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The map label for this gene is tlpA [H]

Identifier: 134300103

GI number: 134300103

Start: 2476060

End: 2477637

Strand: Reverse

Name: tlpA [H]

Synonym: Dred_2263

Alternate gene names: 134300103

Gene position: 2477637-2476060 (Counterclockwise)

Preceding gene: 134300104

Following gene: 134300101

Centisome position: 68.67

GC content: 42.84

Gene sequence:

>1578_bases
ATGAATATGACAGTAAGAAAGAGACTGTTTCTTTCCTATGGTCTATTAATTGGTCTCATTATTTCTCTGGGATTCTATGC
AAGTTTTACCATGAGCAGGATCAACGATAAGTCAACGGAAATTGCCGACTACTGGTTGGCGGGAGTTCAACACGCAGAAG
AAATTAACACCTTAATAGCGGACATTCGTACCAGTGAATATAGGCATATCCTTGCTACAGAAACCGCTGAAATGAAAGCA
ATGGAAGAGAGTATTGCTGAAAACAAAAAGAAAATTAATGCAAATTTTACTGCCTATGAAAAATCCATTGCCAGTGATCA
GGATCGAAATTTGTATACTGTTTTAATGTCCGAATGGAAAAACTACTTAAGCTCAAATGAAAAAGTTTTGGCATTAAGTG
ATAGTGGACAGAAGGAAGAAGCGCTAAAAGTCATGAAGGGAGAATCCTTAACCCTTTATAATGCTGCCGCTGTTGCCGCC
AAGGAAATGGCCAAATACAATCAGGAAAACAGTGCCATGGCCAGTCAGGAAGGGGACAGCCTCCATCACCAATCTATTTT
AATGCTGTCACTGGTAATTTTATTGGCAGTGGGTCTAGGCATTGCTGCAGCCTTATACATTACCCGCAGTATTAATGGAC
CACTCAAGGAGATCGAAGAAAGGGCTAACAAGTTAGCCCAGGGAGATATCAACATTGAGGATATAAAGGTTCGCAGTCAA
GATGAGATAGGACATTTAGCAGAGGCCTTTAACACGATGAAAAATAATATTAAGAACATGCTGAACCAACTTATCGAGAC
AGCTAACCAACTAGCCGATGTTGCTGAAGGCCTCAATGAACAAGCCCAGCAGACTGCTGCCGGTGCTACGGAAACGGCCA
CCACCATGAATGAGATAGCAGCCACGGTAGAACAGATGAACAGCAATGTTCAGGAGGTATCCACAGTTTCAGAAACCACT
GCTAATCGGGCCAATGCAGGAAAGGAAGGGCTGAATAAAGTAACTTCCCAAATCCAAGCCATCACCCATTCAACCGGTGA
AGTATCCGAAGTTATTCATCAACTAAACCAAAAGTCTATGGAAATCAGTAAAATTGTCAACATGATTACCGGTATCGCCG
ATCAGACCAATCTACTGGCCCTCAACGCTGCCATTGAGGCAGCCAGAGCTGGCGAGCAAGGACGGGGATTTGCCGTGGTG
GCAGAAGAGGTAAGAAAGCTGGCGGAGCAGTCTGCCTCAGCCACCAAAGATATATCCAGCCTAATCAATGCCATTCAGAC
CGAAACACATCTAGCCGTTGAAAAAATCGAACAAGGTAATCAAGAAGTGTCCACTGGTAGCGTGGTTATTCAAGAAGTGG
GGAATATTTTCGAAGAAATTATAACTTCAGTACAGGGATTAACTTTACAAATTCATCACATGGCATCAGCAGCCCAACAA
ACCTCCGCTGGGGTTCAAAATGTTGCTGCTTCCACCGAAGAACAAACCGCTGCCATGGAGGAGGTTACTAGTACTGCTGA
GTCCTTAAATGAATTATCCGATCAGCTTAAGAATTTGGTAAAACAATTTAAAATATAA

Upstream 100 bases:

>100_bases
CAGGTTTTTTATTTAAAGGAATTTCGTGGAGGAAAATGAGTTAATTTGTCGAAATACAGCATTAAAATACATTGGAGCTA
ATTATAGGGGGTAGGGTAAA

Downstream 100 bases:

>100_bases
ATGCAAACCCCAGGTTTTTTAAAAACTTGGGGTTTAATTTTGACATGAATATAAAATAATAATCCCTAGGTTTTATACCC
AGGAATGAAATCTACTTTAT

Product: methyl-accepting chemotaxis sensory transducer

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 525; Mature: 525

Protein sequence:

>525_residues
MNMTVRKRLFLSYGLLIGLIISLGFYASFTMSRINDKSTEIADYWLAGVQHAEEINTLIADIRTSEYRHILATETAEMKA
MEESIAENKKKINANFTAYEKSIASDQDRNLYTVLMSEWKNYLSSNEKVLALSDSGQKEEALKVMKGESLTLYNAAAVAA
KEMAKYNQENSAMASQEGDSLHHQSILMLSLVILLAVGLGIAAALYITRSINGPLKEIEERANKLAQGDINIEDIKVRSQ
DEIGHLAEAFNTMKNNIKNMLNQLIETANQLADVAEGLNEQAQQTAAGATETATTMNEIAATVEQMNSNVQEVSTVSETT
ANRANAGKEGLNKVTSQIQAITHSTGEVSEVIHQLNQKSMEISKIVNMITGIADQTNLLALNAAIEAARAGEQGRGFAVV
AEEVRKLAEQSASATKDISSLINAIQTETHLAVEKIEQGNQEVSTGSVVIQEVGNIFEEIITSVQGLTLQIHHMASAAQQ
TSAGVQNVAASTEEQTAAMEEVTSTAESLNELSDQLKNLVKQFKI

Sequences:

>Translated_525_residues
MNMTVRKRLFLSYGLLIGLIISLGFYASFTMSRINDKSTEIADYWLAGVQHAEEINTLIADIRTSEYRHILATETAEMKA
MEESIAENKKKINANFTAYEKSIASDQDRNLYTVLMSEWKNYLSSNEKVLALSDSGQKEEALKVMKGESLTLYNAAAVAA
KEMAKYNQENSAMASQEGDSLHHQSILMLSLVILLAVGLGIAAALYITRSINGPLKEIEERANKLAQGDINIEDIKVRSQ
DEIGHLAEAFNTMKNNIKNMLNQLIETANQLADVAEGLNEQAQQTAAGATETATTMNEIAATVEQMNSNVQEVSTVSETT
ANRANAGKEGLNKVTSQIQAITHSTGEVSEVIHQLNQKSMEISKIVNMITGIADQTNLLALNAAIEAARAGEQGRGFAVV
AEEVRKLAEQSASATKDISSLINAIQTETHLAVEKIEQGNQEVSTGSVVIQEVGNIFEEIITSVQGLTLQIHHMASAAQQ
TSAGVQNVAASTEEQTAAMEEVTSTAESLNELSDQLKNLVKQFKI
>Mature_525_residues
MNMTVRKRLFLSYGLLIGLIISLGFYASFTMSRINDKSTEIADYWLAGVQHAEEINTLIADIRTSEYRHILATETAEMKA
MEESIAENKKKINANFTAYEKSIASDQDRNLYTVLMSEWKNYLSSNEKVLALSDSGQKEEALKVMKGESLTLYNAAAVAA
KEMAKYNQENSAMASQEGDSLHHQSILMLSLVILLAVGLGIAAALYITRSINGPLKEIEERANKLAQGDINIEDIKVRSQ
DEIGHLAEAFNTMKNNIKNMLNQLIETANQLADVAEGLNEQAQQTAAGATETATTMNEIAATVEQMNSNVQEVSTVSETT
ANRANAGKEGLNKVTSQIQAITHSTGEVSEVIHQLNQKSMEISKIVNMITGIADQTNLLALNAAIEAARAGEQGRGFAVV
AEEVRKLAEQSASATKDISSLINAIQTETHLAVEKIEQGNQEVSTGSVVIQEVGNIFEEIITSVQGLTLQIHHMASAAQQ
TSAGVQNVAASTEEQTAAMEEVTSTAESLNELSDQLKNLVKQFKI

Specific function: Chemotactic-signal transducers respond to changes in the concentration of attractants and repellents in the environment, transduce a signal from the outside to the inside of the cell, and facilitate sensory adaptation through the variation of the level of

COG id: COG0840

COG function: function code NT; Methyl-accepting chemotaxis protein

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 methyl-accepting transducer domain [H]

Homologues:

Organism=Escherichia coli, GI1787690, Length=563, Percent_Identity=27.5310834813499, Blast_Score=148, Evalue=8e-37,
Organism=Escherichia coli, GI2367378, Length=325, Percent_Identity=32.3076923076923, Blast_Score=144, Evalue=1e-35,
Organism=Escherichia coli, GI1788195, Length=311, Percent_Identity=33.1189710610932, Blast_Score=134, Evalue=2e-32,
Organism=Escherichia coli, GI1788194, Length=356, Percent_Identity=30.8988764044944, Blast_Score=130, Evalue=2e-31,
Organism=Escherichia coli, GI1789453, Length=336, Percent_Identity=30.952380952381, Blast_Score=124, Evalue=2e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004010
- InterPro:   IPR003122
- InterPro:   IPR004089
- InterPro:   IPR003660
- InterPro:   IPR022094 [H]

Pfam domain/function: PF02743 Cache_1; PF00672 HAMP; PF12332 McpA_N; PF00015 MCPsignal; PF02203 TarH [H]

EC number: NA

Molecular weight: Translated: 57030; Mature: 57030

Theoretical pI: Translated: 4.57; Mature: 4.57

Prosite motif: PS50885 HAMP ; PS50111 CHEMOTAXIS_TRANSDUC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNMTVRKRLFLSYGLLIGLIISLGFYASFTMSRINDKSTEIADYWLAGVQHAEEINTLIA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
DIRTSEYRHILATETAEMKAMEESIAENKKKINANFTAYEKSIASDQDRNLYTVLMSEWK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCHHHHHHHHHHH
NYLSSNEKVLALSDSGQKEEALKVMKGESLTLYNAAAVAAKEMAKYNQENSAMASQEGDS
HHHCCCCEEEEECCCCCHHHHHHHHCCCCEEEHHHHHHHHHHHHHHCCHHHHHHHCCCCH
LHHQSILMLSLVILLAVGLGIAAALYITRSINGPLKEIEERANKLAQGDINIEDIKVRSQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCHHHEEECCH
DEIGHLAEAFNTMKNNIKNMLNQLIETANQLADVAEGLNEQAQQTAAGATETATTMNEIA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
ATVEQMNSNVQEVSTVSETTANRANAGKEGLNKVTSQIQAITHSTGEVSEVIHQLNQKSM
HHHHHHHCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
EISKIVNMITGIADQTNLLALNAAIEAARAGEQGRGFAVVAEEVRKLAEQSASATKDISS
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
LINAIQTETHLAVEKIEQGNQEVSTGSVVIQEVGNIFEEIITSVQGLTLQIHHMASAAQQ
HHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
TSAGVQNVAASTEEQTAAMEEVTSTAESLNELSDQLKNLVKQFKI
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNMTVRKRLFLSYGLLIGLIISLGFYASFTMSRINDKSTEIADYWLAGVQHAEEINTLIA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
DIRTSEYRHILATETAEMKAMEESIAENKKKINANFTAYEKSIASDQDRNLYTVLMSEWK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCHHHHHHHHHHH
NYLSSNEKVLALSDSGQKEEALKVMKGESLTLYNAAAVAAKEMAKYNQENSAMASQEGDS
HHHCCCCEEEEECCCCCHHHHHHHHCCCCEEEHHHHHHHHHHHHHHCCHHHHHHHCCCCH
LHHQSILMLSLVILLAVGLGIAAALYITRSINGPLKEIEERANKLAQGDINIEDIKVRSQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCHHHEEECCH
DEIGHLAEAFNTMKNNIKNMLNQLIETANQLADVAEGLNEQAQQTAAGATETATTMNEIA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
ATVEQMNSNVQEVSTVSETTANRANAGKEGLNKVTSQIQAITHSTGEVSEVIHQLNQKSM
HHHHHHHCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
EISKIVNMITGIADQTNLLALNAAIEAARAGEQGRGFAVVAEEVRKLAEQSASATKDISS
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
LINAIQTETHLAVEKIEQGNQEVSTGSVVIQEVGNIFEEIITSVQGLTLQIHHMASAAQQ
HHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
TSAGVQNVAASTEEQTAAMEEVTSTAESLNELSDQLKNLVKQFKI
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8188684; 9384377 [H]