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The map label for this gene is gyrA [H]

Identifier: 134301444

GI number: 134301444

Start: 344487

End: 347093

Strand: Direct

Name: gyrA [H]

Synonym: FTW_0351

Alternate gene names: 134301444

Gene position: 344487-347093 (Clockwise)

Preceding gene: 134301441

Following gene: 134301445

Centisome position: 18.15

GC content: 35.48

Gene sequence:

>2607_bases
ATGTCTATAATTACTAAAGAGTCATCATCTATAAATATCGAAAAAGAACTAAAACAATCGTATCTTGATTATGCTATGAG
TGTAATTGTTGGTCGTGCTTTGCCAGATGTGCGTGATGGTCTTAAGCCTGTCCATCGTCGTGTACTTTTTGCAATGAATG
AACTATCAAATTATTACAATAGACCATATAAAAAGTCTGCAAGGGTTGTCGGTGATGTAATCGGTAAATATCACCCTCAT
GGAGATACAGCTGTTTACGATACTATTGTCAGAATGGCACAACCTTTCTCATTGCGCTATACGCTAGTAGATGGACAAGG
TAACTTTGGTTCTGTTGATGGTGATTCTCCTGCAGCAATGCGTTATACCGAAATTAGAATGGAAAAACTAACGCATGAGC
TCTTGATCGATATAGATAAAGAAACTGTAGACTTTTCACCTAACTATGATAATACTGAGTTAGTTCCAGACGTGTTGCCA
ACTAGAGTTCCAAACCTTTTAGTAAATGGGTCATCAGGTATTGCTGTTGGTATGGCAACTAATATTCCGCCGCATAATAT
GACTGAGGTTATCAATGGTACTATAGCTCTTATTGATAATCCTAACTTAACTATCGAAGAACTTATTGAGTATATTCTAG
CTCCAGATTTTCCTACGGGGTCATATATTAATGGTACAGATGGTATTTTAGAGGCTTATAAAACTGGTCGCGGCCGTGTG
ATTATGCGTGCTAAAGCTGATATTCATGAAGATGAAGCATCTGGTAAAGCACAGATAATAGTCACAGAGATACCTTACCA
AGTAAACAAAGCTAAGCTTGTAGAGAAGATTGCTGAGCTTGTTAAAGATAAGAAAGTAGCAGGTATATCTGAGTTAAGAG
ATGAGTCTGACAAAGATGGTATTCGAGTTGTTATTGATTTAAAAAGAGATGAGTCACCTGAAGTTGTGTTAAATACTTTA
TATGCTCAAACACAATTACAATGTAGTTTTGGGATTAATATGGTTGCTCTTAGTGACAATAGACCTAAGTTACTGAATCT
TAAAGAAATTCTAGAGCAGTTTATTAAGCATAGAAAGGAAGTAGTAACAAGAAGAACAATTTTTGAACTAAGAAAGTCAA
AAGAGCGAGCGCATATTTTAGAAGGCTTACTACTGTCATTGGCTAATATTGATGAGATGATTGAACTAATTAAGGCATCT
CCATCACCAGCTGATGCAAAAGAGTCAATGCTTGCTAGATCATGGAATGGTTCTATGGTTAAGAGTATGCTAGAGGGTGT
AGATGTTAAAATGTATCGTAAAGAAACTCTAGCATCTCATTATGGCATTCAAGTTGATTCTTCATATAATCTAACTGAAG
AGCAAGCGGATGCAATTCTTGCTTTGAGATTACATCGATTGACAGGTTTGGAACAAGATAAGATTGTTAATGAATTTAAA
GAGCTTATCGATAGAATTAAATATCTAATTAGTATTTTGAGTGATATTAAAGAGCTTATTCGTGTCGTTAAAGATGAACT
TGTTGAGATTCGAGATAACTATGGTGATCAAAGAAAATCAGAAATTATAGAGTCAAGATTAGATCTAACTAGAGAAGATC
TTATCGCAGAAGAAGATATGGTTGTGACTCTATCTATGGATGGCTATGTTAAAACTCAACCGTTAAGTATGTATAATGCG
CAAAAACGTGGTGGCGTTGGTAAATCTGCAACTAAGACTAAAGAAGAAGATAGTATATTTAAGTTAATGCTTGCTTCAAC
TCATGATACTATGTTGTGTTTTTCAAGCTTAGGTAGAGTGTATTGGTCAAAAGTCTATGACTTCCCAGTTGCAAGTAGAA
TTTCTAAAGGTAGACCAATTAACAATATTTTACCATTAGAGAAAGATGAAAGAATAACGGCAATGATGCCAATTTCTCAA
TTTAATGAGGGCTGGTATGTGTTTATGGCAACTAAACTTGGTAGGGTCAAGAAAGTTGACTTATCAGAATTTGCTAGACC
ACGTTCTACGGGTAAGATAGCAATTGGCTTAAATGATGGTGATGAGTTATCCTATGTTGCTCTTACAGATGGTAATAAAC
AAATTATGATGTTTTCTGACGCCGGTAAAGCAATTCGTTTTGATGAGTCTGATGTCAGAGCGATGGGTCGTTCAGCAGCA
GGTGTTACAGGTATGCGTTTACATCATAATCAAAAGATAGTCTCTGTAATTGTTACTAATCCAGATGAGGGGATTGTCTT
AGCTGCAACAGAGAATGGATATGGTAAGCGTACCGCAGTTTCAGAATATCGTAAAACTAAACGAGCAAGTCAAGGTGTAA
TAGCTATATCAACATCTGAAAGAAATGGTAAAGTTGTAGTAGCTGTCCTAGTTGAAAATGATGAAGATATTGTAATGATA
ACTGATAATGGCACTTTGGTAAGAACATCTTCTGATGAGGTTAGAGAATGTGGACGCTCTGCCCAGGGGGTTAGATTAAT
TAATCTGAGAAATAATGAAAAGCTTATTAGCTTAAAAGTAGTTAAGCAAGATGATGTTGAGGATAATCAAGATATAGAAA
ATAATGAAGATATAGAATCTTCTGATGTTACTGTGCAGAGTGAATAA

Upstream 100 bases:

>100_bases
TTTTGATAGGTTTTTGAATGGATTGCTAAAGAGTGCTTTTTAGTATCTATTATGCTAAAATACCGGTTATATGTTTTATC
TTCATTAAAAGCGATAACTA

Downstream 100 bases:

>100_bases
TTGGCATGTTTAAAAAAACTAAGATTACTATATTAGGAGCTACAGGATCTATAGGTGATAGCACTTTAGCTGTTATTAGA
GAGACTAATGATTTTGAAGT

Product: DNA gyrase, subunit A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 868; Mature: 867

Protein sequence:

>868_residues
MSIITKESSSINIEKELKQSYLDYAMSVIVGRALPDVRDGLKPVHRRVLFAMNELSNYYNRPYKKSARVVGDVIGKYHPH
GDTAVYDTIVRMAQPFSLRYTLVDGQGNFGSVDGDSPAAMRYTEIRMEKLTHELLIDIDKETVDFSPNYDNTELVPDVLP
TRVPNLLVNGSSGIAVGMATNIPPHNMTEVINGTIALIDNPNLTIEELIEYILAPDFPTGSYINGTDGILEAYKTGRGRV
IMRAKADIHEDEASGKAQIIVTEIPYQVNKAKLVEKIAELVKDKKVAGISELRDESDKDGIRVVIDLKRDESPEVVLNTL
YAQTQLQCSFGINMVALSDNRPKLLNLKEILEQFIKHRKEVVTRRTIFELRKSKERAHILEGLLLSLANIDEMIELIKAS
PSPADAKESMLARSWNGSMVKSMLEGVDVKMYRKETLASHYGIQVDSSYNLTEEQADAILALRLHRLTGLEQDKIVNEFK
ELIDRIKYLISILSDIKELIRVVKDELVEIRDNYGDQRKSEIIESRLDLTREDLIAEEDMVVTLSMDGYVKTQPLSMYNA
QKRGGVGKSATKTKEEDSIFKLMLASTHDTMLCFSSLGRVYWSKVYDFPVASRISKGRPINNILPLEKDERITAMMPISQ
FNEGWYVFMATKLGRVKKVDLSEFARPRSTGKIAIGLNDGDELSYVALTDGNKQIMMFSDAGKAIRFDESDVRAMGRSAA
GVTGMRLHHNQKIVSVIVTNPDEGIVLAATENGYGKRTAVSEYRKTKRASQGVIAISTSERNGKVVVAVLVENDEDIVMI
TDNGTLVRTSSDEVRECGRSAQGVRLINLRNNEKLISLKVVKQDDVEDNQDIENNEDIESSDVTVQSE

Sequences:

>Translated_868_residues
MSIITKESSSINIEKELKQSYLDYAMSVIVGRALPDVRDGLKPVHRRVLFAMNELSNYYNRPYKKSARVVGDVIGKYHPH
GDTAVYDTIVRMAQPFSLRYTLVDGQGNFGSVDGDSPAAMRYTEIRMEKLTHELLIDIDKETVDFSPNYDNTELVPDVLP
TRVPNLLVNGSSGIAVGMATNIPPHNMTEVINGTIALIDNPNLTIEELIEYILAPDFPTGSYINGTDGILEAYKTGRGRV
IMRAKADIHEDEASGKAQIIVTEIPYQVNKAKLVEKIAELVKDKKVAGISELRDESDKDGIRVVIDLKRDESPEVVLNTL
YAQTQLQCSFGINMVALSDNRPKLLNLKEILEQFIKHRKEVVTRRTIFELRKSKERAHILEGLLLSLANIDEMIELIKAS
PSPADAKESMLARSWNGSMVKSMLEGVDVKMYRKETLASHYGIQVDSSYNLTEEQADAILALRLHRLTGLEQDKIVNEFK
ELIDRIKYLISILSDIKELIRVVKDELVEIRDNYGDQRKSEIIESRLDLTREDLIAEEDMVVTLSMDGYVKTQPLSMYNA
QKRGGVGKSATKTKEEDSIFKLMLASTHDTMLCFSSLGRVYWSKVYDFPVASRISKGRPINNILPLEKDERITAMMPISQ
FNEGWYVFMATKLGRVKKVDLSEFARPRSTGKIAIGLNDGDELSYVALTDGNKQIMMFSDAGKAIRFDESDVRAMGRSAA
GVTGMRLHHNQKIVSVIVTNPDEGIVLAATENGYGKRTAVSEYRKTKRASQGVIAISTSERNGKVVVAVLVENDEDIVMI
TDNGTLVRTSSDEVRECGRSAQGVRLINLRNNEKLISLKVVKQDDVEDNQDIENNEDIESSDVTVQSE
>Mature_867_residues
SIITKESSSINIEKELKQSYLDYAMSVIVGRALPDVRDGLKPVHRRVLFAMNELSNYYNRPYKKSARVVGDVIGKYHPHG
DTAVYDTIVRMAQPFSLRYTLVDGQGNFGSVDGDSPAAMRYTEIRMEKLTHELLIDIDKETVDFSPNYDNTELVPDVLPT
RVPNLLVNGSSGIAVGMATNIPPHNMTEVINGTIALIDNPNLTIEELIEYILAPDFPTGSYINGTDGILEAYKTGRGRVI
MRAKADIHEDEASGKAQIIVTEIPYQVNKAKLVEKIAELVKDKKVAGISELRDESDKDGIRVVIDLKRDESPEVVLNTLY
AQTQLQCSFGINMVALSDNRPKLLNLKEILEQFIKHRKEVVTRRTIFELRKSKERAHILEGLLLSLANIDEMIELIKASP
SPADAKESMLARSWNGSMVKSMLEGVDVKMYRKETLASHYGIQVDSSYNLTEEQADAILALRLHRLTGLEQDKIVNEFKE
LIDRIKYLISILSDIKELIRVVKDELVEIRDNYGDQRKSEIIESRLDLTREDLIAEEDMVVTLSMDGYVKTQPLSMYNAQ
KRGGVGKSATKTKEEDSIFKLMLASTHDTMLCFSSLGRVYWSKVYDFPVASRISKGRPINNILPLEKDERITAMMPISQF
NEGWYVFMATKLGRVKKVDLSEFARPRSTGKIAIGLNDGDELSYVALTDGNKQIMMFSDAGKAIRFDESDVRAMGRSAAG
VTGMRLHHNQKIVSVIVTNPDEGIVLAATENGYGKRTAVSEYRKTKRASQGVIAISTSERNGKVVVAVLVENDEDIVMIT
DNGTLVRTSSDEVRECGRSAQGVRLINLRNNEKLISLKVVKQDDVEDNQDIENNEDIESSDVTVQSE

Specific function: DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings [H]

COG id: COG0188

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the topoisomerase gyrA/parC subunit family [H]

Homologues:

Organism=Homo sapiens, GI19913408, Length=351, Percent_Identity=24.7863247863248, Blast_Score=78, Evalue=4e-14,
Organism=Homo sapiens, GI19913406, Length=177, Percent_Identity=31.638418079096, Blast_Score=74, Evalue=5e-13,
Organism=Escherichia coli, GI1788562, Length=862, Percent_Identity=60.5568445475638, Blast_Score=1053, Evalue=0.0,
Organism=Escherichia coli, GI1789396, Length=707, Percent_Identity=35.7850070721358, Blast_Score=391, Evalue=1e-109,
Organism=Caenorhabditis elegans, GI212645845, Length=399, Percent_Identity=25.31328320802, Blast_Score=76, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI17535065, Length=176, Percent_Identity=32.9545454545455, Blast_Score=76, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI212645657, Length=291, Percent_Identity=27.1477663230241, Blast_Score=74, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6324241, Length=343, Percent_Identity=26.8221574344023, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI17136538, Length=354, Percent_Identity=25.7062146892655, Blast_Score=75, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020899
- InterPro:   IPR005743
- InterPro:   IPR006691
- InterPro:   IPR002205
- InterPro:   IPR013758
- InterPro:   IPR013757
- InterPro:   IPR013760 [H]

Pfam domain/function: PF03989 DNA_gyraseA_C; PF00521 DNA_topoisoIV [H]

EC number: =5.99.1.3 [H]

Molecular weight: Translated: 97173; Mature: 97042

Theoretical pI: Translated: 5.35; Mature: 5.35

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIITKESSSINIEKELKQSYLDYAMSVIVGRALPDVRDGLKPVHRRVLFAMNELSNYYN
CCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHC
RPYKKSARVVGDVIGKYHPHGDTAVYDTIVRMAQPFSLRYTLVDGQGNFGSVDGDSPAAM
CCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCCCCCHH
RYTEIRMEKLTHELLIDIDKETVDFSPNYDNTELVPDVLPTRVPNLLVNGSSGIAVGMAT
HHHHHHHHHHHHHHHEECCCCEEECCCCCCCCCCCHHHHHCCCCCEEEECCCCEEEEEEC
NIPPHNMTEVINGTIALIDNPNLTIEELIEYILAPDFPTGSYINGTDGILEAYKTGRGRV
CCCCCCHHHHHCCEEEEEECCCCCHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHCCCCEE
IMRAKADIHEDEASGKAQIIVTEIPYQVNKAKLVEKIAELVKDKKVAGISELRDESDKDG
EEEECCCCCCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHCCCCCCHHHHHCCCCCCC
IRVVIDLKRDESPEVVLNTLYAQTQLQCSFGINMVALSDNRPKLLNLKEILEQFIKHRKE
EEEEEEECCCCCHHHHHHHHHHHHEEEEECCEEEEEECCCCCCEECHHHHHHHHHHHHHH
VVTRRTIFELRKSKERAHILEGLLLSLANIDEMIELIKASPSPADAKESMLARSWNGSMV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCCCCHHHHHHHHCCCCHHH
KSMLEGVDVKMYRKETLASHYGIQVDSSYNLTEEQADAILALRLHRLTGLEQDKIVNEFK
HHHHCCCCEEEHHHHHHHHHCCEEECCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHH
ELIDRIKYLISILSDIKELIRVVKDELVEIRDNYGDQRKSEIIESRLDLTREDLIAEEDM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCHHHHCCCCCE
VVTLSMDGYVKTQPLSMYNAQKRGGVGKSATKTKEEDSIFKLMLASTHDTMLCFSSLGRV
EEEEECCCEEEECCCHHHCCHHCCCCCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHH
YWSKVYDFPVASRISKGRPINNILPLEKDERITAMMPISQFNEGWYVFMATKLGRVKKVD
HHHHHHCCCHHHHHHCCCCCCCCCCCCCCCCEEEEECHHHCCCCEEEEEEECCCCEEECC
LSEFARPRSTGKIAIGLNDGDELSYVALTDGNKQIMMFSDAGKAIRFDESDVRAMGRSAA
HHHHCCCCCCCEEEEEECCCCCEEEEEEECCCCEEEEEECCCCEEEECCHHHHHHCCCCC
GVTGMRLHHNQKIVSVIVTNPDEGIVLAATENGYGKRTAVSEYRKTKRASQGVIAISTSE
CCCCEEEECCCEEEEEEEECCCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCEEEEEECC
RNGKVVVAVLVENDEDIVMITDNGTLVRTSSDEVRECGRSAQGVRLINLRNNEKLISLKV
CCCCEEEEEEEECCCCEEEEECCCEEEECCCHHHHHHCCCCCCEEEEEECCCCEEEEEEE
VKQDDVEDNQDIENNEDIESSDVTVQSE
EECCCCCCCCCCCCCCCCCCCCCEEECC
>Mature Secondary Structure 
SIITKESSSINIEKELKQSYLDYAMSVIVGRALPDVRDGLKPVHRRVLFAMNELSNYYN
CEEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHC
RPYKKSARVVGDVIGKYHPHGDTAVYDTIVRMAQPFSLRYTLVDGQGNFGSVDGDSPAAM
CCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCCCCCHH
RYTEIRMEKLTHELLIDIDKETVDFSPNYDNTELVPDVLPTRVPNLLVNGSSGIAVGMAT
HHHHHHHHHHHHHHHEECCCCEEECCCCCCCCCCCHHHHHCCCCCEEEECCCCEEEEEEC
NIPPHNMTEVINGTIALIDNPNLTIEELIEYILAPDFPTGSYINGTDGILEAYKTGRGRV
CCCCCCHHHHHCCEEEEEECCCCCHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHCCCCEE
IMRAKADIHEDEASGKAQIIVTEIPYQVNKAKLVEKIAELVKDKKVAGISELRDESDKDG
EEEECCCCCCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHCCCCCCHHHHHCCCCCCC
IRVVIDLKRDESPEVVLNTLYAQTQLQCSFGINMVALSDNRPKLLNLKEILEQFIKHRKE
EEEEEEECCCCCHHHHHHHHHHHHEEEEECCEEEEEECCCCCCEECHHHHHHHHHHHHHH
VVTRRTIFELRKSKERAHILEGLLLSLANIDEMIELIKASPSPADAKESMLARSWNGSMV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCCCCHHHHHHHHCCCCHHH
KSMLEGVDVKMYRKETLASHYGIQVDSSYNLTEEQADAILALRLHRLTGLEQDKIVNEFK
HHHHCCCCEEEHHHHHHHHHCCEEECCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHH
ELIDRIKYLISILSDIKELIRVVKDELVEIRDNYGDQRKSEIIESRLDLTREDLIAEEDM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCHHHHCCCCCE
VVTLSMDGYVKTQPLSMYNAQKRGGVGKSATKTKEEDSIFKLMLASTHDTMLCFSSLGRV
EEEEECCCEEEECCCHHHCCHHCCCCCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHH
YWSKVYDFPVASRISKGRPINNILPLEKDERITAMMPISQFNEGWYVFMATKLGRVKKVD
HHHHHHCCCHHHHHHCCCCCCCCCCCCCCCCEEEEECHHHCCCCEEEEEEECCCCEEECC
LSEFARPRSTGKIAIGLNDGDELSYVALTDGNKQIMMFSDAGKAIRFDESDVRAMGRSAA
HHHHCCCCCCCEEEEEECCCCCEEEEEEECCCCEEEEEECCCCEEEECCHHHHHHCCCCC
GVTGMRLHHNQKIVSVIVTNPDEGIVLAATENGYGKRTAVSEYRKTKRASQGVIAISTSE
CCCCEEEECCCEEEEEEEECCCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCEEEEEECC
RNGKVVVAVLVENDEDIVMITDNGTLVRTSSDEVRECGRSAQGVRLINLRNNEKLISLKV
CCCCEEEEEEEECCCCEEEEECCCEEEECCCHHHHHHCCCCCCEEEEEECCCCEEEEEEE
VKQDDVEDNQDIENNEDIESSDVTVQSE
EECCCCCCCCCCCCCCCCCCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11677609; 8849216 [H]