Click here to switch to the map view.

The map label for this gene is trxB [H]

Identifier: 134300505

GI number: 134300505

Start: 2889671

End: 2890903

Strand: Reverse

Name: trxB [H]

Synonym: Dred_2670

Alternate gene names: 134300505

Gene position: 2890903-2889671 (Counterclockwise)

Preceding gene: 134300506

Following gene: 134300504

Centisome position: 80.12

GC content: 46.39

Gene sequence:

>1233_bases
ATGAGCAATACAACCCATGATATCATCATTATCGGTGCTGGACCTGCGGGGTTAGCGGCAGGAATTTATGGTGCCAGAGC
CAAACTGCGTACCCTTATTATCGAAAAAGGTGCCATAGGGGGTATGGCCTCTAATACCCGGGAAATCGTTAACTATCCCG
GATTTAAACAAACCTCTGGTACTGCGTTAACCAAAGAGATGGCTGAGCATGCCAAGGAAATGGGAACGGAAATCATCAAG
GGAGAAGTAAAAACCGTAGACCTATCCGGGGAGATTAAAAGAGTCGTTACCCGTAAAAAACAAGAATTCACTGCCCGGGC
GGTGATCTTGGCAACGGGTACATTACCCCGGGTGTTGGGGATTCCCGGTGAAAAGGAACTAAGGGGTAATGGTGTAGCCT
ATTGCGCCACCTGTGATGCGGAATTCTTTGAAGGTCAGCATGTGGTAGTGGTGGGCAGCGGCGATCAGGCCATTGAAGAG
GGAATGTTCATTGCTAAGTTTGCCAATCAAGTTACGGTTATTGTTTTACATGATGAAGGAAAACTTGACTGCAACCGCCT
AAGTGCAGAAAAGGCACTGCATCACCCAAAACTGAAGTTTGTTTGGAACTCTACCCTTACTGCGGTACAGGGTGATGAGG
AAGTTACAGGTGTACAGGTTAAAAACATTAAAACTGGAGAAATGTCAGAGATTCCCTGCCAGGGTGTGTTCTTCTTCGTG
GGTATGATACCTGCTACTCACTTCCTAAAAGGACAGGTGGAGTTAGATGATCGTGGTTATGTGATGGTAAATGATTTATT
GGAAACCTCTGTGGAAGGGGTCTTTGCCGCCGGTGACCTGCGTCCCAAATACCTACGCCAGGTGGTTACGGCCACAGCCG
ATGGAGCTGCGGCGGTTGTTGCCGCAGAGCGTTACTTGCAAGAAAAAGAAAACCTACGTACCACTGTTTTAGAAGCAGAA
AAACCCGTTATCCTGGCTTTCTGGAGCCCTGAAGATCAGGCCAGTTTACAGGCAGTTAGTCGTGTAGAAAAGGTAGTGAG
TGAACTGCCAAATGAATATTTGTTTGTTAAGACAGATGTTACCCGCCAAAGGATGTTAGCTAAGAAATATCAAGTAACCA
CCCTGCCCAGGGTATTCGTATTAAACAAGGGTGAGGTTGTTCAGACCATTGATACTGACGCAGAAGTAGATGATATTAAA
GAAATATTAAAGGCCCTCATACAACAGGCATAG

Upstream 100 bases:

>100_bases
AATATGGTCAGTAGCTGTTAACAACGAATATACGGTGAAAATGAAGTTTTTATTTTCACCGTATTTGTTCTTAAACTATA
AATAATGAGAGGGATAGTAT

Downstream 100 bases:

>100_bases
TAAAAAATAATTAATACCATAGGAGGATACCATTATGGCTGACATATTAAGAGCGCTTGATCCTGATAACTTTGATGAAG
TGGTCTACGAAGCAGATAAC

Product: thioredoxin reductase

Products: NA

Alternate protein names: TRXR [H]

Number of amino acids: Translated: 410; Mature: 409

Protein sequence:

>410_residues
MSNTTHDIIIIGAGPAGLAAGIYGARAKLRTLIIEKGAIGGMASNTREIVNYPGFKQTSGTALTKEMAEHAKEMGTEIIK
GEVKTVDLSGEIKRVVTRKKQEFTARAVILATGTLPRVLGIPGEKELRGNGVAYCATCDAEFFEGQHVVVVGSGDQAIEE
GMFIAKFANQVTVIVLHDEGKLDCNRLSAEKALHHPKLKFVWNSTLTAVQGDEEVTGVQVKNIKTGEMSEIPCQGVFFFV
GMIPATHFLKGQVELDDRGYVMVNDLLETSVEGVFAAGDLRPKYLRQVVTATADGAAAVVAAERYLQEKENLRTTVLEAE
KPVILAFWSPEDQASLQAVSRVEKVVSELPNEYLFVKTDVTRQRMLAKKYQVTTLPRVFVLNKGEVVQTIDTDAEVDDIK
EILKALIQQA

Sequences:

>Translated_410_residues
MSNTTHDIIIIGAGPAGLAAGIYGARAKLRTLIIEKGAIGGMASNTREIVNYPGFKQTSGTALTKEMAEHAKEMGTEIIK
GEVKTVDLSGEIKRVVTRKKQEFTARAVILATGTLPRVLGIPGEKELRGNGVAYCATCDAEFFEGQHVVVVGSGDQAIEE
GMFIAKFANQVTVIVLHDEGKLDCNRLSAEKALHHPKLKFVWNSTLTAVQGDEEVTGVQVKNIKTGEMSEIPCQGVFFFV
GMIPATHFLKGQVELDDRGYVMVNDLLETSVEGVFAAGDLRPKYLRQVVTATADGAAAVVAAERYLQEKENLRTTVLEAE
KPVILAFWSPEDQASLQAVSRVEKVVSELPNEYLFVKTDVTRQRMLAKKYQVTTLPRVFVLNKGEVVQTIDTDAEVDDIK
EILKALIQQA
>Mature_409_residues
SNTTHDIIIIGAGPAGLAAGIYGARAKLRTLIIEKGAIGGMASNTREIVNYPGFKQTSGTALTKEMAEHAKEMGTEIIKG
EVKTVDLSGEIKRVVTRKKQEFTARAVILATGTLPRVLGIPGEKELRGNGVAYCATCDAEFFEGQHVVVVGSGDQAIEEG
MFIAKFANQVTVIVLHDEGKLDCNRLSAEKALHHPKLKFVWNSTLTAVQGDEEVTGVQVKNIKTGEMSEIPCQGVFFFVG
MIPATHFLKGQVELDDRGYVMVNDLLETSVEGVFAAGDLRPKYLRQVVTATADGAAAVVAAERYLQEKENLRTTVLEAEK
PVILAFWSPEDQASLQAVSRVEKVVSELPNEYLFVKTDVTRQRMLAKKYQVTTLPRVFVLNKGEVVQTIDTDAEVDDIKE
ILKALIQQA

Specific function: Unknown

COG id: COG0492

COG function: function code O; Thioredoxin reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Escherichia coli, GI1787114, Length=323, Percent_Identity=35.6037151702786, Blast_Score=181, Evalue=8e-47,
Organism=Escherichia coli, GI87081763, Length=307, Percent_Identity=32.5732899022801, Blast_Score=151, Evalue=7e-38,
Organism=Caenorhabditis elegans, GI32565766, Length=329, Percent_Identity=24.9240121580547, Blast_Score=65, Evalue=8e-11,
Organism=Saccharomyces cerevisiae, GI6320560, Length=318, Percent_Identity=34.2767295597484, Blast_Score=181, Evalue=2e-46,
Organism=Saccharomyces cerevisiae, GI6321898, Length=318, Percent_Identity=33.9622641509434, Blast_Score=176, Evalue=7e-45,

Paralogues:

None

Copy number: 808 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013027
- InterPro:   IPR008255
- InterPro:   IPR001327
- InterPro:   IPR000103
- InterPro:   IPR005982 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2 [H]

EC number: =1.8.1.9 [H]

Molecular weight: Translated: 44691; Mature: 44560

Theoretical pI: Translated: 5.75; Mature: 5.75

Prosite motif: PS00573 PYRIDINE_REDOX_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNTTHDIIIIGAGPAGLAAGIYGARAKLRTLIIEKGAIGGMASNTREIVNYPGFKQTSG
CCCCCEEEEEEECCCHHHHHHHHHHHHHHHHEEEECCCCCCCCCCCHHHHCCCCCCCCCC
TALTKEMAEHAKEMGTEIIKGEVKTVDLSGEIKRVVTRKKQEFTARAVILATGTLPRVLG
HHHHHHHHHHHHHHCHHHHCCCEEEEECCHHHHHHHHHHHHHHHEEEEEEECCCCHHHHC
IPGEKELRGNGVAYCATCDAEFFEGQHVVVVGSGDQAIEEGMFIAKFANQVTVIVLHDEG
CCCCCCCCCCCEEEEEECCHHHHCCCEEEEECCCCHHHHHCCHHEEECCCEEEEEEECCC
KLDCNRLSAEKALHHPKLKFVWNSTLTAVQGDEEVTGVQVKNIKTGEMSEIPCQGVFFFV
CCCHHHHHHHHHHCCCCEEEEECCEEEEECCCCCCCCEEEECCCCCCCCCCCCCHHHHHH
GMIPATHFLKGQVELDDRGYVMVNDLLETSVEGVFAAGDLRPKYLRQVVTATADGAAAVV
HHHHHHHHEECEEEECCCCEEEEHHHHHHHHCCEEEECCCCHHHHHHHHHHCCCCHHHHH
AAERYLQEKENLRTTVLEAEKPVILAFWSPEDQASLQAVSRVEKVVSELPNEYLFVKTDV
HHHHHHHHHHHHHEEEEECCCCEEEEEECCCCHHHHHHHHHHHHHHHHCCCCEEEEEECH
TRQRMLAKKYQVTTLPRVFVLNKGEVVQTIDTDAEVDDIKEILKALIQQA
HHHHHHHHHHHHEECCEEEEECCCCEEEEECCCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SNTTHDIIIIGAGPAGLAAGIYGARAKLRTLIIEKGAIGGMASNTREIVNYPGFKQTSG
CCCCEEEEEEECCCHHHHHHHHHHHHHHHHEEEECCCCCCCCCCCHHHHCCCCCCCCCC
TALTKEMAEHAKEMGTEIIKGEVKTVDLSGEIKRVVTRKKQEFTARAVILATGTLPRVLG
HHHHHHHHHHHHHHCHHHHCCCEEEEECCHHHHHHHHHHHHHHHEEEEEEECCCCHHHHC
IPGEKELRGNGVAYCATCDAEFFEGQHVVVVGSGDQAIEEGMFIAKFANQVTVIVLHDEG
CCCCCCCCCCCEEEEEECCHHHHCCCEEEEECCCCHHHHHCCHHEEECCCEEEEEEECCC
KLDCNRLSAEKALHHPKLKFVWNSTLTAVQGDEEVTGVQVKNIKTGEMSEIPCQGVFFFV
CCCHHHHHHHHHHCCCCEEEEECCEEEEECCCCCCCCEEEECCCCCCCCCCCCCHHHHHH
GMIPATHFLKGQVELDDRGYVMVNDLLETSVEGVFAAGDLRPKYLRQVVTATADGAAAVV
HHHHHHHHEECEEEECCCCEEEEHHHHHHHHCCEEEECCCCHHHHHHHHHHCCCCHHHHH
AAERYLQEKENLRTTVLEAEKPVILAFWSPEDQASLQAVSRVEKVVSELPNEYLFVKTDV
HHHHHHHHHHHHHEEEEECCCCEEEEEECCCCHHHHHHHHHHHHHHHHCCCCEEEEEECH
TRQRMLAKKYQVTTLPRVFVLNKGEVVQTIDTDAEVDDIKEILKALIQQA
HHHHHHHHHHHHEECCEEEEECCCCEEEEECCCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8223622; 2537814 [H]