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The map label for this gene is purM [H]

Identifier: 134300203

GI number: 134300203

Start: 2587839

End: 2588891

Strand: Reverse

Name: purM [H]

Synonym: Dred_2364

Alternate gene names: 134300203

Gene position: 2588891-2587839 (Counterclockwise)

Preceding gene: 134300204

Following gene: 134300202

Centisome position: 71.75

GC content: 51.09

Gene sequence:

>1053_bases
ATGACAGAGCAGAAATCACAACCCCTTACCTATGCTGGGGCGGGGGTCAATATCGAAGCAGGAAACCAGGCTGTCAGTCT
CATGAAGCAGGCAGTACGTAGCACCTTTCGACCGGAGGTTCTGACGGACATTGGAGGCTTTGGGGGACTCTTTGCTCTCA
ATGCCGGTAAATATAAGGAGCCGGTATTGGTTTCCGGTACCGATGGCGTAGGCACCAAATTACGTGTGGCTCAACTAACC
GACAATCATCACACCATTGGCATTGATGCCGTGGCCATGTGTGTGAATGATATCTTGGTTCAGGGGGCAGAACCACTGTT
TTTTCTGGATTATCTAGCTGTGGGGAAGCTAGTGCCCGAAAGGGTGGCCGAGATTGTAAAGGGTGTGGCCGAAGGTTGCC
GCCAGGCCGGTTGTGCCTTAATTGGCGGGGAAACAGCAGAAATGCCGGGTTTTTATGCAGTAGAAGAATATGACATTGCC
GGCTTTGCCGTAGGCGTTGTGGAGCGTACGCAGTTAATTGATGGTAGAGGTATTGAAGCAGGGGATGCTGTAATTGGTCT
TCCTTCTTCAGGTCTCCATAGCAATGGTTATTCCTTGGCCCGGAAGGCCCTGCTGGAGGTAGCAGGTTACGGGATGACCG
ATACCGTAAAAGAGCTGGGCCGTTCTGTTGGGGAAGAATTACTGGAACCCACACGTATCTATGTCAAGGCAGTTCAACCG
CTGCTGGAAAAGTTTACTGTCAAGGGAATGGCCCATATTACCGGCGGTGGCTTAACTGAAAATATTCCCCGTATGTTGCC
CGAAGGGGTCAAGGTGGTACTGAACCGTTCCGCTTGGCCGGTATTGCCCGTATGCCAGCTAATTCAACAGATTGGCCAGG
TAGCAGAAGAGGAAATGCTGCGTACCTTTAATATGGGAATCGGCATGGTATTGATTGTACCCGCAGCAGAGTCAGCGGCG
GTGCTGCAGGATTTAGCCAGCCGTCATGAACAGGCCTATCTGATTGGACAGGTGGAAAGTGGTCCTTCACAAGTTGAATA
TATACAGGGTTAA

Upstream 100 bases:

>100_bases
AAAGAACTTCTGTACCGCATGTTTCAACGGCATTTACCCGGTGGAAGTGCCCAAACAGACGCAGGGCGGTAAGTTCAGTC
TGGAATAAGGGAGTGTGTCC

Downstream 100 bases:

>100_bases
AGATCAGCCTTAGGGAGAAATCTTATGAATAAATTACGGATAGGGGTATTGGCTTCGGGGCGGGGTTCCAATTTGCAGTC
CATCCTGGATCGCTGCCAGG

Product: phosphoribosylaminoimidazole synthetase

Products: NA

Alternate protein names: AIR synthase; AIRS; Phosphoribosyl-aminoimidazole synthetase [H]

Number of amino acids: Translated: 350; Mature: 349

Protein sequence:

>350_residues
MTEQKSQPLTYAGAGVNIEAGNQAVSLMKQAVRSTFRPEVLTDIGGFGGLFALNAGKYKEPVLVSGTDGVGTKLRVAQLT
DNHHTIGIDAVAMCVNDILVQGAEPLFFLDYLAVGKLVPERVAEIVKGVAEGCRQAGCALIGGETAEMPGFYAVEEYDIA
GFAVGVVERTQLIDGRGIEAGDAVIGLPSSGLHSNGYSLARKALLEVAGYGMTDTVKELGRSVGEELLEPTRIYVKAVQP
LLEKFTVKGMAHITGGGLTENIPRMLPEGVKVVLNRSAWPVLPVCQLIQQIGQVAEEEMLRTFNMGIGMVLIVPAAESAA
VLQDLASRHEQAYLIGQVESGPSQVEYIQG

Sequences:

>Translated_350_residues
MTEQKSQPLTYAGAGVNIEAGNQAVSLMKQAVRSTFRPEVLTDIGGFGGLFALNAGKYKEPVLVSGTDGVGTKLRVAQLT
DNHHTIGIDAVAMCVNDILVQGAEPLFFLDYLAVGKLVPERVAEIVKGVAEGCRQAGCALIGGETAEMPGFYAVEEYDIA
GFAVGVVERTQLIDGRGIEAGDAVIGLPSSGLHSNGYSLARKALLEVAGYGMTDTVKELGRSVGEELLEPTRIYVKAVQP
LLEKFTVKGMAHITGGGLTENIPRMLPEGVKVVLNRSAWPVLPVCQLIQQIGQVAEEEMLRTFNMGIGMVLIVPAAESAA
VLQDLASRHEQAYLIGQVESGPSQVEYIQG
>Mature_349_residues
TEQKSQPLTYAGAGVNIEAGNQAVSLMKQAVRSTFRPEVLTDIGGFGGLFALNAGKYKEPVLVSGTDGVGTKLRVAQLTD
NHHTIGIDAVAMCVNDILVQGAEPLFFLDYLAVGKLVPERVAEIVKGVAEGCRQAGCALIGGETAEMPGFYAVEEYDIAG
FAVGVVERTQLIDGRGIEAGDAVIGLPSSGLHSNGYSLARKALLEVAGYGMTDTVKELGRSVGEELLEPTRIYVKAVQPL
LEKFTVKGMAHITGGGLTENIPRMLPEGVKVVLNRSAWPVLPVCQLIQQIGQVAEEEMLRTFNMGIGMVLIVPAAESAAV
LQDLASRHEQAYLIGQVESGPSQVEYIQG

Specific function: De novo purine biosynthesis; fifth step. [C]

COG id: COG0150

COG function: function code F; Phosphoribosylaminoimidazole (AIR) synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR synthase family [H]

Homologues:

Organism=Homo sapiens, GI4503915, Length=337, Percent_Identity=50.4451038575668, Blast_Score=327, Evalue=1e-89,
Organism=Homo sapiens, GI209869995, Length=337, Percent_Identity=50.4451038575668, Blast_Score=327, Evalue=1e-89,
Organism=Homo sapiens, GI209869993, Length=337, Percent_Identity=50.4451038575668, Blast_Score=327, Evalue=1e-89,
Organism=Escherichia coli, GI1788845, Length=344, Percent_Identity=53.1976744186046, Blast_Score=354, Evalue=5e-99,
Organism=Caenorhabditis elegans, GI17567511, Length=341, Percent_Identity=45.1612903225806, Blast_Score=267, Evalue=7e-72,
Organism=Saccharomyces cerevisiae, GI6321203, Length=347, Percent_Identity=46.9740634005764, Blast_Score=305, Evalue=5e-84,
Organism=Drosophila melanogaster, GI24582400, Length=287, Percent_Identity=46.6898954703833, Blast_Score=244, Evalue=9e-65,

Paralogues:

None

Copy number: 180 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR004733
- InterPro:   IPR016188 [H]

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C [H]

EC number: =6.3.3.1 [H]

Molecular weight: Translated: 37094; Mature: 36963

Theoretical pI: Translated: 4.65; Mature: 4.65

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEQKSQPLTYAGAGVNIEAGNQAVSLMKQAVRSTFRPEVLTDIGGFGGLFALNAGKYKE
CCCCCCCCCEEECCCCEECCCHHHHHHHHHHHHHHCCCHHHHHCCCCCCEEEECCCCCCC
PVLVSGTDGVGTKLRVAQLTDNHHTIGIDAVAMCVNDILVQGAEPLFFLDYLAVGKLVPE
CEEEECCCCCCCEEEEEEECCCCCEEHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
RVAEIVKGVAEGCRQAGCALIGGETAEMPGFYAVEEYDIAGFAVGVVERTQLIDGRGIEA
HHHHHHHHHHHHHHHCCCEEECCCCCCCCCEEEEECCCCCHHHHHHHHHHHHCCCCCCCC
GDAVIGLPSSGLHSNGYSLARKALLEVAGYGMTDTVKELGRSVGEELLEPTRIYVKAVQP
CCEEEECCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LLEKFTVKGMAHITGGGLTENIPRMLPEGVKVVLNRSAWPVLPVCQLIQQIGQVAEEEML
HHHHHHHCCHHEECCCCCHHHHHHHCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHH
RTFNMGIGMVLIVPAAESAAVLQDLASRHEQAYLIGQVESGPSQVEYIQG
HHHHCCCCEEEEEECCCHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCC
>Mature Secondary Structure 
TEQKSQPLTYAGAGVNIEAGNQAVSLMKQAVRSTFRPEVLTDIGGFGGLFALNAGKYKE
CCCCCCCCEEECCCCEECCCHHHHHHHHHHHHHHCCCHHHHHCCCCCCEEEECCCCCCC
PVLVSGTDGVGTKLRVAQLTDNHHTIGIDAVAMCVNDILVQGAEPLFFLDYLAVGKLVPE
CEEEECCCCCCCEEEEEEECCCCCEEHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
RVAEIVKGVAEGCRQAGCALIGGETAEMPGFYAVEEYDIAGFAVGVVERTQLIDGRGIEA
HHHHHHHHHHHHHHHCCCEEECCCCCCCCCEEEEECCCCCHHHHHHHHHHHHCCCCCCCC
GDAVIGLPSSGLHSNGYSLARKALLEVAGYGMTDTVKELGRSVGEELLEPTRIYVKAVQP
CCEEEECCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LLEKFTVKGMAHITGGGLTENIPRMLPEGVKVVLNRSAWPVLPVCQLIQQIGQVAEEEML
HHHHHHHCCHHEECCCCCHHHHHHHCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHH
RTFNMGIGMVLIVPAAESAAVLQDLASRHEQAYLIGQVESGPSQVEYIQG
HHHHCCCCEEEEEECCCHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA