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The map label for this gene is hisG [H]

Identifier: 134300195

GI number: 134300195

Start: 2576442

End: 2577110

Strand: Reverse

Name: hisG [H]

Synonym: Dred_2356

Alternate gene names: 134300195

Gene position: 2577110-2576442 (Counterclockwise)

Preceding gene: 134300196

Following gene: 134300194

Centisome position: 71.43

GC content: 46.49

Gene sequence:

>669_bases
GTGGTGGCAGCCAGAGAACAATTAACTATTGCTTTGCCCAAGGGAACCCTATACAAAGAAACCGTAAAACTTCTGGGCAT
GGCAGGTTTGGATATAGATTTTATGAAAGATCCCGGGCGTCAGCTACTGCTGCAATCCGAAAAAGAAGCGGTACGCTTTA
TTATCTGTCGGCCCACTGATATTCCTACCTATGTAGAATATGGAGCCGCAGATCTGGGTCTGGTGGGAAAAGATACTATT
ATGGAACAGCATAAGGATATTTACGAGTTATTGGATTTAAAATACGGAGGCTGTCGCTTTGTGGTGGCTGTGCCCGAGGG
CAAGGAACAACAACTTCAGTATTGGAATCAAACCCGTGTAGCCACCAAGTTCCCCCGCATTGCTGAAGAATTCTTTCGCC
AACGGGGTATGCAAATGGAAATTGTTAAATTGCATGGCAACATTGAATTAGCACCCATCGTGGGATTAGCTGAGATGATC
GTGGACCTGGTATCCACTGGTCGTACTCTGCGTGAGAACAAACTGGTACCAGTGGCCGATGTACTTAGTTCAACCACCCG
CTTGATTGCTAACCGGGTCAGTCACCGCTTAAAGAGCGAACGGATAAATCCCCTAGTAGATAGAATGCGGCAAGTTGTGG
AGGAGGGGAAGCTAAATGGAAATGATTAG

Upstream 100 bases:

>100_bases
TTACCACCAAAGGGTATTAAAAATTTTACTTGACACCTTTACTACATGCATTTAACATATCATTATATTAGTAATTTAAT
AAGTTAAAGAGGTGATACCC

Downstream 100 bases:

>100_bases
AGTTATTAAGTCCTCAGATGAGGAAAAAATAGCCAGCTTATTAAATAACAGAATAGACACCCAGGCGGAGGTGGCCCAAC
GGGTTGCTTCTATTATGCAA

Product: ATP phosphoribosyltransferase catalytic subunit

Products: NA

Alternate protein names: ATP-PRT; ATP-PRTase [H]

Number of amino acids: Translated: 222; Mature: 222

Protein sequence:

>222_residues
MVAAREQLTIALPKGTLYKETVKLLGMAGLDIDFMKDPGRQLLLQSEKEAVRFIICRPTDIPTYVEYGAADLGLVGKDTI
MEQHKDIYELLDLKYGGCRFVVAVPEGKEQQLQYWNQTRVATKFPRIAEEFFRQRGMQMEIVKLHGNIELAPIVGLAEMI
VDLVSTGRTLRENKLVPVADVLSSTTRLIANRVSHRLKSERINPLVDRMRQVVEEGKLNGND

Sequences:

>Translated_222_residues
MVAAREQLTIALPKGTLYKETVKLLGMAGLDIDFMKDPGRQLLLQSEKEAVRFIICRPTDIPTYVEYGAADLGLVGKDTI
MEQHKDIYELLDLKYGGCRFVVAVPEGKEQQLQYWNQTRVATKFPRIAEEFFRQRGMQMEIVKLHGNIELAPIVGLAEMI
VDLVSTGRTLRENKLVPVADVLSSTTRLIANRVSHRLKSERINPLVDRMRQVVEEGKLNGND
>Mature_222_residues
MVAAREQLTIALPKGTLYKETVKLLGMAGLDIDFMKDPGRQLLLQSEKEAVRFIICRPTDIPTYVEYGAADLGLVGKDTI
MEQHKDIYELLDLKYGGCRFVVAVPEGKEQQLQYWNQTRVATKFPRIAEEFFRQRGMQMEIVKLHGNIELAPIVGLAEMI
VDLVSTGRTLRENKLVPVADVLSSTTRLIANRVSHRLKSERINPLVDRMRQVVEEGKLNGND

Specific function: Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic

COG id: COG0040

COG function: function code E; ATP phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP phosphoribosyltransferase family. Short subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788330, Length=221, Percent_Identity=31.6742081447964, Blast_Score=92, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6320896, Length=202, Percent_Identity=32.1782178217822, Blast_Score=97, Evalue=2e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001348
- InterPro:   IPR013820
- InterPro:   IPR018198 [H]

Pfam domain/function: PF01634 HisG [H]

EC number: =2.4.2.17 [H]

Molecular weight: Translated: 25124; Mature: 25124

Theoretical pI: Translated: 8.20; Mature: 8.20

Prosite motif: PS01316 ATP_P_PHORIBOSYLTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVAAREQLTIALPKGTLYKETVKLLGMAGLDIDFMKDPGRQLLLQSEKEAVRFIICRPTD
CCCCCCCEEEECCCCCHHHHHHHHHHHCCCCCHHCCCCCHHHHHHCCCCEEEEEEECCCC
IPTYVEYGAADLGLVGKDTIMEQHKDIYELLDLKYGGCRFVVAVPEGKEQQLQYWNQTRV
CCHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHH
ATKFPRIAEEFFRQRGMQMEIVKLHGNIELAPIVGLAEMIVDLVSTGRTLRENKLVPVAD
HHHHHHHHHHHHHHCCCEEEEEEECCCEEEHHHHHHHHHHHHHHHCCCHHHHCCCCHHHH
VLSSTTRLIANRVSHRLKSERINPLVDRMRQVVEEGKLNGND
HHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MVAAREQLTIALPKGTLYKETVKLLGMAGLDIDFMKDPGRQLLLQSEKEAVRFIICRPTD
CCCCCCCEEEECCCCCHHHHHHHHHHHCCCCCHHCCCCCHHHHHHCCCCEEEEEEECCCC
IPTYVEYGAADLGLVGKDTIMEQHKDIYELLDLKYGGCRFVVAVPEGKEQQLQYWNQTRV
CCHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHH
ATKFPRIAEEFFRQRGMQMEIVKLHGNIELAPIVGLAEMIVDLVSTGRTLRENKLVPVAD
HHHHHHHHHHHHHHCCCEEEEEEECCCEEEHHHHHHHHHHHHHHHCCCHHHHCCCCHHHH
VLSSTTRLIANRVSHRLKSERINPLVDRMRQVVEEGKLNGND
HHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA