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The map label for this gene is tmk

Identifier: 134301328

GI number: 134301328

Start: 210845

End: 211474

Strand: Direct

Name: tmk

Synonym: FTW_0202

Alternate gene names: 134301328

Gene position: 210845-211474 (Clockwise)

Preceding gene: 134301327

Following gene: 134301329

Centisome position: 11.11

GC content: 32.38

Gene sequence:

>630_bases
ATGCAAAGTAAATTTATTGTAATAGAAGGTCTTGATGGTGCTGGTAAAAGTACAGCTATTAGCTTTGTTAGGAAATATTT
AGAAAAAAATAATCTAGCAGCAATTTATACTCGTGAACCAGGCGGAACTAAAATAGCTGAAGAATTAAGAAACTTAGTTC
TACATAATAAGTATGATGAAGAAATCCATTCAGATAGTGAGCTATTGATGATTTATGCTGGAAGAGTACAGCATTATAGA
AACCTTATCGCACCAGCTTTAGAAAAGGGTATTAATGTGGTTTCAGATAGATTTTACTGGTCAAGCATGGCTTATCAAGG
TGGTGGTCGTGGGGTTGAGCTAAGCAAAATCAGAGCGTTAAATGATAATTTTCTTAATGGTTGTGAGCCAGATTTAGTAA
TCTATCTTGATATTGATCCAATATTGGGGCTACAAAGAGCTCAAAAAGTTGGAAGTCCTGATAGGATTGAAAAAGCTGGG
CTAGAATTTTTTAATAGAACCCGTAAAGTTTTCAAAGATCTTGTCAAAGATTCAGATAATGCTATTGAAATTGATGCTGC
AAAGTCTATTCAAGAAGTTGAAAAGCAAATATATCTAATATTAGATAAACATTTTAATTTTCAAAATTAA

Upstream 100 bases:

>100_bases
TAAAGTTGCAAGATTTAGTTTAAAAATTCTCTATGGTGCGGTTTTAGTTAGTATACTATCTGCATGTGTTGTCGGATTTA
TTGTTTAGTAAGCCAAAAAA

Downstream 100 bases:

>100_bases
TCTATTTCTAGTAAACTTCTCTTCATTAAATATTATCTTCAAATAGTTAGAAAGAATTATTATGAGTGAATATCTACAAC
AAATCGCTAAGCGTAGGACT

Product: thymidylate kinase

Products: NA

Alternate protein names: dTMP kinase

Number of amino acids: Translated: 209; Mature: 209

Protein sequence:

>209_residues
MQSKFIVIEGLDGAGKSTAISFVRKYLEKNNLAAIYTREPGGTKIAEELRNLVLHNKYDEEIHSDSELLMIYAGRVQHYR
NLIAPALEKGINVVSDRFYWSSMAYQGGGRGVELSKIRALNDNFLNGCEPDLVIYLDIDPILGLQRAQKVGSPDRIEKAG
LEFFNRTRKVFKDLVKDSDNAIEIDAAKSIQEVEKQIYLILDKHFNFQN

Sequences:

>Translated_209_residues
MQSKFIVIEGLDGAGKSTAISFVRKYLEKNNLAAIYTREPGGTKIAEELRNLVLHNKYDEEIHSDSELLMIYAGRVQHYR
NLIAPALEKGINVVSDRFYWSSMAYQGGGRGVELSKIRALNDNFLNGCEPDLVIYLDIDPILGLQRAQKVGSPDRIEKAG
LEFFNRTRKVFKDLVKDSDNAIEIDAAKSIQEVEKQIYLILDKHFNFQN
>Mature_209_residues
MQSKFIVIEGLDGAGKSTAISFVRKYLEKNNLAAIYTREPGGTKIAEELRNLVLHNKYDEEIHSDSELLMIYAGRVQHYR
NLIAPALEKGINVVSDRFYWSSMAYQGGGRGVELSKIRALNDNFLNGCEPDLVIYLDIDPILGLQRAQKVGSPDRIEKAG
LEFFNRTRKVFKDLVKDSDNAIEIDAAKSIQEVEKQIYLILDKHFNFQN

Specific function: Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis

COG id: COG0125

COG function: function code F; Thymidylate kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidylate kinase family

Homologues:

Organism=Escherichia coli, GI1787340, Length=200, Percent_Identity=46, Blast_Score=169, Evalue=2e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): KTHY_FRAT1 (Q14JV8)

Other databases:

- EMBL:   AM286280
- RefSeq:   YP_666318.1
- ProteinModelPortal:   Q14JV8
- SMR:   Q14JV8
- STRING:   Q14JV8
- GeneID:   4200756
- GenomeReviews:   AM286280_GR
- KEGG:   ftf:FTF0117
- eggNOG:   COG0125
- HOGENOM:   HBG626009
- OMA:   KGHIVIS
- PhylomeDB:   Q14JV8
- ProtClustDB:   PRK00698
- BioCyc:   FTUL393115:FTF0117-MONOMER
- HAMAP:   MF_00165
- InterPro:   IPR018095
- InterPro:   IPR018094
- PANTHER:   PTHR10344
- TIGRFAMs:   TIGR00041

Pfam domain/function: PF02223 Thymidylate_kin

EC number: =2.7.4.9

Molecular weight: Translated: 23726; Mature: 23726

Theoretical pI: Translated: 6.53; Mature: 6.53

Prosite motif: PS01331 THYMIDYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQSKFIVIEGLDGAGKSTAISFVRKYLEKNNLAAIYTREPGGTKIAEELRNLVLHNKYDE
CCCCEEEEECCCCCCHHHHHHHHHHHHHCCCEEEEEEECCCCHHHHHHHHHHHHCCCHHH
EIHSDSELLMIYAGRVQHYRNLIAPALEKGINVVSDRFYWSSMAYQGGGRGVELSKIRAL
HHCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEHHHHHHH
NDNFLNGCEPDLVIYLDIDPILGLQRAQKVGSPDRIEKAGLEFFNRTRKVFKDLVKDSDN
CCHHCCCCCCCEEEEEECCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCC
AIEIDAAKSIQEVEKQIYLILDKHFNFQN
EEEEHHHHHHHHHHHHHHHHEECCCCCCC
>Mature Secondary Structure
MQSKFIVIEGLDGAGKSTAISFVRKYLEKNNLAAIYTREPGGTKIAEELRNLVLHNKYDE
CCCCEEEEECCCCCCHHHHHHHHHHHHHCCCEEEEEEECCCCHHHHHHHHHHHHCCCHHH
EIHSDSELLMIYAGRVQHYRNLIAPALEKGINVVSDRFYWSSMAYQGGGRGVELSKIRAL
HHCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEHHHHHHH
NDNFLNGCEPDLVIYLDIDPILGLQRAQKVGSPDRIEKAGLEFFNRTRKVFKDLVKDSDN
CCHHCCCCCCCEEEEEECCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCC
AIEIDAAKSIQEVEKQIYLILDKHFNFQN
EEEEHHHHHHHHHHHHHHHHEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA