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The map label for this gene is yiaY [H]

Identifier: 134300116

GI number: 134300116

Start: 2490219

End: 2491385

Strand: Reverse

Name: yiaY [H]

Synonym: Dred_2277

Alternate gene names: 134300116

Gene position: 2491385-2490219 (Counterclockwise)

Preceding gene: 134300122

Following gene: 134300115

Centisome position: 69.05

GC content: 46.87

Gene sequence:

>1167_bases
ATGACAGTTGGAGAACAAGTATTTGGCTATTTTATTCCTACAGTAAACCTGATGGGTGTAGGTGCACACAAGGAGATTCC
CGATCAAGTTAAAGTATTAGGAGGTTCCAATGTTTTAATTGTAACTGATGCTTTCCTTGGACGTCCTGGCGGTATGGCGG
ATGACATTAAAGGGATGTTGGAAGCTGAGAATATTAAAGTGACCATTTATGCCGGTGCAGAACCTAATCCCACAGATGTT
AACGTTCATGATGGCCTGAAAGTTTATCAGGAGTGCGGTGCTGACATGATCCTTTCCTTGGGCGGCGGTAGTTCCCACGA
CTGTGCCAAGGGCATTGGCATAGTTGCTACCAATGGTGGTAACATTCGCGACTATGAAGGCATTAACAAGAGCAGCAAGG
CGATGCCTCCCTTTATTGCTGTAAACACCACCGCTGGTACCGCTTCTGAAATGACCCGTTTCTGCATTATTACCAATACC
AGCAACCATGTTAAAATGGCGATTGTTGATTGGCGTTGCACCCCCAACATTGCCATTAATGACCCTTTGTTAATGGCTGG
GATGCCTCCAGCATTAACTGCTGCCACAGGTATGGATGCTCTGACCCACGCCATTGAAGCTTACGTATCCGTCGCTGCAA
CTCCAGTCACCGATTCTGCGGCCCTAATGGCTATTAAGTTAATTTCACAATATCTGCGGGCTGCAGTTGCCAACGGAGAG
AATATGGAAGCCCGTGACAAGATGGCTTATGCTGAGTTTTTAGGTGGTATGGCCTTTAATAATGCTTCTTTGGGTTACGT
ACACGCAATGGCTCACCAGTTGGGTGGATTTTACAATCTGCCTCACGGTGTTTGCAACGCTATTCTGCTACCCCATGTGG
AAGCCTTCAACTTGATTGCCTGCCCCGAGCGTTTTGTTGATATTGCTGTCGCAATGGGTGAGAACGTGGAAGGATTGTCT
GTTCGTGATGCTGCGGACAAGGCGCTATCTGCCATTAGAAAGCTATCGGCCGATGTTGGAATTCCTGCAGGTTTAACTGA
ACTGGGTGTTAAGGAAGAAGACCTGAAGACCATGGCAGAAAACGCTATGAAGGATGCTTGCGCCTTAACCAACCCGAGAA
AAGCTACTCTGAATGATATTGTTGGAATCTACAAGACTGCCCTATAA

Upstream 100 bases:

>100_bases
ACTGAAAGGTTTGGCATGCTCTTTGCTTATATAGTTAGTCAGTTAGACAAAGGGAAATATCCCTAAAGCCATAAATATAC
AACTTAAGGAGGAATTCACC

Downstream 100 bases:

>100_bases
GGGAAGTCAATTCCATCTAAACCCCATTCATATATATTTTTTGTAAGGTGGACCAAGTGTCCACCTATTTTTTTTCTATA
AGTTTTGTCTTTTGAATAGT

Product: iron-containing alcohol dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 388; Mature: 387

Protein sequence:

>388_residues
MTVGEQVFGYFIPTVNLMGVGAHKEIPDQVKVLGGSNVLIVTDAFLGRPGGMADDIKGMLEAENIKVTIYAGAEPNPTDV
NVHDGLKVYQECGADMILSLGGGSSHDCAKGIGIVATNGGNIRDYEGINKSSKAMPPFIAVNTTAGTASEMTRFCIITNT
SNHVKMAIVDWRCTPNIAINDPLLMAGMPPALTAATGMDALTHAIEAYVSVAATPVTDSAALMAIKLISQYLRAAVANGE
NMEARDKMAYAEFLGGMAFNNASLGYVHAMAHQLGGFYNLPHGVCNAILLPHVEAFNLIACPERFVDIAVAMGENVEGLS
VRDAADKALSAIRKLSADVGIPAGLTELGVKEEDLKTMAENAMKDACALTNPRKATLNDIVGIYKTAL

Sequences:

>Translated_388_residues
MTVGEQVFGYFIPTVNLMGVGAHKEIPDQVKVLGGSNVLIVTDAFLGRPGGMADDIKGMLEAENIKVTIYAGAEPNPTDV
NVHDGLKVYQECGADMILSLGGGSSHDCAKGIGIVATNGGNIRDYEGINKSSKAMPPFIAVNTTAGTASEMTRFCIITNT
SNHVKMAIVDWRCTPNIAINDPLLMAGMPPALTAATGMDALTHAIEAYVSVAATPVTDSAALMAIKLISQYLRAAVANGE
NMEARDKMAYAEFLGGMAFNNASLGYVHAMAHQLGGFYNLPHGVCNAILLPHVEAFNLIACPERFVDIAVAMGENVEGLS
VRDAADKALSAIRKLSADVGIPAGLTELGVKEEDLKTMAENAMKDACALTNPRKATLNDIVGIYKTAL
>Mature_387_residues
TVGEQVFGYFIPTVNLMGVGAHKEIPDQVKVLGGSNVLIVTDAFLGRPGGMADDIKGMLEAENIKVTIYAGAEPNPTDVN
VHDGLKVYQECGADMILSLGGGSSHDCAKGIGIVATNGGNIRDYEGINKSSKAMPPFIAVNTTAGTASEMTRFCIITNTS
NHVKMAIVDWRCTPNIAINDPLLMAGMPPALTAATGMDALTHAIEAYVSVAATPVTDSAALMAIKLISQYLRAAVANGEN
MEARDKMAYAEFLGGMAFNNASLGYVHAMAHQLGGFYNLPHGVCNAILLPHVEAFNLIACPERFVDIAVAMGENVEGLSV
RDAADKALSAIRKLSADVGIPAGLTELGVKEEDLKTMAENAMKDACALTNPRKATLNDIVGIYKTAL

Specific function: Unknown

COG id: COG1454

COG function: function code C; Alcohol dehydrogenase, class IV

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the iron-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI133922590, Length=411, Percent_Identity=26.2773722627737, Blast_Score=129, Evalue=6e-30,
Organism=Escherichia coli, GI48994951, Length=379, Percent_Identity=58.311345646438, Blast_Score=445, Evalue=1e-126,
Organism=Escherichia coli, GI1789163, Length=374, Percent_Identity=44.1176470588235, Blast_Score=298, Evalue=5e-82,
Organism=Escherichia coli, GI87082107, Length=386, Percent_Identity=36.2694300518135, Blast_Score=228, Evalue=6e-61,
Organism=Escherichia coli, GI1787493, Length=387, Percent_Identity=34.1085271317829, Blast_Score=201, Evalue=6e-53,
Organism=Escherichia coli, GI1789386, Length=377, Percent_Identity=26.790450928382, Blast_Score=87, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI17537053, Length=414, Percent_Identity=24.6376811594203, Blast_Score=111, Evalue=6e-25,
Organism=Saccharomyces cerevisiae, GI6321181, Length=388, Percent_Identity=51.5463917525773, Blast_Score=386, Evalue=1e-108,
Organism=Drosophila melanogaster, GI24657991, Length=411, Percent_Identity=25.5474452554745, Blast_Score=117, Evalue=2e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001670
- InterPro:   IPR018211 [H]

Pfam domain/function: PF00465 Fe-ADH [H]

EC number: =1.1.1.1 [H]

Molecular weight: Translated: 40773; Mature: 40642

Theoretical pI: Translated: 4.95; Mature: 4.95

Prosite motif: PS00913 ADH_IRON_1 ; PS00060 ADH_IRON_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
4.9 %Met     (Translated Protein)
6.7 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
4.7 %Met     (Mature Protein)
6.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVGEQVFGYFIPTVNLMGVGAHKEIPDQVKVLGGSNVLIVTDAFLGRPGGMADDIKGML
CCCHHHHHHHHHCCCEEEECCCCCCCCCHHEEECCCCEEEEEEHHHCCCCCCHHHHHHHE
EAENIKVTIYAGAEPNPTDVNVHDGLKVYQECGADMILSLGGGSSHDCAKGIGIVATNGG
EECCEEEEEEECCCCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCCHHCCCEEEEECCC
NIRDYEGINKSSKAMPPFIAVNTTAGTASEMTRFCIITNTSNHVKMAIVDWRCTPNIAIN
CCCCCCCCCCCCCCCCCEEEEECCCCCHHHCEEEEEEECCCCCEEEEEEEEECCCCCEEC
DPLLMAGMPPALTAATGMDALTHAIEAYVSVAATPVTDSAALMAIKLISQYLRAAVANGE
CCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCC
NMEARDKMAYAEFLGGMAFNNASLGYVHAMAHQLGGFYNLPHGVCNAILLPHVEAFNLIA
CCCHHHHHHHHHHHCCCEECCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHCCHHHHHEEE
CPERFVDIAVAMGENVEGLSVRDAADKALSAIRKLSADVGIPAGLTELGVKEEDLKTMAE
CCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHCCCHHHHHHHHH
NAMKDACALTNPRKATLNDIVGIYKTAL
HHHHHHHHCCCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TVGEQVFGYFIPTVNLMGVGAHKEIPDQVKVLGGSNVLIVTDAFLGRPGGMADDIKGML
CCHHHHHHHHHCCCEEEECCCCCCCCCHHEEECCCCEEEEEEHHHCCCCCCHHHHHHHE
EAENIKVTIYAGAEPNPTDVNVHDGLKVYQECGADMILSLGGGSSHDCAKGIGIVATNGG
EECCEEEEEEECCCCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCCHHCCCEEEEECCC
NIRDYEGINKSSKAMPPFIAVNTTAGTASEMTRFCIITNTSNHVKMAIVDWRCTPNIAIN
CCCCCCCCCCCCCCCCCEEEEECCCCCHHHCEEEEEEECCCCCEEEEEEEEECCCCCEEC
DPLLMAGMPPALTAATGMDALTHAIEAYVSVAATPVTDSAALMAIKLISQYLRAAVANGE
CCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCC
NMEARDKMAYAEFLGGMAFNNASLGYVHAMAHQLGGFYNLPHGVCNAILLPHVEAFNLIA
CCCHHHHHHHHHHHCCCEECCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHCCHHHHHEEE
CPERFVDIAVAMGENVEGLSVRDAADKALSAIRKLSADVGIPAGLTELGVKEEDLKTMAE
CCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHCCCHHHHHHHHH
NAMKDACALTNPRKATLNDIVGIYKTAL
HHHHHHHHCCCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8041620; 9278503; 7768815 [H]