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The map label for this gene is arlS [H]

Identifier: 134301472

GI number: 134301472

Start: 377332

End: 378303

Strand: Reverse

Name: arlS [H]

Synonym: FTW_0385

Alternate gene names: 134301472

Gene position: 378303-377332 (Counterclockwise)

Preceding gene: 134301473

Following gene: 134301471

Centisome position: 19.93

GC content: 30.04

Gene sequence:

>972_bases
ATGGCGATGCTTTTTACAGTCTTATTAGGCTTAAGCATAGTTTCTTGGATTTATATAATCTTCTCTGCAGTTGGTGATAG
AGTAATCGAGCATATTATCCCTTTAAGTATAGGAATCTTTTGCACCGTAAGTGTTGTGATTATAAGCTATTTGATCAGCG
TCTTTGTTGTAAAGAAAATTAATCACATTGCTAGCTCTGCAGCCGCAATAGTTAATACCCAAGATTTTAGCCAAAGAATC
AAATCAAATACGAACTGGGATGATCTTAGTAATCTAGCTAATATTCTTAATATTCTTTTGGCTAACATCAAGGAGCTTTT
AGTAGATATAAAAAGTGTCTCGAACAATATTGCTCATGATTTAAAAACACCTTTAACCCGCTTAAAAAACAAGTTAGAGG
ATCTCGAGCAAACAAACCCAAATAAAGATTCAAGTGACGCGCTAGCAGAATGCAATCAATTACTTGATATTTTCAATAGC
CTACTAAGGCTTAATCTCCTAGAGCATGGGCGTGAAAGTTTAACAAAAAAACGCTTAGACATAAAAAATATCATTGATGA
TGCTATTGAACTATATGAGCCAATCTTTGAACAAAAAAATATCCAACTACAAACTAATATATTAGCTAAAAAACTTAATC
TTAATAAAAATCTTATCTTTCAGAGTATCATAAATATTTTAGATAATTGCTATAAATACTCAAAAGATAATACTGAAATT
TCAATTAATACAAAAATACAAAACTCTAAGTATATAATTGAAATAGCTGATCAAGGAATTGGCATAAATAATGAAAATAC
TGATAAAATCTTTGAAAGATTTTTCCGTGAAGAAAAAAGTCGTAGCCAAACAGGTAATGGCTTAGGACTTGCTCTAGTTA
AAAAAATTATTCAACTACATAATGGTGATATCATTGCTCAAAATAACAAACCCCAAGGTTTAAAAATGATAATATCACTA
CCATTACATTAA

Upstream 100 bases:

>100_bases
TCAGATCCAATAAAAACTATACGAGGCTTTGGCTATGTCATCCAAGAGTAGTCTTTATGATAGCATCCAACGTAGATATA
TCATCAGTTCTAGTTTTAAA

Downstream 100 bases:

>100_bases
CAAATTTTAACTATGTTTTTAAAACTTTAAAAATTAACCTTATAATTAAGCAAAATTCTTATGAGTAATTCTAAACATGG
AAAAAATAGCAGTAATAGGA

Product: two-component system sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 323; Mature: 322

Protein sequence:

>323_residues
MAMLFTVLLGLSIVSWIYIIFSAVGDRVIEHIIPLSIGIFCTVSVVIISYLISVFVVKKINHIASSAAAIVNTQDFSQRI
KSNTNWDDLSNLANILNILLANIKELLVDIKSVSNNIAHDLKTPLTRLKNKLEDLEQTNPNKDSSDALAECNQLLDIFNS
LLRLNLLEHGRESLTKKRLDIKNIIDDAIELYEPIFEQKNIQLQTNILAKKLNLNKNLIFQSIINILDNCYKYSKDNTEI
SINTKIQNSKYIIEIADQGIGINNENTDKIFERFFREEKSRSQTGNGLGLALVKKIIQLHNGDIIAQNNKPQGLKMIISL
PLH

Sequences:

>Translated_323_residues
MAMLFTVLLGLSIVSWIYIIFSAVGDRVIEHIIPLSIGIFCTVSVVIISYLISVFVVKKINHIASSAAAIVNTQDFSQRI
KSNTNWDDLSNLANILNILLANIKELLVDIKSVSNNIAHDLKTPLTRLKNKLEDLEQTNPNKDSSDALAECNQLLDIFNS
LLRLNLLEHGRESLTKKRLDIKNIIDDAIELYEPIFEQKNIQLQTNILAKKLNLNKNLIFQSIINILDNCYKYSKDNTEI
SINTKIQNSKYIIEIADQGIGINNENTDKIFERFFREEKSRSQTGNGLGLALVKKIIQLHNGDIIAQNNKPQGLKMIISL
PLH
>Mature_322_residues
AMLFTVLLGLSIVSWIYIIFSAVGDRVIEHIIPLSIGIFCTVSVVIISYLISVFVVKKINHIASSAAAIVNTQDFSQRIK
SNTNWDDLSNLANILNILLANIKELLVDIKSVSNNIAHDLKTPLTRLKNKLEDLEQTNPNKDSSDALAECNQLLDIFNSL
LRLNLLEHGRESLTKKRLDIKNIIDDAIELYEPIFEQKNIQLQTNILAKKLNLNKNLIFQSIINILDNCYKYSKDNTEIS
INTKIQNSKYIIEIADQGIGINNENTDKIFERFFREEKSRSQTGNGLGLALVKKIIQLHNGDIIAQNNKPQGLKMIISLP
LH

