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The map label for this gene is fabF [H]

Identifier: 134299916

GI number: 134299916

Start: 2268050

End: 2269291

Strand: Reverse

Name: fabF [H]

Synonym: Dred_2070

Alternate gene names: 134299916

Gene position: 2269291-2268050 (Counterclockwise)

Preceding gene: 134299917

Following gene: 134299915

Centisome position: 62.89

GC content: 47.99

Gene sequence:

>1242_bases
TTGTCAAAACGGGTTGTTGTAACCGGTCTGGGAGTAATCTCCCCTGTGGGCACCGGGCTGGACAAATTCTGGACTGCACT
TACTTCGGGTGTTTCTGGAATTGCCAGAATCACCAGGTTCGACCCGTCCGAATACTCCACCCAAATAGCGGGTGAGGTAA
AGGATTTTGATTACTCTAAGTATCTAGATAAAAAAGAGGCCCGTCGTATGGACAAGTTTTCCCAATATGCAGTGGTTTCA
GCGGCCATGGCCATAGAAGATGCGGGTCTTGACTTGGAGGCTTTGGATAAGGACCATACCGGTGTTATCGTTGGCTCTGG
TATTGGTGGAATGGAAACCTTTGAGGAACAATGCAAGGTATTGGTAAACCGGGGACCTAACCGGATTAGTCCCTTCCTGA
TCCCCATGATGATTGCCAATATGGCGGCAGGCCAGATCGCCATTAAATTTGGTCTAAGGGGTCCCAACATTACAACCATT
ACTGCTTGCGCTTCCAGTGGTAATGCCATAGGCGATGCCTTTAAGCTAATTCAAAGGGGTAATGCTGAGGTTGTGATCAC
TGGTGGAACGGAGGCACCGATTACACCCCTGGCCGTAGCAGGATTCTGTGCTGCCAAGGCCATGACAACTAATAATGATG
AACCCGAGCAAGCTAGCAGACCCTTTGATGCTAATCGGGACGGGTTTGTTATGGGTGAGGGTGCAGCCATGCTGGTGCTG
GAAACGCTGGAACATGCTCAAAAACGGGGAGCTCATATCTATGCTGAAATCGTAGGTTATGGTAGTACCTGCGATGCTTA
CCATATTACCGCTCCAGACCCGGAAGGATATGGTGCATCATCAGCTATGCGCATGGCTCTGGAAGATGCAGGATTAAAAC
CGGAGGATGTTCAGTATATCAACGCCCATGGTACTTCTACTCCCGTAGGGGATGTGGCGGAGGTTGGGGCTATTAAAAAA
GTATTTGGAGAACATGCCTATAAGTTAGTGGTAAGCTCAACCAAGTCCATGACCGGGCACATGCTGGGAGCAGCTGGAGC
CATAGAAGGAATGGCCTCCATTCTAACCATTAAAAATAGTATGGTACCGCCTACCATTAACTATGAAAACCCTGATCCTG
ATTGTGATTTGGATTTTGTACCCAATGAGGCCAGAGAAATGAATGTCGATGTGGCACTTTCTAACTCCTTTGGCTTCGGG
GGACATAACGTAACACTGGCCTTTAAAAAGTTTAATTTTTAG

Upstream 100 bases:

>100_bases
TCCGATGGTTTAATCCCTAGTATATTTATAATGCTTGTAGGGCGGTGAACCAAGGGTATAAAGTGCTAAGCTTTTTTCAA
AATGTAAGGAGGAAGTTATT

Downstream 100 bases:

>100_bases
AGCTGTGGTGATTCATTTGTCTAAACAAGACGAGCAAGCTAATCGCCTGAAAACACGTTTGGGTTTTAAGTGGCATAATC
CTACACTGCTGATACAGGCA

Product: beta-ketoacyl synthase

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase II; Beta-ketoacyl-ACP synthase II; KAS II [H]

Number of amino acids: Translated: 413; Mature: 412

Protein sequence:

>413_residues
MSKRVVVTGLGVISPVGTGLDKFWTALTSGVSGIARITRFDPSEYSTQIAGEVKDFDYSKYLDKKEARRMDKFSQYAVVS
AAMAIEDAGLDLEALDKDHTGVIVGSGIGGMETFEEQCKVLVNRGPNRISPFLIPMMIANMAAGQIAIKFGLRGPNITTI
TACASSGNAIGDAFKLIQRGNAEVVITGGTEAPITPLAVAGFCAAKAMTTNNDEPEQASRPFDANRDGFVMGEGAAMLVL
ETLEHAQKRGAHIYAEIVGYGSTCDAYHITAPDPEGYGASSAMRMALEDAGLKPEDVQYINAHGTSTPVGDVAEVGAIKK
VFGEHAYKLVVSSTKSMTGHMLGAAGAIEGMASILTIKNSMVPPTINYENPDPDCDLDFVPNEAREMNVDVALSNSFGFG
GHNVTLAFKKFNF

Sequences:

>Translated_413_residues
MSKRVVVTGLGVISPVGTGLDKFWTALTSGVSGIARITRFDPSEYSTQIAGEVKDFDYSKYLDKKEARRMDKFSQYAVVS
AAMAIEDAGLDLEALDKDHTGVIVGSGIGGMETFEEQCKVLVNRGPNRISPFLIPMMIANMAAGQIAIKFGLRGPNITTI
TACASSGNAIGDAFKLIQRGNAEVVITGGTEAPITPLAVAGFCAAKAMTTNNDEPEQASRPFDANRDGFVMGEGAAMLVL
ETLEHAQKRGAHIYAEIVGYGSTCDAYHITAPDPEGYGASSAMRMALEDAGLKPEDVQYINAHGTSTPVGDVAEVGAIKK
VFGEHAYKLVVSSTKSMTGHMLGAAGAIEGMASILTIKNSMVPPTINYENPDPDCDLDFVPNEAREMNVDVALSNSFGFG
GHNVTLAFKKFNF
>Mature_412_residues
SKRVVVTGLGVISPVGTGLDKFWTALTSGVSGIARITRFDPSEYSTQIAGEVKDFDYSKYLDKKEARRMDKFSQYAVVSA
AMAIEDAGLDLEALDKDHTGVIVGSGIGGMETFEEQCKVLVNRGPNRISPFLIPMMIANMAAGQIAIKFGLRGPNITTIT
ACASSGNAIGDAFKLIQRGNAEVVITGGTEAPITPLAVAGFCAAKAMTTNNDEPEQASRPFDANRDGFVMGEGAAMLVLE
TLEHAQKRGAHIYAEIVGYGSTCDAYHITAPDPEGYGASSAMRMALEDAGLKPEDVQYINAHGTSTPVGDVAEVGAIKKV
FGEHAYKLVVSSTKSMTGHMLGAAGAIEGMASILTIKNSMVPPTINYENPDPDCDLDFVPNEAREMNVDVALSNSFGFGG
HNVTLAFKKFNF

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Has a preference for short chain acid substrates [H]

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family [H]

Homologues:

Organism=Homo sapiens, GI8923559, Length=418, Percent_Identity=44.7368421052632, Blast_Score=371, Evalue=1e-103,
Organism=Homo sapiens, GI223972627, Length=161, Percent_Identity=51.5527950310559, Blast_Score=165, Evalue=6e-41,
Organism=Homo sapiens, GI41872631, Length=423, Percent_Identity=28.8416075650118, Blast_Score=143, Evalue=3e-34,
Organism=Escherichia coli, GI1787337, Length=410, Percent_Identity=53.6585365853659, Blast_Score=423, Evalue=1e-119,
Organism=Escherichia coli, GI1788663, Length=414, Percent_Identity=40.0966183574879, Blast_Score=270, Evalue=1e-73,
Organism=Caenorhabditis elegans, GI71983541, Length=413, Percent_Identity=36.0774818401937, Blast_Score=268, Evalue=3e-72,
Organism=Caenorhabditis elegans, GI71983535, Length=265, Percent_Identity=41.1320754716981, Blast_Score=209, Evalue=2e-54,
Organism=Caenorhabditis elegans, GI212642053, Length=362, Percent_Identity=28.7292817679558, Blast_Score=132, Evalue=5e-31,
Organism=Caenorhabditis elegans, GI17550940, Length=279, Percent_Identity=30.4659498207885, Blast_Score=90, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6320904, Length=450, Percent_Identity=39.3333333333333, Blast_Score=302, Evalue=7e-83,
Organism=Drosophila melanogaster, GI24644341, Length=421, Percent_Identity=43.7054631828979, Blast_Score=340, Evalue=8e-94,
Organism=Drosophila melanogaster, GI19920632, Length=431, Percent_Identity=25.5220417633411, Blast_Score=130, Evalue=1e-30,
Organism=Drosophila melanogaster, GI221330659, Length=431, Percent_Identity=25.5220417633411, Blast_Score=130, Evalue=1e-30,
Organism=Drosophila melanogaster, GI24581345, Length=432, Percent_Identity=25.9259259259259, Blast_Score=127, Evalue=1e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017568
- InterPro:   IPR000794
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C [H]

EC number: =2.3.1.179 [H]

Molecular weight: Translated: 43757; Mature: 43626

Theoretical pI: Translated: 4.86; Mature: 4.86

Prosite motif: PS00606 B_KETOACYL_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKRVVVTGLGVISPVGTGLDKFWTALTSGVSGIARITRFDPSEYSTQIAGEVKDFDYSK
CCCCEEEECCCHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCHHH
YLDKKEARRMDKFSQYAVVSAAMAIEDAGLDLEALDKDHTGVIVGSGIGGMETFEEQCKV
HHCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCCCEEEEECCCCCHHHHHHHHHH
LVNRGPNRISPFLIPMMIANMAAGQIAIKFGLRGPNITTITACASSGNAIGDAFKLIQRG
HHHCCCCCCCHHHHHHHHHHHCCCEEEEEEECCCCCEEEEEEECCCCCHHHHHHHHHHCC
NAEVVITGGTEAPITPLAVAGFCAAKAMTTNNDEPEQASRPFDANRDGFVMGEGAAMLVL
CCEEEEECCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHCCCCCCCCCCEEEECCHHHHHH
ETLEHAQKRGAHIYAEIVGYGSTCDAYHITAPDPEGYGASSAMRMALEDAGLKPEDVQYI
HHHHHHHHCCCEEEEEEEECCCCCCEEEEECCCCCCCCHHHHHHHHHHHCCCCCCCCEEE
NAHGTSTPVGDVAEVGAIKKVFGEHAYKLVVSSTKSMTGHMLGAAGAIEGMASILTIKNS
ECCCCCCCCCHHHHHHHHHHHHHHHHEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCC
MVPPTINYENPDPDCDLDFVPNEAREMNVDVALSNSFGFGGHNVTLAFKKFNF
CCCCCCCCCCCCCCCCCCCCCCCHHHEEEEEEEECCCCCCCCEEEEEEEECCC
>Mature Secondary Structure 
SKRVVVTGLGVISPVGTGLDKFWTALTSGVSGIARITRFDPSEYSTQIAGEVKDFDYSK
CCCEEEECCCHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCHHH
YLDKKEARRMDKFSQYAVVSAAMAIEDAGLDLEALDKDHTGVIVGSGIGGMETFEEQCKV
HHCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCCCEEEEECCCCCHHHHHHHHHH
LVNRGPNRISPFLIPMMIANMAAGQIAIKFGLRGPNITTITACASSGNAIGDAFKLIQRG
HHHCCCCCCCHHHHHHHHHHHCCCEEEEEEECCCCCEEEEEEECCCCCHHHHHHHHHHCC
NAEVVITGGTEAPITPLAVAGFCAAKAMTTNNDEPEQASRPFDANRDGFVMGEGAAMLVL
CCEEEEECCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHCCCCCCCCCCEEEECCHHHHHH
ETLEHAQKRGAHIYAEIVGYGSTCDAYHITAPDPEGYGASSAMRMALEDAGLKPEDVQYI
HHHHHHHHCCCEEEEEEEECCCCCCEEEEECCCCCCCCHHHHHHHHHHHCCCCCCCCEEE
NAHGTSTPVGDVAEVGAIKKVFGEHAYKLVVSSTKSMTGHMLGAAGAIEGMASILTIKNS
ECCCCCCCCCHHHHHHHHHHHHHHHHEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCC
MVPPTINYENPDPDCDLDFVPNEAREMNVDVALSNSFGFGGHNVTLAFKKFNF
CCCCCCCCCCCCCCCCCCCCCCCHHHEEEEEEEECCCCCCCCEEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8905231; 11152607 [H]