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The map label for this gene is purC

Identifier: 134300208

GI number: 134300208

Start: 2593656

End: 2594366

Strand: Reverse

Name: purC

Synonym: Dred_2369

Alternate gene names: 134300208

Gene position: 2594366-2593656 (Counterclockwise)

Preceding gene: 134300209

Following gene: 134300207

Centisome position: 71.9

GC content: 41.91

Gene sequence:

>711_bases
ATGGAAAAGTTAGAAATGATTTATGAAGGTAAAGCAAAAAAGGTTTATCGTACCGATAATCCTGATTTTTACTGGGTTGA
GTATAAAGATGATGCCACTGCCTTTAATGGGCAAAAGAAAGGTACCATTGATAACAAAGGTGTCGTTAACAACAAAGTTT
CAGCAGTTTTTTTTAAACTTATGGAGAGCAAAGGCATTACTACTCATTTTGTTGAGCTGGTAAACGACCGTGAAATGATT
GTTAAGGCCCTGGATATTATCAAAGTAGAAGTTGTGGTCCGTAATATTGTGGCCGGCACCCTGGCAAAAAGAGTGGGACT
TCCGGAAGGAACCATTCTGCCGAAAACAGTTCTTGAATATTATTATAAGGATGACAACTTGGGCGACCCTTTAATTAACG
CCTCACATATTGCAGCCTTGGACCTGGCAACCCCGGAGCAAATGGCTTTTATCAAAGAAACTGCCCTGAAAGTAAATGAC
ATTATGCGAGAATACTTAGCCCCTGTTAACATTGACCTCATTGACTACAAATTAGAATTCGGACTTCATAAAGGTCAAGT
TTTGCTGGGTGATGAAATATCTCCGGACACCTGCCGTTTCTGGGATAAAACCACCGGAGAAAAATTGGATAAAGATCGCT
TCCGCCGGGACTTGGGCAACGTGGAAGGAGCTTACCAGGAAGTACTGCGCCGCTTAACCGGAGAAGCCTAA

Upstream 100 bases:

>100_bases
AGGGTTTGTTGAAATTACTGCAAGGAGCTGTCACAAGTAGAATTTTGCATGCTACCGAAAAGTTATCAACAAGCTGTTAA
ATGTAAAAGGGGAGGATATA

Downstream 100 bases:

>100_bases
TAAATTTAATTAATTAAAACATTAGTTCCATAAGAGCTTTAATTCAACCGTATTTAGAAGTATAACAAAATTCCCCTATA
ATATAATAAAGGTTTTTTAG

Product: phosphoribosylaminoimidazole-succinocarboxamide synthase

Products: NA

Alternate protein names: SAICAR synthetase

Number of amino acids: Translated: 236; Mature: 236

Protein sequence:

>236_residues
MEKLEMIYEGKAKKVYRTDNPDFYWVEYKDDATAFNGQKKGTIDNKGVVNNKVSAVFFKLMESKGITTHFVELVNDREMI
VKALDIIKVEVVVRNIVAGTLAKRVGLPEGTILPKTVLEYYYKDDNLGDPLINASHIAALDLATPEQMAFIKETALKVND
IMREYLAPVNIDLIDYKLEFGLHKGQVLLGDEISPDTCRFWDKTTGEKLDKDRFRRDLGNVEGAYQEVLRRLTGEA

Sequences:

>Translated_236_residues
MEKLEMIYEGKAKKVYRTDNPDFYWVEYKDDATAFNGQKKGTIDNKGVVNNKVSAVFFKLMESKGITTHFVELVNDREMI
VKALDIIKVEVVVRNIVAGTLAKRVGLPEGTILPKTVLEYYYKDDNLGDPLINASHIAALDLATPEQMAFIKETALKVND
IMREYLAPVNIDLIDYKLEFGLHKGQVLLGDEISPDTCRFWDKTTGEKLDKDRFRRDLGNVEGAYQEVLRRLTGEA
>Mature_236_residues
MEKLEMIYEGKAKKVYRTDNPDFYWVEYKDDATAFNGQKKGTIDNKGVVNNKVSAVFFKLMESKGITTHFVELVNDREMI
VKALDIIKVEVVVRNIVAGTLAKRVGLPEGTILPKTVLEYYYKDDNLGDPLINASHIAALDLATPEQMAFIKETALKVND
IMREYLAPVNIDLIDYKLEFGLHKGQVLLGDEISPDTCRFWDKTTGEKLDKDRFRRDLGNVEGAYQEVLRRLTGEA

Specific function: De novo purine biosynthesis; seventh step. [C]

COG id: COG0152

COG function: function code F; Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SAICAR synthetase family

Homologues:

Organism=Homo sapiens, GI119220557, Length=225, Percent_Identity=29.3333333333333, Blast_Score=100, Evalue=9e-22,
Organism=Homo sapiens, GI5453539, Length=225, Percent_Identity=29.3333333333333, Blast_Score=100, Evalue=9e-22,
Organism=Homo sapiens, GI119220559, Length=227, Percent_Identity=28.6343612334802, Blast_Score=92, Evalue=3e-19,
Organism=Escherichia coli, GI1788820, Length=232, Percent_Identity=43.5344827586207, Blast_Score=206, Evalue=1e-54,
Organism=Caenorhabditis elegans, GI17531275, Length=224, Percent_Identity=29.4642857142857, Blast_Score=96, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6319326, Length=257, Percent_Identity=24.124513618677, Blast_Score=63, Evalue=4e-11,
Organism=Drosophila melanogaster, GI24583917, Length=250, Percent_Identity=28.8, Blast_Score=97, Evalue=7e-21,
Organism=Drosophila melanogaster, GI18860083, Length=236, Percent_Identity=27.5423728813559, Blast_Score=93, Evalue=2e-19,

Paralogues:

None

Copy number: 1680 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 13,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): PUR7_DESRM (A4J726)

Other databases:

- EMBL:   CP000612
- RefSeq:   YP_001113704.1
- ProteinModelPortal:   A4J726
- SMR:   A4J726
- STRING:   A4J726
- GeneID:   4956479
- GenomeReviews:   CP000612_GR
- KEGG:   drm:Dred_2369
- eggNOG:   COG0152
- HOGENOM:   HBG306070
- OMA:   YKDDALG
- PhylomeDB:   A4J726
- ProtClustDB:   PRK09362
- BioCyc:   DRED349161:DRED_2369-MONOMER
- HAMAP:   MF_00137
- InterPro:   IPR013816
- InterPro:   IPR001636
- InterPro:   IPR018236
- Gene3D:   G3DSA:3.30.470.20
- PANTHER:   PTHR11609
- TIGRFAMs:   TIGR00081

Pfam domain/function: PF01259 SAICAR_synt

EC number: =6.3.2.6

Molecular weight: Translated: 26827; Mature: 26827

Theoretical pI: Translated: 5.24; Mature: 5.24

Prosite motif: PS01057 SAICAR_SYNTHETASE_1; PS01058 SAICAR_SYNTHETASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKLEMIYEGKAKKVYRTDNPDFYWVEYKDDATAFNGQKKGTIDNKGVVNNKVSAVFFKL
CCHHHHHHCCCCCEEEECCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHH
MESKGITTHFVELVNDREMIVKALDIIKVEVVVRNIVAGTLAKRVGLPEGTILPKTVLEY
HHCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHH
YYKDDNLGDPLINASHIAALDLATPEQMAFIKETALKVNDIMREYLAPVNIDLIDYKLEF
HHCCCCCCCCCCCCHHHEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEEC
GLHKGQVLLGDEISPDTCRFWDKTTGEKLDKDRFRRDLGNVEGAYQEVLRRLTGEA
CCCCCCEEECCCCCCCHHHHCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHCCCC
>Mature Secondary Structure
MEKLEMIYEGKAKKVYRTDNPDFYWVEYKDDATAFNGQKKGTIDNKGVVNNKVSAVFFKL
CCHHHHHHCCCCCEEEECCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHH
MESKGITTHFVELVNDREMIVKALDIIKVEVVVRNIVAGTLAKRVGLPEGTILPKTVLEY
HHCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHH
YYKDDNLGDPLINASHIAALDLATPEQMAFIKETALKVNDIMREYLAPVNIDLIDYKLEF
HHCCCCCCCCCCCCHHHEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEEC
GLHKGQVLLGDEISPDTCRFWDKTTGEKLDKDRFRRDLGNVEGAYQEVLRRLTGEA
CCCCCCEEECCCCCCCHHHHCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA