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The map label for this gene is nupC [H]

Identifier: 134301327

GI number: 134301327

Start: 209630

End: 210832

Strand: Direct

Name: nupC [H]

Synonym: FTW_0201

Alternate gene names: 134301327

Gene position: 209630-210832 (Clockwise)

Preceding gene: 134301326

Following gene: 134301328

Centisome position: 11.04

GC content: 30.76

Gene sequence:

>1203_bases
GTGTTTGTAAAGATTTTATATTTGTTGTTAGGTTTAGTAACGGTTTTTATATTAGCTTTTATTTGGAGTAGTGATAGAAA
AAAAATCAAATATAAGCATTTATTTATTATTTTATTTTTTCAGTTATTAGTTTGTTTTTTTATATTGCAATCTAGTGAAG
GGATAAAGCTTGTAGCTATTATATCTACGGGTTTTGATAAGATATTACAACATGCTCATGAAGGTACGGCATTCGTTTTT
GGTAGCCTTGCTGATACTAGTAAAAATGGCTTTGTTTTCTTTTTTAATGTTGGAATGCCAATAGTGCTTATATCTGGAAT
AATAGGCGTGCTTCAATATTTTAGAATACTTCCTCTTGTTATTAGAGGGGTTGGTTTTATCTTAACTAAAATCACAGGGA
TGGGTAAACTTGAGTCATTTAATGCGGTAAGTTCGTTGACAGTTGGACAGCAGGAAAATTTTCTTATTTATAAAAAAATA
ATTGGTCATTTACCAGCTAATGTATTGTATACAATGGCTGCAACGGCAATGTCTACAGTATCATTAGCAATAGCAGGCTC
GTATATGTCTATAATCGAACCTAAATATGTATGTACAGCTATTGTATTAAATATGCTAAGTACATTTTTTGTTTTACATA
TAATAAATCCATATGATAAAGATCCTAGCTTAAACTACGATACTCTCCATGCTGATTATGAAACAGGTAGGCAGAGCTTT
TTTGAAATGTTATCTGAATATCTTTTAGATGGTTTTAAAATAGCTGTAATAGTTTGTGCGATGCTTGTAGGCTTTATTGC
GTTATTAAATCTTGTTGATGGTATTTTCCAAGAAATATTAGGCATTACTTTTAGACAAATCCTTGGTTATATTTTTTATC
CAATTGCATGGGTTTTAAATATCCACGGTAATGAGATATTTCTATCAAGCCAAATAATGGGAACAAAGATTGTTACAAAT
GAATTTGTTGCAATGCAAGAGCTAGCTAAAAATTCGCAACAGCTTTCAGAGCATACAAAGGCAGTTGTTTCAGTATTTTT
AGTATCTTTTGCCAATTTTAGTTCAATAGGCATAATAGTCGGAGCAGTACAAGCTTTAAACAAAGAGGCATCAATTAAAG
TTGCAAGATTTAGTTTAAAAATTCTCTATGGTGCGGTTTTAGTTAGTATACTATCTGCATGTGTTGTCGGATTTATTGTT
TAG

Upstream 100 bases:

>100_bases
TGCGAGATTTAGTTTAAAGATCCTTTATGGAGCAGTTTTAGTGAGCTTTTTGTCCGCTAATATTGTTGGTTTTATTTTAT
AAATATTTGGGAAAGTAGGT

Downstream 100 bases:

>100_bases
TAAGCCAAAAAAATGCAAAGTAAATTTATTGTAATAGAAGGTCTTGATGGTGCTGGTAAAAGTACAGCTATTAGCTTTGT
TAGGAAATATTTAGAAAAAA

Product: nucleoside permease, NupC family protein

Products: uridine [Cytoplasm]; thymidine [Cytoplasm]; inosine [Cytoplasm]; Deoxyuridine [Cytoplasm]; deoxyinosine [Cytoplasm]; deoxycytidine [Cytoplasm]; deoxyadenosine [Cytoplasm]; cytidine [Cytoplasm]; Proton [Cytoplasm]; adenosine [Cytoplasm] [C]

Alternate protein names: Nucleoside-transport system protein nupC [H]

Number of amino acids: Translated: 400; Mature: 400

Protein sequence:

>400_residues
MFVKILYLLLGLVTVFILAFIWSSDRKKIKYKHLFIILFFQLLVCFFILQSSEGIKLVAIISTGFDKILQHAHEGTAFVF
GSLADTSKNGFVFFFNVGMPIVLISGIIGVLQYFRILPLVIRGVGFILTKITGMGKLESFNAVSSLTVGQQENFLIYKKI
IGHLPANVLYTMAATAMSTVSLAIAGSYMSIIEPKYVCTAIVLNMLSTFFVLHIINPYDKDPSLNYDTLHADYETGRQSF
FEMLSEYLLDGFKIAVIVCAMLVGFIALLNLVDGIFQEILGITFRQILGYIFYPIAWVLNIHGNEIFLSSQIMGTKIVTN
EFVAMQELAKNSQQLSEHTKAVVSVFLVSFANFSSIGIIVGAVQALNKEASIKVARFSLKILYGAVLVSILSACVVGFIV

Sequences:

>Translated_400_residues
MFVKILYLLLGLVTVFILAFIWSSDRKKIKYKHLFIILFFQLLVCFFILQSSEGIKLVAIISTGFDKILQHAHEGTAFVF
GSLADTSKNGFVFFFNVGMPIVLISGIIGVLQYFRILPLVIRGVGFILTKITGMGKLESFNAVSSLTVGQQENFLIYKKI
IGHLPANVLYTMAATAMSTVSLAIAGSYMSIIEPKYVCTAIVLNMLSTFFVLHIINPYDKDPSLNYDTLHADYETGRQSF
FEMLSEYLLDGFKIAVIVCAMLVGFIALLNLVDGIFQEILGITFRQILGYIFYPIAWVLNIHGNEIFLSSQIMGTKIVTN
EFVAMQELAKNSQQLSEHTKAVVSVFLVSFANFSSIGIIVGAVQALNKEASIKVARFSLKILYGAVLVSILSACVVGFIV
>Mature_400_residues
MFVKILYLLLGLVTVFILAFIWSSDRKKIKYKHLFIILFFQLLVCFFILQSSEGIKLVAIISTGFDKILQHAHEGTAFVF
GSLADTSKNGFVFFFNVGMPIVLISGIIGVLQYFRILPLVIRGVGFILTKITGMGKLESFNAVSSLTVGQQENFLIYKKI
IGHLPANVLYTMAATAMSTVSLAIAGSYMSIIEPKYVCTAIVLNMLSTFFVLHIINPYDKDPSLNYDTLHADYETGRQSF
FEMLSEYLLDGFKIAVIVCAMLVGFIALLNLVDGIFQEILGITFRQILGYIFYPIAWVLNIHGNEIFLSSQIMGTKIVTN
EFVAMQELAKNSQQLSEHTKAVVSVFLVSFANFSSIGIIVGAVQALNKEASIKVARFSLKILYGAVLVSILSACVVGFIV

Specific function: Transports nucleosides with a high affinity except guanosine and deoxyguanosine. Driven by a proton motive force [H]

COG id: COG1972

COG function: function code F; Nucleoside permease

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family [H]

Homologues:

Organism=Homo sapiens, GI11545853, Length=411, Percent_Identity=21.8978102189781, Blast_Score=106, Evalue=3e-23,
Organism=Homo sapiens, GI42542381, Length=412, Percent_Identity=21.6019417475728, Blast_Score=97, Evalue=3e-20,
Organism=Homo sapiens, GI227116277, Length=413, Percent_Identity=20.5811138014528, Blast_Score=96, Evalue=8e-20,
Organism=Escherichia coli, GI1788737, Length=406, Percent_Identity=52.2167487684729, Blast_Score=404, Evalue=1e-114,
Organism=Escherichia coli, GI1788485, Length=414, Percent_Identity=27.536231884058, Blast_Score=168, Evalue=7e-43,
Organism=Escherichia coli, GI1788488, Length=414, Percent_Identity=27.7777777777778, Blast_Score=161, Evalue=8e-41,
Organism=Caenorhabditis elegans, GI17560276, Length=392, Percent_Identity=23.2142857142857, Blast_Score=105, Evalue=3e-23,
Organism=Caenorhabditis elegans, GI71991794, Length=398, Percent_Identity=23.8693467336683, Blast_Score=97, Evalue=1e-20,
Organism=Drosophila melanogaster, GI45552519, Length=395, Percent_Identity=22.5316455696203, Blast_Score=103, Evalue=3e-22,
Organism=Drosophila melanogaster, GI45552517, Length=395, Percent_Identity=22.5316455696203, Blast_Score=102, Evalue=3e-22,
Organism=Drosophila melanogaster, GI19921868, Length=395, Percent_Identity=22.5316455696203, Blast_Score=102, Evalue=3e-22,
Organism=Drosophila melanogaster, GI281360430, Length=347, Percent_Identity=22.1902017291066, Blast_Score=87, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008276
- InterPro:   IPR018270
- InterPro:   IPR011657
- InterPro:   IPR002668 [H]

Pfam domain/function: PF07662 Nucleos_tra2_C; PF01773 Nucleos_tra2_N [H]

EC number: NA

Molecular weight: Translated: 44287; Mature: 44287

Theoretical pI: Translated: 8.77; Mature: 8.77

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFVKILYLLLGLVTVFILAFIWSSDRKKIKYKHLFIILFFQLLVCFFILQSSEGIKLVAI
CHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEE
ISTGFDKILQHAHEGTAFVFGSLADTSKNGFVFFFNVGMPIVLISGIIGVLQYFRILPLV
ECCCHHHHHHHHCCCCEEEEECCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHH
IRGVGFILTKITGMGKLESFNAVSSLTVGQQENFLIYKKIIGHLPANVLYTMAATAMSTV
HHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCEEHHHHHHHHCCHHHHHHHHHHHHHHH
SLAIAGSYMSIIEPKYVCTAIVLNMLSTFFVLHIINPYDKDPSLNYDTLHADYETGRQSF
HHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEECCHHHHHHHH
FEMLSEYLLDGFKIAVIVCAMLVGFIALLNLVDGIFQEILGITFRQILGYIFYPIAWVLN
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
IHGNEIFLSSQIMGTKIVTNEFVAMQELAKNSQQLSEHTKAVVSVFLVSFANFSSIGIIV
CCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
GAVQALNKEASIKVARFSLKILYGAVLVSILSACVVGFIV
HHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MFVKILYLLLGLVTVFILAFIWSSDRKKIKYKHLFIILFFQLLVCFFILQSSEGIKLVAI
CHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEE
ISTGFDKILQHAHEGTAFVFGSLADTSKNGFVFFFNVGMPIVLISGIIGVLQYFRILPLV
ECCCHHHHHHHHCCCCEEEEECCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHH
IRGVGFILTKITGMGKLESFNAVSSLTVGQQENFLIYKKIIGHLPANVLYTMAATAMSTV
HHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCEEHHHHHHHHCCHHHHHHHHHHHHHHH
SLAIAGSYMSIIEPKYVCTAIVLNMLSTFFVLHIINPYDKDPSLNYDTLHADYETGRQSF
HHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEECCHHHHHHHH
FEMLSEYLLDGFKIAVIVCAMLVGFIALLNLVDGIFQEILGITFRQILGYIFYPIAWVLN
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
IHGNEIFLSSQIMGTKIVTNEFVAMQELAKNSQQLSEHTKAVVSVFLVSFANFSSIGIIV
CCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
GAVQALNKEASIKVARFSLKILYGAVLVSILSACVVGFIV
HHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: uridine [Periplasm]; thymidine [Periplasm]; inosine [Periplasm]; Deoxyuridine [Periplasm]; deoxyinosine [Periplasm]; deoxycytidine [Periplasm]; deoxyadenosine [Periplasm]; cytidine [Periplasm]; Proton [Periplasm]; adenosine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + uridine [Periplasm] = Proton [Cytoplasm] + uridine [Cytoplasm] Proton [Periplasm] + thymidine [Periplasm] = Proton [Cytoplasm] + thymidine [Cytoplasm] Proton [Periplasm] + inosine [Periplasm] = Proton [Cytoplasm] + inosine [Cytoplasm]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]