Specific function: Member of the two-component regulatory system ArlS/ArlR involved in the regulation of adhesion, autolysis, multidrug resistance and virulence. ArlS probably functions as a sensor protein kinase which is autophosphorylated at a histidine residue and transf

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1788393, Length=256, Percent_Identity=26.953125, Blast_Score=102, Evalue=2e-23,
Organism=Escherichia coli, GI1786912, Length=212, Percent_Identity=26.8867924528302, Blast_Score=89, Evalue=3e-19,
Organism=Escherichia coli, GI1786783, Length=292, Percent_Identity=23.2876712328767, Blast_Score=88, Evalue=7e-19,
Organism=Escherichia coli, GI1790346, Length=233, Percent_Identity=26.1802575107296, Blast_Score=86, Evalue=3e-18,
Organism=Escherichia coli, GI1789808, Length=243, Percent_Identity=23.8683127572016, Blast_Score=85, Evalue=6e-18,
Organism=Escherichia coli, GI1787894, Length=287, Percent_Identity=26.1324041811847, Blast_Score=83, Evalue=2e-17,
Organism=Escherichia coli, GI1790861, Length=211, Percent_Identity=24.6445497630332, Blast_Score=82, Evalue=6e-17,
Organism=Escherichia coli, GI1788713, Length=255, Percent_Identity=23.1372549019608, Blast_Score=75, Evalue=8e-15,
Organism=Escherichia coli, GI1788279, Length=273, Percent_Identity=24.1758241758242, Blast_Score=72, Evalue=6e-14,
Organism=Escherichia coli, GI1788549, Length=226, Percent_Identity=25.2212389380531, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1790436, Length=226, Percent_Identity=23.8938053097345, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1790551, Length=296, Percent_Identity=21.9594594594595, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI87081816, Length=216, Percent_Identity=24.0740740740741, Blast_Score=69, Evalue=6e-13,
Organism=Escherichia coli, GI1786600, Length=214, Percent_Identity=24.7663551401869, Blast_Score=68, Evalue=8e-13,
Organism=Escherichia coli, GI145693157, Length=218, Percent_Identity=25.2293577981651, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1789403, Length=246, Percent_Identity=26.4227642276423, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1789149, Length=208, Percent_Identity=29.8076923076923, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI1787374, Length=235, Percent_Identity=23.4042553191489, Blast_Score=62, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 36475; Mature: 36344

Theoretical pI: Translated: 8.07; Mature: 8.07

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAMLFTVLLGLSIVSWIYIIFSAVGDRVIEHIIPLSIGIFCTVSVVIISYLISVFVVKKI
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NHIASSAAAIVNTQDFSQRIKSNTNWDDLSNLANILNILLANIKELLVDIKSVSNNIAHD
HHHHHHHHHHHCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LKTPLTRLKNKLEDLEQTNPNKDSSDALAECNQLLDIFNSLLRLNLLEHGRESLTKKRLD
HHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IKNIIDDAIELYEPIFEQKNIQLQTNILAKKLNLNKNLIFQSIINILDNCYKYSKDNTEI
HHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCEE
SINTKIQNSKYIIEIADQGIGINNENTDKIFERFFREEKSRSQTGNGLGLALVKKIIQLH
EEEEEECCCEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
NGDIIAQNNKPQGLKMIISLPLH
CCCEEECCCCCCCCEEHEECCCC
>Mature Secondary Structure 
AMLFTVLLGLSIVSWIYIIFSAVGDRVIEHIIPLSIGIFCTVSVVIISYLISVFVVKKI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NHIASSAAAIVNTQDFSQRIKSNTNWDDLSNLANILNILLANIKELLVDIKSVSNNIAHD
HHHHHHHHHHHCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LKTPLTRLKNKLEDLEQTNPNKDSSDALAECNQLLDIFNSLLRLNLLEHGRESLTKKRLD
HHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IKNIIDDAIELYEPIFEQKNIQLQTNILAKKLNLNKNLIFQSIINILDNCYKYSKDNTEI
HHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCEE
SINTKIQNSKYIIEIADQGIGINNENTDKIFERFFREEKSRSQTGNGLGLALVKKIIQLH
EEEEEECCCEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
NGDIIAQNNKPQGLKMIISLPLH
CCCEEECCCCCCCCEEHEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA