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The map label for this gene is ygcA [C]

Identifier: 134300101

GI number: 134300101

Start: 2473541

End: 2474914

Strand: Reverse

Name: ygcA [C]

Synonym: Dred_2261

Alternate gene names: 134300101

Gene position: 2474914-2473541 (Counterclockwise)

Preceding gene: 134300103

Following gene: 134300100

Centisome position: 68.59

GC content: 44.32

Gene sequence:

>1374_bases
TTGGGAAATAATGCAACCGTAGGCGATATTGTTGATCTTGAGATACATGGATTGGGTCATTCAGGAGAAGGGGTCGGCAG
ATATCAAAAATTGGCTGTATTCGTGCCGGGCGCTCTGATTGGTGAAAGGGTGCGAGTTCGAATAAATCAAGTGAAAAAGT
CCTTTGCCAGAGGGCAACTGGTGGAAATTTTAAAGCAAACAACTGCTCGTATAGTGCCAAATTGTGAATCTTACCAGGTC
TGCGGCGGCTGCCAACTGCAACATTTGGATTATCAAGAACAATTGACATATAAAAGATCTGTAGTTGAAAGTGCCCTATT
CAAAATTGGTGGTTTAAAAGGGGTTGAGGTTTTACCTACTCTTGGTATGAGAAATCCGTGGCACTACCGAAACAAAATTC
ATCTGCAGGTGAAAGAAGCAAAAGGAAGGATCAAGCTTGGCTTCTATGCAGAGGGCAGCTATGAGCTGGCTGCTGGATTA
GCAGGGCAGTCTTGCCTGCTGGTACAGAAAGAGATCAATCAGGTTATTGCGATATTAGAAGAATTGATTAATAGTTATAA
ATTAACACCTTATCACTGGGGGGAAAAAAGGGGTCTGTTGCGCCATGTTATGATTCGTCAGGGATTTCATAGCGGGCAGT
GTATGGTTGTGCTGGTAACCTCACCGGAAGAATGGCAGGCAGAAAATGCATTTTCTCGGGCTTTGGTAGCCCGACAGCCA
AAGATTGTCTCAGTGATTCGCAACATCAACAGAAACCCAGGAAGAATAGTGTTGGGTGAGGAAAATCGGGTAATGTATGG
CAAAGAATATATTGTTGACGAGTTAAACGGCTTGAATTTTAACATATCTGCCAATTCCTTCTACCAGGTCAATACCCTAC
AGACCGAAGAGCTATATCAAAAGGCAAAGGAGTTTGCTCAATTGCAAGGACATGAGAGGGTAATAGATGCTTATTGTGGT
ATTGGTACCATCGCTCTATATTTAGCCCGCTCAACCGTTGAAGTTGTTGGCATGGAAATTGTGCCACCAGCGGTGGCAGA
TGCCAAAGAAAATGCTCGCCTAAACGGAATCACCAATACAAAATTCTTCCAGGGCGCCGTGGAGAAACTATTGCCCCGAA
TGGCCAAGGATCTAAAACCAGACGTAGTTGTTTTAGATCCCCCTAGGAAAGGTTGTGAAAAGGAAGTCTTAACGGCTATC
AGTGAATCAAAGGTGCCCAGGATTGTTTATGTTTCCTGTGACCCGGCAACCTTGGCCCGGGACTTGGGAGTATTAGATAA
GTTAGGCTATCAAACCCTGCAGGTACAGCCAGTGGATATGTTCCCCTGGACCTATCATGTTGAGTGTGTAGTGTTGATGT
CAAGCAATATATAG

Upstream 100 bases:

>100_bases
AGCCATAGTAGCCACTCCAAAGGGAAATTATTCCTTTACTCATATATATGTGACTTGGTAGAAAAAAGTTACACAACACT
AATAAGAGGTGTAAAAAGTT

Downstream 100 bases:

>100_bases
CGTTATATAACTACGACCTTACAATATATTGTGTTTTGGCGTATTTGAAACGTGAATATAGCCTACTTATCATTAACGCT
AAAATGGAATGAAAATAGGT

Product: RNA methyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 457; Mature: 456

Protein sequence:

>457_residues
MGNNATVGDIVDLEIHGLGHSGEGVGRYQKLAVFVPGALIGERVRVRINQVKKSFARGQLVEILKQTTARIVPNCESYQV
CGGCQLQHLDYQEQLTYKRSVVESALFKIGGLKGVEVLPTLGMRNPWHYRNKIHLQVKEAKGRIKLGFYAEGSYELAAGL
AGQSCLLVQKEINQVIAILEELINSYKLTPYHWGEKRGLLRHVMIRQGFHSGQCMVVLVTSPEEWQAENAFSRALVARQP
KIVSVIRNINRNPGRIVLGEENRVMYGKEYIVDELNGLNFNISANSFYQVNTLQTEELYQKAKEFAQLQGHERVIDAYCG
IGTIALYLARSTVEVVGMEIVPPAVADAKENARLNGITNTKFFQGAVEKLLPRMAKDLKPDVVVLDPPRKGCEKEVLTAI
SESKVPRIVYVSCDPATLARDLGVLDKLGYQTLQVQPVDMFPWTYHVECVVLMSSNI

Sequences:

>Translated_457_residues
MGNNATVGDIVDLEIHGLGHSGEGVGRYQKLAVFVPGALIGERVRVRINQVKKSFARGQLVEILKQTTARIVPNCESYQV
CGGCQLQHLDYQEQLTYKRSVVESALFKIGGLKGVEVLPTLGMRNPWHYRNKIHLQVKEAKGRIKLGFYAEGSYELAAGL
AGQSCLLVQKEINQVIAILEELINSYKLTPYHWGEKRGLLRHVMIRQGFHSGQCMVVLVTSPEEWQAENAFSRALVARQP
KIVSVIRNINRNPGRIVLGEENRVMYGKEYIVDELNGLNFNISANSFYQVNTLQTEELYQKAKEFAQLQGHERVIDAYCG
IGTIALYLARSTVEVVGMEIVPPAVADAKENARLNGITNTKFFQGAVEKLLPRMAKDLKPDVVVLDPPRKGCEKEVLTAI
SESKVPRIVYVSCDPATLARDLGVLDKLGYQTLQVQPVDMFPWTYHVECVVLMSSNI
>Mature_456_residues
GNNATVGDIVDLEIHGLGHSGEGVGRYQKLAVFVPGALIGERVRVRINQVKKSFARGQLVEILKQTTARIVPNCESYQVC
GGCQLQHLDYQEQLTYKRSVVESALFKIGGLKGVEVLPTLGMRNPWHYRNKIHLQVKEAKGRIKLGFYAEGSYELAAGLA
GQSCLLVQKEINQVIAILEELINSYKLTPYHWGEKRGLLRHVMIRQGFHSGQCMVVLVTSPEEWQAENAFSRALVARQPK
IVSVIRNINRNPGRIVLGEENRVMYGKEYIVDELNGLNFNISANSFYQVNTLQTEELYQKAKEFAQLQGHERVIDAYCGI
GTIALYLARSTVEVVGMEIVPPAVADAKENARLNGITNTKFFQGAVEKLLPRMAKDLKPDVVVLDPPRKGCEKEVLTAIS
ESKVPRIVYVSCDPATLARDLGVLDKLGYQTLQVQPVDMFPWTYHVECVVLMSSNI

Specific function: Could Be A 23s rRNA (Uracil-5-)-Methyltransferase. [C]

COG id: COG2265

COG function: function code J; SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 TRAM domain [H]

Homologues:

Organism=Homo sapiens, GI34222389, Length=360, Percent_Identity=28.6111111111111, Blast_Score=132, Evalue=8e-31,
Organism=Homo sapiens, GI51173878, Length=360, Percent_Identity=28.6111111111111, Blast_Score=132, Evalue=8e-31,
Organism=Homo sapiens, GI269784678, Length=359, Percent_Identity=28.6908077994429, Blast_Score=119, Evalue=5e-27,
Organism=Homo sapiens, GI269784680, Length=359, Percent_Identity=28.6908077994429, Blast_Score=119, Evalue=7e-27,
Organism=Homo sapiens, GI269784676, Length=359, Percent_Identity=28.6908077994429, Blast_Score=119, Evalue=7e-27,
Organism=Homo sapiens, GI20149688, Length=359, Percent_Identity=28.6908077994429, Blast_Score=119, Evalue=7e-27,
Organism=Escherichia coli, GI1789148, Length=459, Percent_Identity=29.6296296296296, Blast_Score=180, Evalue=1e-46,
Organism=Escherichia coli, GI1787083, Length=378, Percent_Identity=26.7195767195767, Blast_Score=120, Evalue=2e-28,
Organism=Escherichia coli, GI1790403, Length=298, Percent_Identity=26.510067114094, Blast_Score=91, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI71997438, Length=164, Percent_Identity=32.3170731707317, Blast_Score=72, Evalue=5e-13,
Organism=Saccharomyces cerevisiae, GI6322909, Length=420, Percent_Identity=24.2857142857143, Blast_Score=94, Evalue=4e-20,
Organism=Drosophila melanogaster, GI24666579, Length=431, Percent_Identity=29.6983758700696, Blast_Score=150, Evalue=1e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016027
- InterPro:   IPR001566
- InterPro:   IPR002792
- InterPro:   IPR010280 [H]

Pfam domain/function: PF01938 TRAM; PF05958 tRNA_U5-meth_tr [H]

EC number: NA

Molecular weight: Translated: 51008; Mature: 50877

Theoretical pI: Translated: 8.58; Mature: 8.58

Prosite motif: PS50926 TRAM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGNNATVGDIVDLEIHGLGHSGEGVGRYQKLAVFVPGALIGERVRVRINQVKKSFARGQL
CCCCCCCCCEEEEEEEECCCCCCCCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHH
VEILKQTTARIVPNCESYQVCGGCQLQHLDYQEQLTYKRSVVESALFKIGGLKGVEVLPT
HHHHHHHHHHHCCCCCCEEECCCCEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHCC
LGMRNPWHYRNKIHLQVKEAKGRIKLGFYAEGSYELAAGLAGQSCLLVQKEINQVIAILE
CCCCCCCCCCCEEEEEEEECCCEEEEEEEECCCEEEEECCCCCEEEEEHHHHHHHHHHHH
ELINSYKLTPYHWGEKRGLLRHVMIRQGFHSGQCMVVLVTSPEEWQAENAFSRALVARQP
HHHHHCCCCCEECCCHHHHHHHHHHHCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHCCC
KIVSVIRNINRNPGRIVLGEENRVMYGKEYIVDELNGLNFNISANSFYQVNTLQTEELYQ
HHHHHHHHCCCCCCEEEECCCCCEEECHHHHHHCCCCCEEEEECCCEEEEECCCHHHHHH
KAKEFAQLQGHERVIDAYCGIGTIALYLARSTVEVVGMEIVPPAVADAKENARLNGITNT
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCCCCCCEECCCCCH
KFFQGAVEKLLPRMAKDLKPDVVVLDPPRKGCEKEVLTAISESKVPRIVYVSCDPATLAR
HHHHHHHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHHCCCCEEEEEECCHHHHHH
DLGVLDKLGYQTLQVQPVDMFPWTYHVECVVLMSSNI
HHHHHHHCCCEEEEEEECEECCCEEEEEEEEEEECCC
>Mature Secondary Structure 
GNNATVGDIVDLEIHGLGHSGEGVGRYQKLAVFVPGALIGERVRVRINQVKKSFARGQL
CCCCCCCCEEEEEEEECCCCCCCCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHH
VEILKQTTARIVPNCESYQVCGGCQLQHLDYQEQLTYKRSVVESALFKIGGLKGVEVLPT
HHHHHHHHHHHCCCCCCEEECCCCEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHCC
LGMRNPWHYRNKIHLQVKEAKGRIKLGFYAEGSYELAAGLAGQSCLLVQKEINQVIAILE
CCCCCCCCCCCEEEEEEEECCCEEEEEEEECCCEEEEECCCCCEEEEEHHHHHHHHHHHH
ELINSYKLTPYHWGEKRGLLRHVMIRQGFHSGQCMVVLVTSPEEWQAENAFSRALVARQP
HHHHHCCCCCEECCCHHHHHHHHHHHCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHCCC
KIVSVIRNINRNPGRIVLGEENRVMYGKEYIVDELNGLNFNISANSFYQVNTLQTEELYQ
HHHHHHHHCCCCCCEEEECCCCCEEECHHHHHHCCCCCEEEEECCCEEEEECCCHHHHHH
KAKEFAQLQGHERVIDAYCGIGTIALYLARSTVEVVGMEIVPPAVADAKENARLNGITNT
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCCCCCCEECCCCCH
KFFQGAVEKLLPRMAKDLKPDVVVLDPPRKGCEKEVLTAISESKVPRIVYVSCDPATLAR
HHHHHHHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHHCCCCEEEEEECCHHHHHH
DLGVLDKLGYQTLQVQPVDMFPWTYHVECVVLMSSNI
HHHHHHHCCCEEEEEEECEECCCEEEEEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12552129 [H]