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The map label for this gene is era [H]

Identifier: 134300318

GI number: 134300318

Start: 2700966

End: 2701874

Strand: Reverse

Name: era [H]

Synonym: Dred_2479

Alternate gene names: 134300318

Gene position: 2701874-2700966 (Counterclockwise)

Preceding gene: 134300319

Following gene: 134300317

Centisome position: 74.88

GC content: 45.76

Gene sequence:

>909_bases
ATGCTAAATACACCCGAAGGATATCGCTCGGGTTTTGTGGCCCTGGTGGGCCGCCCCAATGTGGGGAAATCTACTTTACT
AAATAAGCTGGTTGGTCAAAAAGTAGCCATTATGTCGGACAAACCCCAGACCACCCGTCATAAAATTCACTCTGTCCTTA
CTAGAAATGATGCCCAGATGGTCTTTCTTGATACTCCGGGTATCCATAAACCCAGGCATAAATTAGGAGAATATATGGTG
GATGTAGCACTGGGAGCTCTGAAAGAAGTAGACGTTGCACTTTTTCTGGTGGAGGCATCAGAAGCCCCAGGCCCTGGCGA
CCAGTATATTGCCGAGCAATTAAAGGGTATAAAAACCCCAGTATTCTTAATGCTGAACAAAGTCGATCTCATTCAAAGGG
AAGCTGTATTAGAAAGAATCCTCCAATATAAGGATCTGCTGCCCTTTGCTGAAGTGATTCCCGTTTCCGCTTTGGCCGGG
GAAAACGTGGAGCGGCTCATTGATACAATTATTAAGTATTTGCCCGAAGGACCTCAATATTACCCCGCAGATATGGTAAC
CGATCGACCCGAGCGGTTTATCATGGCGGAAATCATCCGGGAAAAGGTATTGCATTTAACCAGCGAAGAAATACCCCATT
CGGTGGCAGTGGTGGTAGAGCAAATCAAAGAACGCAATAACGGTGTGGTGGCTGTAAGTGCTGTCATTTATACCGAGCGT
GACTCCCAGAAGGCTATCTTAATTGGTAAGGGTGGCAACATGTTGAAGGAAGTAGGCCGCCGCTCCCGGGAAGAGATCGA
AAATCTGCTGGGTTCTAAGGTATTTCTTGAATTATGGGTTAAGGTGAAGAAGGATTGGCGCAATAAGATGACCGATATAC
GAAATTTTGGTTTTACCAAAGAAGATTAG

Upstream 100 bases:

>100_bases
TATGGGCTATGAGCTGAAAGCTAAAAGCTCAAGGCCCAAGGCTCACAGCCGACCCCAAAGACATACCCATAAGCACCAAA
AGCAACAAGGAGGAAACGAT

Downstream 100 bases:

>100_bases
TACAATAAATGGGTGGGCTTAGTCCCACCTTTTATTGTTAGGACTGTAAAATAGGACCAAGGTTTTATCATAAACCCCCA
ACAAAAAATCAAATAATGCC

Product: GTP-binding protein Era

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 302; Mature: 302

Protein sequence:

>302_residues
MLNTPEGYRSGFVALVGRPNVGKSTLLNKLVGQKVAIMSDKPQTTRHKIHSVLTRNDAQMVFLDTPGIHKPRHKLGEYMV
DVALGALKEVDVALFLVEASEAPGPGDQYIAEQLKGIKTPVFLMLNKVDLIQREAVLERILQYKDLLPFAEVIPVSALAG
ENVERLIDTIIKYLPEGPQYYPADMVTDRPERFIMAEIIREKVLHLTSEEIPHSVAVVVEQIKERNNGVVAVSAVIYTER
DSQKAILIGKGGNMLKEVGRRSREEIENLLGSKVFLELWVKVKKDWRNKMTDIRNFGFTKED

Sequences:

>Translated_302_residues
MLNTPEGYRSGFVALVGRPNVGKSTLLNKLVGQKVAIMSDKPQTTRHKIHSVLTRNDAQMVFLDTPGIHKPRHKLGEYMV
DVALGALKEVDVALFLVEASEAPGPGDQYIAEQLKGIKTPVFLMLNKVDLIQREAVLERILQYKDLLPFAEVIPVSALAG
ENVERLIDTIIKYLPEGPQYYPADMVTDRPERFIMAEIIREKVLHLTSEEIPHSVAVVVEQIKERNNGVVAVSAVIYTER
DSQKAILIGKGGNMLKEVGRRSREEIENLLGSKVFLELWVKVKKDWRNKMTDIRNFGFTKED
>Mature_302_residues
MLNTPEGYRSGFVALVGRPNVGKSTLLNKLVGQKVAIMSDKPQTTRHKIHSVLTRNDAQMVFLDTPGIHKPRHKLGEYMV
DVALGALKEVDVALFLVEASEAPGPGDQYIAEQLKGIKTPVFLMLNKVDLIQREAVLERILQYKDLLPFAEVIPVSALAG
ENVERLIDTIIKYLPEGPQYYPADMVTDRPERFIMAEIIREKVLHLTSEEIPHSVAVVVEQIKERNNGVVAVSAVIYTER
DSQKAILIGKGGNMLKEVGRRSREEIENLLGSKVFLELWVKVKKDWRNKMTDIRNFGFTKED

Specific function: An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism [H]

COG id: COG1159

COG function: function code R; GTPase

Gene ontology:

Cell location: Cytoplasm. Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 KH type-2 domain [H]

Homologues:

Organism=Homo sapiens, GI24307899, Length=338, Percent_Identity=26.9230769230769, Blast_Score=99, Evalue=6e-21,
Organism=Escherichia coli, GI1788919, Length=294, Percent_Identity=38.4353741496599, Blast_Score=224, Evalue=8e-60,
Organism=Escherichia coli, GI87082120, Length=159, Percent_Identity=33.3333333333333, Blast_Score=90, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6323665, Length=237, Percent_Identity=25.3164556962025, Blast_Score=70, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24646434, Length=312, Percent_Identity=26.6025641025641, Blast_Score=104, Evalue=8e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005662
- InterPro:   IPR015946
- InterPro:   IPR009019
- InterPro:   IPR004044
- InterPro:   IPR002917
- InterPro:   IPR005225 [H]

Pfam domain/function: PF07650 KH_2; PF01926 MMR_HSR1 [H]

EC number: NA

Molecular weight: Translated: 34010; Mature: 34010

Theoretical pI: Translated: 8.69; Mature: 8.69

Prosite motif: PS50823 KH_TYPE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLNTPEGYRSGFVALVGRPNVGKSTLLNKLVGQKVAIMSDKPQTTRHKIHSVLTRNDAQM
CCCCCCCHHCCEEEEEECCCCCHHHHHHHHHCCEEEEECCCCHHHHHHHHHHHHCCCCEE
VFLDTPGIHKPRHKLGEYMVDVALGALKEVDVALFLVEASEAPGPGDQYIAEQLKGIKTP
EEEECCCCCCHHHHHHHHHHHHHHHHHHHHCEEEEEEECCCCCCCCHHHHHHHHHCCCCH
VFLMLNKVDLIQREAVLERILQYKDLLPFAEVIPVSALAGENVERLIDTIIKYLPEGPQY
HHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCC
YPADMVTDRPERFIMAEIIREKVLHLTSEEIPHSVAVVVEQIKERNNGVVAVSAVIYTER
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCEEEEEEEEEECC
DSQKAILIGKGGNMLKEVGRRSREEIENLLGSKVFLELWVKVKKDWRNKMTDIRNFGFTK
CCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
ED
CC
>Mature Secondary Structure
MLNTPEGYRSGFVALVGRPNVGKSTLLNKLVGQKVAIMSDKPQTTRHKIHSVLTRNDAQM
CCCCCCCHHCCEEEEEECCCCCHHHHHHHHHCCEEEEECCCCHHHHHHHHHHHHCCCCEE
VFLDTPGIHKPRHKLGEYMVDVALGALKEVDVALFLVEASEAPGPGDQYIAEQLKGIKTP
EEEECCCCCCHHHHHHHHHHHHHHHHHHHHCEEEEEEECCCCCCCCHHHHHHHHHCCCCH
VFLMLNKVDLIQREAVLERILQYKDLLPFAEVIPVSALAGENVERLIDTIIKYLPEGPQY
HHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCC
YPADMVTDRPERFIMAEIIREKVLHLTSEEIPHSVAVVVEQIKERNNGVVAVSAVIYTER
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCEEEEEEEEEECC
DSQKAILIGKGGNMLKEVGRRSREEIENLLGSKVFLELWVKVKKDWRNKMTDIRNFGFTK
CCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
ED
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA