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The map label for this gene is hisD [H]

Identifier: 134300194

GI number: 134300194

Start: 2575163

End: 2576455

Strand: Reverse

Name: hisD [H]

Synonym: Dred_2355

Alternate gene names: 134300194

Gene position: 2576455-2575163 (Counterclockwise)

Preceding gene: 134300195

Following gene: 134300193

Centisome position: 71.41

GC content: 50.19

Gene sequence:

>1293_bases
ATGGAAATGATTAGAGTTATTAAGTCCTCAGATGAGGAAAAAATAGCCAGCTTATTAAATAACAGAATAGACACCCAGGC
GGAGGTGGCCCAACGGGTTGCTTCTATTATGCAAGAGGTGAGAGAACAGGGAGATAAAGCCCTATGTTTTTTTGCCCGGC
GTTTTGATAAAGCAAGTCTGGAACCAACAAGTTTAAAGGTAACTCCGGAGGAAATTGAAGCAGCCTACCAGCAAGTGGAC
CCGGAGATTTTAGCATCCCTGCGTCTGGCCAAGCAGCGGATTGAAAACTTTCATCAGAAGCAACTGACCCGTTCCTGGTT
CCAACCAGATCCAGAGGGCAGCGTCCTAGGTCAGTTGATTACTCCATTGGATCGGGTGGGTATTTATGTTCCCGGTGGAA
CCGCTTCTTATCCATCTTCAGTATTGATGAATGCTATTCCCGCTAAAGTAGCTGGGGTTACACAAATTGTTATGGTTACG
CCACCCATGAACGATGGAAAGATCAATCCGTATACCCTGGTGGCTGCGGCAGAAGCCGAAGTCGATGACATCTATAAAGT
GGGTGGAGCCCAGGCCGTTGCTGCCCTGGCCTATGGCACAGAAACCATTGCTCCGGTGGATAAAATCACAGGACCCGGCA
ACATCTATGTAACCCTGGCCAAACGGATGGTTTATGGGGTAGTGGGTATTGACATGCTGGCAGGTCCCAGTGAAGTGTTG
GTGGTGGCAGATGGCACTGCTAAACCTGACTGTGCGGCTGCGGATATGCTCTCCCAGGCTGAGCATGATCCCATGGCATC
GGCCATTTTACTAACTCACGATACTGCCTTGGCGGAGGCCGTTAGCATGGAATTAGAACGACAGTTGGCTGAATTGCCTA
GACAGGAAATTGCTCGTCAGTCCTTGTCCAATCATAGTGCCATCATTTTAACAGAAAGCATCGACGAATCTCTGCAGTGG
GCCAACCGCTTTGCTCCGGAGCATCTGGAACTGTTGCTGAACGAACCAGTTAAGTACTTAGGCAAAGTTAAACATGCCGG
AGCTGTTTTCCTGGGTCACTATTCCCCGGAACCGGTGGGAGATTATCTGGCGGGTCCCAACCATGTCCTGCCCACCGGCG
GCACAGCCCGCTTTTACTCACCACTGAATGTGGATACCTTTATGAAAAAAACCAGCGTGATCGGCTTTTCGGAAGAAAGC
TTGCAGAAGCTGGGACCGGACATTATTCGTCTGGCCGAGGTAGAGGGACTGCAGGCCCACGCCAACGCTGTGAAGGTACG
TTTGGGTAAATAG

Upstream 100 bases:

>100_bases
ACCCGCTTGATTGCTAACCGGGTCAGTCACCGCTTAAAGAGCGAACGGATAAATCCCCTAGTAGATAGAATGCGGCAAGT
TGTGGAGGAGGGGAAGCTAA

Downstream 100 bases:

>100_bases
ATTGACAAGAAGGTATTTGCTATCGGTGCGGAGACCGGAGCTAATGGGGATAACTTAAATATTAGATGTGTATATATTCA
TTGCACCGAAGAAAAACTGG

Product: histidinol dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 430; Mature: 430

Protein sequence:

>430_residues
MEMIRVIKSSDEEKIASLLNNRIDTQAEVAQRVASIMQEVREQGDKALCFFARRFDKASLEPTSLKVTPEEIEAAYQQVD
PEILASLRLAKQRIENFHQKQLTRSWFQPDPEGSVLGQLITPLDRVGIYVPGGTASYPSSVLMNAIPAKVAGVTQIVMVT
PPMNDGKINPYTLVAAAEAEVDDIYKVGGAQAVAALAYGTETIAPVDKITGPGNIYVTLAKRMVYGVVGIDMLAGPSEVL
VVADGTAKPDCAAADMLSQAEHDPMASAILLTHDTALAEAVSMELERQLAELPRQEIARQSLSNHSAIILTESIDESLQW
ANRFAPEHLELLLNEPVKYLGKVKHAGAVFLGHYSPEPVGDYLAGPNHVLPTGGTARFYSPLNVDTFMKKTSVIGFSEES
LQKLGPDIIRLAEVEGLQAHANAVKVRLGK

Sequences:

>Translated_430_residues
MEMIRVIKSSDEEKIASLLNNRIDTQAEVAQRVASIMQEVREQGDKALCFFARRFDKASLEPTSLKVTPEEIEAAYQQVD
PEILASLRLAKQRIENFHQKQLTRSWFQPDPEGSVLGQLITPLDRVGIYVPGGTASYPSSVLMNAIPAKVAGVTQIVMVT
PPMNDGKINPYTLVAAAEAEVDDIYKVGGAQAVAALAYGTETIAPVDKITGPGNIYVTLAKRMVYGVVGIDMLAGPSEVL
VVADGTAKPDCAAADMLSQAEHDPMASAILLTHDTALAEAVSMELERQLAELPRQEIARQSLSNHSAIILTESIDESLQW
ANRFAPEHLELLLNEPVKYLGKVKHAGAVFLGHYSPEPVGDYLAGPNHVLPTGGTARFYSPLNVDTFMKKTSVIGFSEES
LQKLGPDIIRLAEVEGLQAHANAVKVRLGK
>Mature_430_residues
MEMIRVIKSSDEEKIASLLNNRIDTQAEVAQRVASIMQEVREQGDKALCFFARRFDKASLEPTSLKVTPEEIEAAYQQVD
PEILASLRLAKQRIENFHQKQLTRSWFQPDPEGSVLGQLITPLDRVGIYVPGGTASYPSSVLMNAIPAKVAGVTQIVMVT
PPMNDGKINPYTLVAAAEAEVDDIYKVGGAQAVAALAYGTETIAPVDKITGPGNIYVTLAKRMVYGVVGIDMLAGPSEVL
VVADGTAKPDCAAADMLSQAEHDPMASAILLTHDTALAEAVSMELERQLAELPRQEIARQSLSNHSAIILTESIDESLQW
ANRFAPEHLELLLNEPVKYLGKVKHAGAVFLGHYSPEPVGDYLAGPNHVLPTGGTARFYSPLNVDTFMKKTSVIGFSEES
LQKLGPDIIRLAEVEGLQAHANAVKVRLGK

Specific function: Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine [H]

COG id: COG0141

COG function: function code E; Histidinol dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histidinol dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1788331, Length=420, Percent_Identity=42.1428571428571, Blast_Score=301, Evalue=5e-83,
Organism=Saccharomyces cerevisiae, GI6319819, Length=438, Percent_Identity=39.4977168949772, Blast_Score=292, Evalue=7e-80,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016161
- InterPro:   IPR022695
- InterPro:   IPR001692
- InterPro:   IPR012131 [H]

Pfam domain/function: PF00815 Histidinol_dh [H]

EC number: =1.1.1.23 [H]

Molecular weight: Translated: 46560; Mature: 46560

Theoretical pI: Translated: 4.92; Mature: 4.92

Prosite motif: PS00611 HISOL_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEMIRVIKSSDEEKIASLLNNRIDTQAEVAQRVASIMQEVREQGDKALCFFARRFDKASL
CCHHHHHHCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCEEHHHHHHHCCCCC
EPTSLKVTPEEIEAAYQQVDPEILASLRLAKQRIENFHQKQLTRSWFQPDPEGSVLGQLI
CCCEEEECHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
TPLDRVGIYVPGGTASYPSSVLMNAIPAKVAGVTQIVMVTPPMNDGKINPYTLVAAAEAE
CCHHHCCEEECCCCCCCCHHHHHHHHHHHHHCCEEEEEECCCCCCCCCCCEEEEEECCCC
VDDIYKVGGAQAVAALAYGTETIAPVDKITGPGNIYVTLAKRMVYGVVGIDMLAGPSEVL
HHHHHHHCCHHHHHHHHHCCCCCCCHHHCCCCCCEEEHHHHHHHHHHHHHHHHCCCCCEE
VVADGTAKPDCAAADMLSQAEHDPMASAILLTHDTALAEAVSMELERQLAELPRQEIARQ
EEECCCCCCCHHHHHHHHHHCCCCCHHEEEEECHHHHHHHHHHHHHHHHHHCCHHHHHHH
SLSNHSAIILTESIDESLQWANRFAPEHLELLLNEPVKYLGKVKHAGAVFLGHYSPEPVG
HHCCCCEEEEECCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCH
DYLAGPNHVLPTGGTARFYSPLNVDTFMKKTSVIGFSEESLQKLGPDIIRLAEVEGLQAH
HHHCCCCCCCCCCCCEEEECCCCHHHHHHHHHCCCCCHHHHHHHCHHHHHHHHHCCHHHH
ANAVKVRLGK
CCEEEEEECC
>Mature Secondary Structure
MEMIRVIKSSDEEKIASLLNNRIDTQAEVAQRVASIMQEVREQGDKALCFFARRFDKASL
CCHHHHHHCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCEEHHHHHHHCCCCC
EPTSLKVTPEEIEAAYQQVDPEILASLRLAKQRIENFHQKQLTRSWFQPDPEGSVLGQLI
CCCEEEECHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
TPLDRVGIYVPGGTASYPSSVLMNAIPAKVAGVTQIVMVTPPMNDGKINPYTLVAAAEAE
CCHHHCCEEECCCCCCCCHHHHHHHHHHHHHCCEEEEEECCCCCCCCCCCEEEEEECCCC
VDDIYKVGGAQAVAALAYGTETIAPVDKITGPGNIYVTLAKRMVYGVVGIDMLAGPSEVL
HHHHHHHCCHHHHHHHHHCCCCCCCHHHCCCCCCEEEHHHHHHHHHHHHHHHHCCCCCEE
VVADGTAKPDCAAADMLSQAEHDPMASAILLTHDTALAEAVSMELERQLAELPRQEIARQ
EEECCCCCCCHHHHHHHHHHCCCCCHHEEEEECHHHHHHHHHHHHHHHHHHCCHHHHHHH
SLSNHSAIILTESIDESLQWANRFAPEHLELLLNEPVKYLGKVKHAGAVFLGHYSPEPVG
HHCCCCEEEEECCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCH
DYLAGPNHVLPTGGTARFYSPLNVDTFMKKTSVIGFSEESLQKLGPDIIRLAEVEGLQAH
HHHCCCCCCCCCCCCEEEECCCCHHHHHHHHHCCCCCHHHHHHHCHHHHHHHHHCCHHHH
ANAVKVRLGK
CCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12446909 [H]