Click here to switch to the map view.

The map label for this gene is hemE

Identifier: 134301261

GI number: 134301261

Start: 132372

End: 133406

Strand: Direct

Name: hemE

Synonym: FTW_0123

Alternate gene names: 134301261

Gene position: 132372-133406 (Clockwise)

Preceding gene: 134301260

Following gene: 134301262

Centisome position: 6.97

GC content: 35.75

Gene sequence:

>1035_bases
ATGAGAAAATTATTTTTGGATGCATTTGGCGAAAAGAAATTAGATAAGCCCCCAGTTTGGATAATGCGTCAAGCTGGTAG
ATATCTACCAGAGTATCGTGCAGTTAGGGCAAAGTTTGATAATTTTATGGATATGTGCCGCAATGCTGATGCTTGTTGTG
AAGTTGCGCTTCATCCACTTCAGAGGTATGATCTTGACGCAGCAATTGTTTTTTCAGATATTCTGACAATTCCAGAAGCT
ATGGGGATGGACCTAAAATTTATAAAAGGTACGGGGCCAGTCTTTTCTGAGCCGATACAATCGCAAAAAGATTTAGATAA
GCTAAAATCTATTGAAGATAGTATTGGTTCGCTAGATTATGTTTATAATGCTGTCAAGACTACTAGTTCAGCAATAAATG
TACCTTTAATAGGCTTTACTGGAAGTCCTTGGACTTTAGCGGCATATATGATTGAAGGTTCAGGATCTAAGCAGTTCAAT
AAATTGCGTAAGATGATGTATGCAAATCCTCAGTTGATGCATAGCTTATTACAACGCCTTGCAGATATAACAATTATCTA
TTTGCTTGAGCAGGTTAAGGCTGGCGCGAGTTCTGTGATGATATTTGATACTTGGGGAGGTATACTACCTTTAGAACATT
ATAAAAATTTCTCTCTTAAATATATGGAGTATATTGCTAAGAATGTAAAGCAAAAAATTAATATACCTATAGTTTTCTTT
ACTAAGGGTGGATCAAACTTTTTTGAAGAGATAAAAGATAAATCCTGTGATGGAGTAGGAGTTGATTGGAGTGTTACATT
AAAACAGGCACGACACAGAATAGGGGTTGGGAAAGTTCTGCAAGGGAACTTTGATCCCGCATTTTTATATGGGTCTAAGC
AAAGTATTAGGGAGACTGTTAGAGCCAATATTGAATTTATCCAGTCAGATAAGCTAAATAATTATATTGTCAACTTAGGT
CATGGAATTTATCCTGATATAGATCCTGATAGTGTTAGAGTTATGATAGATGCGATTAGAGAATTTAGTGCTTAA

Upstream 100 bases:

>100_bases
TCCAAGAAGCTATTAGTTATAGAAAAATGGATAAGTTTATCAAGTAAGTGATATAAATTTAGTGGTTAATTATTATTTAT
TAATTTAATGAAGGTAATAT

Downstream 100 bases:

>100_bases
TTATTTAGAAATGAGTGTCACATCAAAAAGTCTTGACATCACTAAAAATGTTGATATCATATATTGCAATAGACGCGGGG
TGGAGCAGCTTGGTAGCTCG

Product: uroporphyrinogen decarboxylase

Products: NA

Alternate protein names: UPD; URO-D

Number of amino acids: Translated: 344; Mature: 344

Protein sequence:

>344_residues
MRKLFLDAFGEKKLDKPPVWIMRQAGRYLPEYRAVRAKFDNFMDMCRNADACCEVALHPLQRYDLDAAIVFSDILTIPEA
MGMDLKFIKGTGPVFSEPIQSQKDLDKLKSIEDSIGSLDYVYNAVKTTSSAINVPLIGFTGSPWTLAAYMIEGSGSKQFN
KLRKMMYANPQLMHSLLQRLADITIIYLLEQVKAGASSVMIFDTWGGILPLEHYKNFSLKYMEYIAKNVKQKINIPIVFF
TKGGSNFFEEIKDKSCDGVGVDWSVTLKQARHRIGVGKVLQGNFDPAFLYGSKQSIRETVRANIEFIQSDKLNNYIVNLG
HGIYPDIDPDSVRVMIDAIREFSA

Sequences:

>Translated_344_residues
MRKLFLDAFGEKKLDKPPVWIMRQAGRYLPEYRAVRAKFDNFMDMCRNADACCEVALHPLQRYDLDAAIVFSDILTIPEA
MGMDLKFIKGTGPVFSEPIQSQKDLDKLKSIEDSIGSLDYVYNAVKTTSSAINVPLIGFTGSPWTLAAYMIEGSGSKQFN
KLRKMMYANPQLMHSLLQRLADITIIYLLEQVKAGASSVMIFDTWGGILPLEHYKNFSLKYMEYIAKNVKQKINIPIVFF
TKGGSNFFEEIKDKSCDGVGVDWSVTLKQARHRIGVGKVLQGNFDPAFLYGSKQSIRETVRANIEFIQSDKLNNYIVNLG
HGIYPDIDPDSVRVMIDAIREFSA
>Mature_344_residues
MRKLFLDAFGEKKLDKPPVWIMRQAGRYLPEYRAVRAKFDNFMDMCRNADACCEVALHPLQRYDLDAAIVFSDILTIPEA
MGMDLKFIKGTGPVFSEPIQSQKDLDKLKSIEDSIGSLDYVYNAVKTTSSAINVPLIGFTGSPWTLAAYMIEGSGSKQFN
KLRKMMYANPQLMHSLLQRLADITIIYLLEQVKAGASSVMIFDTWGGILPLEHYKNFSLKYMEYIAKNVKQKINIPIVFF
TKGGSNFFEEIKDKSCDGVGVDWSVTLKQARHRIGVGKVLQGNFDPAFLYGSKQSIRETVRANIEFIQSDKLNNYIVNLG
HGIYPDIDPDSVRVMIDAIREFSA

Specific function: Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III

COG id: COG0407

COG function: function code H; Uroporphyrinogen-III decarboxylase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uroporphyrinogen decarboxylase family

Homologues:

Organism=Homo sapiens, GI71051616, Length=347, Percent_Identity=42.0749279538905, Blast_Score=301, Evalue=6e-82,
Organism=Escherichia coli, GI2367337, Length=344, Percent_Identity=47.093023255814, Blast_Score=338, Evalue=4e-94,
Organism=Saccharomyces cerevisiae, GI6320252, Length=347, Percent_Identity=39.7694524495677, Blast_Score=260, Evalue=3e-70,
Organism=Drosophila melanogaster, GI19921920, Length=336, Percent_Identity=36.9047619047619, Blast_Score=242, Evalue=3e-64,
Organism=Drosophila melanogaster, GI221330099, Length=336, Percent_Identity=36.9047619047619, Blast_Score=241, Evalue=4e-64,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DCUP_FRAT1 (Q14K23)

Other databases:

- EMBL:   AM286280
- RefSeq:   YP_666253.1
- ProteinModelPortal:   Q14K23
- SMR:   Q14K23
- STRING:   Q14K23
- GeneID:   4200374
- GenomeReviews:   AM286280_GR
- KEGG:   ftf:FTF0047
- eggNOG:   COG0407
- HOGENOM:   HBG628392
- OMA:   AVQLFDS
- PhylomeDB:   Q14K23
- ProtClustDB:   PRK00115
- BioCyc:   FTUL393115:FTF0047-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00218
- InterPro:   IPR006361
- InterPro:   IPR000257
- PANTHER:   PTHR21091:SF2
- TIGRFAMs:   TIGR01464

Pfam domain/function: PF01208 URO-D

EC number: =4.1.1.37

Molecular weight: Translated: 38876; Mature: 38876

Theoretical pI: Translated: 8.53; Mature: 8.53

Prosite motif: PS00906 UROD_1; PS00907 UROD_2

Important sites: BINDING 73-73 BINDING 149-149 BINDING 204-204 BINDING 321-321

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRKLFLDAFGEKKLDKPPVWIMRQAGRYLPEYRAVRAKFDNFMDMCRNADACCEVALHPL
CCCHHHHHHCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHH
QRYDLDAAIVFSDILTIPEAMGMDLKFIKGTGPVFSEPIQSQKDLDKLKSIEDSIGSLDY
HHCCCCHHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCHHHH
VYNAVKTTSSAINVPLIGFTGSPWTLAAYMIEGSGSKQFNKLRKMMYANPQLMHSLLQRL
HHHHHHHCCCCCCCEEEEECCCCCEEEEEEEECCCCHHHHHHHHHHHCCHHHHHHHHHHH
ADITIIYLLEQVKAGASSVMIFDTWGGILPLEHYKNFSLKYMEYIAKNVKQKINIPIVFF
HHHHHHHHHHHHHCCCCEEEEEECCCCCEEHHHHCCCCHHHHHHHHHHHHHHCCCCEEEE
TKGGSNFFEEIKDKSCDGVGVDWSVTLKQARHRIGVGKVLQGNFDPAFLYGSKQSIRETV
ECCCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCEEECCCCCEEEECCHHHHHHHH
RANIEFIQSDKLNNYIVNLGHGIYPDIDPDSVRVMIDAIREFSA
HHHHHHHHCCCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure
MRKLFLDAFGEKKLDKPPVWIMRQAGRYLPEYRAVRAKFDNFMDMCRNADACCEVALHPL
CCCHHHHHHCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHH
QRYDLDAAIVFSDILTIPEAMGMDLKFIKGTGPVFSEPIQSQKDLDKLKSIEDSIGSLDY
HHCCCCHHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCHHHH
VYNAVKTTSSAINVPLIGFTGSPWTLAAYMIEGSGSKQFNKLRKMMYANPQLMHSLLQRL
HHHHHHHCCCCCCCEEEEECCCCCEEEEEEEECCCCHHHHHHHHHHHCCHHHHHHHHHHH
ADITIIYLLEQVKAGASSVMIFDTWGGILPLEHYKNFSLKYMEYIAKNVKQKINIPIVFF
HHHHHHHHHHHHHCCCCEEEEEECCCCCEEHHHHCCCCHHHHHHHHHHHHHHCCCCEEEE
TKGGSNFFEEIKDKSCDGVGVDWSVTLKQARHRIGVGKVLQGNFDPAFLYGSKQSIRETV
ECCCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCEEECCCCCEEEECCHHHHHHHH
RANIEFIQSDKLNNYIVNLGHGIYPDIDPDSVRVMIDAIREFSA
HHHHHHHHCCCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA