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The map label for this gene is hemB [H]

Identifier: 134300006

GI number: 134300006

Start: 2363511

End: 2364491

Strand: Reverse

Name: hemB [H]

Synonym: Dred_2160

Alternate gene names: 134300006

Gene position: 2364491-2363511 (Counterclockwise)

Preceding gene: 134300007

Following gene: 134300005

Centisome position: 65.53

GC content: 49.75

Gene sequence:

>981_bases
ATGCCCCAATTTCCTACTATCCGTCACAGGCGTCTAAGACTGAATGATCGTGTAAGACGACTGGTTAGAGAAAACCACCT
TTCAGTGAACGACCTTATTTACCCTGTTTTTGCCACCTATGGTCAGGGGGTACGTCGGGAAGTAACCAGTATGCCGGGTG
TCTACAACCTTTCCATTGATCTTTTAATAGAGGACTTAAAGAACATTGAAGAACTGGGTATACCGGGGATTATGGTTTTT
GGTGTACCGGAACAAAAGGATGAAGTTGGTTCTGGTGCCTATGATCCCGAAGGCATTGTGCAGCAAGCTGTTAGGGCTAT
AAAAAAGGCGTATCCCGAGATGTTGGTAATTACCGATGTTTGCCTGTGTGAATATACCAGCCATGGCCACTGCGGTTTAA
TTAAAGGAGATACCGTAGAGAACGACACAACTCTGGACCTACTTGCCCAAACTGCCTTGTCCCATGTGCAGGCCGGGGCC
GATATGGTGGCTCCCTCGGATATGATGGATGGGCGGGTGGCAGCTATCCGGGCCAGATTGGACGCAGAGGGCTATACTAA
TGTGCCCATTATGGCTTATTCAGCCAAGTACGCTTCAGCCTATTATGGACCTTTCCGGGAGGCTGCGGGGTCCACACCGC
AGTTTGGTGACCGTAAGACGTACCAAATGGATCCTGCCAACGGAGATGAGGCTCTCCGGGAAACCCTGCAGGATATTGAA
GAAGGTGCGGACATTGTGATGGTGAAACCTGCCCTAGCCTATATGGATATCATTCGTCGGGTTAAGGATCAGTTTAATTA
CCCGGTGGCTGCCTACAACGTCAGTGGTGAATATTCAATGGTGAAGGCCGCTGCCCAGTTGGGCTGGATCGATGAAAAGA
AGATTGTTCTCGAGACACTTACCGGCTTAAAACGGGCTGGGGCAGATATGCTTATTACCTACCATGCTCCGGAGGTTGCC
AACTGGCTGAAGGAGGGATAA

Upstream 100 bases:

>100_bases
TTGAATGTCTAGCCATTAACTTACTGGCCTATGACCAGTGGTTGTTGGCTTATCCTATAATTATAGGTTCCATAATAAAC
CAATCATGGAGGTGCTAACC

Downstream 100 bases:

>100_bases
GCATGATTATATCTTGGAATACAACCAACGCCTGTAACTTGTATTGTGAACACTGCTACCGGGATGCAGGTGTAAAGGCA
GAGGAAGAGCTTTCTACCGA

Product: delta-aminolevulinic acid dehydratase

Products: NA

Alternate protein names: ALAD; ALADH; Porphobilinogen synthase [H]

Number of amino acids: Translated: 326; Mature: 325

Protein sequence:

>326_residues
MPQFPTIRHRRLRLNDRVRRLVRENHLSVNDLIYPVFATYGQGVRREVTSMPGVYNLSIDLLIEDLKNIEELGIPGIMVF
GVPEQKDEVGSGAYDPEGIVQQAVRAIKKAYPEMLVITDVCLCEYTSHGHCGLIKGDTVENDTTLDLLAQTALSHVQAGA
DMVAPSDMMDGRVAAIRARLDAEGYTNVPIMAYSAKYASAYYGPFREAAGSTPQFGDRKTYQMDPANGDEALRETLQDIE
EGADIVMVKPALAYMDIIRRVKDQFNYPVAAYNVSGEYSMVKAAAQLGWIDEKKIVLETLTGLKRAGADMLITYHAPEVA
NWLKEG

Sequences:

>Translated_326_residues
MPQFPTIRHRRLRLNDRVRRLVRENHLSVNDLIYPVFATYGQGVRREVTSMPGVYNLSIDLLIEDLKNIEELGIPGIMVF
GVPEQKDEVGSGAYDPEGIVQQAVRAIKKAYPEMLVITDVCLCEYTSHGHCGLIKGDTVENDTTLDLLAQTALSHVQAGA
DMVAPSDMMDGRVAAIRARLDAEGYTNVPIMAYSAKYASAYYGPFREAAGSTPQFGDRKTYQMDPANGDEALRETLQDIE
EGADIVMVKPALAYMDIIRRVKDQFNYPVAAYNVSGEYSMVKAAAQLGWIDEKKIVLETLTGLKRAGADMLITYHAPEVA
NWLKEG
>Mature_325_residues
PQFPTIRHRRLRLNDRVRRLVRENHLSVNDLIYPVFATYGQGVRREVTSMPGVYNLSIDLLIEDLKNIEELGIPGIMVFG
VPEQKDEVGSGAYDPEGIVQQAVRAIKKAYPEMLVITDVCLCEYTSHGHCGLIKGDTVENDTTLDLLAQTALSHVQAGAD
MVAPSDMMDGRVAAIRARLDAEGYTNVPIMAYSAKYASAYYGPFREAAGSTPQFGDRKTYQMDPANGDEALRETLQDIEE
GADIVMVKPALAYMDIIRRVKDQFNYPVAAYNVSGEYSMVKAAAQLGWIDEKKIVLETLTGLKRAGADMLITYHAPEVAN
WLKEG

Specific function: Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen [H]

COG id: COG0113

COG function: function code H; Delta-aminolevulinic acid dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ALADH family [H]

Homologues:

Organism=Homo sapiens, GI189083849, Length=304, Percent_Identity=47.0394736842105, Blast_Score=283, Evalue=2e-76,
Organism=Escherichia coli, GI87081728, Length=314, Percent_Identity=48.0891719745223, Blast_Score=300, Evalue=6e-83,
Organism=Saccharomyces cerevisiae, GI6321398, Length=314, Percent_Identity=42.0382165605096, Blast_Score=251, Evalue=8e-68,
Organism=Drosophila melanogaster, GI21358291, Length=294, Percent_Identity=41.8367346938776, Blast_Score=251, Evalue=4e-67,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001731
- InterPro:   IPR013785 [H]

Pfam domain/function: PF00490 ALAD [H]

EC number: =4.2.1.24 [H]

Molecular weight: Translated: 36139; Mature: 36008

Theoretical pI: Translated: 4.90; Mature: 4.90

Prosite motif: PS00169 D_ALA_DEHYDRATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPQFPTIRHRRLRLNDRVRRLVRENHLSVNDLIYPVFATYGQGVRREVTSMPGVYNLSID
CCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCHHHHHHHHCCCEEEHHHH
LLIEDLKNIEELGIPGIMVFGVPEQKDEVGSGAYDPEGIVQQAVRAIKKAYPEMLVITDV
HHHHHHHHHHHHCCCEEEEECCCCCHHHCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHH
CLCEYTSHGHCGLIKGDTVENDTTLDLLAQTALSHVQAGADMVAPSDMMDGRVAAIRARL
HHHHCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHCCHHHHHHHHH
DAEGYTNVPIMAYSAKYASAYYGPFREAAGSTPQFGDRKTYQMDPANGDEALRETLQDIE
CCCCCCCCCEEEECCHHHHHHCCCHHHHCCCCCCCCCCCCEEECCCCCHHHHHHHHHHHH
EGADIVMVKPALAYMDIIRRVKDQFNYPVAAYNVSGEYSMVKAAAQLGWIDEKKIVLETL
CCCCEEEECHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHCCCCCHHHHHHHH
TGLKRAGADMLITYHAPEVANWLKEG
HHHHHCCCCEEEEECCHHHHHHHHCC
>Mature Secondary Structure 
PQFPTIRHRRLRLNDRVRRLVRENHLSVNDLIYPVFATYGQGVRREVTSMPGVYNLSID
CCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCHHHHHHHHCCCEEEHHHH
LLIEDLKNIEELGIPGIMVFGVPEQKDEVGSGAYDPEGIVQQAVRAIKKAYPEMLVITDV
HHHHHHHHHHHHCCCEEEEECCCCCHHHCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHH
CLCEYTSHGHCGLIKGDTVENDTTLDLLAQTALSHVQAGADMVAPSDMMDGRVAAIRARL
HHHHCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHCCHHHHHHHHH
DAEGYTNVPIMAYSAKYASAYYGPFREAAGSTPQFGDRKTYQMDPANGDEALRETLQDIE
CCCCCCCCCEEEECCHHHHHHCCCHHHHCCCCCCCCCCCCEEECCCCCHHHHHHHHHHHH
EGADIVMVKPALAYMDIIRRVKDQFNYPVAAYNVSGEYSMVKAAAQLGWIDEKKIVLETL
CCCCEEEECHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHCCCCCHHHHHHHH
TGLKRAGADMLITYHAPEVANWLKEG
HHHHHCCCCEEEEECCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11058132 [H]