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The map label for this gene is thrS [H]

Identifier: 134301672

GI number: 134301672

Start: 606122

End: 608026

Strand: Direct

Name: thrS [H]

Synonym: FTW_0612

Alternate gene names: 134301672

Gene position: 606122-608026 (Clockwise)

Preceding gene: 134301670

Following gene: 134301673

Centisome position: 31.93

GC content: 36.33

Gene sequence:

>1905_bases
ATGATAAATATCAGATTTCCAGATGGTTCGATAAGAGAATTTGAAGCCGGTGTTAATTCTCTAGATGTTGCTAAATCAAT
ATCTCCAAGCTTAGCTAAAGCTACAATGGCTGCGTATATTGATGACCAGCTCAAAGATGCAAAAGATGCGATTAACAGTA
ACTGTGAATTAAGATTGATAACAGTAAAAGATCCAGAGGGTCTCGAAATTCTAAGACATTCTTGCGCTCATCTTTTAGCT
CATGCTGTCAAAGAGTTGTATCCAAATACTGAAGTAACTATAGGTCCGGTAGTTGATAATGGCTTTTATTATGATTTTTC
TTTCAAAGAGTCTATAGGTGAAGCAGATTTACCTACTATCGAAAAGAAAATGAAAGAATTAGCAAAAAAGTCTGCACCTG
TTAGTTATAGAGTGGTTCCTAAAGCTGAAGCAATTGAGTTTTTTAAGGCTCAAGGTGAGAACTATAAGGTTGAGATTATT
GATAGCATTGCTGATGAGCAGATGAAAATATATACCCAAGATAATTTTAGTGACTTGTGTAGAGGTCCTCATATTCCAAA
TACATCAGTATTAAAAGCATTTAAGTTGACAAAACTAGCAGGAGCTTATTGGCGAGGTAACTCTGATAATGAAATGCTAA
CTAGAATCTATGGCACATGCTGGGCAACTAAAGAAGATTTAGAGCAATATTTGAATATGCTTGAAGAGGCTGAAAAGCGT
GATCATAGAAAAATTGGTAAAGTTCTTGATCTATTTCATTTTCAAGAAGACTCACCAGGCATAGCTTTTTGGCATGATAA
TGGTGTGAGAATATGGCGTCAAGTAGAAGATTATATGCGAGCTTCTAATAATAAATATGGCTGTAGTGAGATTAGAACCC
CACTTATTGCAGATTTTAGTTTGTGGCAAAAATCTGGTCACGCATCTAAGTATGCTGAGAATATGTTTGCAACAAAGTCT
GAGAACAGGGATTTTGCTATCAGACCAATGAACTGTCCAACTTGTGTACAGGTTTATAATACAAAGCTACATAGTTATAG
AGATCTACCTATAAGGATGGCTGAGTTCGGTATAGTACATAGGAATGAACCATCTGGATCGCTACACGGGTTATTAAGAG
TACGTAGCTTTACTCAAGATGATGGGCATATTTTCTGTACCCCTGAGCAGGTTGAAGAAGAAGTGATTTTGATGGTACAG
CAGTGTTTTGAAGTATACAAAGATTTTGGTTTTAATGATTTTGCGATCAAGATTGCACTTAGACCTGAAAATAGAATCGG
AGATGATGAAACTTGGGATAAATCTGAACAGATGCTCAAAAATGCTCTTGACGCTAATAATGTTAGTTATGAACTACTTC
CAGGTGAGGGTGCATTTTATGGTCCTAAGATTGAGTTTCATCTCAAAGATGCAATTGGTAGAAGCTGGCAGTGTGGCACT
ATACAACTAGATTTTTCAATGCCACAAAGGCTAGGAGCTACATATATTGACAAGAATGGCGAGAAACAGGTGCCAGTTAT
GCTTCACAGAGCTATCGTTGGTTCTTTGGAGAGATTTATAGGTATGCTTATTGAGCATTATGCTGGAAATTTACCATTGT
GGTTAGCTCCAGTCCAAGTTGCTGTGATGGGAATTAGTAATAATCAGGATGACTACTGTAAAGAAGTATTTATAATGCTT
GAAAAAAATGGTATCCGAGCTAAATTAGACTTGAGAAATGAGAAAATAGGGTTTAAAATACGTGAGCATACTCTTTTGCG
TGTACCATACCTTGTTATCCTTGGTAAAAACGAGCAAGAGCAAAAGATTATCACAATAAGAAAGCATAGCGGCGAAGATC
TAGGACAGATGTCTGTAGATGATTTTTGTGCTTTTTTAGATAAGCAAATACAGGCTAAAGAATAA

Upstream 100 bases:

>100_bases
TTAAGTTTATTGATAAATAATTTACATAATTATAGCCATACAATATAATATATACTCTATGTAATATTTCATTAACAATA
TAATAGATTAAGTACTGCAA

Downstream 100 bases:

>100_bases
TAATTTCTGCGGAGGAAAAAGATTATTAAAACGGATAAAAAAGCACCTATAAATGAGCAAATTAAAGCAAAAGAGGTGCG
TCTAGTTGGTGTTGATGGTC

Product: threonyl-tRNA synthetase

Products: NA

Alternate protein names: Threonine--tRNA ligase; ThrRS [H]

Number of amino acids: Translated: 634; Mature: 634

Protein sequence:

>634_residues
MINIRFPDGSIREFEAGVNSLDVAKSISPSLAKATMAAYIDDQLKDAKDAINSNCELRLITVKDPEGLEILRHSCAHLLA
HAVKELYPNTEVTIGPVVDNGFYYDFSFKESIGEADLPTIEKKMKELAKKSAPVSYRVVPKAEAIEFFKAQGENYKVEII
DSIADEQMKIYTQDNFSDLCRGPHIPNTSVLKAFKLTKLAGAYWRGNSDNEMLTRIYGTCWATKEDLEQYLNMLEEAEKR
DHRKIGKVLDLFHFQEDSPGIAFWHDNGVRIWRQVEDYMRASNNKYGCSEIRTPLIADFSLWQKSGHASKYAENMFATKS
ENRDFAIRPMNCPTCVQVYNTKLHSYRDLPIRMAEFGIVHRNEPSGSLHGLLRVRSFTQDDGHIFCTPEQVEEEVILMVQ
QCFEVYKDFGFNDFAIKIALRPENRIGDDETWDKSEQMLKNALDANNVSYELLPGEGAFYGPKIEFHLKDAIGRSWQCGT
IQLDFSMPQRLGATYIDKNGEKQVPVMLHRAIVGSLERFIGMLIEHYAGNLPLWLAPVQVAVMGISNNQDDYCKEVFIML
EKNGIRAKLDLRNEKIGFKIREHTLLRVPYLVILGKNEQEQKIITIRKHSGEDLGQMSVDDFCAFLDKQIQAKE

Sequences:

>Translated_634_residues
MINIRFPDGSIREFEAGVNSLDVAKSISPSLAKATMAAYIDDQLKDAKDAINSNCELRLITVKDPEGLEILRHSCAHLLA
HAVKELYPNTEVTIGPVVDNGFYYDFSFKESIGEADLPTIEKKMKELAKKSAPVSYRVVPKAEAIEFFKAQGENYKVEII
DSIADEQMKIYTQDNFSDLCRGPHIPNTSVLKAFKLTKLAGAYWRGNSDNEMLTRIYGTCWATKEDLEQYLNMLEEAEKR
DHRKIGKVLDLFHFQEDSPGIAFWHDNGVRIWRQVEDYMRASNNKYGCSEIRTPLIADFSLWQKSGHASKYAENMFATKS
ENRDFAIRPMNCPTCVQVYNTKLHSYRDLPIRMAEFGIVHRNEPSGSLHGLLRVRSFTQDDGHIFCTPEQVEEEVILMVQ
QCFEVYKDFGFNDFAIKIALRPENRIGDDETWDKSEQMLKNALDANNVSYELLPGEGAFYGPKIEFHLKDAIGRSWQCGT
IQLDFSMPQRLGATYIDKNGEKQVPVMLHRAIVGSLERFIGMLIEHYAGNLPLWLAPVQVAVMGISNNQDDYCKEVFIML
EKNGIRAKLDLRNEKIGFKIREHTLLRVPYLVILGKNEQEQKIITIRKHSGEDLGQMSVDDFCAFLDKQIQAKE
>Mature_634_residues
MINIRFPDGSIREFEAGVNSLDVAKSISPSLAKATMAAYIDDQLKDAKDAINSNCELRLITVKDPEGLEILRHSCAHLLA
HAVKELYPNTEVTIGPVVDNGFYYDFSFKESIGEADLPTIEKKMKELAKKSAPVSYRVVPKAEAIEFFKAQGENYKVEII
DSIADEQMKIYTQDNFSDLCRGPHIPNTSVLKAFKLTKLAGAYWRGNSDNEMLTRIYGTCWATKEDLEQYLNMLEEAEKR
DHRKIGKVLDLFHFQEDSPGIAFWHDNGVRIWRQVEDYMRASNNKYGCSEIRTPLIADFSLWQKSGHASKYAENMFATKS
ENRDFAIRPMNCPTCVQVYNTKLHSYRDLPIRMAEFGIVHRNEPSGSLHGLLRVRSFTQDDGHIFCTPEQVEEEVILMVQ
QCFEVYKDFGFNDFAIKIALRPENRIGDDETWDKSEQMLKNALDANNVSYELLPGEGAFYGPKIEFHLKDAIGRSWQCGT
IQLDFSMPQRLGATYIDKNGEKQVPVMLHRAIVGSLERFIGMLIEHYAGNLPLWLAPVQVAVMGISNNQDDYCKEVFIML
EKNGIRAKLDLRNEKIGFKIREHTLLRVPYLVILGKNEQEQKIITIRKHSGEDLGQMSVDDFCAFLDKQIQAKE

Specific function: Thrs Is Also A Translational Repressor Protein, It Controls The Translation Of Its Own Gene By Binding To Its mRNA. [C]

COG id: COG0441

COG function: function code J; Threonyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family [H]

Homologues:

Organism=Homo sapiens, GI38570111, Length=624, Percent_Identity=37.1794871794872, Blast_Score=433, Evalue=1e-121,
Organism=Homo sapiens, GI38202255, Length=625, Percent_Identity=36.64, Blast_Score=429, Evalue=1e-120,
Organism=Homo sapiens, GI20070344, Length=642, Percent_Identity=34.5794392523364, Blast_Score=395, Evalue=1e-110,
Organism=Escherichia coli, GI1788013, Length=635, Percent_Identity=52.9133858267717, Blast_Score=723, Evalue=0.0,
Organism=Escherichia coli, GI1786392, Length=161, Percent_Identity=26.0869565217391, Blast_Score=68, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI71984184, Length=628, Percent_Identity=36.7834394904459, Blast_Score=446, Evalue=1e-125,
Organism=Caenorhabditis elegans, GI71984192, Length=628, Percent_Identity=36.7834394904459, Blast_Score=446, Evalue=1e-125,
Organism=Saccharomyces cerevisiae, GI6322112, Length=627, Percent_Identity=36.5231259968102, Blast_Score=427, Evalue=1e-120,
Organism=Saccharomyces cerevisiae, GI6322654, Length=389, Percent_Identity=37.0179948586118, Blast_Score=271, Evalue=2e-73,
Organism=Drosophila melanogaster, GI24583842, Length=631, Percent_Identity=36.7670364500792, Blast_Score=455, Evalue=1e-128,
Organism=Drosophila melanogaster, GI28574141, Length=631, Percent_Identity=36.7670364500792, Blast_Score=455, Evalue=1e-128,
Organism=Drosophila melanogaster, GI24583839, Length=631, Percent_Identity=36.7670364500792, Blast_Score=455, Evalue=1e-128,

Paralogues:

None

Copy number: 700 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR004154
- InterPro:   IPR012675
- InterPro:   IPR004095
- InterPro:   IPR012676
- InterPro:   IPR002320
- InterPro:   IPR018163
- InterPro:   IPR012947 [H]

Pfam domain/function: PF03129 HGTP_anticodon; PF02824 TGS; PF00587 tRNA-synt_2b; PF07973 tRNA_SAD [H]

EC number: =6.1.1.3 [H]

Molecular weight: Translated: 72390; Mature: 72390

Theoretical pI: Translated: 5.88; Mature: 5.88

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MINIRFPDGSIREFEAGVNSLDVAKSISPSLAKATMAAYIDDQLKDAKDAINSNCELRLI
CEEEECCCCCHHHHHCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEE
TVKDPEGLEILRHSCAHLLAHAVKELYPNTEVTIGPVVDNGFYYDFSFKESIGEADLPTI
EECCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCEEEEEEHHHCCCCCCCHHH
EKKMKELAKKSAPVSYRVVPKAEAIEFFKAQGENYKVEIIDSIADEQMKIYTQDNFSDLC
HHHHHHHHHHCCCCEEEECCCHHHHHHHHHCCCCEEEEEEEHHCCCCEEEEECCCHHHHH
RGPHIPNTSVLKAFKLTKLAGAYWRGNSDNEMLTRIYGTCWATKEDLEQYLNMLEEAEKR
CCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
DHRKIGKVLDLFHFQEDSPGIAFWHDNGVRIWRQVEDYMRASNNKYGCSEIRTPLIADFS
HHHHHHHHHHHHHCCCCCCCEEEEECCCHHHHHHHHHHHHHCCCCCCHHHHCCCHHHHHH
LWQKSGHASKYAENMFATKSENRDFAIRPMNCPTCVQVYNTKLHSYRDLPIRMAEFGIVH
HHHCCCCHHHHHHHHHHCCCCCCCEEEECCCCCHHHHHHHHHHHCCCCCCEEHHHCCEEE
RNEPSGSLHGLLRVRSFTQDDGHIFCTPEQVEEEVILMVQQCFEVYKDFGFNDFAIKIAL
CCCCCCHHHHHHHHHHCCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEE
RPENRIGDDETWDKSEQMLKNALDANNVSYELLPGEGAFYGPKIEFHLKDAIGRSWQCGT
CCCCCCCCCCCCCHHHHHHHHHHCCCCCEEEEECCCCCEECCEEEEEEHHHCCCCCCCCE
IQLDFSMPQRLGATYIDKNGEKQVPVMLHRAIVGSLERFIGMLIEHYAGNLPLWLAPVQV
EEECCCCHHHCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECEEE
AVMGISNNQDDYCKEVFIMLEKNGIRAKLDLRNEKIGFKIREHTLLRVPYLVILGKNEQE
EEEECCCCCHHHHHHHHHEEECCCCEEEEECCCCCCCEEEECCEEEECCEEEEECCCCCC
QKIITIRKHSGEDLGQMSVDDFCAFLDKQIQAKE
CEEEEEECCCCCCCCCCCHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MINIRFPDGSIREFEAGVNSLDVAKSISPSLAKATMAAYIDDQLKDAKDAINSNCELRLI
CEEEECCCCCHHHHHCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEE
TVKDPEGLEILRHSCAHLLAHAVKELYPNTEVTIGPVVDNGFYYDFSFKESIGEADLPTI
EECCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCEEEEEEHHHCCCCCCCHHH
EKKMKELAKKSAPVSYRVVPKAEAIEFFKAQGENYKVEIIDSIADEQMKIYTQDNFSDLC
HHHHHHHHHHCCCCEEEECCCHHHHHHHHHCCCCEEEEEEEHHCCCCEEEEECCCHHHHH
RGPHIPNTSVLKAFKLTKLAGAYWRGNSDNEMLTRIYGTCWATKEDLEQYLNMLEEAEKR
CCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
DHRKIGKVLDLFHFQEDSPGIAFWHDNGVRIWRQVEDYMRASNNKYGCSEIRTPLIADFS
HHHHHHHHHHHHHCCCCCCCEEEEECCCHHHHHHHHHHHHHCCCCCCHHHHCCCHHHHHH
LWQKSGHASKYAENMFATKSENRDFAIRPMNCPTCVQVYNTKLHSYRDLPIRMAEFGIVH
HHHCCCCHHHHHHHHHHCCCCCCCEEEECCCCCHHHHHHHHHHHCCCCCCEEHHHCCEEE
RNEPSGSLHGLLRVRSFTQDDGHIFCTPEQVEEEVILMVQQCFEVYKDFGFNDFAIKIAL
CCCCCCHHHHHHHHHHCCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEE
RPENRIGDDETWDKSEQMLKNALDANNVSYELLPGEGAFYGPKIEFHLKDAIGRSWQCGT
CCCCCCCCCCCCCHHHHHHHHHHCCCCCEEEEECCCCCEECCEEEEEEHHHCCCCCCCCE
IQLDFSMPQRLGATYIDKNGEKQVPVMLHRAIVGSLERFIGMLIEHYAGNLPLWLAPVQV
EEECCCCHHHCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECEEE
AVMGISNNQDDYCKEVFIMLEKNGIRAKLDLRNEKIGFKIREHTLLRVPYLVILGKNEQE
EEEECCCCCHHHHHHHHHEEECCCCEEEEECCCCCCCEEEECCEEEECCEEEEECCCCCC
QKIITIRKHSGEDLGQMSVDDFCAFLDKQIQAKE
CEEEEEECCCCCCCCCCCHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA