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The map label for this gene is ung

Identifier: 134301441

GI number: 134301441

Start: 341865

End: 342527

Strand: Direct

Name: ung

Synonym: FTW_0348

Alternate gene names: 134301441

Gene position: 341865-342527 (Clockwise)

Preceding gene: 134301440

Following gene: 134301444

Centisome position: 18.01

GC content: 33.33

Gene sequence:

>663_bases
ATGACTTGGTCAGATATCTTAGCAGAAGAAAAACAAAAACCTTATTTTAAACAAATACTTGACTTTTTGGCGTGTGAAAG
CGCTAAAGGTAAGGTAATTTTCCCAACGAAGGAAAATATTTTTAATGCTTTTAAGTATACTGAGCTAGATAATCTAAAAG
TAGTCATTTTAGGGCAAGATCCATATCACAACTATAATCAAGCTCATGGTTTAGCGTTCTCAGTGCAAAAAGGGGTGGAT
ATTCCACCATCATTGCAAAATATCTATAAAGAGCTTGCCCGCAGTATTCCAGAATTTAAAACTCCAAATCATGGTTATTT
AGTTGATTGGGCAAAGCAAGGAGTGTTTTTATTAAATACTACTTTGACAGTTGAGGCTCATAAAGCAAATTCACATAAGG
ATATAGGTTGGGAGACTTTTACGGATACTGTAATTAACAAAATTTCAGAAAATAAACACAATGTTGTGTTTATGCTTTGG
GGTTCGCATGCACGTAAGAAAAAAGTTCTTATTGATAGTTCAAGGCATTTGATTTTAGAGTCTACACATCCATCGCCTTT
ATCAGCACATAGAGGTTTTCTGGGTTGTAATCATTTTGTTGATTGTAATAAGTATTTGATTGAAAAGAAAGATCAGAAGA
TAGATTGGAATTTACTTTGCTGA

Upstream 100 bases:

>100_bases
TCTTTGAAGGTTTGCAGAAGCAATTACCTGATGTTGAAATTAGATTTAAAACCAGGGTAAATAAACAGGAATTGTCTAAT
ATTTTACAGGAGTACCAAAA

Downstream 100 bases:

>100_bases
ACGATTCCATTATGTGCAGCTTAGAAAAAAAATAATTACTTAACAATATTCCAAGGATCTTGATATTGAGTATGGTTTTC
TACAGGGTTAACTCCTTTAT

Product: uracil-DNA glycosylase

Products: NA

Alternate protein names: UDG

Number of amino acids: Translated: 220; Mature: 219

Protein sequence:

>220_residues
MTWSDILAEEKQKPYFKQILDFLACESAKGKVIFPTKENIFNAFKYTELDNLKVVILGQDPYHNYNQAHGLAFSVQKGVD
IPPSLQNIYKELARSIPEFKTPNHGYLVDWAKQGVFLLNTTLTVEAHKANSHKDIGWETFTDTVINKISENKHNVVFMLW
GSHARKKKVLIDSSRHLILESTHPSPLSAHRGFLGCNHFVDCNKYLIEKKDQKIDWNLLC

Sequences:

>Translated_220_residues
MTWSDILAEEKQKPYFKQILDFLACESAKGKVIFPTKENIFNAFKYTELDNLKVVILGQDPYHNYNQAHGLAFSVQKGVD
IPPSLQNIYKELARSIPEFKTPNHGYLVDWAKQGVFLLNTTLTVEAHKANSHKDIGWETFTDTVINKISENKHNVVFMLW
GSHARKKKVLIDSSRHLILESTHPSPLSAHRGFLGCNHFVDCNKYLIEKKDQKIDWNLLC
>Mature_219_residues
TWSDILAEEKQKPYFKQILDFLACESAKGKVIFPTKENIFNAFKYTELDNLKVVILGQDPYHNYNQAHGLAFSVQKGVDI
PPSLQNIYKELARSIPEFKTPNHGYLVDWAKQGVFLLNTTLTVEAHKANSHKDIGWETFTDTVINKISENKHNVVFMLWG
SHARKKKVLIDSSRHLILESTHPSPLSAHRGFLGCNHFVDCNKYLIEKKDQKIDWNLLC

Specific function: Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine

COG id: COG0692

COG function: function code L; Uracil DNA glycosylase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uracil-DNA glycosylase family

Homologues:

Organism=Homo sapiens, GI19718751, Length=218, Percent_Identity=50.9174311926605, Blast_Score=233, Evalue=8e-62,
Organism=Homo sapiens, GI6224979, Length=218, Percent_Identity=50.9174311926605, Blast_Score=233, Evalue=1e-61,
Organism=Escherichia coli, GI1788934, Length=216, Percent_Identity=59.7222222222222, Blast_Score=289, Evalue=9e-80,
Organism=Caenorhabditis elegans, GI17556304, Length=216, Percent_Identity=53.7037037037037, Blast_Score=235, Evalue=1e-62,
Organism=Saccharomyces cerevisiae, GI6323620, Length=237, Percent_Identity=44.7257383966245, Blast_Score=193, Evalue=2e-50,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UNG_FRAT1 (Q14G45)

Other databases:

- EMBL:   AM286280
- RefSeq:   YP_667632.1
- ProteinModelPortal:   Q14G45
- SMR:   Q14G45
- STRING:   Q14G45
- GeneID:   4198983
- GenomeReviews:   AM286280_GR
- KEGG:   ftf:FTF1578c
- eggNOG:   COG0692
- HOGENOM:   HBG605450
- OMA:   GAHAQKK
- PhylomeDB:   Q14G45
- ProtClustDB:   PRK05254
- BioCyc:   FTUL393115:FTF1578C-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00148
- InterPro:   IPR002043
- InterPro:   IPR018085
- InterPro:   IPR005122
- Gene3D:   G3DSA:3.40.470.10
- PANTHER:   PTHR11264
- TIGRFAMs:   TIGR00628

Pfam domain/function: PF03167 UDG; SSF52141 UDNA_glycsylseSF

EC number: =3.2.2.27

Molecular weight: Translated: 25298; Mature: 25167

Theoretical pI: Translated: 8.60; Mature: 8.60

Prosite motif: PS00130 U_DNA_GLYCOSYLASE

Important sites: ACT_SITE 60-60

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTWSDILAEEKQKPYFKQILDFLACESAKGKVIFPTKENIFNAFKYTELDNLKVVILGQD
CCHHHHHHHHCCCCHHHHHHHHHHCCCCCCCEEECCHHHHHHHHHCCCCCCEEEEEEECC
PYHNYNQAHGLAFSVQKGVDIPPSLQNIYKELARSIPEFKTPNHGYLVDWAKQGVFLLNT
CCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCEEEEEE
TLTVEAHKANSHKDIGWETFTDTVINKISENKHNVVFMLWGSHARKKKVLIDSSRHLILE
EEEEEEECCCCCCCCCHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCEEEEECCCEEEEE
STHPSPLSAHRGFLGCNHFVDCNKYLIEKKDQKIDWNLLC
CCCCCCCHHHCCCCCCCCHHCCCHHHHCCCCCCCCEEECC
>Mature Secondary Structure 
TWSDILAEEKQKPYFKQILDFLACESAKGKVIFPTKENIFNAFKYTELDNLKVVILGQD
CHHHHHHHHCCCCHHHHHHHHHHCCCCCCCEEECCHHHHHHHHHCCCCCCEEEEEEECC
PYHNYNQAHGLAFSVQKGVDIPPSLQNIYKELARSIPEFKTPNHGYLVDWAKQGVFLLNT
CCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCEEEEEE
TLTVEAHKANSHKDIGWETFTDTVINKISENKHNVVFMLWGSHARKKKVLIDSSRHLILE
EEEEEEECCCCCCCCCHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCEEEEECCCEEEEE
STHPSPLSAHRGFLGCNHFVDCNKYLIEKKDQKIDWNLLC
CCCCCCCHHHCCCCCCCCHHCCCHHHHCCCCCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA