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The map label for this gene is ribE [H]

Identifier: 134299938

GI number: 134299938

Start: 2287920

End: 2288483

Strand: Reverse

Name: ribE [H]

Synonym: Dred_2092

Alternate gene names: 134299938

Gene position: 2288483-2287920 (Counterclockwise)

Preceding gene: 134299939

Following gene: 134299937

Centisome position: 63.43

GC content: 45.92

Gene sequence:

>564_bases
GTGTTGCAGGATACAAGAATTGGTGACAGTATTGCAGTAAATGGTGTTTGTTTGACAGCTACCACTTTTGGTGAGGGAGT
TTTTGTTGCCGATGTAATGGCAGAGACTTTGGCTAAAACAAACCTAAGGGATCTCAGACCCGGCAGTCAGGTTAACCTGG
AAAGGGCATTAAGGCTGGGAGACAGGTTGGGGGGCCACATGGTTTCTGGGCACGTGGATGGCGTGGGAACCATTGCCGGC
AAGGAAAAACATGATATTGCCACTTTGATTACCATACAAGCCCCGCCCCAGGTAATGAAATACATTATAAAGAAGGGTTC
CATAGCCATTGATGGCACCAGTCTGACTGTGGTTGATTTTGAGGGAGATAAATTTCAAGTATCACTAATTCCCCATACTG
CCCATGCTACGGTGCTGGGGAACAAGAAAATCGGTGATTCCGTTAACTTGGAATCCGACGTTTTAGGTAAATATATTGAA
CGCTTGCTGCAGGGACGTCAAGAAGAGGAACGCCCCGGTAGTAAAATGAACCTGGAGTTTTTGGCAACCAATGGATTTCT
ATAA

Upstream 100 bases:

>100_bases
GGGACAAGATATCTTTACTGGAATTGTAGAAGAGATTGGCACCATTAGAGGGATTTCCAAGGGCCCGGATTCAGCCAGGC
TTCATATATTAGGGTCAAAG

Downstream 100 bases:

>100_bases
GGAGGGGTAAGGTATGACATATAAATTTAATACCATTGAAGAGGCCATTGAAGATATTCGTGCAGGTAAAATTGTTGTGG
TCGTGGATGATGAGGATCGC

Product: riboflavin synthase subunit alpha

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 187; Mature: 187

Protein sequence:

>187_residues
MLQDTRIGDSIAVNGVCLTATTFGEGVFVADVMAETLAKTNLRDLRPGSQVNLERALRLGDRLGGHMVSGHVDGVGTIAG
KEKHDIATLITIQAPPQVMKYIIKKGSIAIDGTSLTVVDFEGDKFQVSLIPHTAHATVLGNKKIGDSVNLESDVLGKYIE
RLLQGRQEEERPGSKMNLEFLATNGFL

Sequences:

>Translated_187_residues
MLQDTRIGDSIAVNGVCLTATTFGEGVFVADVMAETLAKTNLRDLRPGSQVNLERALRLGDRLGGHMVSGHVDGVGTIAG
KEKHDIATLITIQAPPQVMKYIIKKGSIAIDGTSLTVVDFEGDKFQVSLIPHTAHATVLGNKKIGDSVNLESDVLGKYIE
RLLQGRQEEERPGSKMNLEFLATNGFL
>Mature_187_residues
MLQDTRIGDSIAVNGVCLTATTFGEGVFVADVMAETLAKTNLRDLRPGSQVNLERALRLGDRLGGHMVSGHVDGVGTIAG
KEKHDIATLITIQAPPQVMKYIIKKGSIAIDGTSLTVVDFEGDKFQVSLIPHTAHATVLGNKKIGDSVNLESDVLGKYIE
RLLQGRQEEERPGSKMNLEFLATNGFL

Specific function: Riboflavin synthase is a bifunctional enzyme complex catalyzing the formation of riboflavin from 5-amino-6-(1'-D)- ribityl-amino-2,4(1H,3H)-pyrimidinedione and L-3,4-dihydrohy-2- butanone-4-phosphate via 6,7-dimethyl-8-lumazine. The alpha subunit catalyze

COG id: COG0307

COG function: function code H; Riboflavin synthase alpha chain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 lumazine-binding repeats [H]

Homologues:

Organism=Escherichia coli, GI1787952, Length=182, Percent_Identity=40.1098901098901, Blast_Score=117, Evalue=6e-28,
Organism=Saccharomyces cerevisiae, GI6319733, Length=184, Percent_Identity=41.8478260869565, Blast_Score=135, Evalue=5e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001783
- InterPro:   IPR017938 [H]

Pfam domain/function: PF00677 Lum_binding [H]

EC number: =2.5.1.9 [H]

Molecular weight: Translated: 20112; Mature: 20112

Theoretical pI: Translated: 6.36; Mature: 6.36

Prosite motif: PS00693 LUM_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLQDTRIGDSIAVNGVCLTATTFGEGVFVADVMAETLAKTNLRDLRPGSQVNLERALRLG
CCCCCCCCCCEEECCEEEEEEECCCCEEHHHHHHHHHHHCCHHHCCCCCCCCHHHHHHHH
DRLGGHMVSGHVDGVGTIAGKEKHDIATLITIQAPPQVMKYIIKKGSIAIDGTSLTVVDF
HHCCCEEEECCCCCEEECCCCCCCCEEEEEEEECCHHHHHHHHHCCCEEECCCEEEEEEE
EGDKFQVSLIPHTAHATVLGNKKIGDSVNLESDVLGKYIERLLQGRQEEERPGSKMNLEF
CCCEEEEEEECCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHCCCCHHHCCCCCEEEEE
LATNGFL
EECCCCC
>Mature Secondary Structure
MLQDTRIGDSIAVNGVCLTATTFGEGVFVADVMAETLAKTNLRDLRPGSQVNLERALRLG
CCCCCCCCCCEEECCEEEEEEECCCCEEHHHHHHHHHHHCCHHHCCCCCCCCHHHHHHHH
DRLGGHMVSGHVDGVGTIAGKEKHDIATLITIQAPPQVMKYIIKKGSIAIDGTSLTVVDF
HHCCCEEEECCCCCEEECCCCCCCCEEEEEEEECCHHHHHHHHHCCCEEECCCEEEEEEE
EGDKFQVSLIPHTAHATVLGNKKIGDSVNLESDVLGKYIERLLQGRQEEERPGSKMNLEF
CCCEEEEEEECCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHCCCCHHHCCCCCEEEEE
LATNGFL
EECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8522537 [H]