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The map label for this gene is dhaT [H]

Identifier: 134300115

GI number: 134300115

Start: 2488759

End: 2489925

Strand: Reverse

Name: dhaT [H]

Synonym: Dred_2276

Alternate gene names: 134300115

Gene position: 2489925-2488759 (Counterclockwise)

Preceding gene: 134300116

Following gene: 134300114

Centisome position: 69.01

GC content: 46.1

Gene sequence:

>1167_bases
ATGCCAATGAATAGTTTGCTTCATATAAGTAAATTTGTGGCCCCGGAAATTATATTTGGCCTGGGAGCCTTAAGTCAAGT
GGGCGAAAGTGCTGCCCGTTTAGGGATTAAAAAGGCCCTTTTAGTTAGCGACCTGGGAGTCTTGGAGGCCGGTTGGTGCG
ATAAAGTCCTTGACTTTTTGAAAGAGGTTGGGATTGACGCTAAGGTCTGGTATGATGTAACTACCAACCCGAAGGATCTT
GAAGTAGCCGCTGCGGTTGAGTCTTATCTAGAAAGTAACTGTGATGGGATTGTTGCTGTGGGTGGGGGCAGTCCCATTGA
TGTGGCCAAAGCCATTGCCATTATTGCCACGAATGGTGGTCAAATTAAGGATTATGAAGGGGTTAATAAGATTACCTGTC
CCTTACCACCAATGGTTGTTGTATCCACAACCGGGGGTTCTGGTGCGGAGGTTTCCCAATTCTCAATGATTGTGGAGAAA
GAACGGCAGGTTAAAATGGCCATCATTTCTAAGTCCTTAGTTCCAGATATCGCCATTGTGGACCCTCATTTGCTGCAAAC
TAAAAGCGCCAGGTTAACGGCTGCCACAGGGGTGGATGCATTATGCCATGCTGTGGAGGCCTATGTTTCATTGGCAGCTA
CGCCTCTTACGGATGTACATGCCCTAGCGGCCATCCGTTTGATAGCTTCAAACTTAAGGGAATCGGTTGCCTGTAAAACA
AACCTGAAAGCGAAGGCAGCCATGGCCATGGCTAGTCTTCAGGCGGGCTTGGCTTTCTCCAATGCCATTTTAGGGGCCAC
CCATGCCATGACCCATCAGGTAGATGGTTTGTTAGATTTACACCATGGAGAAACAAATGGTATTCTTCTACCCCATGTAA
TGGAGTTTAATATGATCTCTTGCGGTGAGAAATTTATTAATATCGCTGAGGCAATGGGCGTGCAGATAACTGGTTTAGGT
AAATGGAAATCAGCGGAAAAAGGAATATGTGCTGTGCGTAAATTGCTGCGAGATATAGAGATACCGGAGCATTTGGCACA
GGTGGGGATGAAAGAAGAATATATTCAAAAACTAAGTGCCAACGCTGTTAAAGATGCCTGTCTGGTAACAAATCCCCGGG
ATTGCAGTGTCGAGCAAATTGAAGCACTTTATCGAAAAGCCCTCTAG

Upstream 100 bases:

>100_bases
TTTAGATAGGGCAGGGATGTTTATGTTTATGGAGAATATTTTATAAATAATCACACAGATAGAGAGTTGTTTTTAAAGAT
TTACCCGGAGGTACTTGCCC

Downstream 100 bases:

>100_bases
GAGGGATACCTATGTTTGACGATAAACTAACCATCATACAAAATTTAACTGGTGTTAACTCTTCAAAATTAAATTATTAC
TTGGCAGCCCAACGGTCCAA

Product: iron-containing alcohol dehydrogenase

Products: NA

Alternate protein names: 1,3-propanediol oxidoreductase; 3-hydroxypropionaldehyde reductase [H]

Number of amino acids: Translated: 388; Mature: 387

Protein sequence:

>388_residues
MPMNSLLHISKFVAPEIIFGLGALSQVGESAARLGIKKALLVSDLGVLEAGWCDKVLDFLKEVGIDAKVWYDVTTNPKDL
EVAAAVESYLESNCDGIVAVGGGSPIDVAKAIAIIATNGGQIKDYEGVNKITCPLPPMVVVSTTGGSGAEVSQFSMIVEK
ERQVKMAIISKSLVPDIAIVDPHLLQTKSARLTAATGVDALCHAVEAYVSLAATPLTDVHALAAIRLIASNLRESVACKT
NLKAKAAMAMASLQAGLAFSNAILGATHAMTHQVDGLLDLHHGETNGILLPHVMEFNMISCGEKFINIAEAMGVQITGLG
KWKSAEKGICAVRKLLRDIEIPEHLAQVGMKEEYIQKLSANAVKDACLVTNPRDCSVEQIEALYRKAL

Sequences:

>Translated_388_residues
MPMNSLLHISKFVAPEIIFGLGALSQVGESAARLGIKKALLVSDLGVLEAGWCDKVLDFLKEVGIDAKVWYDVTTNPKDL
EVAAAVESYLESNCDGIVAVGGGSPIDVAKAIAIIATNGGQIKDYEGVNKITCPLPPMVVVSTTGGSGAEVSQFSMIVEK
ERQVKMAIISKSLVPDIAIVDPHLLQTKSARLTAATGVDALCHAVEAYVSLAATPLTDVHALAAIRLIASNLRESVACKT
NLKAKAAMAMASLQAGLAFSNAILGATHAMTHQVDGLLDLHHGETNGILLPHVMEFNMISCGEKFINIAEAMGVQITGLG
KWKSAEKGICAVRKLLRDIEIPEHLAQVGMKEEYIQKLSANAVKDACLVTNPRDCSVEQIEALYRKAL
>Mature_387_residues
PMNSLLHISKFVAPEIIFGLGALSQVGESAARLGIKKALLVSDLGVLEAGWCDKVLDFLKEVGIDAKVWYDVTTNPKDLE
VAAAVESYLESNCDGIVAVGGGSPIDVAKAIAIIATNGGQIKDYEGVNKITCPLPPMVVVSTTGGSGAEVSQFSMIVEKE
RQVKMAIISKSLVPDIAIVDPHLLQTKSARLTAATGVDALCHAVEAYVSLAATPLTDVHALAAIRLIASNLRESVACKTN
LKAKAAMAMASLQAGLAFSNAILGATHAMTHQVDGLLDLHHGETNGILLPHVMEFNMISCGEKFINIAEAMGVQITGLGK
WKSAEKGICAVRKLLRDIEIPEHLAQVGMKEEYIQKLSANAVKDACLVTNPRDCSVEQIEALYRKAL

Specific function: Most active with substrates containing two primary alcohol groups separated by one or two carbon atoms. In the physiological direction, 3-hydroxypropionaldehyde is the preferred substrate [H]

COG id: COG1454

COG function: function code C; Alcohol dehydrogenase, class IV

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the iron-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI133922590, Length=383, Percent_Identity=27.4151436031332, Blast_Score=129, Evalue=5e-30,
Organism=Escherichia coli, GI48994951, Length=380, Percent_Identity=41.8421052631579, Blast_Score=299, Evalue=2e-82,
Organism=Escherichia coli, GI1789163, Length=371, Percent_Identity=36.3881401617251, Blast_Score=236, Evalue=1e-63,
Organism=Escherichia coli, GI87082107, Length=384, Percent_Identity=35.6770833333333, Blast_Score=229, Evalue=2e-61,
Organism=Escherichia coli, GI1787493, Length=388, Percent_Identity=28.8659793814433, Blast_Score=159, Evalue=3e-40,
Organism=Escherichia coli, GI1789386, Length=357, Percent_Identity=26.890756302521, Blast_Score=85, Evalue=9e-18,
Organism=Caenorhabditis elegans, GI17537053, Length=412, Percent_Identity=26.9417475728155, Blast_Score=139, Evalue=2e-33,
Organism=Saccharomyces cerevisiae, GI6321181, Length=376, Percent_Identity=38.031914893617, Blast_Score=254, Evalue=2e-68,
Organism=Drosophila melanogaster, GI24657991, Length=418, Percent_Identity=26.0765550239234, Blast_Score=131, Evalue=7e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001670
- InterPro:   IPR018211 [H]

Pfam domain/function: PF00465 Fe-ADH [H]

EC number: =1.1.1.202 [H]

Molecular weight: Translated: 41116; Mature: 40985

Theoretical pI: Translated: 6.18; Mature: 6.18

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPMNSLLHISKFVAPEIIFGLGALSQVGESAARLGIKKALLVSDLGVLEAGWCDKVLDFL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHCCCCHHHHHHHH
KEVGIDAKVWYDVTTNPKDLEVAAAVESYLESNCDGIVAVGGGSPIDVAKAIAIIATNGG
HHCCCCEEEEEEECCCCCCHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHEEEEEECCCC
QIKDYEGVNKITCPLPPMVVVSTTGGSGAEVSQFSMIVEKERQVKMAIISKSLVPDIAIV
CEECCCCCCEEECCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEC
DPHLLQTKSARLTAATGVDALCHAVEAYVSLAATPLTDVHALAAIRLIASNLRESVACKT
CCHHHCCCCCCEEEHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHC
NLKAKAAMAMASLQAGLAFSNAILGATHAMTHQVDGLLDLHHGETNGILLPHVMEFNMIS
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCEECCHHHHHHHHH
CGEKFINIAEAMGVQITGLGKWKSAEKGICAVRKLLRDIEIPEHLAQVGMKEEYIQKLSA
HHHHHHHHHHHCCEEEEECCCCCCCCCHHHHHHHHHHHCCCHHHHHHCCCHHHHHHHHHH
NAVKDACLVTNPRDCSVEQIEALYRKAL
HHHHHHHEECCCCCCCHHHHHHHHHHCC
>Mature Secondary Structure 
PMNSLLHISKFVAPEIIFGLGALSQVGESAARLGIKKALLVSDLGVLEAGWCDKVLDFL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHCCCCHHHHHHHH
KEVGIDAKVWYDVTTNPKDLEVAAAVESYLESNCDGIVAVGGGSPIDVAKAIAIIATNGG
HHCCCCEEEEEEECCCCCCHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHEEEEEECCCC
QIKDYEGVNKITCPLPPMVVVSTTGGSGAEVSQFSMIVEKERQVKMAIISKSLVPDIAIV
CEECCCCCCEEECCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEC
DPHLLQTKSARLTAATGVDALCHAVEAYVSLAATPLTDVHALAAIRLIASNLRESVACKT
CCHHHCCCCCCEEEHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHC
NLKAKAAMAMASLQAGLAFSNAILGATHAMTHQVDGLLDLHHGETNGILLPHVMEFNMIS
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCEECCHHHHHHHHH
CGEKFINIAEAMGVQITGLGKWKSAEKGICAVRKLLRDIEIPEHLAQVGMKEEYIQKLSA
HHHHHHHHHHHCCEEEEECCCCCCCCCHHHHHHHHHHHCCCHHHHHHCCCHHHHHHHHHH
NAVKDACLVTNPRDCSVEQIEALYRKAL
HHHHHHHEECCCCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7721705 [H]