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The map label for this gene is mprA [H]

Identifier: 134301473

GI number: 134301473

Start: 378353

End: 379042

Strand: Reverse

Name: mprA [H]

Synonym: FTW_0386

Alternate gene names: 134301473

Gene position: 379042-378353 (Counterclockwise)

Preceding gene: 134301484

Following gene: 134301472

Centisome position: 19.97

GC content: 34.2

Gene sequence:

>690_bases
ATGAGTGACAACCCAAAAGTCTTAGTTGCTGATGATGACAAGAAAATAGCTCAATTCATAAAAACCAAATTTGAAGAAAA
TGGTATTGATACAACTGTAGCTTTTGATGGCAAGGAAGCTCTATTTCTAATCAATACCAATAACTATGATGTCATAGTTA
TAGATTGGATGATGCCATATTTAGATGGTATTTCTTTGCTTAAGATATTGCGTAAACAAAATATAAATACTCCTGTTATC
ATTCTAAGTGCTCTTGATAGTACCGAAAATAAAATCGAAGGTCTTAAATCAGGTAGTGATGACTATCTTACTAAGCCTTT
TTCGATAGATGAATTAATTATTAGGGTAAATATACTCTACAAAAGAACTAAGCAAATTACTGAGGCTCAAACTCATAAGT
TAAGTTGTGGTGATATTGTTCTTGACGAGCTTGCTCATGAGGTACGCCGCAATCGTGAGTTAATACTTCTACAACAACGT
GAATATAAAGTTTTACACCTCCTCTTAAAACATAAAAATGAAGTTGTCAGTAAAACGATGATACTCAAAGAAGTCTGGGA
TTATGACTTTGATCCACAAACCAATGTTGTAGAGGTGCATATCTCTCGCTTGCGTAACAAATTAACTGAAGGTGGGCTCT
CAGATCCAATAAAAACTATACGAGGCTTTGGCTATGTCATCCAAGAGTAG

Upstream 100 bases:

>100_bases
TCTTTGTTATTTAAATAAGTTTTATAGCTATTTTTTCAAGATACAAAACTATTAATTAGTTATAATTAGGTTATTAGCTT
AAAATTATAAACCAAATACG

Downstream 100 bases:

>100_bases
TCTTTATGATAGCATCCAACGTAGATATATCATCAGTTCTAGTTTTAAAATGGCGATGCTTTTTACAGTCTTATTAGGCT
TAAGCATAGTTTCTTGGATT

Product: two component response regulator

Products: NA

Alternate protein names: Mycobacterial persistence regulator A [H]

Number of amino acids: Translated: 229; Mature: 228

Protein sequence:

>229_residues
MSDNPKVLVADDDKKIAQFIKTKFEENGIDTTVAFDGKEALFLINTNNYDVIVIDWMMPYLDGISLLKILRKQNINTPVI
ILSALDSTENKIEGLKSGSDDYLTKPFSIDELIIRVNILYKRTKQITEAQTHKLSCGDIVLDELAHEVRRNRELILLQQR
EYKVLHLLLKHKNEVVSKTMILKEVWDYDFDPQTNVVEVHISRLRNKLTEGGLSDPIKTIRGFGYVIQE

Sequences:

>Translated_229_residues
MSDNPKVLVADDDKKIAQFIKTKFEENGIDTTVAFDGKEALFLINTNNYDVIVIDWMMPYLDGISLLKILRKQNINTPVI
ILSALDSTENKIEGLKSGSDDYLTKPFSIDELIIRVNILYKRTKQITEAQTHKLSCGDIVLDELAHEVRRNRELILLQQR
EYKVLHLLLKHKNEVVSKTMILKEVWDYDFDPQTNVVEVHISRLRNKLTEGGLSDPIKTIRGFGYVIQE
>Mature_228_residues
SDNPKVLVADDDKKIAQFIKTKFEENGIDTTVAFDGKEALFLINTNNYDVIVIDWMMPYLDGISLLKILRKQNINTPVII
LSALDSTENKIEGLKSGSDDYLTKPFSIDELIIRVNILYKRTKQITEAQTHKLSCGDIVLDELAHEVRRNRELILLQQRE
YKVLHLLLKHKNEVVSKTMILKEVWDYDFDPQTNVVEVHISRLRNKLTEGGLSDPIKTIRGFGYVIQE

Specific function: Member of the two-component regulatory system mprB/mprA which contributes to maintaining a balance among several systems involved in stress resistance and is required for establishment and maintenance of persistent infection in the host. Functions as a tr

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786784, Length=224, Percent_Identity=33.9285714285714, Blast_Score=157, Evalue=6e-40,
Organism=Escherichia coli, GI87082012, Length=220, Percent_Identity=35, Blast_Score=147, Evalue=8e-37,
Organism=Escherichia coli, GI1786599, Length=222, Percent_Identity=32.4324324324324, Blast_Score=139, Evalue=2e-34,
Organism=Escherichia coli, GI1789402, Length=227, Percent_Identity=33.0396475770925, Blast_Score=132, Evalue=2e-32,
Organism=Escherichia coli, GI1790552, Length=222, Percent_Identity=30.6306306306306, Blast_Score=122, Evalue=3e-29,
Organism=Escherichia coli, GI1787375, Length=223, Percent_Identity=29.1479820627803, Blast_Score=117, Evalue=9e-28,
Organism=Escherichia coli, GI2367329, Length=228, Percent_Identity=33.7719298245614, Blast_Score=114, Evalue=7e-27,
Organism=Escherichia coli, GI1786911, Length=224, Percent_Identity=30.3571428571429, Blast_Score=109, Evalue=1e-25,
Organism=Escherichia coli, GI1789809, Length=233, Percent_Identity=28.3261802575107, Blast_Score=109, Evalue=2e-25,
Organism=Escherichia coli, GI1790860, Length=224, Percent_Identity=29.4642857142857, Blast_Score=91, Evalue=5e-20,
Organism=Escherichia coli, GI1788550, Length=121, Percent_Identity=35.5371900826446, Blast_Score=90, Evalue=1e-19,
Organism=Escherichia coli, GI1788394, Length=225, Percent_Identity=25.3333333333333, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI1790863, Length=230, Percent_Identity=28.2608695652174, Blast_Score=86, Evalue=2e-18,
Organism=Escherichia coli, GI1787229, Length=229, Percent_Identity=27.5109170305677, Blast_Score=84, Evalue=6e-18,
Organism=Escherichia coli, GI145693140, Length=232, Percent_Identity=26.2931034482759, Blast_Score=78, Evalue=6e-16,
Organism=Escherichia coli, GI1790437, Length=110, Percent_Identity=34.5454545454545, Blast_Score=74, Evalue=8e-15,
Organism=Escherichia coli, GI1790299, Length=110, Percent_Identity=33.6363636363636, Blast_Score=72, Evalue=4e-14,
Organism=Escherichia coli, GI1788191, Length=120, Percent_Identity=30, Blast_Score=64, Evalue=8e-12,
Organism=Escherichia coli, GI1787487, Length=101, Percent_Identity=29.7029702970297, Blast_Score=62, Evalue=2e-11,
Organism=Escherichia coli, GI1788713, Length=116, Percent_Identity=31.0344827586207, Blast_Score=60, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 26372; Mature: 26241

Theoretical pI: Translated: 6.05; Mature: 6.05

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDNPKVLVADDDKKIAQFIKTKFEENGIDTTVAFDGKEALFLINTNNYDVIVIDWMMPY
CCCCCEEEEECCCHHHHHHHHHHHHCCCCCEEEEECCCCEEEEEECCCCEEEEEECHHHH
LDGISLLKILRKQNINTPVIILSALDSTENKIEGLKSGSDDYLTKPFSIDELIIRVNILY
HHHHHHHHHHHHCCCCCCEEEEEECCCCHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHH
KRTKQITEAQTHKLSCGDIVLDELAHEVRRNRELILLQQREYKVLHLLLKHKNEVVSKTM
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCEEEEECHHHHHHHHHHHHHHHHHHHHH
ILKEVWDYDFDPQTNVVEVHISRLRNKLTEGGLSDPIKTIRGFGYVIQE
HHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCEECC
>Mature Secondary Structure 
SDNPKVLVADDDKKIAQFIKTKFEENGIDTTVAFDGKEALFLINTNNYDVIVIDWMMPY
CCCCEEEEECCCHHHHHHHHHHHHCCCCCEEEEECCCCEEEEEECCCCEEEEEECHHHH
LDGISLLKILRKQNINTPVIILSALDSTENKIEGLKSGSDDYLTKPFSIDELIIRVNILY
HHHHHHHHHHHHCCCCCCEEEEEECCCCHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHH
KRTKQITEAQTHKLSCGDIVLDELAHEVRRNRELILLQQREYKVLHLLLKHKNEVVSKTM
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCEEEEECHHHHHHHHHHHHHHHHHHHHH
ILKEVWDYDFDPQTNVVEVHISRLRNKLTEGGLSDPIKTIRGFGYVIQE
HHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA