Click here to switch to the map view.

The map label for this gene is 134300052

Identifier: 134300052

GI number: 134300052

Start: 2417222

End: 2417878

Strand: Reverse

Name: 134300052

Synonym: Dred_2208

Alternate gene names: NA

Gene position: 2417878-2417222 (Counterclockwise)

Preceding gene: 134300053

Following gene: 134300051

Centisome position: 67.01

GC content: 40.64

Gene sequence:

>657_bases
ATGCTACTACCTCAAATACCAGTGACAATTTCAAAGGATAAAGTTTTCTTGTATCTGGGTATAAATGATCAGGGTAAGGT
TAACTCGGAAATGTTAGAGCAGATACAACAGGTTATTCAGGCGGGAAGAGTGCTCTTAAGTCCCACCGGGATTTTAAACC
AGGTACCATTGAGGTTTCATGAAAAATCCATTTTTATTAGCCATGACATTAAGCTTAGGATGAAGAACAGCTTCCTTAAA
AATTGCACCACTGCCAGTGTGGTAGCAGTGACCGTAGGAGAAACTATTGATAAAGAAGTAGCTAAGTTATTTGAAAAGGG
AGAAGCGACCAGCGGGATTATTCTGGACGCTGTGGGAACTGTTGCTGTTGAAGAAGCAGCGGATCAAGTGGTTAGGATGT
TATCTCAGCAAATGAGATTAAAGGGACTTTTTGCAACACCAAGGCTTGGGCCTGGTTATCAGGGCATGCCCATAGAATGC
TTGCCAGAGGTTCTTTATTTGGCAGGGGGAGGGAAAATTAAAATTACCACCAATGAATATTATCAGATGATACCGGCTAA
ATCCCTGTGCTTTATATTAGGTTGGAGTTCCCAACCTAGTAAATACCATAAAAAATGTGATTTTTGCCATAAAACAGACT
GCCAATATCGTAGTTAG

Upstream 100 bases:

>100_bases
TCCTGCAGGACTTTTAGTTCTTGAGAGATAAGGTGCGCGATTGGATAGCTGTAACCATTAACGCCCTTATTGGGCGTTTT
TTTATTATGCGGAGGGTATT

Downstream 100 bases:

>100_bases
GATGGAAGGGGAGAAAGAAATTGTCTTTTAGGAAAAGAGTAAAAAAAGAAGTTCTCATCATTGATGGCGCAATGGGTACA
CTGTTGCAGCAGAGGGGTCT

Product: vitamin B12 dependent methionine synthase, activation region

Products: tetrahydrofolate; L-methionine

Alternate protein names: 5-Methyltetrahydrofolate-Homocysteine Methyltransferase

Number of amino acids: Translated: 218; Mature: 218

Protein sequence:

>218_residues
MLLPQIPVTISKDKVFLYLGINDQGKVNSEMLEQIQQVIQAGRVLLSPTGILNQVPLRFHEKSIFISHDIKLRMKNSFLK
NCTTASVVAVTVGETIDKEVAKLFEKGEATSGIILDAVGTVAVEEAADQVVRMLSQQMRLKGLFATPRLGPGYQGMPIEC
LPEVLYLAGGGKIKITTNEYYQMIPAKSLCFILGWSSQPSKYHKKCDFCHKTDCQYRS

Sequences:

>Translated_218_residues
MLLPQIPVTISKDKVFLYLGINDQGKVNSEMLEQIQQVIQAGRVLLSPTGILNQVPLRFHEKSIFISHDIKLRMKNSFLK
NCTTASVVAVTVGETIDKEVAKLFEKGEATSGIILDAVGTVAVEEAADQVVRMLSQQMRLKGLFATPRLGPGYQGMPIEC
LPEVLYLAGGGKIKITTNEYYQMIPAKSLCFILGWSSQPSKYHKKCDFCHKTDCQYRS
>Mature_218_residues
MLLPQIPVTISKDKVFLYLGINDQGKVNSEMLEQIQQVIQAGRVLLSPTGILNQVPLRFHEKSIFISHDIKLRMKNSFLK
NCTTASVVAVTVGETIDKEVAKLFEKGEATSGIILDAVGTVAVEEAADQVVRMLSQQMRLKGLFATPRLGPGYQGMPIEC
LPEVLYLAGGGKIKITTNEYYQMIPAKSLCFILGWSSQPSKYHKKCDFCHKTDCQYRS

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: 2.1.1.13

Molecular weight: Translated: 24227; Mature: 24227

Theoretical pI: Translated: 8.78; Mature: 8.78

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.8 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
2.8 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLLPQIPVTISKDKVFLYLGINDQGKVNSEMLEQIQQVIQAGRVLLSPTGILNQVPLRFH
CCCCCCCEEEECCEEEEEEECCCCCCCCHHHHHHHHHHHHHCCEEECCCCCHHCCCCEEE
EKSIFISHDIKLRMKNSFLKNCTTASVVAVTVGETIDKEVAKLFEKGEATSGIILDAVGT
CCEEEEECCEEEEEHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHCCCCCCCEEEEHHHH
VAVEEAADQVVRMLSQQMRLKGLFATPRLGPGYQGMPIECLPEVLYLAGGGKIKITTNEY
HHHHHHHHHHHHHHHHHHHHHCEECCCCCCCCCCCCCHHHHHHHHEEECCCEEEEEEHHH
YQMIPAKSLCFILGWSSQPSKYHKKCDFCHKTDCQYRS
HHHCCCCCEEEEEECCCCCHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure
MLLPQIPVTISKDKVFLYLGINDQGKVNSEMLEQIQQVIQAGRVLLSPTGILNQVPLRFH
CCCCCCCEEEECCEEEEEEECCCCCCCCHHHHHHHHHHHHHCCEEECCCCCHHCCCCEEE
EKSIFISHDIKLRMKNSFLKNCTTASVVAVTVGETIDKEVAKLFEKGEATSGIILDAVGT
CCEEEEECCEEEEEHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHCCCCCCCEEEEHHHH
VAVEEAADQVVRMLSQQMRLKGLFATPRLGPGYQGMPIECLPEVLYLAGGGKIKITTNEY
HHHHHHHHHHHHHHHHHHHHHCEECCCCCCCCCCCCCHHHHHHHHEEECCCEEEEEEHHH
YQMIPAKSLCFILGWSSQPSKYHKKCDFCHKTDCQYRS
HHHCCCCCEEEEEECCCCCHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 5-methyltetrahydrofolate; L-homocysteine

Specific reaction: 5-methyltetrahydrofolate + L-homocysteine = tetrahydrofolate + L-methionine

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA