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The map label for this gene is clpP

Identifier: 134300401

GI number: 134300401

Start: 2790726

End: 2791313

Strand: Reverse

Name: clpP

Synonym: Dred_2562

Alternate gene names: 134300401

Gene position: 2791313-2790726 (Counterclockwise)

Preceding gene: 134300402

Following gene: 134300400

Centisome position: 77.36

GC content: 48.98

Gene sequence:

>588_bases
TTGTCAGGCTTAGTACCAATAGTAGTAGAACAGACTAACCGGGGCGAGCGGGCATACGATATTTATTCACGGTTGTTGAA
GGATCGTATAATTTTTATTGGTGGACCCATTGACGACCATATTGCCAACCTGGTAATTGCACAGTTCTTATTTCTGGAGG
CTGAGGATCCTGAGAAGGATATCCACCTTTATATTAACTCTCCGGGCGGGGTTGTTACTGCGGGGCTGGCAATCTACGAT
ACCATGCAGTATATTAAACCTGCTGTATCCACCATTTGTCTGGGGCAAGCTGCAAGCATGGGATCCTTCTTGCTGGCTGC
TGGAGCACCAGGAAAGCGCTACGCTCTCCCGATGGCTAGAATTATGATTCATCAGCCCCTGGGAGGCGTTCAGGGTCAGG
CTACCGATATTGATATTCATGCCAAGGAAATTCTTCGCATGAAAGACTTACTCAATGACCGGTTGGCCCACCACACCGGT
CAACCACTGGAACAAATTACCCGGGACACTGAGCGTGACTACTTTATGTCGGCCGAAGAAGCCAAGAAGTACGGACTCAT
CGACGAGGTGATGCCGTATCGGAAGTAA

Upstream 100 bases:

>100_bases
GTTGAAGGCACAAAAGAGGACTAAGTTGAATATATTGGCTAAGTAAAGCCCTGTAGAATAGCTATTAACAAGATCTAGAT
ATATCAAGGAGGCGATGGAC

Downstream 100 bases:

>100_bases
AGATAAAAGAGGTGGAAATATGTTTAACGAGAAAGGCCAGCTCAAATGCTCCTTCTGTGGCAAAATGCAGGATCAGGTGA
AAAAGCTTGTGGCCGGCCCC

Product: ATP-dependent Clp protease proteolytic subunit

Products: NA

Alternate protein names: Endopeptidase Clp

Number of amino acids: Translated: 195; Mature: 194

Protein sequence:

>195_residues
MSGLVPIVVEQTNRGERAYDIYSRLLKDRIIFIGGPIDDHIANLVIAQFLFLEAEDPEKDIHLYINSPGGVVTAGLAIYD
TMQYIKPAVSTICLGQAASMGSFLLAAGAPGKRYALPMARIMIHQPLGGVQGQATDIDIHAKEILRMKDLLNDRLAHHTG
QPLEQITRDTERDYFMSAEEAKKYGLIDEVMPYRK

Sequences:

>Translated_195_residues
MSGLVPIVVEQTNRGERAYDIYSRLLKDRIIFIGGPIDDHIANLVIAQFLFLEAEDPEKDIHLYINSPGGVVTAGLAIYD
TMQYIKPAVSTICLGQAASMGSFLLAAGAPGKRYALPMARIMIHQPLGGVQGQATDIDIHAKEILRMKDLLNDRLAHHTG
QPLEQITRDTERDYFMSAEEAKKYGLIDEVMPYRK
>Mature_194_residues
SGLVPIVVEQTNRGERAYDIYSRLLKDRIIFIGGPIDDHIANLVIAQFLFLEAEDPEKDIHLYINSPGGVVTAGLAIYDT
MQYIKPAVSTICLGQAASMGSFLLAAGAPGKRYALPMARIMIHQPLGGVQGQATDIDIHAKEILRMKDLLNDRLAHHTGQ
PLEQITRDTERDYFMSAEEAKKYGLIDEVMPYRK

Specific function: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins

COG id: COG0740

COG function: function code OU; Protease subunit of ATP-dependent Clp proteases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S14 family

Homologues:

Organism=Homo sapiens, GI5174419, Length=188, Percent_Identity=63.8297872340426, Blast_Score=250, Evalue=5e-67,
Organism=Escherichia coli, GI1786641, Length=193, Percent_Identity=69.4300518134715, Blast_Score=299, Evalue=1e-82,
Organism=Caenorhabditis elegans, GI17538017, Length=186, Percent_Identity=56.989247311828, Blast_Score=224, Evalue=3e-59,
Organism=Drosophila melanogaster, GI20129427, Length=190, Percent_Identity=63.6842105263158, Blast_Score=253, Evalue=5e-68,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CLPP_DESRM (A4J7L9)

Other databases:

- EMBL:   CP000612
- RefSeq:   YP_001113897.1
- ProteinModelPortal:   A4J7L9
- SMR:   A4J7L9
- STRING:   A4J7L9
- MEROPS:   S14.001
- GeneID:   4958064
- GenomeReviews:   CP000612_GR
- KEGG:   drm:Dred_2562
- eggNOG:   COG0740
- HOGENOM:   HBG558421
- OMA:   SPMEAQD
- PhylomeDB:   A4J7L9
- ProtClustDB:   PRK00277
- BioCyc:   DRED349161:DRED_2562-MONOMER
- GO:   GO:0005737
- GO:   GO:0006508
- HAMAP:   MF_00444
- InterPro:   IPR001907
- InterPro:   IPR018215
- PANTHER:   PTHR10381
- PRINTS:   PR00127
- TIGRFAMs:   TIGR00493

Pfam domain/function: PF00574 CLP_protease

EC number: =3.4.21.92

Molecular weight: Translated: 21669; Mature: 21538

Theoretical pI: Translated: 5.94; Mature: 5.94

Prosite motif: PS00382 CLP_PROTEASE_HIS; PS00381 CLP_PROTEASE_SER

Important sites: ACT_SITE 99-99 ACT_SITE 124-124

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGLVPIVVEQTNRGERAYDIYSRLLKDRIIFIGGPIDDHIANLVIAQFLFLEAEDPEKD
CCCCEEEEEECCCCCCHHHHHHHHHHHCCEEEEECCHHHHHHHHHHHHHHHHCCCCCCCE
IHLYINSPGGVVTAGLAIYDTMQYIKPAVSTICLGQAASMGSFLLAAGAPGKRYALPMAR
EEEEECCCCCEEHHHHHHHHHHHHHHHHHHHHHHHCHHCCCCEEEECCCCCCCHHHHHHH
IMIHQPLGGVQGQATDIDIHAKEILRMKDLLNDRLAHHTGQPLEQITRDTERDYFMSAEE
HHHHCCCCCCCCCCCEECHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCHHH
AKKYGLIDEVMPYRK
HHHCCCHHHHCCCCC
>Mature Secondary Structure 
SGLVPIVVEQTNRGERAYDIYSRLLKDRIIFIGGPIDDHIANLVIAQFLFLEAEDPEKD
CCCEEEEEECCCCCCHHHHHHHHHHHCCEEEEECCHHHHHHHHHHHHHHHHCCCCCCCE
IHLYINSPGGVVTAGLAIYDTMQYIKPAVSTICLGQAASMGSFLLAAGAPGKRYALPMAR
EEEEECCCCCEEHHHHHHHHHHHHHHHHHHHHHHHCHHCCCCEEEECCCCCCCHHHHHHH
IMIHQPLGGVQGQATDIDIHAKEILRMKDLLNDRLAHHTGQPLEQITRDTERDYFMSAEE
HHHHCCCCCCCCCCCEECHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCHHH
AKKYGLIDEVMPYRK
HHHCCCHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA