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The map label for this gene is ribBA [H]

Identifier: 134299937

GI number: 134299937

Start: 2286674

End: 2287906

Strand: Reverse

Name: ribBA [H]

Synonym: Dred_2091

Alternate gene names: 134299937

Gene position: 2287906-2286674 (Counterclockwise)

Preceding gene: 134299938

Following gene: 134299936

Centisome position: 63.41

GC content: 45.42

Gene sequence:

>1233_bases
ATGACATATAAATTTAATACCATTGAAGAGGCCATTGAAGATATTCGTGCAGGTAAAATTGTTGTGGTCGTGGATGATGA
GGATCGCGAAAATGAAGGGGATTTGGTGATGGCCGCAGAATTGGCCACCACAGAAGCTGTTAACTTTATGGCCACCTATG
GCCGAGGATTAATTTGCATGCCGATCTATGGCGAGCGTCTGGATGAATTGGATTTACCAGCAATGGTTAGTAATAATACG
GACCCCAATGGAACTGCTTTTACCGTATCGGTAGATGCCAAAGAATGTACCACTGGCATCTCGGCTGTTGAAAGGGCCTT
AACCATTAAAAAGATACTGGATCCCACTACTAAGCCGGAAGATCTGCGTCGTCCTGGTCACATATTCCCTCTACGGGCAA
AGGAAGGCGGCGTGTTGGTACGTTCTGGTCATACCGAAGCGGTGGTGGATTTAGCGAGGCTGGCAGGTTTGAAATCAGCG
GGTGTTATCTGTGAAATAATGAAAGATGATGGAACCATGGCAAGAGTTCCGGAACTTGTAGAGTTTTGCAAAGAACATAA
TTTAAAGTTAATTACCATTGCTGATTTAATTAAATATCGGAGACACCACGAAAAATTTATTAAGAAAATTGATTCTGCCA
AGATGCCTACTAAATATGGTGAGTTTGTGGCAGTGGGCTATGAAGGTCTGATCGACGGCAAAGGGCATGTTGCTCTGGTA
AAAGGGGATTTGTCCAGCGTTGAGGCCCCATTGGTACGTGTTCATTCTGAGTGTTTAACTGGAGATGTTTTTGGATCCAT
GCGCTGTGATTGTGGGGACCAACTGGCCAAAGCCATGCAGGCCATTGAGGAAGAGGGAGTGGGTGTCCTCCTTTACATGC
GGCAGGAAGGCCGGGGAATCGGCCTTATGAATAAAATAAAGGCTTATCGTCTACAGGATATGGGGGCAGATACCGTGGAA
GCCAACCTGGCCCTAGGTTTCCCTGCGGATCTGCGGGATTATGGCATTGGGGCACAAATCTTAGCTGACCTGGGACTCAC
GAAAATAAGATTACTTACTAATAACCCTCGTAAAATTGCAGGTTTGGAAGGCTACGGCCTCCAGGTGGTGGGTCGGGTAC
CCATTGAAATTGACGCAGTAACAACCAATAAAAAGTACCTGAGTACTAAAAAATGCAAACTGGGTCATCTTTTAACCCTG
GAAGAAAAGTCTAAGAAATCGGTCAATGAATAA

Upstream 100 bases:

>100_bases
GAACGCTTGCTGCAGGGACGTCAAGAAGAGGAACGCCCCGGTAGTAAAATGAACCTGGAGTTTTTGGCAACCAATGGATT
TCTATAAGGAGGGGTAAGGT

Downstream 100 bases:

>100_bases
AATCATTACGAATTATAAGTAACAGGAGGACAAAAATATGCCGAAAGTATTTGAAGGACATTTACTGGGACAAGAATTAA
AGTTTGGTATTGTTGTTGGT

Product: GTP cyclohydrolase II

Products: NA

Alternate protein names: 3,4-dihydroxy-2-butanone 4-phosphate synthase; DHBP synthase; GTP cyclohydrolase-2; GTP cyclohydrolase II [H]

Number of amino acids: Translated: 410; Mature: 409

Protein sequence:

>410_residues
MTYKFNTIEEAIEDIRAGKIVVVVDDEDRENEGDLVMAAELATTEAVNFMATYGRGLICMPIYGERLDELDLPAMVSNNT
DPNGTAFTVSVDAKECTTGISAVERALTIKKILDPTTKPEDLRRPGHIFPLRAKEGGVLVRSGHTEAVVDLARLAGLKSA
GVICEIMKDDGTMARVPELVEFCKEHNLKLITIADLIKYRRHHEKFIKKIDSAKMPTKYGEFVAVGYEGLIDGKGHVALV
KGDLSSVEAPLVRVHSECLTGDVFGSMRCDCGDQLAKAMQAIEEEGVGVLLYMRQEGRGIGLMNKIKAYRLQDMGADTVE
ANLALGFPADLRDYGIGAQILADLGLTKIRLLTNNPRKIAGLEGYGLQVVGRVPIEIDAVTTNKKYLSTKKCKLGHLLTL
EEKSKKSVNE

Sequences:

>Translated_410_residues
MTYKFNTIEEAIEDIRAGKIVVVVDDEDRENEGDLVMAAELATTEAVNFMATYGRGLICMPIYGERLDELDLPAMVSNNT
DPNGTAFTVSVDAKECTTGISAVERALTIKKILDPTTKPEDLRRPGHIFPLRAKEGGVLVRSGHTEAVVDLARLAGLKSA
GVICEIMKDDGTMARVPELVEFCKEHNLKLITIADLIKYRRHHEKFIKKIDSAKMPTKYGEFVAVGYEGLIDGKGHVALV
KGDLSSVEAPLVRVHSECLTGDVFGSMRCDCGDQLAKAMQAIEEEGVGVLLYMRQEGRGIGLMNKIKAYRLQDMGADTVE
ANLALGFPADLRDYGIGAQILADLGLTKIRLLTNNPRKIAGLEGYGLQVVGRVPIEIDAVTTNKKYLSTKKCKLGHLLTL
EEKSKKSVNE
>Mature_409_residues
TYKFNTIEEAIEDIRAGKIVVVVDDEDRENEGDLVMAAELATTEAVNFMATYGRGLICMPIYGERLDELDLPAMVSNNTD
PNGTAFTVSVDAKECTTGISAVERALTIKKILDPTTKPEDLRRPGHIFPLRAKEGGVLVRSGHTEAVVDLARLAGLKSAG
VICEIMKDDGTMARVPELVEFCKEHNLKLITIADLIKYRRHHEKFIKKIDSAKMPTKYGEFVAVGYEGLIDGKGHVALVK
GDLSSVEAPLVRVHSECLTGDVFGSMRCDCGDQLAKAMQAIEEEGVGVLLYMRQEGRGIGLMNKIKAYRLQDMGADTVEA
NLALGFPADLRDYGIGAQILADLGLTKIRLLTNNPRKIAGLEGYGLQVVGRVPIEIDAVTTNKKYLSTKKCKLGHLLTLE
EKSKKSVNE

Specific function: Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate [H]

COG id: COG0108

COG function: function code H; 3,4-dihydroxy-2-butanone 4-phosphate synthase

Gene ontology:

Cell location: Membrane-Associated [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the GTP cyclohydrolase II family [H]

Homologues:

Organism=Escherichia coli, GI1789420, Length=202, Percent_Identity=51.980198019802, Blast_Score=226, Evalue=1e-60,
Organism=Escherichia coli, GI1787533, Length=193, Percent_Identity=54.4041450777202, Blast_Score=213, Evalue=3e-56,
Organism=Saccharomyces cerevisiae, GI6320695, Length=204, Percent_Identity=45.0980392156863, Blast_Score=176, Evalue=6e-45,
Organism=Saccharomyces cerevisiae, GI6319438, Length=170, Percent_Identity=48.2352941176471, Blast_Score=143, Evalue=6e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017945
- InterPro:   IPR000422
- InterPro:   IPR000926
- InterPro:   IPR016299 [H]

Pfam domain/function: PF00926 DHBP_synthase; PF00925 GTP_cyclohydro2 [H]

EC number: =4.1.99.12; =3.5.4.25 [H]

Molecular weight: Translated: 44824; Mature: 44692

Theoretical pI: Translated: 5.94; Mature: 5.94

Prosite motif: PS00430 TONB_DEPENDENT_REC_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTYKFNTIEEAIEDIRAGKIVVVVDDEDRENEGDLVMAAELATTEAVNFMATYGRGLICM
CCEECHHHHHHHHHHCCCEEEEEECCCCCCCCCCEEEEEEHHHHHHHHHHHHHCCCEEEE
PIYGERLDELDLPAMVSNNTDPNGTAFTVSVDAKECTTGISAVERALTIKKILDPTTKPE
ECCCCCCCCCCCCEEECCCCCCCCEEEEEEECHHHHHHHHHHHHHHHHHHHHHCCCCCHH
DLRRPGHIFPLRAKEGGVLVRSGHTEAVVDLARLAGLKSAGVICEIMKDDGTMARVPELV
HHCCCCCEEEEEECCCCEEEECCCHHHHHHHHHHHCCCCCCEEEEEECCCCCHHHHHHHH
EFCKEHNLKLITIADLIKYRRHHEKFIKKIDSAKMPTKYGEFVAVGYEGLIDGKGHVALV
HHHHHCCCEEEEHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCEEECCCCCEEEE
KGDLSSVEAPLVRVHSECLTGDVFGSMRCDCGDQLAKAMQAIEEEGVGVLLYMRQEGRGI
ECCCHHHHHHHHHHHHHHHCCHHCCCCCCCHHHHHHHHHHHHHHCCCEEEEEEECCCCCC
GLMNKIKAYRLQDMGADTVEANLALGFPADLRDYGIGAQILADLGLTKIRLLTNNPRKIA
CHHHHHHHHHHHHCCCCCEEEEEEECCCCCHHHCCCCHHHHHHCCCEEEEEEECCCCEEE
GLEGYGLQVVGRVPIEIDAVTTNKKYLSTKKCKLGHLLTLEEKSKKSVNE
CCCCCCEEEEEECCEEEEEEECCCHHHCCCCCCCCEEEEECCHHHCCCCC
>Mature Secondary Structure 
TYKFNTIEEAIEDIRAGKIVVVVDDEDRENEGDLVMAAELATTEAVNFMATYGRGLICM
CEECHHHHHHHHHHCCCEEEEEECCCCCCCCCCEEEEEEHHHHHHHHHHHHHCCCEEEE
PIYGERLDELDLPAMVSNNTDPNGTAFTVSVDAKECTTGISAVERALTIKKILDPTTKPE
ECCCCCCCCCCCCEEECCCCCCCCEEEEEEECHHHHHHHHHHHHHHHHHHHHHCCCCCHH
DLRRPGHIFPLRAKEGGVLVRSGHTEAVVDLARLAGLKSAGVICEIMKDDGTMARVPELV
HHCCCCCEEEEEECCCCEEEECCCHHHHHHHHHHHCCCCCCEEEEEECCCCCHHHHHHHH
EFCKEHNLKLITIADLIKYRRHHEKFIKKIDSAKMPTKYGEFVAVGYEGLIDGKGHVALV
HHHHHCCCEEEEHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCEEECCCCCEEEE
KGDLSSVEAPLVRVHSECLTGDVFGSMRCDCGDQLAKAMQAIEEEGVGVLLYMRQEGRGI
ECCCHHHHHHHHHHHHHHHCCHHCCCCCCCHHHHHHHHHHHHHHCCCEEEEEEECCCCCC
GLMNKIKAYRLQDMGADTVEANLALGFPADLRDYGIGAQILADLGLTKIRLLTNNPRKIA
CHHHHHHHHHHHHCCCCCEEEEEEECCCCCHHHCCCCHHHHHHCCCEEEEEEECCCCEEE
GLEGYGLQVVGRVPIEIDAVTTNKKYLSTKKCKLGHLLTLEEKSKKSVNE
CCCCCCEEEEEECCEEEEEEECCCHHHCCCCCCCCEEEEECCHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA