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The map label for this gene is hpt [H]

Identifier: 134300215

GI number: 134300215

Start: 2601442

End: 2601981

Strand: Reverse

Name: hpt [H]

Synonym: Dred_2376

Alternate gene names: 134300215

Gene position: 2601981-2601442 (Counterclockwise)

Preceding gene: 134300216

Following gene: 134300214

Centisome position: 72.11

GC content: 41.48

Gene sequence:

>540_bases
ATGCATCCCCATGTGGAAAAAATACTGTTAGAAGAAAATCAAATTAATGAACGGATTCAGCAGTTAGGGCAACAGATTAC
ACAGGATTATCAAGGTAAGGATATTTTAATGGTAGGTATTCTTAAAGGGGCCATGATTTTTCTGGCTGACCTGGTACGTA
ACATTGAGGTACCTACTTTTTTTGATTTTATGGCTGTTTCCAGCTATGGGGCCGGAACTGTTTCTTCTGGTGTGGTTCGC
ATCTTAAAGGATTTGGATAAAAGTATTGAGGGTAAACACATTATTATTGTGGAAGACATTGTTGATACCGGTCTTACCCT
GCAATATATGGTAGAGAATATAAAATCCCGGGGTCCTGCCAGTGTCAAGGTTTGCACCTTGCTGGATAAGCCGGACCGTC
GCAAAGTGGAAGTACCCATCGATTATAACGGTTTCCAGATCCCCGATGAGTTTGTTGTTGGTTTTGGCCTGGATTATAAT
GAGCGTTACCGTAACTTACCGTACATTGCCGTGCTGAAGCCGGAAATTTACCAAAGTTAA

Upstream 100 bases:

>100_bases
GAAAATCTAAACTAAGAATCTTCCCTCAGAGCTATTGACGAAAAATGACTATTTTTGTTATGCTCATTTGGTAGGTAATG
ACTGGTAAGGAGTGAAAGAA

Downstream 100 bases:

>100_bases
TACTTAGCCTGGGTAACCAGGCCTAATATTTTAGGATTGAACGGAGGTACATACATGTCCTTGGCAGAACAAGAATTAAT
TCTAGTTCTTGATTTTGGTG

Product: hypoxanthine phosphoribosyltransferase

Products: NA

Alternate protein names: HGPRT; HGPRTase [H]

Number of amino acids: Translated: 179; Mature: 179

Protein sequence:

>179_residues
MHPHVEKILLEENQINERIQQLGQQITQDYQGKDILMVGILKGAMIFLADLVRNIEVPTFFDFMAVSSYGAGTVSSGVVR
ILKDLDKSIEGKHIIIVEDIVDTGLTLQYMVENIKSRGPASVKVCTLLDKPDRRKVEVPIDYNGFQIPDEFVVGFGLDYN
ERYRNLPYIAVLKPEIYQS

Sequences:

>Translated_179_residues
MHPHVEKILLEENQINERIQQLGQQITQDYQGKDILMVGILKGAMIFLADLVRNIEVPTFFDFMAVSSYGAGTVSSGVVR
ILKDLDKSIEGKHIIIVEDIVDTGLTLQYMVENIKSRGPASVKVCTLLDKPDRRKVEVPIDYNGFQIPDEFVVGFGLDYN
ERYRNLPYIAVLKPEIYQS
>Mature_179_residues
MHPHVEKILLEENQINERIQQLGQQITQDYQGKDILMVGILKGAMIFLADLVRNIEVPTFFDFMAVSSYGAGTVSSGVVR
ILKDLDKSIEGKHIIIVEDIVDTGLTLQYMVENIKSRGPASVKVCTLLDKPDRRKVEVPIDYNGFQIPDEFVVGFGLDYN
ERYRNLPYIAVLKPEIYQS

Specific function: This Enzyme Acts Exclusively On Hypoxanthine; It Does Not Act On Guanine (By Similarity). [C]

COG id: COG0634

COG function: function code F; Hypoxanthine-guanine phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI4504483, Length=178, Percent_Identity=34.2696629213483, Blast_Score=110, Evalue=7e-25,
Organism=Homo sapiens, GI9910262, Length=178, Percent_Identity=37.0786516853933, Blast_Score=105, Evalue=3e-23,
Organism=Escherichia coli, GI87081689, Length=169, Percent_Identity=50.887573964497, Blast_Score=186, Evalue=6e-49,
Organism=Caenorhabditis elegans, GI17510817, Length=184, Percent_Identity=34.2391304347826, Blast_Score=106, Evalue=5e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005904
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.8 [H]

Molecular weight: Translated: 20303; Mature: 20303

Theoretical pI: Translated: 4.87; Mature: 4.87

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHPHVEKILLEENQINERIQQLGQQITQDYQGKDILMVGILKGAMIFLADLVRNIEVPTF
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHCCCCHH
FDFMAVSSYGAGTVSSGVVRILKDLDKSIEGKHIIIVEDIVDTGLTLQYMVENIKSRGPA
HHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEEHHHCCCCHHHHHHHHHHCCCCC
SVKVCTLLDKPDRRKVEVPIDYNGFQIPDEFVVGFGLDYNERYRNLPYIAVLKPEIYQS
CEEEEEEECCCCCCEEEEEECCCCCCCCHHHEEECCCCHHHHHCCCCEEEEECCHHHCC
>Mature Secondary Structure
MHPHVEKILLEENQINERIQQLGQQITQDYQGKDILMVGILKGAMIFLADLVRNIEVPTF
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHCCCCHH
FDFMAVSSYGAGTVSSGVVRILKDLDKSIEGKHIIIVEDIVDTGLTLQYMVENIKSRGPA
HHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEEHHHCCCCHHHHHHHHHHCCCCC
SVKVCTLLDKPDRRKVEVPIDYNGFQIPDEFVVGFGLDYNERYRNLPYIAVLKPEIYQS
CEEEEEEECCCCCCEEEEEECCCCCCCCHHHEEECCCCHHHHHCCCCEEEEECCHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12663927 [H]