percent_Identity=28.8888888888889, Blast_Score=148, Evalue=8e-36,
Organism=Homo sapiens, GI284448556, Length=350, Percent_Identity=28.8571428571429, Blast_Score=147, Evalue=2e-35,
Organism=Homo sapiens, GI83977440, Length=338, Percent_Identity=29.8816568047337, Blast_Score=129, Evalue=6e-30,
Organism=Homo sapiens, GI83977442, Length=338, Percent_Identity=29.8816568047337, Blast_Score=129, Evalue=6e-30,
Organism=Homo sapiens, GI83977444, Length=338, Percent_Identity=29.8816568047337, Blast_Score=128, Evalue=8e-30,
Organism=Homo sapiens, GI4502025, Length=358, Percent_Identity=27.3743016759777, Blast_Score=119, Evalue=4e-27,
Organism=Homo sapiens, GI40316939, Length=358, Percent_Identity=27.3743016759777, Blast_Score=119, Evalue=4e-27,
Organism=Homo sapiens, GI119220554, Length=377, Percent_Identity=25.1989389920424, Blast_Score=114, Evalue=1e-25,
Organism=Homo sapiens, GI4758668, Length=362, Percent_Identity=23.2044198895028, Blast_Score=113, Evalue=3e-25,
Organism=Homo sapiens, GI5454084, Length=322, Percent_Identity=26.0869565217391, Blast_Score=98, Evalue=1e-20,
Organism=Escherichia coli, GI1786993, Length=349, Percent_Identity=33.5243553008596, Blast_Score=179, Evalue=2e-46,
Organism=Escherichia coli, GI1790046, Length=354, Percent_Identity=31.3559322033898, Blast_Score=179, Evalue=2e-46,
Organism=Caenorhabditis elegans, GI71994529, Length=371, Percent_Identity=31.266846361186, Blast_Score=165, Evalue=3e-41,
Organism=Caenorhabditis elegans, GI32566772, Length=393, Percent_Identity=22.9007633587786, Blast_Score=107, Evalue=9e-24,
Organism=Caenorhabditis elegans, GI17560914, Length=359, Percent_Identity=23.3983286908078, Blast_Score=99, Evalue=4e-21,
Organism=Caenorhabditis elegans, GI17560912, Length=359, Percent_Identity=23.3983286908078, Blast_Score=99, Evalue=4e-21,
Organism=Caenorhabditis elegans, GI71982617, Length=303, Percent_Identity=24.4224422442244, Blast_Score=94, Evalue=9e-20,
Organism=Caenorhabditis elegans, GI71982625, Length=303, Percent_Identity=24.4224422442244, Blast_Score=94, Evalue=9e-20,
Organism=Saccharomyces cerevisiae, GI6320438, Length=382, Percent_Identity=26.7015706806283, Blast_Score=129, Evalue=7e-31,
Organism=Saccharomyces cerevisiae, GI6320267, Length=366, Percent_Identity=24.5901639344262, Blast_Score=110, Evalue=5e-25,
Organism=Saccharomyces cerevisiae, GI6323954, Length=295, Percent_Identity=23.0508474576271, Blast_Score=90, Evalue=5e-19,
Organism=Drosophila melanogaster, GI24662918, Length=343, Percent_Identity=29.4460641399417, Blast_Score=161, Evalue=5e-40,
Organism=Drosophila melanogaster, GI17137420, Length=347, Percent_Identity=25.9365994236311, Blast_Score=115, Evalue=5e-26,
Organism=Drosophila melanogaster, GI17136286, Length=322, Percent_Identity=25.1552795031056, Blast_Score=100, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24653280, Length=298, Percent_Identity=24.496644295302, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24653276, Length=298, Percent_Identity=24.496644295302, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24653278, Length=298, Percent_Identity=24.496644295302, Blast_Score=97, Evalue=2e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022834
- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR004723
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.3.1.47 [H]

Molecular weight: Translated: 42551; Mature: 42551

Theoretical pI: Translated: 9.01; Mature: 9.01

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLNLQDKYTQYQRDNLLRELTPFIKDDSIIDFTTSDYLNLSSAHNLKHAIVNGFDKYGFG
CCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCHHHHHHHHHHCCHHHCCCC
SKGSNIVCGYTDETQQFEHEFAKFINYPRAIFFSSGFMANLAIYSTLFSKHDSIFADKYI
CCCCCEEEECCCHHHHHHHHHHHHHCCCHHEEECCCHHHHHHHHHHHHHHCCCHHHHHHH
HASIIDGIKLSQAKLRRYKHQQLSQLQDIYDGKSFITTEGVFSTSGSITQLDKLAKITPE
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCHHHHHHHHHCCHH
KLIVDEAHSFGVLGKNGRGAINSFRISYKNCPICVFPLGKAFGGVGAVVCTTEAIAEYLI
HHHHHCCCCCCCCCCCCCCCCEEEEEEECCCCEEEEECHHHHCCCHHHHHHHHHHHHHHH
QFARNYIYTTALPPMILKAALIQLKNLENANDNRARLQQNITFFNELCDAKDLELVSKDL
HHHHHHEEHHCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHH
SPIRSIQLNNANLAIRLKDKLFENKIIVSCFRYPTVPKDQAILRFSLHSNNTFDQIQQAL
HHHHEEEECCCEEEEEEHHHHHCCHHHHHHHCCCCCCCCCEEEEEEECCCCCHHHHHHHH
KIISKEVKYEYIRSN
HHHHHHHHHHHHCCC
>Mature Secondary Structure
MLNLQDKYTQYQRDNLLRELTPFIKDDSIIDFTTSDYLNLSSAHNLKHAIVNGFDKYGFG
CCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCHHHHHHHHHHCCHHHCCCC
SKGSNIVCGYTDETQQFEHEFAKFINYPRAIFFSSGFMANLAIYSTLFSKHDSIFADKYI
CCCCCEEEECCCHHHHHHHHHHHHHCCCHHEEECCCHHHHHHHHHHHHHHCCCHHHHHHH
HASIIDGIKLSQAKLRRYKHQQLSQLQDIYDGKSFITTEGVFSTSGSITQLDKLAKITPE
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCHHHHHHHHHCCHH
KLIVDEAHSFGVLGKNGRGAINSFRISYKNCPICVFPLGKAFGGVGAVVCTTEAIAEYLI
HHHHHCCCCCCCCCCCCCCCCEEEEEEECCCCEEEEECHHHHCCCHHHHHHHHHHHHHHH
QFARNYIYTTALPPMILKAALIQLKNLENANDNRARLQQNITFFNELCDAKDLELVSKDL
HHHHHHEEHHCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHH
SPIRSIQLNNANLAIRLKDKLFENKIIVSCFRYPTVPKDQAILRFSLHSNNTFDQIQQAL
HHHHEEEECCCEEEEEEHHHHHCCHHHHHHHCCCCCCCCCEEEEEEECCCCCHHHHHHHH
KIISKEVKYEYIRSN
HHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA