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The map label for this gene is guaA [H]

Identifier: 134300214

GI number: 134300214

Start: 2599846

End: 2601387

Strand: Reverse

Name: guaA [H]

Synonym: Dred_2375

Alternate gene names: 134300214

Gene position: 2601387-2599846 (Counterclockwise)

Preceding gene: 134300215

Following gene: 134300213

Centisome position: 72.1

GC content: 47.99

Gene sequence:

>1542_bases
ATGTCCTTGGCAGAACAAGAATTAATTCTAGTTCTTGATTTTGGTGGCCAATATACCCAACTGATTGCCCGTCGTATTCG
GGATGTCAATGTGTATTGCGAAATTGAGCCCCATAATGTATCAATCGATAAAATAAAGGCAAAAAATCCTAAGGGTATCA
TATTTTCAGGTGGACCCTCCAGTGTTTACGGTGAAAAAGCTCCCACCGTTGATCCGGCAGTTTACGAACTGGATATACCA
GTACTGGGGATCTGCTACGGTATGCAGCTAATGACTCAACAGTTAAAGGGTAAAGTGGTGCCCGCCGAGATGCGTGAATA
TGGGCGTACCACATTAAGGGTTATGCAGTGTGACAATATCCTGAAGAACCTGACAGCTGATGAAGAATGCTGGATGAGCC
ATGGCGACCGGGTTGAGGAAGTTCCTCCGGGTTTTCAGGTGCTTGCCCAAACCGAAAAGGCTCCGGTGGCTGCCATGGCA
AACCCCGAAAAAAAACTTTTTGCAGTGCAATTCCACCCAGAAGTGATCCATACCCCAAAGGGTATGGAAGTTTTAAAGAG
CTTTCTTTTTGATATCTGCGGCTGTAGTGGTTCATGGAGTATGGGTTCCTTCTTGGACGAAGCCGTTAAAGAGGTTAAAC
AAAGGGTCGGTAATCGTCAGGTTCTTTGTGCCCTGAGCGGTGGCGTCGACTCTTCTGTGGCTGCGGTTTTGGTGCACCGG
GCAGTAGGTGATAACTTAACCTGTGTCTTTGTTGATCACGGTCTGTTGCGGAAAAACGAAGCTGAACAGGTTGTTAAGAC
CTTCCGGGATCAGTTTAATATTAAGCTGGTTCATGTGGATGCTTCGGAACGCTTCTTAGGAAAACTGCAGGGTGTAACCG
ATCCAGAACAAAAACGTAAAATTATTGGCACTGAGTTCATCCGTGTCTTTGAAGAAGAGGCCAGAAAACTGGGTGAAATT
GATTTTCTTGTACAGGGAACCCTGTATCCGGACGTTGTTGAGAGCGGTACCGCCACCGCGGAAGTTATTAAATCCCATCA
TAATGTAGGCGGCCTGCCGGAAGATATGAAGTTTGATCTGGTAGAACCTTTACGTTGGCTTTTTAAAGACGAAGTTCGCC
GCTTGGGTGAGGAATTGGGAATGCCTGAGGAGATTGTCTGGCGTCAACCCTTCCCTGGTCCGGGACTGGCCGTTCGTATC
CTAGGGGAAATCACCAAACCAAAGCTGGCCATTCTGCGTGAAGCTGATTTCGTGGTAACCGATGAAATTAAGAACGCCGG
TTTAAACCGGGAAATTTGGCAGTATTTTGCTGTCTTGCCAGACATGCGCAGTGTGGGTGTCATGGGCGATGGCCGTACCT
ATGCTTATGCAATTGTGGTACGGGCTGTTTACAGCCATGACGGCATGACAGCAGACTGGGCGAAGATTCCCCACGATGTG
CTGGGTAATATCTCCACCCGTTTGGTGAATGAGGTGGCAGAGATCAATAGGGTTGTTTACGACATCACCTCCAAGCCCCC
AGGTACCATTGAGTGGGAGTAG

Upstream 100 bases:

>100_bases
CTTACCGTACATTGCCGTGCTGAAGCCGGAAATTTACCAAAGTTAATACTTAGCCTGGGTAACCAGGCCTAATATTTTAG
GATTGAACGGAGGTACATAC

Downstream 100 bases:

>100_bases
GGTTAAGAAAAGCCTTCTGGACAATACCAGGAGGCTTTTTAGTATATCAAAAGAATAAATTTTTCTGATATGATAAAGGC
AAACTAAGAGGGATTAAACC

Product: GMP synthase

Products: NA

Alternate protein names: GMP synthetase; Glutamine amidotransferase [H]

Number of amino acids: Translated: 513; Mature: 512

Protein sequence:

>513_residues
MSLAEQELILVLDFGGQYTQLIARRIRDVNVYCEIEPHNVSIDKIKAKNPKGIIFSGGPSSVYGEKAPTVDPAVYELDIP
VLGICYGMQLMTQQLKGKVVPAEMREYGRTTLRVMQCDNILKNLTADEECWMSHGDRVEEVPPGFQVLAQTEKAPVAAMA
NPEKKLFAVQFHPEVIHTPKGMEVLKSFLFDICGCSGSWSMGSFLDEAVKEVKQRVGNRQVLCALSGGVDSSVAAVLVHR
AVGDNLTCVFVDHGLLRKNEAEQVVKTFRDQFNIKLVHVDASERFLGKLQGVTDPEQKRKIIGTEFIRVFEEEARKLGEI
DFLVQGTLYPDVVESGTATAEVIKSHHNVGGLPEDMKFDLVEPLRWLFKDEVRRLGEELGMPEEIVWRQPFPGPGLAVRI
LGEITKPKLAILREADFVVTDEIKNAGLNREIWQYFAVLPDMRSVGVMGDGRTYAYAIVVRAVYSHDGMTADWAKIPHDV
LGNISTRLVNEVAEINRVVYDITSKPPGTIEWE

Sequences:

>Translated_513_residues
MSLAEQELILVLDFGGQYTQLIARRIRDVNVYCEIEPHNVSIDKIKAKNPKGIIFSGGPSSVYGEKAPTVDPAVYELDIP
VLGICYGMQLMTQQLKGKVVPAEMREYGRTTLRVMQCDNILKNLTADEECWMSHGDRVEEVPPGFQVLAQTEKAPVAAMA
NPEKKLFAVQFHPEVIHTPKGMEVLKSFLFDICGCSGSWSMGSFLDEAVKEVKQRVGNRQVLCALSGGVDSSVAAVLVHR
AVGDNLTCVFVDHGLLRKNEAEQVVKTFRDQFNIKLVHVDASERFLGKLQGVTDPEQKRKIIGTEFIRVFEEEARKLGEI
DFLVQGTLYPDVVESGTATAEVIKSHHNVGGLPEDMKFDLVEPLRWLFKDEVRRLGEELGMPEEIVWRQPFPGPGLAVRI
LGEITKPKLAILREADFVVTDEIKNAGLNREIWQYFAVLPDMRSVGVMGDGRTYAYAIVVRAVYSHDGMTADWAKIPHDV
LGNISTRLVNEVAEINRVVYDITSKPPGTIEWE
>Mature_512_residues
SLAEQELILVLDFGGQYTQLIARRIRDVNVYCEIEPHNVSIDKIKAKNPKGIIFSGGPSSVYGEKAPTVDPAVYELDIPV
LGICYGMQLMTQQLKGKVVPAEMREYGRTTLRVMQCDNILKNLTADEECWMSHGDRVEEVPPGFQVLAQTEKAPVAAMAN
PEKKLFAVQFHPEVIHTPKGMEVLKSFLFDICGCSGSWSMGSFLDEAVKEVKQRVGNRQVLCALSGGVDSSVAAVLVHRA
VGDNLTCVFVDHGLLRKNEAEQVVKTFRDQFNIKLVHVDASERFLGKLQGVTDPEQKRKIIGTEFIRVFEEEARKLGEID
FLVQGTLYPDVVESGTATAEVIKSHHNVGGLPEDMKFDLVEPLRWLFKDEVRRLGEELGMPEEIVWRQPFPGPGLAVRIL
GEITKPKLAILREADFVVTDEIKNAGLNREIWQYFAVLPDMRSVGVMGDGRTYAYAIVVRAVYSHDGMTADWAKIPHDVL
GNISTRLVNEVAEINRVVYDITSKPPGTIEWE

Specific function: Catalyzes the synthesis of GMP from XMP [H]

COG id: COG0519

COG function: function code F; GMP synthase, PP-ATPase domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GMP-binding domain [H]

Homologues:

Organism=Homo sapiens, GI4504035, Length=551, Percent_Identity=36.1161524500907, Blast_Score=315, Evalue=9e-86,
Organism=Escherichia coli, GI1788854, Length=516, Percent_Identity=52.7131782945737, Blast_Score=558, Evalue=1e-160,
Organism=Escherichia coli, GI1789760, Length=160, Percent_Identity=30, Blast_Score=66, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI71992710, Length=571, Percent_Identity=34.8511383537653, Blast_Score=307, Evalue=7e-84,
Organism=Caenorhabditis elegans, GI71992717, Length=571, Percent_Identity=34.8511383537653, Blast_Score=307, Evalue=7e-84,
Organism=Caenorhabditis elegans, GI133901714, Length=571, Percent_Identity=34.8511383537653, Blast_Score=307, Evalue=8e-84,
Organism=Saccharomyces cerevisiae, GI6323873, Length=526, Percent_Identity=49.6197718631179, Blast_Score=524, Evalue=1e-149,
Organism=Drosophila melanogaster, GI281365319, Length=502, Percent_Identity=36.0557768924303, Blast_Score=301, Evalue=9e-82,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006220
- InterPro:   IPR001317
- InterPro:   IPR011702
- InterPro:   IPR017926
- InterPro:   IPR000991
- InterPro:   IPR001674
- InterPro:   IPR004739
- InterPro:   IPR022955
- InterPro:   IPR022310
- InterPro:   IPR014729 [H]

Pfam domain/function: PF00117 GATase; PF00958 GMP_synt_C; PF02540 NAD_synthase [H]

EC number: =6.3.5.2 [H]

Molecular weight: Translated: 57250; Mature: 57118

Theoretical pI: Translated: 5.21; Mature: 5.21

Prosite motif: PS00442 GATASE_TYPE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLAEQELILVLDFGGQYTQLIARRIRDVNVYCEIEPHNVSIDKIKAKNPKGIIFSGGPS
CCCCCCCEEEEEECCCHHHHHHHHHHHCCEEEEEEECCCCCCEEEECCCCCEEEECCCCC
SVYGEKAPTVDPAVYELDIPVLGICYGMQLMTQQLKGKVVPAEMREYGRTTLRVMQCDNI
CCCCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHCCCCCCHHHHHCCHHHHHHHHHHHH
LKNLTADEECWMSHGDRVEEVPPGFQVLAQTEKAPVAAMANPEKKLFAVQFHPEVIHTPK
HHHCCCCHHHHHCCCCCCCCCCCCHHHHHHCCCCCEEECCCCCCEEEEEEECCHHHCCCC
GMEVLKSFLFDICGCSGSWSMGSFLDEAVKEVKQRVGNRQVLCALSGGVDSSVAAVLVHR
HHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHH
AVGDNLTCVFVDHGLLRKNEAEQVVKTFRDQFNIKLVHVDASERFLGKLQGVTDPEQKRK
HHCCCEEEEEECCCCCCCCHHHHHHHHHHHCCCEEEEEECCHHHHHHHHCCCCCHHHHHH
IIGTEFIRVFEEEARKLGEIDFLVQGTLYPDVVESGTATAEVIKSHHNVGGLPEDMKFDL
HHHHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHCCCHHHHHHHHHCCCCCCCCCCCHHH
VEPLRWLFKDEVRRLGEELGMPEEIVWRQPFPGPGLAVRILGEITKPKLAILREADFVVT
HHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCCEEHHHHHCCCCHHHHHCCCCEEEE
DEIKNAGLNREIWQYFAVLPDMRSVGVMGDGRTYAYAIVVRAVYSHDGMTADWAKIPHDV
HHHHCCCCCHHHHHHHHHCCCHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHCCHHH
LGNISTRLVNEVAEINRVVYDITSKPPGTIEWE
HHHHHHHHHHHHHHHHHHEEEECCCCCCCCCCC
>Mature Secondary Structure 
SLAEQELILVLDFGGQYTQLIARRIRDVNVYCEIEPHNVSIDKIKAKNPKGIIFSGGPS
CCCCCCEEEEEECCCHHHHHHHHHHHCCEEEEEEECCCCCCEEEECCCCCEEEECCCCC
SVYGEKAPTVDPAVYELDIPVLGICYGMQLMTQQLKGKVVPAEMREYGRTTLRVMQCDNI
CCCCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHCCCCCCHHHHHCCHHHHHHHHHHHH
LKNLTADEECWMSHGDRVEEVPPGFQVLAQTEKAPVAAMANPEKKLFAVQFHPEVIHTPK
HHHCCCCHHHHHCCCCCCCCCCCCHHHHHHCCCCCEEECCCCCCEEEEEEECCHHHCCCC
GMEVLKSFLFDICGCSGSWSMGSFLDEAVKEVKQRVGNRQVLCALSGGVDSSVAAVLVHR
HHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHH
AVGDNLTCVFVDHGLLRKNEAEQVVKTFRDQFNIKLVHVDASERFLGKLQGVTDPEQKRK
HHCCCEEEEEECCCCCCCCHHHHHHHHHHHCCCEEEEEECCHHHHHHHHCCCCCHHHHHH
IIGTEFIRVFEEEARKLGEIDFLVQGTLYPDVVESGTATAEVIKSHHNVGGLPEDMKFDL
HHHHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHCCCHHHHHHHHHCCCCCCCCCCCHHH
VEPLRWLFKDEVRRLGEELGMPEEIVWRQPFPGPGLAVRILGEITKPKLAILREADFVVT
HHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCCEEHHHHHCCCCHHHHHCCCCEEEE
DEIKNAGLNREIWQYFAVLPDMRSVGVMGDGRTYAYAIVVRAVYSHDGMTADWAKIPHDV
HHHHCCCCCHHHHHHHHHCCCHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHCCHHH
LGNISTRLVNEVAEINRVVYDITSKPPGTIEWE
HHHHHHHHHHHHHHHHHHEEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA